8CYZ
 
 | | Crystal structure of SARS-CoV-2 Mpro with compound C4 | | 分子名称: | 3C-like proteinase, N-[(4-chlorothiophen-2-yl)methyl]-2-(isoquinolin-4-yl)-N-[4-(methylsulfanyl)phenyl]acetamide | | 著者 | Worrall, L.J, Lee, J, Strynadka, N.C.J. | | 登録日 | 2022-05-24 | | 公開日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants.
Emerg Microbes Infect, 12, 2023
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8CZ7
 | | Crystal structure of SARS-CoV-2 Mpro with compound C2 | | 分子名称: | 3C-like proteinase, N-[(4-chlorothiophen-2-yl)methyl]-2-(isoquinolin-4-yl)-N-(4-methoxyphenyl)acetamide | | 著者 | Worrall, L.J, Lee, J, Strynadka, N.C.J. | | 登録日 | 2022-05-24 | | 公開日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants.
Emerg Microbes Infect, 12, 2023
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8CYU
 | | Crystal structure of SARS-CoV-2 Mpro with compound C5 | | 分子名称: | 3C-like proteinase, N-[(4-chlorothiophen-2-yl)methyl]-N-[4-(dimethylamino)phenyl]-2-(isoquinolin-4-yl)acetamide | | 著者 | Worrall, L.J, Lee, J, Strynadka, N.C.J. | | 登録日 | 2022-05-24 | | 公開日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants.
Emerg Microbes Infect, 12, 2023
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8CZ4
 | | Crystal structure of SARS-CoV-2 Mpro with compound C3 | | 分子名称: | 3C-like proteinase, N-(4-tert-butylphenyl)-N-[(4-chlorothiophen-2-yl)methyl]-2-(isoquinolin-4-yl)acetamide | | 著者 | Worrall, L.J, Lee, J, Strynadka, N.C.J. | | 登録日 | 2022-05-24 | | 公開日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants.
Emerg Microbes Infect, 12, 2023
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1LX8
 | | Regulation of directionality in bacteriophage lambda site-specific recombination: structure of the Xis protein | | 分子名称: | Excisionase | | 著者 | Sam, M.D, Papagiannis, C, Connolly, K.M, Corselli, L, Iwahara, J, Lee, J, Phillips, M, Wojciak, J.M, Johnson, R.C, Clubb, R.T. | | 登録日 | 2002-06-04 | | 公開日 | 2003-06-10 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Regulation of directionality in bacteriophage lambda site-specific recombination: structure of the Xis protein
J.Mol.Biol., 324, 2002
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6KZ7
 | | The crystal structure of BAF155 SWIRM domain and N-terminal elongated hSNF5 RPT1 domain complex: Chromatin remodeling complex | | 分子名称: | SWI/SNF complex subunit SMARCC1, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 | | 著者 | Lee, W, Han, J, Kim, I, Park, J.H, Joo, K, Lee, J, Suh, J.Y. | | 登録日 | 2019-09-23 | | 公開日 | 2020-07-08 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | | 主引用文献 | A Coil-to-Helix Transition Serves as a Binding Motif for hSNF5 and BAF155 Interaction.
Int J Mol Sci, 21, 2020
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3CRG
 | | Crystal structure of human fibroblast growth factor-1 with mutations Glu81Ala, Glu82Asn and Lys101Ala | | 分子名称: | FORMIC ACID, GLYCEROL, Heparin-binding growth factor 1, ... | | 著者 | Meher, A.K, Honjo, E, Kuroki, R, Lee, J, Somasundaram, T, Blaber, M. | | 登録日 | 2008-04-07 | | 公開日 | 2009-02-17 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Engineering an improved crystal contact across a solvent-mediated interface of human fibroblast growth factor 1.
Acta Crystallogr.,Sect.F, 65, 2009
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2FB8
 | | Structure of the B-Raf kinase domain bound to SB-590885 | | 分子名称: | (1Z)-5-(2-{4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL}-5-PYRIDIN-4-YL-1H-IMIDAZOL-4-YL)INDAN-1-ONE OXIME, B-Raf proto-oncogene serine/threonine-protein kinase | | 著者 | Lougheed, J.C, Lee, J, Chau, D.C, Stout, T.J. | | 登録日 | 2005-12-08 | | 公開日 | 2006-12-12 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885.
Cancer Res., 66, 2006
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1S36
 | | Crystal structure of a Ca2+-discharged photoprotein: Implications for the mechanisms of the calcium trigger and the bioluminescence | | 分子名称: | CHLORIDE ION, GLYCEROL, N-[3-BENZYL-5-(4-HYDROXYPHENYL)PYRAZIN-2-YL]-2-(4-HYDROXYPHENYL)ACETAMIDE, ... | | 著者 | Deng, L, Markova, S.V, Vysotski, E.S, Liu, Z.-J, Lee, J, Rose, J, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG) | | 登録日 | 2004-01-12 | | 公開日 | 2004-10-05 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Crystal structure of a Ca2+-discharged photoprotein: implications for mechanisms of the calcium trigger and bioluminescence
J.Biol.Chem., 279, 2004
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1SL9
 | | Obelin from Obelia longissima | | 分子名称: | C2-HYDROPEROXY-COELENTERAZINE, Obelin | | 著者 | Deng, L, Markova, S, Vysotski, E, Liu, Z.-J, Lee, J, Rose, J, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG) | | 登録日 | 2004-03-05 | | 公開日 | 2005-07-19 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.17 Å) | | 主引用文献 | Obelin from Obelia longissima
To be Published
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1SL8
 | | Calcium-loaded apo-aequorin from Aequorea victoria | | 分子名称: | Aequorin 1, CALCIUM ION | | 著者 | Deng, L, Markova, S.V, Vysotski, E.S, Liu, Z.J, Lee, J, Rose, J, Wang, B.C, Southeast Collaboratory for Structural Genomics (SECSG) | | 登録日 | 2004-03-05 | | 公開日 | 2004-12-28 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | All three Ca2+-binding loops of photoproteins bind calcium ions: The crystal structures of calcium-loaded apo-aequorin and apo-obelin.
Protein Sci., 14, 2005
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1SL7
 | | Crystal structure of calcium-loaded apo-obelin from Obelia longissima | | 分子名称: | CALCIUM ION, Obelin | | 著者 | Deng, L, Markova, S.V, Vysotski, E.S, Liu, Z.J, Lee, J, Rose, J, Wang, B.C, Southeast Collaboratory for Structural Genomics (SECSG) | | 登録日 | 2004-03-05 | | 公開日 | 2004-12-28 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | All three Ca2+-binding loops of photoproteins bind calcium ions: The crystal structures of calcium-loaded apo-aequorin and apo-obelin.
Protein Sci., 14, 2005
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2F8P
 | | Crystal structure of obelin following Ca2+ triggered bioluminescence suggests neutral coelenteramide as the primary excited state | | 分子名称: | CALCIUM ION, N-[3-BENZYL-5-(4-HYDROXYPHENYL)PYRAZIN-2-YL]-2-(4-HYDROXYPHENYL)ACETAMIDE, Obelin | | 著者 | Liu, Z.J, Stepanyuk, G.A, Vysotski, E.S, Lee, J, Wang, B.C, Southeast Collaboratory for Structural Genomics (SECSG) | | 登録日 | 2005-12-03 | | 公開日 | 2006-02-14 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | Crystal structure of obelin after Ca2+-triggered bioluminescence suggests neutral coelenteramide as the primary excited state.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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2RVC
 | | Solution structure of Zalpha domain of goldfish ZBP-containing protein kinase | | 分子名称: | Interferon-inducible and double-stranded-dependent eIF-2kinase | | 著者 | Lee, A, Park, C, Park, J, Kwon, M, Choi, Y, Kim, K, Choi, B, Lee, J. | | 登録日 | 2015-07-08 | | 公開日 | 2016-02-03 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the Z-DNA binding domain of PKR-like protein kinase from Carassius auratus and quantitative analyses of the intermediate complex during B-Z transition.
Nucleic Acids Res., 44, 2016
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8IS3
 | | Structural model for the micelle-bound indolicidin-like peptide in solution | | 分子名称: | Indolicidin-like antimicrobial peptide | | 著者 | Kim, B, Ko, Y.H, Kim, J, Lee, J, Nam, C.H, Kim, J.H. | | 登録日 | 2023-03-20 | | 公開日 | 2024-03-20 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural model for the micelle-bound indolicidin-like peptide in solution
To Be Published
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8SXR
 | | Crystal structure of SARS-CoV-2 Mpro with C5a | | 分子名称: | 3C-like proteinase nsp5, N-[(4-chlorothiophen-2-yl)methyl]-N-[4-(dimethylamino)phenyl]-2-(5-hydroxyisoquinolin-4-yl)acetamide | | 著者 | Worrall, L.J, Kenward, C, Lee, J, Strynadka, N.C.J. | | 登録日 | 2023-05-23 | | 公開日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.114 Å) | | 主引用文献 | A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants.
Emerg Microbes Infect, 12, 2023
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8H26
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4APP
 | | Crystal Structure of the Human p21-Activated Kinase 4 in Complex with (S)-N-(5-(3-benzyl-1-methylpiperazine-4-carbonyl)-6,6-dimethyl-1,4,5, 6-tetrahydropyrrolo(3,4-c)pyrazol-3-yl)-3-phenoxybenzamide | | 分子名称: | GLYCEROL, N-[6,6-dimethyl-5-[(2S)-4-methyl-2-(phenylmethyl)piperazin-1-yl]carbonyl-2,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-3-phenoxy-benzamide, SERINE/THREONINE-PROTEIN KINASE PAK 4 | | 著者 | Knighton, D.D, Deng, Y.L, Wang, C, Guo, C, McAlpine, I, Zhang, J, Kephart, S, Johnson, M.C, Li, H, Bouzida, D, Yang, A, Dong, L, Marakovits, J, Tikhe, J, Richardson, P, Guo, L.C, Kania, R, Edwards, M.P, Kraynov, E, Christensen, J, Piraino, J, Lee, J, Dagostino, E, Del-Carmen, C, Smeal, T, Murray, B.W. | | 登録日 | 2012-04-04 | | 公開日 | 2012-06-06 | | 最終更新日 | 2019-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Discovery of Pyrroloaminopyrazoles as Novel Pak Inhibitors.
J.Med.Chem., 55, 2012
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6N8V
 | | Hsp104DWB open conformation | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein 104 | | 著者 | Lee, S, Rho, S.H, Lee, J, Sung, N, Liu, J, Tsai, F.T.F. | | 登録日 | 2018-11-30 | | 公開日 | 2019-01-02 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (9.3 Å) | | 主引用文献 | Cryo-EM Structures of the Hsp104 Protein Disaggregase Captured in the ATP Conformation.
Cell Rep, 26, 2019
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6N8Z
 | | HSP104DWB extended conformation | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein 104 | | 著者 | Lee, S, Rho, S.H, Lee, J, Sung, N, Liu, J, Tsai, F.T.F. | | 登録日 | 2018-11-30 | | 公開日 | 2019-01-02 | | 最終更新日 | 2019-01-16 | | 実験手法 | ELECTRON MICROSCOPY (9.3 Å) | | 主引用文献 | Cryo-EM Structures of the Hsp104 Protein Disaggregase Captured in the ATP Conformation.
Cell Rep, 26, 2019
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6N8T
 | | Hsp104DWB closed conformation | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein 104 | | 著者 | Lee, S, Rho, S.H, Lee, J, Sung, N, Liu, J, Tsai, F.T.F. | | 登録日 | 2018-11-30 | | 公開日 | 2019-01-02 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (7.7 Å) | | 主引用文献 | Cryo-EM Structures of the Hsp104 Protein Disaggregase Captured in the ATP Conformation.
Cell Rep, 26, 2019
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1QV1
 | | Atomic resolution structure of obelin from Obelia longissima | | 分子名称: | C2-HYDROPEROXY-COELENTERAZINE, CALCIUM ION, COBALT (II) ION, ... | | 著者 | Liu, Z.J, Vysotski, E.S, Deng, L, Lee, J, Rose, J, Wang, B.C. | | 登録日 | 2003-08-26 | | 公開日 | 2003-11-11 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Atomic resolution structure of obelin: soaking with calcium enhances electron density of the second oxygen atom substituted at the C2-position of coelenterazine.
Biochem.Biophys.Res.Commun., 311, 2003
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1QV0
 | | Atomic resolution structure of obelin from Obelia longissima | | 分子名称: | C2-HYDROPEROXY-COELENTERAZINE, COBALT (II) ION, GLYCEROL, ... | | 著者 | Liu, Z.J, Vysotski, E.S, Deng, L, Lee, J, Rose, J, Wang, B.C. | | 登録日 | 2003-08-26 | | 公開日 | 2003-11-11 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Atomic resolution structure of obelin: soaking with calcium enhances electron density of the second oxygen atom substituted at the C2-position of coelenterazine.
Biochem.Biophys.Res.Commun., 311, 2003
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8H1A
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8H27
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