6PVO
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8G9V
| Crystal structures of 17-beta-hydroxysteroid dehydrogenase 13 | 分子名称: | 17-beta-hydroxysteroid dehydrogenase 13, 4-{[2,5-dimethyl-3-(4-methylbenzene-1-sulfonyl)benzene-1-sulfonyl]amino}benzoic acid, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | 著者 | Liu, S. | 登録日 | 2023-02-22 | 公開日 | 2023-08-09 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.645 Å) | 主引用文献 | Structural basis of lipid-droplet localization of 17-beta-hydroxysteroid dehydrogenase 13. Nat Commun, 14, 2023
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8G93
| Crystal structures of 17-beta-hydroxysteroid dehydrogenase 13 | 分子名称: | 3-fluoro-N-({(1r,4r)-4-[(2-fluorophenoxy)methyl]-1-hydroxycyclohexyl}methyl)-4-hydroxybenzamide, Hydroxysteroid 17-beta dehydrogenase 13, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Liu, S. | 登録日 | 2023-02-21 | 公開日 | 2023-08-09 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Structural basis of lipid-droplet localization of 17-beta-hydroxysteroid dehydrogenase 13. Nat Commun, 14, 2023
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8G84
| Crystal structures of HSD17B13 complexes | 分子名称: | Hydroxysteroid 17-beta dehydrogenase 13, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Liu, S. | 登録日 | 2023-02-17 | 公開日 | 2023-08-09 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.467 Å) | 主引用文献 | Structural basis of lipid-droplet localization of 17-beta-hydroxysteroid dehydrogenase 13. Nat Commun, 14, 2023
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8G89
| HSD17B13 in complex with cofactor and inhibitor | 分子名称: | 3-fluoro-N-({(1r,4r)-4-[(2-fluorophenoxy)methyl]-1-hydroxycyclohexyl}methyl)-4-hydroxybenzamide, Hydroxysteroid 17-beta dehydrogenase 13, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Liu, S. | 登録日 | 2023-02-17 | 公開日 | 2023-08-09 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.222 Å) | 主引用文献 | Structural basis of lipid-droplet localization of 17-beta-hydroxysteroid dehydrogenase 13. Nat Commun, 14, 2023
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5YLX
| Integrated illustration of a valid epitope based on the SLA class I structure and tetramer technique could carry forward the development of molecular vaccine in swine species | 分子名称: | Beta-2-microglobulin, MHC class I antigen, PRRSV-NSP9-TMP9 peptide | 著者 | Pan, X.C, Wei, X.H, Zhang, N, Xia, C. | 登録日 | 2017-10-20 | 公開日 | 2018-10-24 | 最終更新日 | 2020-05-06 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Illumination of PRRSV Cytotoxic T Lymphocyte Epitopes by the Three-Dimensional Structure and Peptidome of Swine Lymphocyte Antigen Class I (SLA-I). Front Immunol, 10, 2019
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6PW4
| Cryo-EM Structure of Thermo-Sensitive TRP Channel TRP1 from the Alga Chlamydomonas reinhardtii in Detergent | 分子名称: | (2S)-3-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dihexadecanoate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | 著者 | McGoldrick, L.L, Singh, A.K, Sobolevsky, A.I. | 登録日 | 2019-07-22 | 公開日 | 2019-09-25 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.53 Å) | 主引用文献 | Structure of the thermo-sensitive TRP channel TRP1 from the alga Chlamydomonas reinhardtii. Nat Commun, 10, 2019
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5IL9
| Crystal structure of Deg9 | 分子名称: | GLYCEROL, Protease Do-like 9 | 著者 | Ouyang, M, Liu, L, Li, X.Y, Zhao, S, Zhang, L.X. | 登録日 | 2016-03-04 | 公開日 | 2017-03-08 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The crystal structure of Deg9 reveals a novel octameric-type HtrA protease Nat Plants, 3, 2017
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3CIC
| Structure of BACE Bound to SCH709583 | 分子名称: | Beta-secretase 1, D(-)-TARTARIC ACID, N'-[(1S,2S)-2-[(2S)-4-benzyl-3-oxopiperazin-2-yl]-1-(3,5-difluorobenzyl)-2-hydroxyethyl]-5-methyl-N,N-dipropylbenzene-1,3-dicarboxamide | 著者 | Strickland, C, Cumming, J. | 登録日 | 2008-03-11 | 公開日 | 2008-06-10 | 最終更新日 | 2017-10-25 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Rational design of novel, potent piperazinone and imidazolidinone BACE1 inhibitors Bioorg.Med.Chem.Lett., 18, 2008
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7A25
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8W2O
| Yeast U1 snRNP with humanized U1C Zinc-Finger domain | 分子名称: | 56 kDa U1 small nuclear ribonucleoprotein component, ACT1 pre-mRNA, Pre-mRNA-processing factor 39, ... | 著者 | Shi, S.S, Kuang, Z.L, Zhao, R. | 登録日 | 2024-02-20 | 公開日 | 2024-05-15 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.49 Å) | 主引用文献 | Selected humanization of yeast U1 snRNP leads to global suppression of pre-mRNA splicing and mitochondrial dysfunction in the budding yeast. Rna, 30, 2024
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6PVP
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8KB0
| Crystal structure of 01JD-AEAIIVAMV | 分子名称: | Beta2-microglobulin, MHC class I antigen alpha chain, peptide of AIV | 著者 | Tang, Z, Zhang, N. | 登録日 | 2023-08-03 | 公開日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | The impact of micropolymorphism in Anpl-UAA on structural stability and peptide presentation. Int.J.Biol.Macromol., 267, 2024
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8KB1
| Crystal structure of 11JD | 分子名称: | Beta2-microglobulin, MHC class I antigen, peptide of AIV | 著者 | Tang, Z, Zhang, N. | 登録日 | 2023-08-03 | 公開日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | 主引用文献 | The impact of micropolymorphism in Anpl-UAA on structural stability and peptide presentation. Int.J.Biol.Macromol., 267, 2024
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5E8Y
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3U3Q
| The S-SAD phased crystal structure of the ecto-domain of Death Receptor 6 (DR6) | 分子名称: | Tumor necrosis factor receptor superfamily member 21 | 著者 | Ru, H, Zhao, L.X, Ding, W, Jiao, L.Y, Shaw, N, Zhang, L.G, Hung, L.W, Matsugaki, N, Wakatsuki, S, Liu, Z.J. | 登録日 | 2011-10-06 | 公開日 | 2012-05-02 | 最終更新日 | 2013-07-10 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | S-SAD phasing study of death receptor 6 and its solution conformation revealed by SAXS. Acta Crystallogr.,Sect.D, 68, 2012
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2Q1J
| The discovery of glycine and related amino acid-based factor xa inhibitors | 分子名称: | 1-(butyl{[(4-chlorophenyl)amino]carbonyl}amino)-N-[3-fluoro-2'-(methylsulfonyl)biphenyl-4-yl]cyclopropanecarboxamide, Activated factor Xa heavy chain (EC 3.4.21.6), CALCIUM ION, ... | 著者 | Kohrt, J.T, Filipski, K.J, Cody, W.L, Bigge, C.F, Zhang, E, Finzel, B.C. | 登録日 | 2007-05-24 | 公開日 | 2007-08-14 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The Discovery of Glycine and Related Amino Acid-Based Factor Xa Inhibitors BIOORG.MED.CHEM., 14, 2006
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5HDM
| Crystal structure of Arabidopsis thaliana glutamate-1-semialdehyde-2,1-aminomutase | 分子名称: | 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, Glutamate-1-semialdehyde 2,1-aminomutase 1, chloroplastic, ... | 著者 | Song, Y, Pu, H, Liu, L. | 登録日 | 2016-01-05 | 公開日 | 2016-06-15 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Crystal structure of glutamate-1-semialdehyde-2,1-aminomutase from Arabidopsis thaliana. Acta Crystallogr.,Sect.F, 72, 2016
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7EJ2
| human voltage-gated potassium channel KV1.3 H451N mutant | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Potassium voltage-gated channel subfamily A member 3, Voltage-gated potassium channel subunit beta-2 | 著者 | Liu, S, Zhao, Y, Tian, C. | 登録日 | 2021-04-01 | 公開日 | 2021-06-09 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structures of wild-type and H451N mutant human lymphocyte potassium channel K V 1.3. Cell Discov, 7, 2021
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7EJ1
| human voltage-gated potassium channel KV1.3 | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Potassium voltage-gated channel subfamily A member 3, Voltage-gated potassium channel subunit beta-2 | 著者 | Liu, S, Zhao, Y, Tian, C. | 登録日 | 2021-04-01 | 公開日 | 2021-06-09 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structures of wild-type and H451N mutant human lymphocyte potassium channel K V 1.3. Cell Discov, 7, 2021
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3CE3
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6DBK
| Tyk2 with compound 8 | 分子名称: | 4-({4-[(1S,4S)-5-(cyanoacetyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl]pyrimidin-2-yl}amino)-N-ethylbenzamide, Non-receptor tyrosine-protein kinase TYK2 | 著者 | Vajdos, F.F. | 登録日 | 2018-05-03 | 公開日 | 2018-08-29 | 最終更新日 | 2018-11-07 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841). J. Med. Chem., 61, 2018
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5E8V
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5E8X
| TGF-BETA RECEPTOR TYPE 1 KINASE DOMAIN (T204D,I211V,Y249F,S280T, Y282F,S287N,A350C,L352F) IN COMPLEX WITH STAUROSPORINE | 分子名称: | GLYCEROL, STAUROSPORINE, TGF-beta receptor type-1 | 著者 | Sheriff, S. | 登録日 | 2015-10-14 | 公開日 | 2016-05-11 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Crystal structures of apo and inhibitor-bound TGF beta R2 kinase domain: insights into TGF beta R isoform selectivity. Acta Crystallogr D Struct Biol, 72, 2016
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7XS8
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