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Porcine pancreatic elastase complexed with beta-casomorphin-7 and Lys-Ser at pH 5.0
分子名称:	CALCIUM ION, Elastase-1, LYSINE, ...
著者	Liu, B, Schofield, C.J, Wilmouth, R.C.
登録日	2005-10-20
公開日	2006-05-30
最終更新日	2023-10-25
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	Structural analyses on intermediates in serine protease catalysis J.Biol.Chem., 281, 2006

7UQ3

JmjC domain-containing protein 5 (JMJD5) in complex with Mn and (S)-2-(1-hydroxy-2,5-dioxopyrrolidin-3-yl)acetic acid
分子名称:	Bifunctional peptidase and arginyl-hydroxylase JMJD5, GLYCEROL, MANGANESE (II) ION, ...
著者	Chowdhury, R, Islam, M.S, Schofield, C.J.
登録日	2022-04-19
公開日	2022-12-21
最終更新日	2023-10-25
実験手法	X-RAY DIFFRACTION (1.49 Å)
主引用文献	Structural analysis of the 2-oxoglutarate binding site of the circadian rhythm linked oxygenase JMJD5. Sci Rep, 12, 2022

2BB4

Porcine pancreatic elastase complexed with beta-casomorphin-7 and Asp-Phe at pH 5.0
分子名称:	ASPARTIC ACID, CALCIUM ION, Elastase-1, ...
著者	Liu, B, Schofield, C.J, Wilmouth, R.C.
登録日	2005-10-17
公開日	2006-05-30
最終更新日	2023-10-25
実験手法	X-RAY DIFFRACTION (1.6 Å)
主引用文献	Structural analyses on intermediates in serine protease catalysis J.Biol.Chem., 281, 2006

1YCI

Factor inhibiting HIF-1 alpha in complex with N-(carboxycarbonyl)-D-phenylalanine
分子名称:	FE (II) ION, Hypoxia-inducible factor 1 alpha inhibitor, N-(CARBOXYCARBONYL)-D-PHENYLALANINE, ...
著者	McDonough, M.A, Schofield, C.J.
登録日	2004-12-22
公開日	2005-05-31
最終更新日	2023-10-25
実験手法	X-RAY DIFFRACTION (2.7 Å)
主引用文献	Selective inhibition of factor inhibiting hypoxia-inducible factor J.Am.Chem.Soc., 127, 2005

2ILM

Factor Inhibiting HIF-1 Alpha D201A Mutant in Complex with FE(II), Alpha-Ketoglutarate and HIF-1 Alpha 35mer
分子名称:	2-OXOGLUTARIC ACID, BICARBONATE ION, FE (II) ION, ...
著者	Mcdonough, M.A, Schofield, C.J.
登録日	2006-10-03
公開日	2007-08-14
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH). J.Biol.Chem., 283, 2008

6QGV

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with a Spiro[4.5]decanone inhibitor (JPHM-2-167)
分子名称:	8-[(3-methylpyridin-2-yl)methyl]-3-(4-phenylphenyl)-1-pyrimidin-2-yl-1,3,8-triazaspiro[4.5]decane-2,4-dione, Egl nine homolog 1, GLYCEROL, ...
著者	Chowdhury, R, Holt-Martyn, J.P, Rahman, M.Z, Schofield, C.J.
登録日	2019-01-13
公開日	2020-02-05
最終更新日	2024-01-24
実験手法	X-RAY DIFFRACTION (1.4 Å)
主引用文献	Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors. Medchemcomm, 10, 2019

6ST3

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with 4-hydroxy-N-(4-phenoxybenzyl)-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamide
分子名称:	4-oxidanyl-~{N}-[(4-phenoxyphenyl)methyl]-2-pyrazol-1-yl-pyrimidine-5-carboxamide, Egl nine homolog 1, FORMIC ACID, ...
著者	Chowdhury, R, Holt-Martyn, J.P, Schofield, C.J.
登録日	2019-09-10
公開日	2019-12-04
最終更新日	2024-01-24
実験手法	X-RAY DIFFRACTION (2.426 Å)
主引用文献	Structure-Activity Relationship and Crystallographic Studies on 4-Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors. Chemmedchem, 15, 2020

2ZGG

Asn-hydroxylation stabilises the ankyrin repeat domain fold
分子名称:	3 repeat synthetic ankyrin, CADMIUM ION, COBALT (II) ION
著者	McDonough, M.A, Schofield, C.J.
登録日	2008-01-21
公開日	2008-02-05
最終更新日	2023-11-01
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Asparagine beta-hydroxylation stabilizes the ankyrin repeat domain fold Mol Biosyst, 5, 2009

2Y34

S-nitrosylated PHD2 (NO exposed) in complex with Fe(II) and UN9
分子名称:	EGL NINE HOMOLOG 1, FE (II) ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE
著者	Chowdhury, R, McDonough, M.A, Schofield, C.J.
登録日	2010-12-18
公開日	2010-12-29
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (2.01 Å)
主引用文献	Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1). J. Mol. Biol., 410, 2011

2Y33

S-nitrosylated PHD2 (GSNO soaked) in complex with Zn(II) and UN9
分子名称:	EGL NINE HOMOLOG 1, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ZINC ION
著者	Chowdhury, R, Clifton, I.J, Schofield, C.J.
登録日	2010-12-18
公開日	2010-12-29
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Studies on the Reaction of Nitric Oxide with the Hypoxia-Inducible Factor Prolyl Hydroxylase Domain 2 (Egln1) J.Mol.Biol., 410, 2011

2ZGD

Asn-hydroxylation stabilises the ankyrin repeat domain fold
分子名称:	3 repeat synthetic ankyrin, CADMIUM ION, CHLORIDE ION
著者	McDonough, M.A, Schofield, C.J.
登録日	2008-01-21
公開日	2008-02-05
最終更新日	2023-11-01
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Asparagine beta-hydroxylation stabilizes the ankyrin repeat domain fold Mol Biosyst, 5, 2009

5LAS

HIF prolyl hydroxylase 2 (PHD2-R281C/P317C/R396T) cross-linked to HIF-1alpha NODD-L397C/D412C and N-oxalylglycine (NOG) (complex-3)
分子名称:	Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, MANGANESE (II) ION, ...
著者	Chowdhury, R, Schofield, C.J.
登録日	2016-06-14
公開日	2016-08-31
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LB6

HIF prolyl hydroxylase 2 (PHD2/EGLN1) R371H variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)
分子名称:	Egl nine homolog 1, GLYCEROL, MANGANESE (II) ION, ...
著者	Chowdhury, R, Schofield, C.J.
登録日	2016-06-15
公開日	2016-08-31
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LBE

HIF prolyl hydroxylase 2 (PHD2/EGLN1) G294E variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/FG2216)
分子名称:	BICARBONATE ION, Egl nine homolog 1, MANGANESE (II) ION, ...
著者	Chowdhury, R, Schofield, C.J.
登録日	2016-06-15
公開日	2016-08-31
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.749 Å)
主引用文献	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LBC

HIF prolyl hydroxylase 2 (PHD2/EGLN1) I280V/R281L/I292V variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/FG2216)
分子名称:	BICARBONATE ION, CHLORIDE ION, Egl nine homolog 1, ...
著者	Chowdhury, R, Schofield, C.J.
登録日	2016-06-15
公開日	2016-08-31
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.816 Å)
主引用文献	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LBB

HIF prolyl hydroxylase 2 (PHD2/EGLN1) R396T variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)
分子名称:	BICARBONATE ION, Egl nine homolog 1, MANGANESE (II) ION, ...
著者	Chowdhury, R, Schofield, C.J.
登録日	2016-06-15
公開日	2016-08-31
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5L9R

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with N-oxalylglycine (NOG)
分子名称:	Egl nine homolog 1, GLYCEROL, MANGANESE (II) ION, ...
著者	Chowdhury, R, Schofield, C.J.
登録日	2016-06-10
公開日	2016-08-31
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.81 Å)
主引用文献	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LBF

HIF prolyl hydroxylase 2 (PHD2/EGLN1) K293K/G294E variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/FG2216)
分子名称:	BICARBONATE ION, Egl nine homolog 1, MANGANESE (II) ION, ...
著者	Chowdhury, R, Schofield, C.J.
登録日	2016-06-16
公開日	2016-08-31
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.8995 Å)
主引用文献	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LAT

HIF prolyl hydroxylase 2 (PHD2/EGLN1) P317R variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)
分子名称:	BICARBONATE ION, Egl nine homolog 1, GLYCEROL, ...
著者	Chowdhury, R, Schofield, C.J.
登録日	2016-06-15
公開日	2016-08-31
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5L9B

HIF PROLYL HYDROXYLASE 2 (PHD2/ EGLN1) IN COMPLEX WITH 2-OXOGLUTARATE (2OG) AND HIF-1ALPHA CODD (556-574)
分子名称:	2-OXOGLUTARIC ACID, Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, ...
著者	Chowdhury, R, Schofield, C.J.
登録日	2016-06-10
公開日	2016-08-31
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.95 Å)
主引用文献	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LA9

HIF prolyl hydroxylase 2 (PHD2-R281C/V314C) cross-linked to HIF-1alpha NODD-L397C/D412C and N-oxalylglycine (NOG) (complex-2)
分子名称:	Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, MANGANESE (II) ION, ...
著者	Chowdhury, R, Schofield, C.J.
登録日	2016-06-14
公開日	2016-08-31
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (2.813 Å)
主引用文献	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

7YXI

Drosophila melanogaster JMJD7 (dmJMJD7) in complex with Mn and N-oxalylglycine (NOG)
分子名称:	1,2-ETHANEDIOL, GH14974p, MANGANESE (II) ION, ...
著者	Chowdhury, R, Schofield, C.J.
登録日	2022-02-16
公開日	2022-04-27
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans. Sci Rep, 12, 2022

7YXL

Drosophila melanogaster JMJD7 (dmJMJD7) in complex with Mn and N-oxalyl-D-phenylalanine (NOFD)
分子名称:	1,2-ETHANEDIOL, ACETATE ION, GH14974p, ...
著者	Chowdhury, R, Schofield, C.J.
登録日	2022-02-16
公開日	2022-04-27
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans. Sci Rep, 12, 2022

7YXG

Drosophila melanogaster JMJD7 (dmJMJD7) in complex with Mn and 2OG
分子名称:	1,2-ETHANEDIOL, 2-OXOGLUTARIC ACID, GH14974p, ...
著者	Chowdhury, R, Schofield, C.J.
登録日	2022-02-16
公開日	2022-04-27
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (1.641 Å)
主引用文献	Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans. Sci Rep, 12, 2022

7YXK

Drosophila melanogaster JMJD7 (dmJMJD7) in complex with Mn and N-oxalyl-D-alanine (NODA)
分子名称:	(2~{R})-2-(carboxycarbonylamino)propanoic acid, 1,2-ETHANEDIOL, ACETATE ION, ...
著者	Chowdhury, R, Schofield, C.J.
登録日	2022-02-16
公開日	2022-04-27
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (2.43 Å)
主引用文献	Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans. Sci Rep, 12, 2022

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