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Design of an insulin analog with enhanced receptor-binding selectivity. Rationale, structure, and therapeutic implications
分子名称:	Insulin, ZINC ION
著者	Zhao, M, Wan, Z.L, Whittaker, L, Xu, B, Phillips, N, Katsoyannis, P, Whittaker, J, Weiss, M.A.
登録日	2009-01-07
公開日	2009-08-04
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (1.35 Å)
主引用文献	Design of an insulin analog with enhanced receptor binding selectivity: rationale, structure, and therapeutic implications. J.Biol.Chem., 284, 2009

1CID

CRYSTAL STRUCTURE OF DOMAINS 3 & 4 OF RAT CD4 AND THEIR RELATIONSHIP TO THE NH2-TERMINAL DOMAINS
分子名称:	SULFATE ION, T CELL SURFACE GLYCOPROTEIN CD4
著者	Brady, R.L, Dodson, E.J, Lange, G.
登録日	1993-01-28
公開日	1993-07-15
最終更新日	2024-06-05
実験手法	X-RAY DIFFRACTION (2.8 Å)
主引用文献	Crystal structure of domains 3 and 4 of rat CD4: relation to the NH2-terminal domains. Science, 260, 1993

1XW7

Diabetes-Associated Mutations in Human Insulin: Crystal Structure and Photo-Cross-Linking Studies of A-Chain Variant Insulin Wakayama
分子名称:	CHLORIDE ION, Insulin, PHENOL, ...
著者	Wan, Z.L, Huang, K, Xu, B, Chu, Y.C, Hu, S.Q, Katsoyannis, P.G, Weiss, M.A.
登録日	2004-10-29
公開日	2005-04-12
最終更新日	2023-08-23
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Diabetes-associated mutations in human insulin: crystal structure and photo-cross-linking studies of a-chain variant insulin wakayama Biochemistry, 44, 2005

1MYI

HIGH RESOLUTION X-RAY STRUCTURES OF PIG METMYOGLOBIN AND TWO CD3 MUTANTS MB(LYS45-> ARG) AND MB(LYS45-> SER)
分子名称:	MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE
著者	Smerdon, S.J, Oldfield, T.J, Wilkinson, A.J, Dauter, Z, Petratos, K, Wilson, K.S.
登録日	1992-02-27
公開日	1994-01-31
最終更新日	2024-02-14
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	High-resolution X-ray structures of pig metmyoglobin and two CD3 mutants: Mb(Lys45----Arg) and Mb(Lys45----Ser). Biochemistry, 31, 1992

3V19

Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
分子名称:	CHLORIDE ION, Insulin, PHENOL, ...
著者	Wan, Z.L, Hua, Q.X, Wickramasinghe, N.P, Huang, K, Petkova, A.T, Hu, S.Q, Phillips, N.B, Yeh, I.J, Whittake, J, Ismail-Beigi, F, Katsoyyannis, P.G, Tycko, R, Weiss, M.A.
登録日	2011-12-09
公開日	2012-12-12
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health To be Published

3V1G

Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
分子名称:	CHLORIDE ION, Insulin, PHENOL, ...
著者	Wan, Z.L, Hua, Q.X, Wickramasinghe, N.P, Huang, K, Petkova, A.T, Hu, S.Q, Phillips, N.B, Yeh, I.J, Whittake, J, Ismail-Beigi, F, Katsoyyannis, P.G, Tycko, R, Weiss, M.A.
登録日	2011-12-09
公開日	2012-12-12
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health To be Published

3BXQ

The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition
分子名称:	ZINC ION, insulin A chain, insulin B chain
著者	Wan, Z.L, Huang, K, Hu, S.Q, Whittaker, J, Weiss, M.A.
登録日	2008-01-14
公開日	2008-05-20
最終更新日	2024-10-16
実験手法	X-RAY DIFFRACTION (1.3 Å)
主引用文献	The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition. J.Biol.Chem., 283, 2008

1WAP

TRP RNA-BINDING ATTENUATION PROTEIN IN COMPLEX WITH L-TRYPTOPHAN
分子名称:	TRP RNA-BINDING ATTENUATION PROTEIN, TRYPTOPHAN
著者	Antson, A.A, Dodson, E.J, Gollnick, P.
登録日	1995-02-03
公開日	1995-06-03
最終更新日	2024-02-14
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	The structure of trp RNA-binding attenuation protein. Nature, 374, 1995

2HF0

Bifidobacterium longum bile salt hydrolase
分子名称:	Bile salt hydrolase
著者	Suresh, C.G, Kumar, R.S, Brannigan, J.A.
登録日	2006-06-22
公開日	2006-09-19
最終更新日	2024-02-14
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Structural and Functional Analysis of a Conjugated Bile Salt Hydrolase from Bifidobacterium longum Reveals an Evolutionary Relationship with Penicillin V Acylase. J.Biol.Chem., 281, 2006

4ENG

STRUCTURE OF ENDOGLUCANASE V CELLOHEXAOSE COMPLEX
分子名称:	ENDOGLUCANASE V CELLOHEXAOSE COMPLEX, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-alpha-D-glucopyranose
著者	Davies, G.J, Schulein, M.
登録日	1996-10-17
公開日	1997-06-16
最終更新日	2023-08-09
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Structure determination and refinement of the Humicola insolens endoglucanase V at 1.5 A resolution. Acta Crystallogr.,Sect.D, 52, 1996

2HEZ

Bifidobacterium longum bile salt hydrolase
分子名称:	Bile salt hydrolase, SULFATE ION
著者	Suresh, C.G, Kumar, R.S, Brannigan, J.A.
登録日	2006-06-22
公開日	2006-09-19
最終更新日	2023-11-15
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Structural and Functional Analysis of a Conjugated Bile Salt Hydrolase from Bifidobacterium longum Reveals an Evolutionary Relationship with Penicillin V Acylase. J.Biol.Chem., 281, 2006

1BNI

BARNASE WILDTYPE STRUCTURE AT PH 6.0
分子名称:	BARNASE
著者	Cameron, A, Henrick, K, Fersht, A.R, Dodson, G, Buckle, A.M.
登録日	1995-05-17
公開日	1995-09-15
最終更新日	2024-02-07
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	Crystal structural analysis of mutations in the hydrophobic cores of barnase. J.Mol.Biol., 234, 1993

2OLB

OLIGOPEPTIDE BINDING PROTEIN (OPPA) COMPLEXED WITH TRI-LYSINE
分子名称:	ACETATE ION, OLIGO-PEPTIDE BINDING PROTEIN, TRIPEPTIDE LYS-LYS-LYS, ...
著者	Tame, J, Wilkinson, A.J.
登録日	1995-09-10
公開日	1996-01-29
最終更新日	2011-07-13
実験手法	X-RAY DIFFRACTION (1.4 Å)
主引用文献	The crystal structures of the oligopeptide-binding protein OppA complexed with tripeptide and tetrapeptide ligands. Structure, 3, 1995

1TGL

A SERINE PROTEASE TRIAD FORMS THE CATALYTIC CENTRE OF A TRIACYLGLYCEROL LIPASE
分子名称:	TRIACYL-GLYCEROL ACYLHYDROLASE
著者	Brady, L, Brzozowski, A.M, Derewenda, Z.S, Dodson, E.J, Dodson, G.G, Tolley, S.P, Turkenburg, J.P, Christiansen, L, Huge-Jensen, B, Norskov, L, Thim, L.
登録日	1990-02-05
公開日	1990-10-15
最終更新日	2024-02-14
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	A serine protease triad forms the catalytic centre of a triacylglycerol lipase. Nature, 343, 1990

1JET

OLIGO-PEPTIDE BINDING PROTEIN (OPPA) COMPLEXED WITH KAK
分子名称:	OLIGO-PEPTIDE BINDING PROTEIN, PEPTIDE LYS ALA LYS, URANYL (VI) ION
著者	Tame, J, Wilkinson, A.J.
登録日	1996-07-03
公開日	1997-05-15
最終更新日	2023-08-09
実験手法	X-RAY DIFFRACTION (1.2 Å)
主引用文献	The role of water in sequence-independent ligand binding by an oligopeptide transporter protein. Nat.Struct.Biol., 3, 1996

1MYH

HIGH RESOLUTION X-RAY STRUCTURES OF PIG METMYOGLOBIN AND TWO CD3 MUTANTS MB(LYS45-> ARG) AND MB(LYS45-> SER)
分子名称:	MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION
著者	Smerdon, S.J, Oldfield, T.J, Wilkinson, A.J, Dauter, Z, Petratos, K, Wilson, K.S.
登録日	1992-02-27
公開日	1994-01-31
最終更新日	2024-02-14
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	High-resolution X-ray structures of pig metmyoglobin and two CD3 mutants: Mb(Lys45----Arg) and Mb(Lys45----Ser). Biochemistry, 31, 1992

2RJI

Malarial EBA-175 region VI crystallographic structure reveals a KIX-like binding interface
分子名称:	CALCIUM ION, Erythrocyte binding antigen 175
著者	Withers-Martinez, C, Blackman, M.J.
登録日	2007-10-15
公開日	2007-11-27
最終更新日	2024-10-16
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Malarial EBA-175 Region VI Crystallographic Structure Reveals a KIX-Like Binding Interface J.Mol.Biol., 375, 2008

2RBI

STRUCTURE OF BINASE MUTANT HIS 101 ASN
分子名称:	RIBONUCLEASE
著者	Offen, W.A, Okorokov, A.L.
登録日	1996-11-12
公開日	1997-03-12
最終更新日	2024-04-03
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	RNA cleavage without hydrolysis. Splitting the catalytic activities of binase with Asn101 and Thr101 mutations. Protein Eng., 10, 1997

1OLA

THE STRUCTURAL BASIS OF MULTISPECIFICITY IN THE OLIGOPEPTIDE-BINDING PROTEIN OPPA
分子名称:	OLIGO-PEPTIDE BINDING PROTEIN, PEPTIDE VAL-LYS-PRO-GLY, URANYL (VI) ION
著者	Tame, J, Wilkinson, A.J.
登録日	1994-04-26
公開日	1994-07-31
最終更新日	2024-06-05
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	The structural basis of sequence-independent peptide binding by OppA protein. Science, 264, 1994

3ENG

STRUCTURE OF ENDOGLUCANASE V CELLOBIOSE COMPLEX
分子名称:	ENDOGLUCANASE V CELLOBIOSE COMPLEX, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose
著者	Davies, G.J, Schulein, M.
登録日	1996-10-17
公開日	1997-06-16
最終更新日	2024-10-16
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Structure determination and refinement of the Humicola insolens endoglucanase V at 1.5 A resolution. Acta Crystallogr.,Sect.D, 52, 1996

1RKM

STRUCTURE OF OPPA
分子名称:	OLIGO-PEPTIDE BINDING PROTEIN
著者	Sleigh, S.H, Tame, J.R.H, Wilkinson, A.J.
登録日	1997-03-25
公開日	1997-07-29
最終更新日	2023-08-09
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	Peptide binding in OppA, the crystal structures of the periplasmic oligopeptide binding protein in the unliganded form and in complex with lysyllysine. Biochemistry, 36, 1997

1OLC

OLIGO-PEPTIDE BINDING PROTEIN (OPPA) COMPLEXED WITH LYS-LYS-LYS-ALA
分子名称:	LYS-LYS-LYS-ALA, OLIGO-PEPTIDE BINDING PROTEIN, URANYL (VI) ION
著者	Tame, J, Wilkinson, A.J.
登録日	1995-09-10
公開日	1996-01-29
最終更新日	2011-07-13
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	The crystal structures of the oligopeptide-binding protein OppA complexed with tripeptide and tetrapeptide ligands. Structure, 3, 1995

1QKA

OLIGO-PEPTIDE BINDING PROTEIN (OPPA) COMPLEXED WITH KRK
分子名称:	LYS-ARG-LYS, PERIPLASMIC OLIGOPEPTIDE-BINDING PROTEIN, URANYL (VI) ION
著者	Tame, J.R.H, Wilkinson, A.J.
登録日	1999-07-14
公開日	1999-09-09
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Crystallographic and Calorimetric Analysis of Peptide Binding to Oppa Protein J.Mol.Biol., 291, 1999

1QKB

OLIGO-PEPTIDE BINDING PROTEIN (OPPA) COMPLEXED WITH KVK
分子名称:	ACETATE ION, PEPTIDE LYS-VAL-LYS, PERIPLASMIC OLIGOPEPTIDE-BINDING PROTEIN, ...
著者	Tame, J.R.H, Sleigh, S.H, Wilkinson, A.J.
登録日	1999-07-14
公開日	1999-09-09
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Crystallographic and Calorimetric Analysis of Peptide Binding to Oppa Protein J.Mol.Biol., 291, 1999

4LVN

Crystal structure of PfSUB1-prodomain-NIMP.M7 Fab complex
分子名称:	CALCIUM ION, NICKEL (II) ION, NIMP.M7 Fab heavy chain, ...
著者	Withers-Martinez, C, Blackman, M.J.
登録日	2013-07-26
公開日	2014-05-07
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.25 Å)
主引用文献	The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin. Nat Commun, 5, 2014

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