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5E92

TGF-BETA RECEPTOR TYPE 2 KINASE DOMAIN (E431A,R433A,E485A,K488A,R493A,R495A) IN COMPLEX WITH AMPPNP

Summary for 5E92
Entry DOI10.2210/pdb5e92/pdb
Related5E8S 5E8T 5E8U 5E8V 5E8W 5E8X 5E8Y 5E8Z 5E90 5E91
DescriptorTGF-beta receptor type-2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ... (4 entities in total)
Functional Keywordskinase domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCell membrane ; Single-pass type I membrane protein : P37173
Total number of polymer chains1
Total formula weight36395.49
Authors
Sheriff, S. (deposition date: 2015-10-14, release date: 2016-05-11, Last modification date: 2023-09-27)
Primary citationTebben, A.J.,Ruzanov, M.,Gao, M.,Xie, D.,Kiefer, S.E.,Yan, C.,Newitt, J.A.,Zhang, L.,Kim, K.,Lu, H.,Kopcho, L.M.,Sheriff, S.
Crystal structures of apo and inhibitor-bound TGF beta R2 kinase domain: insights into TGF beta R isoform selectivity.
Acta Crystallogr D Struct Biol, 72:658-674, 2016
Cited by
PubMed: 27139629
DOI: 10.1107/S2059798316003624
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.08 Å)
Structure validation

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