5CBM
| Crystal structure of PfA-M17 with virtual ligand inhibitor | 分子名称: | (2S)-2-{[(R)-[(R)-amino(phenyl)methyl](hydroxy)phosphoryl]methyl}-4-methylpentanoic acid, CARBONATE ION, GLYCEROL, ... | 著者 | Ruggeri, C, Drinkwater, N, McGowan, S. | 登録日 | 2015-07-01 | 公開日 | 2015-10-07 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Identification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual Screening. Plos One, 10, 2015
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4R1B
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4R1C
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4QXT
| Crystal Structure of anti-MSP2 Fv fragment (mAb6D8)in complex with FC27-MSP2 14-30 | 分子名称: | Fv fragment(mAb6D8) heavy chain, Fv fragment(mAb6D8) light chain, Merozoite surface antigen 2 | 著者 | Morales, R.A.V, MacRaild, C.A, Seow, J, Bankala, K, Drinkwater, N, McGowan, S, Rouet, R, Christ, D, Anders, R.F, Norton, R.S. | 登録日 | 2014-07-22 | 公開日 | 2015-06-03 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Structural basis for epitope masking and strain specificity of a conserved epitope in an intrinsically disordered malaria vaccine candidate. Sci Rep, 5, 2015
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4QYO
| Crystal Structure of anti-MSP2 Fv fragment (mAb6D8)in complex with MSP2 14-22 | 分子名称: | Fv fragment(mAb6D8) heavy chain, Fv fragment(mAb6D8) light chain, Merozoite surface antigen 2 | 著者 | Morales, R.A.V, MacRaild, C.A, Seow, J, Bankala, K, Drinkwater, N, McGowan, S, Rouet, R, Christ, D, Anders, R.F, Norton, R.S. | 登録日 | 2014-07-24 | 公開日 | 2015-06-03 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.208 Å) | 主引用文献 | Structural basis for epitope masking and strain specificity of a conserved epitope in an intrinsically disordered malaria vaccine candidate. Sci Rep, 5, 2015
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4R19
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4R1A
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4R3S
| Crystal Structure of anti-MSP2 Fv fragment (mAb6D8)in complex with MSP2 11-23 | 分子名称: | FV FRAGMENT(MAB6D8) HEAVY CHAIN, FV FRAGMENT(MAB6D8) LIGHT CHAIN, Merozoite surface protein | 著者 | Morales, R.A.V, MacRaild, C.A, Seow, J, Bankala, K, Drinkwater, N, McGowan, S, Rouet, R, Christ, D, Anders, R.F, Norton, R.S. | 登録日 | 2014-08-18 | 公開日 | 2015-06-03 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural basis for epitope masking and strain specificity of a conserved epitope in an intrinsically disordered malaria vaccine candidate Sci Rep, 5, 2015
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4QY8
| Crystal Structure of anti-MSP2 Fv fragment (mAb6D8) in complex with 3D7-MSP2 14-30 | 分子名称: | Fv fragment(mAb6D8) heavy chain, Fv fragment(mAb6D8) light chain, Merozoite surface antigen 2 | 著者 | Morales, R.A.V, MacRaild, C.A, Seow, J, Bankala, K, Drinkwater, N, McGowan, S, Rouet, R, Christ, D, Anders, R.F, Norton, R.S. | 登録日 | 2014-07-24 | 公開日 | 2015-06-03 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.353 Å) | 主引用文献 | Structural basis for epitope masking and strain specificity of a conserved epitope in an intrinsically disordered malaria vaccine candidate. Sci Rep, 5, 2015
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8SLO
| Plasmodium falciparum M1 aminopeptidase bound to selective inhibitor MIPS2673 | 分子名称: | 2-hydroxy-N-[(1R)-2-(hydroxyamino)-2-oxo-1-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)ethyl]-2-methylpropanamide, GLYCEROL, M1 family aminopeptidase, ... | 著者 | McGowan, S.M, Drinkwater, N. | 登録日 | 2023-04-24 | 公開日 | 2024-04-03 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy. Elife, 13, 2024
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3H7T
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3H7O
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4U6W
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4U71
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4U75
| HsMetAP (F309M) in complex with Methionine | 分子名称: | COBALT (II) ION, GLYCEROL, METHIONINE, ... | 著者 | Arya, T, Addlagatta, A. | 登録日 | 2014-07-30 | 公開日 | 2015-03-25 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases J.Med.Chem., 58, 2015
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4U6E
| HsMetAP in complex with (amino(phenyl)methyl)phosphonic acid | 分子名称: | COBALT (II) ION, Methionine aminopeptidase 1, [(R)-amino(phenyl)methyl]phosphonic acid | 著者 | Arya, T, Addlagatta, A. | 登録日 | 2014-07-28 | 公開日 | 2015-03-25 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases J.Med.Chem., 58, 2015
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4U6Z
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4U1B
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4U6J
| HsMetAP in complex with methionine | 分子名称: | COBALT (II) ION, GLYCEROL, METHIONINE, ... | 著者 | Arya, T, Addlagatta, A. | 登録日 | 2014-07-29 | 公開日 | 2015-03-25 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases J.Med.Chem., 58, 2015
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4U6C
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4U69
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4U70
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4U76
| HsMetAP (F309M) holo form | 分子名称: | COBALT (II) ION, GLYCEROL, Methionine aminopeptidase 1, ... | 著者 | Arya, T, Addlagatta, A. | 登録日 | 2014-07-30 | 公開日 | 2015-03-25 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | 主引用文献 | Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases J.Med.Chem., 58, 2015
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4U73
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3LPC
| Crystal structure of a subtilisin-like protease | 分子名称: | ACETATE ION, AprB2, CALCIUM ION, ... | 著者 | Porter, C.J, Wong, W, Whisstock, J.C, Rood, J.I, Kennan, R.M. | 登録日 | 2010-02-05 | 公開日 | 2010-12-08 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | The Subtilisin-Like Protease AprV2 Is Required for Virulence and Uses a Novel Disulphide-Tethered Exosite to Bind Substrates Plos Pathog., 6, 2010
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