8I1H
 
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8I1J
 | | Crystal structure of human MTH1(G2K/D120N mutant) in complex with 2-oxo-dATP at pH 9.7 | | 分子名称: | 7,8-dihydro-8-oxoguanine triphosphatase, SODIUM ION, [[(2R,3S,5R)-5-(6-azanyl-2-oxidanylidene-1H-purin-9-yl)-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate | | 著者 | Nakamura, T, Yamagata, Y. | | 登録日 | 2023-01-13 | | 公開日 | 2023-03-22 | | 最終更新日 | 2023-07-26 | | 実験手法 | X-RAY DIFFRACTION (1.08 Å) | | 主引用文献 | Protonation states of Asp residues in the human Nudix hydrolase MTH1 contribute to its broad substrate recognition.
Febs Lett., 597, 2023
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8I8T
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8I1F
 | | Crystal structure of human MTH1(G2K mutant) in complex with 2-oxo-dATP at pH 8.6 | | 分子名称: | 7,8-dihydro-8-oxoguanine triphosphatase, SODIUM ION, [[(2R,3S,5R)-5-(6-azanyl-2-oxidanylidene-1H-purin-9-yl)-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate | | 著者 | Nakamura, T, Yamagata, Y. | | 登録日 | 2023-01-13 | | 公開日 | 2023-03-22 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | | 主引用文献 | Protonation states of Asp residues in the human Nudix hydrolase MTH1 contribute to its broad substrate recognition.
Febs Lett., 597, 2023
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8I8S
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8I1G
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8HSH
 | | Thermus thermophilus RNA polymerase coreenzyme | | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | 著者 | Murayama, Y, Ehara, H, Sekine, S. | | 登録日 | 2022-12-19 | | 公開日 | 2023-05-03 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase from Thermus thermophilus.
Sci Adv, 9, 2023
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8HSG
 | | Thermus thermophilus RNA polymerase elongation complex | | 分子名称: | DNA (27-MER), DNA (37-MER), DNA-directed RNA polymerase subunit alpha, ... | | 著者 | Murayama, Y, Ehara, H, Sekine, S. | | 登録日 | 2022-12-19 | | 公開日 | 2023-05-03 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase from Thermus thermophilus.
Sci Adv, 9, 2023
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8HSL
 | | Thermus thermophilus RNA polymerase bound with an inverted Rho hexamer | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA-directed RNA polymerase subunit alpha, ... | | 著者 | Murayama, Y, Ehara, H, Sekine, S. | | 登録日 | 2022-12-19 | | 公開日 | 2023-05-03 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (5.8 Å) | | 主引用文献 | Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase from Thermus thermophilus.
Sci Adv, 9, 2023
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8HSJ
 | | Thermus thermophilus transcription termination factor Rho bound with ADP-BeF3 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | | 著者 | Murayama, Y, Ehara, H, Sekine, S. | | 登録日 | 2022-12-19 | | 公開日 | 2023-05-03 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase from Thermus thermophilus.
Sci Adv, 9, 2023
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8HSR
 | | Thermus thermophilus Rho-engaged RNAP elongation complex (composite structure) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (31-MER), ... | | 著者 | Murayama, Y, Ehara, H, Sekine, S. | | 登録日 | 2022-12-20 | | 公開日 | 2023-05-03 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase from Thermus thermophilus.
Sci Adv, 9, 2023
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1V7C
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1VB3
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5Y6Q
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1KA9
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1Y37
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2YXO
 | | Histidinol Phosphate Phosphatase complexed with Sulfate | | 分子名称: | FE (III) ION, GLYCEROL, Histidinol phosphatase, ... | | 著者 | Omi, R. | | 登録日 | 2007-04-26 | | 公開日 | 2007-11-27 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Crystal Structure of Monofunctional Histidinol Phosphate Phosphatase from Thermus thermophilus HB8.
Biochemistry, 46, 2007
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2YZ5
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2Z4G
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5Y9L
 | | Human kallikrein 7 in complex with 1,3,6-trisubstituted 1,4-diazepane-7-one | | 分子名称: | 3-[2-[(3Z,6R)-6-[(5-chloranyl-2-methoxy-phenyl)methyl]-3-(dimethylhydrazinylidene)-7-oxidanylidene-1,4-diazepan-1-yl]ethanoylamino]benzoic acid, CHLORIDE ION, Kallikrein-7 | | 著者 | Sugawara, H. | | 登録日 | 2017-08-25 | | 公開日 | 2017-11-29 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Discovery and structure-activity relationship study of 1,3,6-trisubstituted 1,4-diazepane-7-ones as novel human kallikrein 7 inhibitors
Bioorg. Med. Chem. Lett., 27, 2017
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5YJK
 | | Human kallikrein 7 in complex with 1,4-diazepane-7-one 1-acetamide derivative | | 分子名称: | (R)-2-(6-(5-chloro-2-methoxybenzyl)-3-(2,2-dimethylhydrazono)-7-oxo-1,4-diazepan-1-yl)-N-(3-(methylsulfonyl)phenyl)acetamide, CHLORIDE ION, Kallikrein-7 | | 著者 | Sugawara, H. | | 登録日 | 2017-10-11 | | 公開日 | 2017-12-06 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Discovery and structure-activity relationship study of 1,3,6-trisubstituted 1,4-diazepane-7-ones as novel human kallikrein 7 inhibitors
Bioorg. Med. Chem. Lett., 27, 2017
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3A9Z
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3A9Y
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3A9X
 | | Crystal structure of rat selenocysteine lyase | | 分子名称: | PHOSPHATE ION, PYRIDOXAL-5'-PHOSPHATE, Selenocysteine lyase | | 著者 | Omi, R, Hirotsu, K. | | 登録日 | 2009-11-08 | | 公開日 | 2010-03-16 | | 最終更新日 | 2013-10-30 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Reaction mechanism and molecular basis for selenium/sulfur discrimination of selenocysteine lyase.
J.Biol.Chem., 285, 2010
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6M9L
 | | Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridine-2-one based p38 MAP Kinase Inhibitors by scaffold hopping - compound 10 | | 分子名称: | 3-benzyl-6-[(2,4-difluorophenyl)amino]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one, Mitogen-activated protein kinase 14 | | 著者 | Lane, W, Okada, K. | | 登録日 | 2018-08-23 | | 公開日 | 2019-04-17 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridin-2-one-Based p38 MAP Kinase Inhibitors: Part 1.
Chemmedchem, 14, 2019
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