7GT9
 
 | | PanDDA Analysis group deposition -- Crystal structure of PTP1B in complex with FMSOA000463b | | 分子名称: | (3R)-4-oxo-3,4-dihydro-2H-1-benzopyran-3-carbonitrile, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1 | | 著者 | Mehlman, T, Ginn, H.M, Keedy, D.A. | | 登録日 | 2024-01-03 | | 公開日 | 2024-01-24 | | 最終更新日 | 2024-04-24 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | An expanded view of ligandability in the allosteric enzyme PTP1B from computational reanalysis of large-scale crystallographic data.
Biorxiv, 2024
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7GSE
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7GTI
 | | PanDDA Analysis group deposition -- Crystal structure of PTP1B in complex with FMOOA000571a | | 分子名称: | 1-{(1S,4R,5S,6R)-6-hydroxy-4-[(pyridin-2-yl)oxy]-2-azabicyclo[3.3.1]nonan-2-yl}ethan-1-one, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1 | | 著者 | Mehlman, T, Ginn, H.M, Keedy, D.A. | | 登録日 | 2024-01-03 | | 公開日 | 2024-01-24 | | 最終更新日 | 2024-04-24 | | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | | 主引用文献 | An expanded view of ligandability in the allosteric enzyme PTP1B from computational reanalysis of large-scale crystallographic data.
Biorxiv, 2024
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7GSG
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7GSH
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7GSJ
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7GSX
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7GT8
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8U1E
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9CYO
 | | Crystal structure of wild-type human PTP1B (PTPN1) at room temperature (298 K) | | 分子名称: | BETA-MERCAPTOETHANOL, MAGNESIUM ION, Tyrosine-protein phosphatase non-receptor type 1 | | 著者 | Ebrahim, A, Perdikari, A, Woods, V.A, Lawler, K, Bounds, R, Singh, N.I, Mehlman, T, Riley, B.T, Sharma, S, Morris, J.W, Keogh, J.M, Henning, E, Smith, M, Farooqi, I.S, Keedy, D.A. | | 登録日 | 2024-08-02 | | 公開日 | 2024-08-21 | | 最終更新日 | 2024-08-28 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | Structures of human PTP1B variants reveal allosteric sites to target for weight loss therapy.
Biorxiv, 2024
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9CYQ
 | | Crystal structure of Q78R mutant human PTP1B (PTPN1) at room temperature (298 K) | | 分子名称: | BETA-MERCAPTOETHANOL, MAGNESIUM ION, Tyrosine-protein phosphatase non-receptor type 1 | | 著者 | Ebrahim, A, Perdikari, A, Woods, V.A, Lawler, K, Bounds, R, Singh, N.I, Mehlman, T, Riley, B.T, Sharma, S, Morris, J.W, Keogh, J.M, Henning, E, Smith, M, Farooqi, I.S, Keedy, D.A. | | 登録日 | 2024-08-02 | | 公開日 | 2024-08-21 | | 最終更新日 | 2024-08-28 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structures of human PTP1B variants reveal allosteric sites to target for weight loss therapy.
Biorxiv, 2024
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9CYR
 | | Crystal structure of D245G mutant human PTP1B (PTPN1) at room temperature (298 K) | | 分子名称: | BETA-MERCAPTOETHANOL, MAGNESIUM ION, Tyrosine-protein phosphatase non-receptor type 1 | | 著者 | Ebrahim, A, Perdikari, A, Woods, V.A, Lawler, K, Bounds, R, Singh, N.I, Mehlman, T, Riley, B.T, Sharma, S, Morris, J.W, Keogh, J.M, Henning, E, Smith, M, Farooqi, I.S, Keedy, D.A. | | 登録日 | 2024-08-02 | | 公開日 | 2024-08-21 | | 最終更新日 | 2024-08-28 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Structures of human PTP1B variants reveal allosteric sites to target for weight loss therapy.
Biorxiv, 2024
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9CYP
 | | Crystal structure of I19V mutant human PTP1B (PTPN1) at room temperature (298 K) | | 分子名称: | BETA-MERCAPTOETHANOL, MAGNESIUM ION, Tyrosine-protein phosphatase non-receptor type 1 | | 著者 | Ebrahim, A, Perdikari, A, Woods, V.A, Lawler, K, Bounds, R, Singh, N.I, Mehlman, T, Riley, B.T, Sharma, S, Morris, J.W, Keogh, J.M, Henning, E, Smith, M, Farooqi, I.S, Keedy, D.A. | | 登録日 | 2024-08-02 | | 公開日 | 2024-08-21 | | 最終更新日 | 2024-08-28 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | Structures of human PTP1B variants reveal allosteric sites to target for weight loss therapy.
Biorxiv, 2024
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7R65
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6QJZ
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6YBH
 | | Deoxyribonucleoside Kinase | | 分子名称: | Deoxynucleoside kinase, GLYCEROL, Pyrrolo-dC, ... | | 著者 | Allouche-Arnon, H, Bar-Shir, A, Dym, O. | | 登録日 | 2020-03-17 | | 公開日 | 2021-03-31 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Computationally designed dual-color MRI reporters for noninvasive imaging of transgene expression.
Nat.Biotechnol., 40, 2022
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3M31
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8FNW
 | | Structure of RdrA-RdrB complex from Escherichia coli RADAR defense system | | 分子名称: | Adenosine deaminase, Archaeal ATPase, ZINC ION | | 著者 | Duncan-Lowey, B, Johnson, A.G, Rawson, S, Mayer, M.L, Kranzusch, P.J. | | 登録日 | 2022-12-28 | | 公開日 | 2023-02-01 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (6.73 Å) | | 主引用文献 | Cryo-EM structure of the RADAR supramolecular anti-phage defense complex.
Cell, 186, 2023
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8FNT
 | | Structure of RdrA from Escherichia coli RADAR defense system | | 分子名称: | Archaeal ATPase | | 著者 | Duncan-Lowey, B, Johnson, A.G, Rawson, S, Mayer, M.L, Kranzusch, P.J. | | 登録日 | 2022-12-28 | | 公開日 | 2023-02-01 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (2.52 Å) | | 主引用文献 | Cryo-EM structure of the RADAR supramolecular anti-phage defense complex.
Cell, 186, 2023
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8FNV
 | | Structure of RdrB from Escherichia coli RADAR defense system | | 分子名称: | Adenosine deaminase, ZINC ION | | 著者 | Duncan-Lowey, B, Johnson, A.G, Rawson, S, Mayer, M.L, Kranzusch, P.J. | | 登録日 | 2022-12-28 | | 公開日 | 2023-02-01 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (2.11 Å) | | 主引用文献 | Cryo-EM structure of the RADAR supramolecular anti-phage defense complex.
Cell, 186, 2023
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8FNU
 | | Structure of RdrA from Streptococcus suis RADAR defense system | | 分子名称: | KAP NTPase domain-containing protein | | 著者 | Duncan-Lowey, B, Johnson, A.G, Rawson, S, Mayer, M.L, Kranzusch, P.J. | | 登録日 | 2022-12-28 | | 公開日 | 2023-02-01 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | Cryo-EM structure of the RADAR supramolecular anti-phage defense complex.
Cell, 186, 2023
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6ZBS
 | | Beta ODAP Synthetase (BOS) | | 分子名称: | Beta ODAP Synthetase (BOS), DI(HYDROXYETHYL)ETHER, MAGNESIUM ION | | 著者 | Dym, O. | | 登録日 | 2020-06-09 | | 公開日 | 2022-01-12 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Identification and characterization of the key enzyme in the biosynthesis of the neurotoxin beta-ODAP in grass pea.
J.Biol.Chem., 298, 2022
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3T59
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3T58
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3NVJ
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