2OHQ
| X-ray crystal structure of beta secretase complexed with compound 4 | 分子名称: | 6-[2-(3'-METHOXYBIPHENYL-3-YL)ETHYL]PYRIDIN-2-AMINE, Beta-secretase 1, DIMETHYL SULFOXIDE, ... | 著者 | Patel, S. | 登録日 | 2007-01-10 | 公開日 | 2007-03-13 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Application of fragment screening by X-ray crystallography to the discovery of aminopyridines as inhibitors of beta-secretase. J.Med.Chem., 50, 2007
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2OHT
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5EOC
| Crystal structure of Fab C2 in complex with a Cyclic variant of Hepatitis C Virus E2 epitope I | 分子名称: | ALA-CYS-GLN-LEU-ILE-ASN-THR-ASN-GLY-SER-TRP-HIS-ILE-CYS, Fab fragment (Heavy chain), Fab fragment (Light chain) | 著者 | Berisio, R, Ruggiero, A, Sandomenico, A, Patel, A.H, Ruvo, M, Vitagliano, L. | 登録日 | 2015-11-10 | 公開日 | 2016-02-10 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Generation and Characterization of Monoclonal Antibodies against a Cyclic Variant of Hepatitis C Virus E2 Epitope 412-422. J.Virol., 90, 2016
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7AU7
| Crystal structure of Nod Factor Perception ectodomain | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Serine/threonine receptor-like kinase NFP, ... | 著者 | Gysel, K, Blaise, M, Andersen, K.R. | 登録日 | 2020-11-02 | 公開日 | 2021-11-10 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.547 Å) | 主引用文献 | Kinetic proofreading of lipochitooligosaccharides determines signal activation of symbiotic plant receptors. Proc.Natl.Acad.Sci.USA, 118, 2021
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7RB2
| Cryo-EM structure of SARS-CoV-2 NSP15 NendoU in BIS-Tris pH 6.0 | 分子名称: | Uridylate-specific endoribonuclease | 著者 | Godoy, A.S, Song, Y, Nakamura, A.M, Noske, G.D, Gawriljuk, V.O, Fernandes, R.S, Oliva, G. | 登録日 | 2021-07-05 | 公開日 | 2021-07-14 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | 主引用文献 | Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease. Nucleic Acids Res., 51, 2023
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7RB0
| Cryo-EM structure of SARS-CoV-2 NSP15 NendoU at pH 7.5 | 分子名称: | Uridylate-specific endoribonuclease | 著者 | Godoy, A.S, Song, Y, Nakamura, A.M, Noske, G.D, Gawriljuk, V.O, Fernandes, R.S, Oliva, G. | 登録日 | 2021-07-05 | 公開日 | 2021-07-14 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | 主引用文献 | Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease. Nucleic Acids Res., 51, 2023
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7P40
| P5C3 is a potent fab neutralizer | 分子名称: | Spike glycoprotein, Variable Heavy Chain P5C3 (VH), Variable Light Chain P5C3 (VL) | 著者 | perez, L. | 登録日 | 2021-07-09 | 公開日 | 2021-10-13 | 最終更新日 | 2023-04-12 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | A highly potent antibody effective against SARS-CoV-2 variants of concern. Cell Rep, 37, 2021
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7BAX
| Crystal structure of LYS11 ectodomain | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, LysM type receptor kinase | 著者 | Laursen, M, Cheng, J, Gysel, K, Blaise, M, Andersen, K.R. | 登録日 | 2020-12-16 | 公開日 | 2021-11-10 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Kinetic proofreading of lipochitooligosaccharides determines signal activation of symbiotic plant receptors. Proc.Natl.Acad.Sci.USA, 118, 2021
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7XAD
| Crystal strucutre of PD-L1 and DBL2_02 designed protein binder | 分子名称: | DBL2_02 binder, Programmed cell death 1 ligand 1 | 著者 | Liu, K.F, Xu, Z.P, Han, P, Pacesa, M, Gao, G.F, Chai, Y, Tan, S.G. | 登録日 | 2022-03-17 | 公開日 | 2023-04-12 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | De novo design of protein interactions with learned surface fingerprints. Nature, 617, 2023
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4J35
| Molecular Engineering of Organophosphate Hydrolysis Activity from a Weak Promiscuous Lactonase Template | 分子名称: | COBALT (II) ION, Phosphotriesterase, putative | 著者 | Sterner, R, Raushel, F, Meier, M, Rajendran, C, Malisi, C, Fox, N, Schlee, S, Barondeau, D, Cker, B.H. | 登録日 | 2013-02-05 | 公開日 | 2013-07-24 | 最終更新日 | 2013-09-04 | 実験手法 | X-RAY DIFFRACTION (1.783 Å) | 主引用文献 | Molecular engineering of organophosphate hydrolysis activity from a weak promiscuous lactonase template. J.Am.Chem.Soc., 135, 2013
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7XYQ
| Crystal strucutre of PD-L1 and the computationally designed DBL1_03 protein binder | 分子名称: | ARGININE, CD274 molecule, DBL1_03 | 著者 | Liu, K, Xu, Z, Han, P, Pacesa, M, Gao, G.F, Chai, Y, Tan, S. | 登録日 | 2022-06-02 | 公開日 | 2023-04-12 | 最終更新日 | 2023-05-17 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | De novo design of protein interactions with learned surface fingerprints. Nature, 617, 2023
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1ZXC
| Crystal structure of catalytic domain of TNF-alpha converting enzyme (TACE) with inhibitor | 分子名称: | (3S)-4-{[4-(BUT-2-YNYLOXY)PHENYL]SULFONYL}-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDE, ADAM 17, ZINC ION | 著者 | Levin, J.I, Chen, J.M, Laakso, L.M, Du, M, Schmid, J, Xu, W, Cummons, T, Xu, J, Zhang, Y, Jin, G, Cowling, R, Barone, D, Skotnicki, J.S. | 登録日 | 2005-06-07 | 公開日 | 2005-09-27 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Acetylenic TACE inhibitors. Part 2: SAR of six-membered cyclic sulfonamide hydroxamates. Bioorg.Med.Chem.Lett., 15, 2005
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5SSN
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5SS6
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5SSO
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5SS8
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5SSM
| PanDDA analysis group deposition -- Crystal structure of SARS-CoV-2 NSP3 macrodomain in complex with Z5459166256 - (R,R) and (S,S) isomers | 分子名称: | (1R,2R)-1-[(1H-benzimidazole-5-carbonyl)amino]-4-hydroxy-2,3-dihydro-1H-indene-2-carboxylic acid, (1S,2S)-1-[(1H-benzimidazole-5-carbonyl)amino]-4-hydroxy-2,3-dihydro-1H-indene-2-carboxylic acid, Non-structural protein 3 | 著者 | Correy, G.J, Fraser, J.S. | 登録日 | 2022-06-09 | 公開日 | 2022-07-06 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 120, 2023
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5SS9
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5SSR
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5SRC
| PanDDA analysis group deposition -- Crystal structure of SARS-CoV-2 NSP3 macrodomain in complex with Z5198562500 - (R,R) and (R,S) isomers | 分子名称: | (2R)-[(3R)-1-(7-fluoro-9H-pyrimido[4,5-b]indol-4-yl)piperidin-3-yl](hydroxy)acetic acid, (2S)-[(3R)-1-(7-fluoro-9H-pyrimido[4,5-b]indol-4-yl)piperidin-3-yl](hydroxy)acetic acid, Non-structural protein 3 | 著者 | Correy, G.J, Fraser, J.S. | 登録日 | 2022-06-09 | 公開日 | 2022-07-06 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | 主引用文献 | Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 120, 2023
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5SRD
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5SRE
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5SRF
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5SRG
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5SRH
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