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6QHL
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BU of 6qhl by Molmil
14-3-3 sigma with RelA/p65 binding site pS45
分子名称: 14-3-3 protein sigma, GLYCEROL, Transcription factor p65
著者Wolter, M, Ottmann, C.
登録日2019-01-16
公開日2020-05-13
最終更新日2020-12-30
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Selectivity via Cooperativity: Preferential Stabilization of the p65/14-3-3 Interaction with Semisynthetic Natural Products.
J.Am.Chem.Soc., 142, 2020
6HMT
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BU of 6hmt by Molmil
Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C42 mutant bound to disulfide fragment PPI stabilizer 2
分子名称: 14-3-3 protein sigma, 2-(4-chloranylphenoxy)-2-methyl-~{N}-(2-sulfanylethyl)propanamide, Estrogen Receptor, ...
著者Sijbesma, E, Hallenbeck, K.K, Leysen, S, Arkin, M.R, Ottmann, C.
登録日2018-09-12
公開日2019-02-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers.
J. Am. Chem. Soc., 141, 2019
6HKB
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BU of 6hkb by Molmil
Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C42 mutant bound to disulfide fragment PPI stabilizer 3
分子名称: (1~{R},2~{S})-2-[methyl-[(~{R})-(2-methylpropan-2-yl)oxy-oxidanyl-methyl]amino]-2-phenyl-1-(2-sulfanylethylamino)ethanol, 14-3-3 protein sigma, Estrogen receptor, ...
著者Sijbesma, E, Hallenbeck, K.K, Leysen, S, Arkin, M.R, Ottmann, C.
登録日2018-09-06
公開日2019-02-27
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers.
J. Am. Chem. Soc., 141, 2019
6HEP
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BU of 6hep by Molmil
Crystal structure of human 14-3-3 beta in complex with CFTR R-domain peptide pS753-pS768
分子名称: 14-3-3 protein beta/alpha, 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Cystic fibrosis transmembrane conductance regulator
著者Stevers, L.M, Ottmann, C, Brunsveld, L.
登録日2018-08-20
公開日2018-10-24
最終更新日2018-11-07
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献A Thermodynamic Model for Multivalency in 14-3-3 Protein-Protein Interactions.
J. Am. Chem. Soc., 140, 2018
6HMU
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BU of 6hmu by Molmil
Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C45 mutant bound to disulfide fragment PPI stabilizer 6
分子名称: 14-3-3 protein sigma, 2-(4-chloranylphenoxy)-2-methyl-~{N}-(3-sulfanylpropyl)propanamide, Estrogen receptor, ...
著者Sijbesma, E, Hallenbeck, K.K, Leysen, S, Arkin, M.R, Ottmann, C.
登録日2018-09-12
公開日2019-02-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers.
J. Am. Chem. Soc., 141, 2019
6HN2
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BU of 6hn2 by Molmil
Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C42 mutant bound to disulfide fragment PPI stabilizer 5
分子名称: 14-3-3 protein sigma, 2-(3,4-dichlorophenyl)-~{N}-(2-sulfanylethyl)ethanamide, Estrogen Receptor, ...
著者Sijbesma, E, Hallenbeck, K.K, Leysen, S, Arkin, M.R, Ottmann, C.
登録日2018-09-13
公開日2019-02-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers.
J. Am. Chem. Soc., 141, 2019
6HHP
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BU of 6hhp by Molmil
Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C42 mutant bound to disulfide fragment PPI stabilizer 1
分子名称: (1~{R})-2-(4-chloranylphenoxy)-2-methyl-1-[methyl(2-sulfanylethyl)amino]propan-1-ol, 14-3-3 protein sigma, Estrogen receptor, ...
著者Sijbesma, E, Hallenbeck, K.K, Leysen, S, Arkin, M.R, Ottmann, C.
登録日2018-08-28
公開日2019-02-27
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.802 Å)
主引用文献Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers.
J. Am. Chem. Soc., 141, 2019
6HKF
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BU of 6hkf by Molmil
Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C42 mutant bound to disulfide fragment PPI stabilizer 4
分子名称: (1~{S})-2,2-diphenyl-1-(2-sulfanylethylamino)propan-1-ol, 14-3-3 protein sigma, Estrogen receptor, ...
著者Sijbesma, E, Hallenbeck, K.K, Leysen, S, Arkin, M.R, Ottmann, C.
登録日2018-09-06
公開日2019-02-27
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.801 Å)
主引用文献Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers.
J. Am. Chem. Soc., 141, 2019
7OR7
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BU of 7or7 by Molmil
Ternary complex of 14-3-3 sigma, NotchpS1917 phosphopeptide, and WQ178
分子名称: 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ...
著者Centorrino, F, Wu, Q, Ottmann, C.
登録日2021-06-04
公開日2022-07-20
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A crystallography-based study of fragment extensions into the 14-3-3 binding groove
To Be Published
7OR5
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BU of 7or5 by Molmil
Ternary complex of 14-3-3 sigma, NotchpS1917 phosphopeptide, and WQ162
分子名称: 14-3-3 protein sigma, CHLORIDE ION, Neurogenic locus notch homolog protein 4, ...
著者Centorrino, F, Wu, Q, Ottmann, C.
登録日2021-06-04
公開日2022-07-20
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A crystallography-based study of fragment extensions into the 14-3-3 binding groove
To Be Published
7OQA
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BU of 7oqa by Molmil
Ternary complex of 14-3-3 sigma, Pin1pS72 phosphopeptide, and WQ162
分子名称: 14-3-3 protein sigma, CHLORIDE ION, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, ...
著者Centorrino, F, Ottmann, C.
登録日2021-06-02
公開日2022-08-10
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A crystallography-based study of fragment extensions into the 14-3-3 binding groove
To Be Published
7OQ9
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BU of 7oq9 by Molmil
Ternary complex of 14-3-3 sigma, Pin1pS72 phosphopeptide, and WQ136
分子名称: 14-3-3 protein sigma, CHLORIDE ION, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, ...
著者Centorrino, F, Ottmann, C.
登録日2021-06-02
公開日2022-08-10
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A crystallography-based study of fragment extensions into the 14-3-3 binding groove
To Be Published
3P1R
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BU of 3p1r by Molmil
Crystal structure of human 14-3-3 sigma C38V/N166H in complex with TASK-3 peptide
分子名称: 14-3-3 protein sigma, 6-mer peptide from Potassium channel subfamily K member 9, CALCIUM ION, ...
著者Anders, C, Higuchi, Y, Schumacher, B, Thiel, P, Kato, N, Ottmann, C.
登録日2010-09-30
公開日2011-10-12
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface
Chem. Biol., 20, 2013
3P1P
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BU of 3p1p by Molmil
Crystal structure of human 14-3-3 sigma C38N/N166H in complex with TASK-3 peptide
分子名称: 14-3-3 protein sigma, 6-mer peptide from Potassium channel subfamily K member 9, CHLORIDE ION, ...
著者Anders, C, Higuchi, Y, Schumacher, B, Thiel, P, Kato, N, Ottmann, C.
登録日2010-09-30
公開日2011-10-12
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface
Chem. Biol., 20, 2013
3P1Q
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BU of 3p1q by Molmil
Crystal structure of human 14-3-3 sigma C38N/N166H in complex with TASK-3 Peptide and stabilizer fusicoccin A
分子名称: 14-3-3 protein sigma, 6-mer peptide from Potassium channel subfamily K member 9, CALCIUM ION, ...
著者Anders, C, Higuchi, Y, Schumacher, B, Thiel, P, Kato, N, Ottmann, C.
登録日2010-09-30
公開日2011-10-12
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface
Chem. Biol., 20, 2013
3P1S
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BU of 3p1s by Molmil
Crystal structure of human 14-3-3 sigma C38N/N166H in complex with TASK-3 peptide and stabilizer fusicoccin A
分子名称: 14-3-3 protein sigma, 6-mer peptide from Potassium channel subfamily K member 9, CHLORIDE ION, ...
著者Anders, C, Higuchi, Y, Schumacher, B, Thiel, P, Kato, N, Ottmann, C.
登録日2010-09-30
公開日2011-10-12
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface
Chem. Biol., 20, 2013
3P1O
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BU of 3p1o by Molmil
Crystal structure of human 14-3-3 sigma in complex with TASK-3 peptide and stabilisator Fusicoccin A
分子名称: 14-3-3 protein sigma, 6-mer peptide from Potassium channel subfamily K member 9, CALCIUM ION, ...
著者Anders, C, Higuchi, Y, Schumacher, B, Thiel, P, Kato, N, Ottmann, C.
登録日2010-09-30
公開日2011-10-12
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface
Chem. Biol., 20, 2013
3P1N
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BU of 3p1n by Molmil
Crystal structure of human 14-3-3 sigma in complex with TASK-3 peptide
分子名称: 14-3-3 protein sigma, 6-mer peptide from Potassium channel subfamily K member 9, CHLORIDE ION, ...
著者Anders, C, Higuchi, Y, Schumacher, B, Thiel, P, Kato, N, Ottmann, C.
登録日2010-09-30
公開日2011-10-12
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface
Chem. Biol., 20, 2013
6ZVC
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BU of 6zvc by Molmil
14-3-3 Sigma in complex with phosphorylated Gab2pT391 peptide - 48h incubation
分子名称: 14-3-3 protein sigma, MAGNESIUM ION, phosphorylated Gab2pT391 peptide
著者Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C.
登録日2020-07-24
公開日2021-08-04
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献A new soaking procedure for X-ray crystallography structural determination of protein-peptide complexes
To Be Published
6ZVB
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BU of 6zvb by Molmil
14-3-3 Sigma in complex with phosphorylated Gab2pT391 peptide - 24h incubation
分子名称: 14-3-3 protein sigma, MAGNESIUM ION, phosphorylated Gab2pT391 peptide
著者Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C.
登録日2020-07-24
公開日2021-08-04
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献A new soaking procedure for X-ray crystallography structural determination of protein-peptide complexes
To Be Published
6ZVD
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BU of 6zvd by Molmil
14-3-3 Sigma in complex with phosphorylated Gab2pT391 peptide - 96h incubation
分子名称: 14-3-3 protein sigma, MAGNESIUM ION, phosphorylated Gab2pT391 peptide
著者Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C.
登録日2020-07-24
公開日2021-08-04
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献A new soaking procedure for X-ray crystallography structural determination of protein-peptide complexes
To Be Published
6ZVE
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BU of 6zve by Molmil
14-3-3 Sigma in complex with phosphorylated Gab2pT391 peptide - 1h incubation
分子名称: 14-3-3 protein sigma, MAGNESIUM ION, phosphorylated Gab2pT391 peptide
著者Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C.
登録日2020-07-24
公開日2021-08-04
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献A new soaking procedure for X-ray crystallography structural determination of protein-peptide complexes
To Be Published
7AXN
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BU of 7axn by Molmil
14-3-3 sigma in complex with Pin1 binding site pS72 and covalently bound TCF521-026
分子名称: 14-3-3 protein sigma, 3-chloranyl-4-imidazol-1-yl-benzaldehyde, CALCIUM ION, ...
著者Wolter, M, Dijck, L.v, Ottmann, C.
登録日2020-11-10
公開日2021-06-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions.
J.Am.Chem.Soc., 143, 2021
7AYF
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BU of 7ayf by Molmil
14-3-3 sigma with Pin1 binding site pS72 and covalently bound TCF521-110
分子名称: 14-3-3 protein sigma, 6-(2-bromanylimidazol-1-yl)pyridine-3-carbaldehyde, CALCIUM ION, ...
著者Wolter, M, Dijck, L.v, Ottmann, C.
登録日2020-11-12
公開日2021-06-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.752 Å)
主引用文献Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions.
J.Am.Chem.Soc., 143, 2021
7AZ2
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BU of 7az2 by Molmil
14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1014
分子名称: 1-[4-methyl-2-(trifluoromethyl)phenyl]-2-phenyl-imidazole, 14-3-3 protein sigma, CALCIUM ION, ...
著者Wolter, M, Dijck, L.v, Ottmann, C.
登録日2020-11-14
公開日2021-06-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.081 Å)
主引用文献Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions.
J.Am.Chem.Soc., 143, 2021

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件を2024-06-12に公開中

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