2MUW
 
 | | NOE-based model of the influenza A virus N31S mutant (19-49) bound to drug 11 | | 分子名称: | (3s,5s,7s)-N-[(5-bromothiophen-2-yl)methyl]tricyclo[3.3.1.1~3,7~]decan-1-aminium, Matrix protein 2 | | 著者 | Wu, Y, Wang, J, DeGrado, W. | | 登録日 | 2014-09-18 | | 公開日 | 2014-12-24 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Flipping in the Pore: Discovery of Dual Inhibitors That Bind in Different Orientations to the Wild-Type versus the Amantadine-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel.
J.Am.Chem.Soc., 136, 2014
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6W70
 | | Crystal Structure of apixaban-bound ABLE | | 分子名称: | 1-(4-METHOXYPHENYL)-7-OXO-6-[4-(2-OXOPIPERIDIN-1-YL)PHENYL]-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[3,4-C]PYRIDINE-3-CARBOXAMIDE, ACETATE ION, De novo designed ABLE, ... | | 著者 | Polizzi, N.F. | | 登録日 | 2020-03-18 | | 公開日 | 2020-08-26 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.296 Å) | | 主引用文献 | A defined structural unit enables de novo design of small-molecule-binding proteins.
Science, 369, 2020
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6W6X
 | | Crystal Structure of ABLE Apo-protein | | 分子名称: | ACETATE ION, De novo designed ABLE protein, SULFATE ION | | 著者 | Polizzi, N.F. | | 登録日 | 2020-03-18 | | 公開日 | 2020-08-26 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.297 Å) | | 主引用文献 | A defined structural unit enables de novo design of small-molecule-binding proteins.
Science, 369, 2020
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7PGG
 | | NaVAb1p detergent (DM) | | 分子名称: | 2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}ethyl heptadecanoate, Ion transport protein | | 著者 | Lolicato, M, Arrigoni, C. | | 登録日 | 2021-08-13 | | 公開日 | 2022-06-15 | | 最終更新日 | 2022-06-29 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Quaternary structure independent folding of voltage-gated ion channel pore domain subunits.
Nat.Struct.Mol.Biol., 29, 2022
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7PGH
 | | NaVAe1/Sp1CTDp (DDM) | | 分子名称: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, DODECAETHYLENE GLYCOL, DODECANE, ... | | 著者 | Lolicato, M, Arrigoni, C. | | 登録日 | 2021-08-14 | | 公開日 | 2022-06-15 | | 最終更新日 | 2022-06-29 | | 実験手法 | X-RAY DIFFRACTION (4.194 Å) | | 主引用文献 | Quaternary structure independent folding of voltage-gated ion channel pore domain subunits.
Nat.Struct.Mol.Biol., 29, 2022
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7PGI
 | | NaVAb1p (bicelles) | | 分子名称: | ACETATE ION, Ion transport protein, MAGNESIUM ION, ... | | 著者 | Lolicato, M, Arrigoni, C. | | 登録日 | 2021-08-14 | | 公開日 | 2022-06-08 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (3.638 Å) | | 主引用文献 | Quaternary structure independent folding of voltage-gated ion channel pore domain subunits.
Nat.Struct.Mol.Biol., 29, 2022
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7PGF
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7PG8
 | | NaV_Ae1/Sp1CTD_pore-ANT05 complex | | 分子名称: | ANT05 H12 fab fragment, heavy chain, light chain, ... | | 著者 | Lolicato, M, Arrigoni, C. | | 登録日 | 2021-08-13 | | 公開日 | 2022-06-08 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (4.5 Å) | | 主引用文献 | Quaternary structure independent folding of voltage-gated ion channel pore domain subunits.
Nat.Struct.Mol.Biol., 29, 2022
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7PGB
 | | NaV_Ae1/Sp1CTD_pore-SAT09 complex | | 分子名称: | 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 4-NITROBENZOIC ACID, ... | | 著者 | Lolicato, M, Arrigoni, C. | | 登録日 | 2021-08-13 | | 公開日 | 2022-06-08 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | Quaternary structure independent folding of voltage-gated ion channel pore domain subunits.
Nat.Struct.Mol.Biol., 29, 2022
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4DAC
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1BYZ
 | | DESIGNED PEPTIDE ALPHA-1, P1 FORM | | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, ... | | 著者 | Prive, G.G, Anderson, D.H, Wesson, L, Cascio, D, Eisenberg, D. | | 登録日 | 1998-10-20 | | 公開日 | 1998-10-28 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (0.9 Å) | | 主引用文献 | Packed protein bilayers in the 0.90 A resolution structure of a designed alpha helical bundle.
Protein Sci., 8, 1999
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2KV9
 | | Integrin beta3 subunit in a disulfide linked alphaIIb-beta3 cytosolic domain | | 分子名称: | Integrin beta-3 | | 著者 | Metcalf, D.G, Kielec, J.M, Valentine, K.G, Wand, A, Bennett, J.S, William, D.F, Moore, D.T, Molnar, K. | | 登録日 | 2010-03-10 | | 公開日 | 2011-01-12 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR analysis of the {alpha}IIb{beta}3 cytoplasmic interaction suggests a mechanism for integrin regulation.
Proc.Natl.Acad.Sci.USA, 107, 2010
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1MFT
 | | Crystal Structure Of Four-Helix Bundle Model | | 分子名称: | Four-helix bundle model, ZINC ION | | 著者 | Lahr, S.J, Stayrook, S.E, North, B, Kaplan, J, Geremia, S, DeGrado, W. | | 登録日 | 2002-08-13 | | 公開日 | 2004-01-20 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Analysis and Design of Turns in alpha-Helical Hairpins
J.Mol.Biol., 346, 2005
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6C4Y
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6C4Z
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6C4X
 | | Cross-alpha Amyloid-like Structure alphaAmmem | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ZINC ION, cross-alpha amyloid-like membrane peptide alpha-AmMEM | | 著者 | Liu, L, Zhang, S.Q. | | 登録日 | 2018-01-13 | | 公開日 | 2018-08-15 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (3.55 Å) | | 主引用文献 | Designed peptides that assemble into cross-alpha amyloid-like structures.
Nat. Chem. Biol., 14, 2018
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6C50
 | | Cross-alpha Amyloid-like Structure alphaAmS | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Cross-alpha Amyloid-like Structure alphaAmS, FORMIC ACID | | 著者 | Liu, L, Zhang, S.Q. | | 登録日 | 2018-01-13 | | 公開日 | 2018-08-15 | | 最終更新日 | 2019-12-18 | | 実験手法 | X-RAY DIFFRACTION (2.503 Å) | | 主引用文献 | Designed peptides that assemble into cross-alpha amyloid-like structures.
Nat. Chem. Biol., 14, 2018
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6C52
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6C51
 | | Cross-alpha Amyloid-like Structure alphaAmL | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Cross-alpha Amyloid-like Structure alphaAmL, PHOSPHATE ION | | 著者 | Liu, L, Zhang, S.Q. | | 登録日 | 2018-01-13 | | 公開日 | 2018-08-15 | | 最終更新日 | 2019-12-18 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Designed peptides that assemble into cross-alpha amyloid-like structures.
Nat. Chem. Biol., 14, 2018
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4QK7
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5TGW
 | | NMR structure of apo-PS1 | | 分子名称: | PS1 | | 著者 | Polizzi, N.F, Wu, Y. | | 登録日 | 2016-09-28 | | 公開日 | 2017-08-09 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | De novo design of a hyperstable non-natural protein-ligand complex with sub- angstrom accuracy.
Nat Chem, 9, 2017
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5TGY
 | | NMR structure of holo-PS1 | | 分子名称: | PS1, [5,10,15,20-tetrakis(trifluoromethyl)porphyrinato(2-)-kappa~4~N~21~,N~22~,N~23~,N~24~]zinc | | 著者 | Polizzi, N.F, Wu, Y. | | 登録日 | 2016-09-28 | | 公開日 | 2017-08-09 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | De novo design of a hyperstable non-natural protein-ligand complex with sub- angstrom accuracy.
Nat Chem, 9, 2017
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