8DCP
 
 | | PI 3-kinase alpha with nanobody 3-126 | | 分子名称: | Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | | 著者 | Hart, J.R, Liu, X, Pan, C, Liang, A, Ueno, L, Xu, Y, Quezada, A, Zou, X, Yang, S, Zhou, Q, Schoonooghe, S, Hassanzadeh-Ghassabeh, G, Xia, T, Shui, W, Yang, D, Vogt, P.K, Wang, M.-W. | | 登録日 | 2022-06-17 | | 公開日 | 2022-09-21 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (2.41 Å) | | 主引用文献 | Nanobodies and chemical cross-links advance the structural and functional analysis of PI3K alpha.
Proc.Natl.Acad.Sci.USA, 119, 2022
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8DD8
 | | PI 3-kinase alpha with nanobody 3-142, crosslinked with DSG | | 分子名称: | Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | | 著者 | Hart, J.R, Liu, X, Pan, C, Liang, A, Ueno, L, Xu, Y, Quezada, A, Zou, X, Yang, S, Zhou, Q, Schoonooghe, S, Hassanzadeh-Ghassabeh, G, Xia, T, Shui, W, Yang, D, Vogt, P.K, Wang, M.-W. | | 登録日 | 2022-06-17 | | 公開日 | 2022-09-21 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Nanobodies and chemical cross-links advance the structural and functional analysis of PI3K alpha.
Proc.Natl.Acad.Sci.USA, 119, 2022
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8DD4
 | | PI 3-kinase alpha with nanobody 3-142 | | 分子名称: | Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | | 著者 | Hart, J.R, Liu, X, Pan, C, Liang, A, Ueno, L, Xu, Y, Quezada, A, Zou, X, Yang, S, Zhou, Q, Schoonooghe, S, Hassanzadeh-Ghassabeh, G, Xia, T, Shui, W, Yang, D, Vogt, P.K, Wang, M.-W. | | 登録日 | 2022-06-17 | | 公開日 | 2022-09-21 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Nanobodies and chemical cross-links advance the structural and functional analysis of PI3K alpha.
Proc.Natl.Acad.Sci.USA, 119, 2022
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8DCX
 | | PI 3-kinase alpha with nanobody 3-159 | | 分子名称: | Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | | 著者 | Hart, J.R, Liu, X, Pan, C, Liang, A, Ueno, L, Xu, Y, Quezada, A, Zou, X, Yang, S, Zhou, Q, Schoonooghe, S, Hassanzadeh-Ghassabeh, G, Xia, T, Shui, W, Yang, D, Vogt, P.K, Wang, M.-W. | | 登録日 | 2022-06-17 | | 公開日 | 2022-09-21 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Nanobodies and chemical cross-links advance the structural and functional analysis of PI3K alpha.
Proc.Natl.Acad.Sci.USA, 119, 2022
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9J1P
 | | Cryo-EM structure of the g1:Ox-bound human GLP-1R-Gs complex | | 分子名称: | Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Fan, S, Li, J, Zhuang, J, Zhou, Q, Mai, Y, Lin, B, Wang, M.-W, Wu, C. | | 登録日 | 2024-08-05 | | 公開日 | 2025-02-26 | | 実験手法 | ELECTRON MICROSCOPY (2.99 Å) | | 主引用文献 | Disulfide-Directed Multicyclic Peptides with N-Terminally Extendable alpha-Helices for Recognition and Activation of G Protein-Coupled Receptors.
J.Am.Chem.Soc., 147, 2025
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9JVX
 | | Overall structure of human EAAT2 bound with activator (GT949) | | 分子名称: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 3-[(~{R})-(4-cyclohexylpiperazin-1-yl)-[1-(2-phenylethyl)-1,2,3,4-tetrazol-5-yl]methyl]-6-methoxy-1~{H}-quinolin-2-one, CHOLESTEROL, ... | | 著者 | Xia, L.Y, Zhang, Y.Y, Shi, Y, Huang, J, Zhou, Q. | | 登録日 | 2024-10-09 | | 公開日 | 2025-04-09 | | 実験手法 | ELECTRON MICROSCOPY (3.97 Å) | | 主引用文献 | Structural study of human glutamate transporter EAAT2
Dian Zi Xian Wei Xue Bao, 2025
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9JVW
 | | Overall structure of human EAAT2 bound with inhibitor (WAY-213613) | | 分子名称: | (2S)-2-azanyl-4-[[4-[2-bromanyl-4,5-bis(fluoranyl)phenoxy]phenyl]amino]-4-oxidanylidene-butanoic acid, CHOLESTEROL, Excitatory amino acid transporter 2 | | 著者 | Xia, L.Y, Zhang, Y.Y, Shi, Y, Huang, J, Zhou, Q. | | 登録日 | 2024-10-09 | | 公開日 | 2025-04-30 | | 実験手法 | ELECTRON MICROSCOPY (3.41 Å) | | 主引用文献 | Structural study of human glutamate transporter EAAT2
Dian Zi Xian Wei Xue Bao, 2025
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9JVV
 | | Overall structure of human EAAT2 in the substrate-free state | | 分子名称: | CHOLESTEROL, Excitatory amino acid transporter 2 | | 著者 | Xia, L.Y, Zhang, Y.Y, Shi, Y, Huang, J, Zhou, Q. | | 登録日 | 2024-10-09 | | 公開日 | 2025-04-30 | | 実験手法 | ELECTRON MICROSCOPY (2.82 Å) | | 主引用文献 | Structural study of human glutamate transporter EAAT2
Dian Zi Xian Wei Xue Bao, 2025
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5VBL
 | | Structure of apelin receptor in complex with agonist peptide | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Apelin receptor,Rubredoxin,Apelin receptor Chimera, ZINC ION, ... | | 著者 | Ma, Y, Yue, Y, Ma, Y, Zhang, Q, Zhou, Q, Song, Y, Shen, Y, Li, X, Ma, X, Li, C, Hanson, M.A, Han, G.W, Sickmier, E.A, Swaminath, G, Zhao, S, Stevems, R.C, Hu, L.A, Zhong, W, Zhang, M, Xu, F. | | 登録日 | 2017-03-29 | | 公開日 | 2017-05-31 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural Basis for Apelin Control of the Human Apelin Receptor
Structure, 25, 2017
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6A69
 | | Cryo-EM structure of a P-type ATPase | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Neuroplastin, Plasma membrane calcium-transporting ATPase 1 | | 著者 | Gong, D.S, Chi, X.M, Ren, K, Huang, G.X.Y, Zhou, G.W, Yan, N, Lei, J.L, Zhou, Q. | | 登録日 | 2018-06-27 | | 公開日 | 2018-09-19 | | 最終更新日 | 2024-11-06 | | 実験手法 | ELECTRON MICROSCOPY (4.11 Å) | | 主引用文献 | Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin.
Nat Commun, 9, 2018
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6JH6
 | | Structure of RyR2 (F/A/Ca2+ dataset) | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, RyR2, ... | | 著者 | Chi, X.M, Gong, D.S, Ren, K, Zhou, G.W, Huang, G.X.Y, Lei, J.L, Zhou, Q, Yan, N. | | 登録日 | 2019-02-17 | | 公開日 | 2019-12-11 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | | 主引用文献 | Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators.
Proc.Natl.Acad.Sci.USA, 116, 2019
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6JGZ
 | | Structure of RyR2 (F/P/Ca2+ dataset) | | 分子名称: | Peptidyl-prolyl cis-trans isomerase FKBP1B, RyR2, ZINC ION | | 著者 | Chi, X.M, Gong, D.S, Ren, K, Zhou, G.W, Huang, G.X.Y, Lei, J.L, Zhou, Q, Yan, N. | | 登録日 | 2019-02-16 | | 公開日 | 2019-12-11 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | | 主引用文献 | Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators.
Proc.Natl.Acad.Sci.USA, 116, 2019
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6JG3
 | | Cryo-EM structure of RyR2 (Ca2+ alone dataset) | | 分子名称: | Ryanodine receptor 2, ZINC ION | | 著者 | Chi, X.M, Gong, D.S, Ren, K, Zhou, G.W, Huang, G.X.Y, Lei, J.L, Zhou, Q, Yan, N. | | 登録日 | 2019-02-13 | | 公開日 | 2019-12-11 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (6.1 Å) | | 主引用文献 | Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators.
Proc.Natl.Acad.Sci.USA, 116, 2019
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8XL2
 | | Human acetyl-CoA carboxylase 1 filament in complex with acetyl-CoA (ACC1-inact) | | 分子名称: | ACETYL COENZYME *A, Acetyl-CoA carboxylase 1 | | 著者 | Zhou, F.Y, Zhang, Y.Y, Zhou, Q, Hu, Q. | | 登録日 | 2023-12-25 | | 公開日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (2.73 Å) | | 主引用文献 | Filament structures unveil the dynamic organization of human acetyl-CoA carboxylase.
Sci Adv, 10, 2024
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8XL1
 | | Core region of the human acetyl-CoA carboxylase 1 filament in complex with acetyl-CoA (ACC1-inact) | | 分子名称: | ACETYL COENZYME *A, Acetyl-CoA carboxylase 1 | | 著者 | Zhou, F.Y, Zhang, Y.Y, Zhou, Q, Hu, Q. | | 登録日 | 2023-12-25 | | 公開日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (2.57 Å) | | 主引用文献 | Filament structures unveil the dynamic organization of human acetyl-CoA carboxylase.
Sci Adv, 10, 2024
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8XL8
 | | Structure of human 3-methylcrotonyl-CoA carboxylase in complex with propionyl-CoA (MCC-PCO) | | 分子名称: | BIOTIN, Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial, ... | | 著者 | Zhou, F.Y, Zhang, Y.Y, Zhou, Q, Hu, Q. | | 登録日 | 2023-12-25 | | 公開日 | 2024-10-30 | | 最終更新日 | 2024-11-27 | | 実験手法 | ELECTRON MICROSCOPY (2.36 Å) | | 主引用文献 | Structural insights into human propionyl-CoA carboxylase (PCC) and 3-methylcrotonyl-CoA carboxylase (MCC)
Elife, 2024
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8XL0
 | | Citrate-induced filament of human acetyl-coenzyme A carboxylase 1 (ACC1-citrate) | | 分子名称: | Acetyl-CoA carboxylase 1, BIOTIN | | 著者 | Zhou, F.Y, Zhang, Y.Y, Zhou, Q, Hu, Q. | | 登録日 | 2023-12-25 | | 公開日 | 2024-10-23 | | 最終更新日 | 2024-11-20 | | 実験手法 | ELECTRON MICROSCOPY (4.14 Å) | | 主引用文献 | Filament structures unveil the dynamic organization of human acetyl-CoA carboxylase.
Sci Adv, 10, 2024
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8XKZ
 | | Core region of the citrate-induced human acetyl-CoA carboxylase 1 filament (ACC1-citrate) | | 分子名称: | Acetyl-CoA carboxylase 1, BIOTIN | | 著者 | Zhou, F.Y, Zhang, Y.Y, Zhou, Q, Hu, Q. | | 登録日 | 2023-12-25 | | 公開日 | 2024-10-23 | | 最終更新日 | 2024-11-06 | | 実験手法 | ELECTRON MICROSCOPY (2.55 Å) | | 主引用文献 | Filament structures unveil the dynamic organization of human acetyl-CoA carboxylase.
Sci Adv, 10, 2024
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8XL3
 | | Structure of human propionyl-CoA carboxylase at apo-state (PCC-Apo) | | 分子名称: | BIOTIN, Propionyl-CoA carboxylase alpha chain, mitochondrial, ... | | 著者 | Zhou, F.Y, Zhang, Y.Y, Zhou, Q, Hu, Q. | | 登録日 | 2023-12-25 | | 公開日 | 2024-10-30 | | 最終更新日 | 2024-11-20 | | 実験手法 | ELECTRON MICROSCOPY (3.02 Å) | | 主引用文献 | Structural insights into human propionyl-CoA carboxylase (PCC) and 3-methylcrotonyl-CoA carboxylase (MCC)
Elife, 2024
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8XL6
 | | Structure of human 3-methylcrotonyl-CoA carboxylase at apo-state (MCC-Apo) | | 分子名称: | BIOTIN, Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial, ... | | 著者 | Zhou, F.Y, Zhang, Y.Y, Zhou, Q, Hu, Q. | | 登録日 | 2023-12-25 | | 公開日 | 2024-10-30 | | 最終更新日 | 2024-11-27 | | 実験手法 | ELECTRON MICROSCOPY (2.29 Å) | | 主引用文献 | Structural insights into human propionyl-CoA carboxylase (PCC) and 3-methylcrotonyl-CoA carboxylase (MCC)
Elife, 2024
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8XL5
 | | Structure of human propionyl-CoA carboxylase in complex with propionyl-CoA (PCC-PCO) | | 分子名称: | BIOTIN, Propionyl-CoA carboxylase alpha chain, mitochondrial, ... | | 著者 | Zhou, F.Y, Zhang, Y.Y, Zhou, Q, Hu, Q. | | 登録日 | 2023-12-25 | | 公開日 | 2024-10-30 | | 最終更新日 | 2024-11-20 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structural insights into human propionyl-CoA carboxylase (PCC) and 3-methylcrotonyl-CoA carboxylase (MCC)
Elife, 2024
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8XL4
 | | Structure of human propionyl-CoA carboxylase in complex with acetyl-CoA (PCC-ACO) | | 分子名称: | ACETYL COENZYME *A, BIOTIN, Propionyl-CoA carboxylase alpha chain, ... | | 著者 | Zhou, F.Y, Zhang, Y.Y, Zhou, Q, Hu, Q. | | 登録日 | 2023-12-25 | | 公開日 | 2024-10-30 | | 最終更新日 | 2024-11-20 | | 実験手法 | ELECTRON MICROSCOPY (3.38 Å) | | 主引用文献 | Structural insights into human propionyl-CoA carboxylase (PCC) and 3-methylcrotonyl-CoA carboxylase (MCC)
Elife, 2024
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8XL7
 | | Structure of human 3-methylcrotonyl-CoA carboxylase in complex with acetyl-CoA (MCC-ACO) | | 分子名称: | ACETYL COENZYME *A, BIOTIN, Methylcrotonoyl-CoA carboxylase beta chain, ... | | 著者 | Zhou, F.Y, Zhang, Y.Y, Zhou, Q, Hu, Q. | | 登録日 | 2023-12-25 | | 公開日 | 2024-10-30 | | 最終更新日 | 2024-11-20 | | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | | 主引用文献 | Structural insights into human propionyl-CoA carboxylase (PCC) and 3-methylcrotonyl-CoA carboxylase (MCC)
Elife, 2024
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8WYI
 | | T cell receptor delta 2 gamma 9 with TCRD TM domain chimera of TRAC | | 分子名称: | Signal peptide,flag tag,T cell receptor delta variable 2,T cell receptor delta constant,T cell receptor alpha chain constant,T cell receptor delta variable 2,T cell receptor delta constant,T cell receptor alpha chain constant, Signal peptide,flag tag,T cell receptor gamma variable 9,T cell receptor gamma constant 1,T cell receptor gamma variable 9,T cell receptor gamma constant 1, T-cell surface glycoprotein CD3 delta chain, ... | | 著者 | Xin, W, Huang, B, Chi, X, Liu, Y, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. | | 登録日 | 2023-10-31 | | 公開日 | 2024-05-08 | | 最終更新日 | 2024-11-13 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structures of human gamma delta T cell receptor-CD3 complex.
Nature, 630, 2024
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8WY0
 | | T cell receptor delta 2 gamma 9 with F283A, F290A, and F291A | | 分子名称: | CHOLESTEROL, Signal peptide,flag tag,T cell receptor delta variable 2,T cell receptor delta constant, Signal peptide,flag tag,T cell receptor gamma variable 9,T cell receptor gamma constant 1, ... | | 著者 | Xin, W, Huang, B, Chi, X, Liu, Y, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. | | 登録日 | 2023-10-30 | | 公開日 | 2024-05-08 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structures of human gamma delta T cell receptor-CD3 complex.
Nature, 630, 2024
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