2Q1J

The discovery of glycine and related amino acid-based factor xa inhibitors

Summary for 2Q1J

Entry DOI	10.2210/pdb2q1j/pdb
Descriptor	Activated factor Xa heavy chain (EC 3.4.21.6), Factor X light chain (EC 3.4.21.6), CALCIUM ION, ... (5 entities in total)
Functional Keywords	coagulation fxa, blood coagulation, calcium, cleavage on pair of basic residues, egf-like domain, gamma-carboxyglutamic acid, glycoprotein, hydrolase, hydroxylation, polymorphism, protease, serine protease, zymogen
Biological source	Homo sapiens (human) More
Cellular location	Secreted: P00742 P00742
Total number of polymer chains	2
Total formula weight	32505.30
Authors	Kohrt, J.T.,Filipski, K.J.,Cody, W.L.,Bigge, C.F.,Zhang, E.,Finzel, B.C. (deposition date: 2007-05-24, release date: 2007-08-14, Last modification date: 2011-07-13)
Primary citation	Kohrt, J.T.,Filipski, K.J.,Cody, W.L.,Bigge, C.F.,La, F.,Welch, K.,Dahring, T.,Bryant, J.W.,Leonard, D.,Bolton, G.,Narasimhan, L.,Zhang, E.,Peterson, J.T.,Haarer, S.,Sahasrabudhe, V.,Janiczek, N.,Desiraju, S.,Hena, M.,Fiakpui, C.,Saraswat, N.,Sharma, R.,Sun, S.,Maiti, S.N.,Leadley, R.,Edmunds, J.J. The Discovery of Glycine and Related Amino Acid-Based Factor Xa Inhibitors BIOORG.MED.CHEM., 14:4379-4392, 2006 Cited by PubMed: 16529937 DOI: 10.1016/j.bmc.2006.02.040 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation