1IM6
 
 | |
5KIQ
 | | SrpA with sialyl LewisX | | 分子名称: | ACETATE ION, CALCIUM ION, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Iverson, T.M. | | 登録日 | 2016-06-16 | | 公開日 | 2017-05-24 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.638 Å) | | 主引用文献 | Structures of the Streptococcus sanguinis SrpA Binding Region with Human Sialoglycans Suggest Features of the Physiological Ligand.
Biochemistry, 2016
|
|
6LQN
 | | EBV tegument protein BBRF2 | | 分子名称: | Cytoplasmic envelopment protein 1, NITRATE ION, SULFATE ION | | 著者 | He, H.P, Luo, M, Cao, Y.L, Gao, S. | | 登録日 | 2020-01-14 | | 公開日 | 2020-10-07 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.600022 Å) | | 主引用文献 | Structure of Epstein-Barr virus tegument protein complex BBRF2-BSRF1 reveals its potential role in viral envelopment.
Nat Commun, 11, 2020
|
|
4NSX
 | | Crystal Structure of the Utp21 tandem WD Domain | | 分子名称: | CITRATE ANION, U3 small nucleolar RNA-associated protein 21 | | 著者 | Zhang, C, Ye, K. | | 登録日 | 2013-11-29 | | 公開日 | 2014-02-19 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structure of Utp21 Tandem WD Domain Provides Insight into the Organization of the UTPB Complex Involved in Ribosome Synthesis
Plos One, 9, 2014
|
|
1IRB
 | | CARBOXYLIC ESTER HYDROLASE | | 分子名称: | CALCIUM ION, PHOSPHOLIPASE A2 | | 著者 | Sundaralingam, M. | | 登録日 | 1997-08-13 | | 公開日 | 1997-12-24 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Phospholipase A2 engineering. Deletion of the C-terminus segment changes substrate specificity and uncouples calcium and substrate binding at the zwitterionic interface.
Biochemistry, 35, 1996
|
|
5WCC
 | | Crystal structure of the broadly neutralizing Influenza A antibody VRC 315 02-1F07 Fab. | | 分子名称: | GLYCEROL, POLYETHYLENE GLYCOL (N=34), SULFATE ION, ... | | 著者 | Joyce, M.G, Andrews, S.F, Mascola, J.R, McDermott, A.B, Kwong, P.D. | | 登録日 | 2017-06-29 | | 公開日 | 2017-12-13 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.461 Å) | | 主引用文献 | Preferential induction of cross-group influenza A hemagglutinin stem-specific memory B cells after H7N9 immunization in humans.
Sci Immunol, 2, 2017
|
|
9GGL
 | | Cryo-EM structure of KBTBD4 WT-HDAC2 2:1 complex mediated by molecular glue UM171 | | 分子名称: | (1r,4r)-N~1~-[(7P)-2-benzyl-7-(2-methyl-2H-tetrazol-5-yl)-9H-pyrimido[4,5-b]indol-4-yl]cyclohexane-1,4-diamine, Histone deacetylase 2, Isoform 1 of Kelch repeat and BTB domain-containing protein 4, ... | | 著者 | Chen, Z, Chi, G, Pike, A.C.W, Montes, B, Bullock, A.N. | | 登録日 | 2024-08-13 | | 公開日 | 2025-04-09 | | 実験手法 | ELECTRON MICROSCOPY (3.13 Å) | | 主引用文献 | Structural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitment.
Nat Commun, 16, 2025
|
|
9GGN
 | | Cryo-EM structure of KBTBD4 WT-HDAC2 2:2 complex mediated by molecular glue UM171 | | 分子名称: | (1r,4r)-N~1~-[(7P)-2-benzyl-7-(2-methyl-2H-tetrazol-5-yl)-9H-pyrimido[4,5-b]indol-4-yl]cyclohexane-1,4-diamine, Histone deacetylase 2, Isoform 1 of Kelch repeat and BTB domain-containing protein 4, ... | | 著者 | Chen, Z, Chi, G, Pike, A.C.W, Montes, B, Bullock, A.N. | | 登録日 | 2024-08-13 | | 公開日 | 2025-04-09 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitment.
Nat Commun, 16, 2025
|
|
9GGM
 | | Cryo-EM structure of KBTBD4 P313PRR mutant-HDAC2 2:2 complex | | 分子名称: | Histone deacetylase 2, Isoform 1 of Kelch repeat and BTB domain-containing protein 4, ZINC ION | | 著者 | Chen, Z, Chi, G, Pike, A.C.W, Montes, B, Bullock, A.N. | | 登録日 | 2024-08-13 | | 公開日 | 2025-04-09 | | 実験手法 | ELECTRON MICROSCOPY (2.71 Å) | | 主引用文献 | Structural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitment.
Nat Commun, 16, 2025
|
|
5WCA
 | | Crystal structure of the broadly neutralizing Influenza A antibody VRC 315 27-1C08 Fab. | | 分子名称: | VRC315 27-1C08 Fab Heavy chain, VRC315 27-1C08 Fab Light chain | | 著者 | Joyce, M.G, Andrews, S.F, Mascola, J.R, McDermott, A.B, Kwong, P.D. | | 登録日 | 2017-06-29 | | 公開日 | 2017-08-02 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.369 Å) | | 主引用文献 | Preferential induction of cross-group influenza A hemagglutinin stem-specific memory B cells after H7N9 immunization in humans.
Sci Immunol, 2, 2017
|
|
5WCD
 | | Crystal structure of the broadly neutralizing Influenza A antibody VRC 315 04-1D02 Fab. | | 分子名称: | PHOSPHATE ION, SULFATE ION, VRC315 04-1D02 Fab Heavy chain, ... | | 著者 | Joyce, M.G, Andrews, S.F, Mascola, J.R, McDermott, A.B, Kwong, P.D. | | 登録日 | 2017-06-29 | | 公開日 | 2017-08-23 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.814 Å) | | 主引用文献 | Preferential induction of cross-group influenza A hemagglutinin stem-specific memory B cells after H7N9 immunization in humans.
Sci Immunol, 2, 2017
|
|
9I2C
 | | Cryo-EM structure of KBTBD4 WT-HDAC2-CoREST1 2:1:1 complex mediated by molecular glue UM171 | | 分子名称: | (1r,4r)-N~1~-[(7P)-2-benzyl-7-(2-methyl-2H-tetrazol-5-yl)-9H-pyrimido[4,5-b]indol-4-yl]cyclohexane-1,4-diamine, Histone deacetylase 2, Isoform 1 of Kelch repeat and BTB domain-containing protein 4, ... | | 著者 | Chen, Z, Chi, G, Pike, A.C.W, Montes, B, Bullock, A.N. | | 登録日 | 2025-01-20 | | 公開日 | 2025-04-09 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitment.
Nat Commun, 16, 2025
|
|
1HQ2
 | | CRYSTAL STRUCTURE OF A TERNARY COMPLEX OF E.COLI HPPK(R82A) WITH MGAMPCPP AND 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN AT 1.25 ANGSTROM RESOLUTION | | 分子名称: | 2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE, 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE, ACETATE ION, ... | | 著者 | Blaszczyk, J, Ji, X. | | 登録日 | 2000-12-13 | | 公開日 | 2003-04-15 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Dynamic Roles of Arginine Residues 82 and 92 of Escherichia coli
6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase: Crystallographic
Studies
Biochemistry, 42, 2003
|
|
4ZKI
 | |
5C5S
 | |
5C93
 | | Histidine kinase with ATP | | 分子名称: | Histidine kinase, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SULFATE ION | | 著者 | Cai, Y. | | 登録日 | 2015-06-26 | | 公開日 | 2016-07-27 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.518 Å) | | 主引用文献 | Conformational dynamics of the essential sensor histidine kinase WalK.
Acta Crystallogr D Struct Biol, 73, 2017
|
|
8FQ7
 | | Nanobody with WIW inserted in CDR3 loop to Inhibit Growth of Alzheimer's Tau fibrils | | 分子名称: | GLYCEROL, Nanobody with WIW insert in CDR3 loop to target tau fibrils | | 著者 | Abskharon, R, Sawaya, M.R, Cascio, D.C, Eisenberg, D.S. | | 登録日 | 2023-01-05 | | 公開日 | 2023-10-04 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils.
Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
5HDX
 | |
5HE4
 | | BACE-1 in complex with (4aR,7aS)-7a-(2,6-difluorophenyl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-3-methyl-4-oxooctahydro-2H-pyrrolo[3,4-d]pyrimidin-2-iminium | | 分子名称: | (2E,4aR,7aS)-7a-(2,6-difluorophenyl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-2-imino-3-methyloctahydro-4H-pyrrolo[3,4-d]pyrimidin-4-one, Beta-secretase 1, L(+)-TARTARIC ACID | | 著者 | Orth, P. | | 登録日 | 2016-01-05 | | 公開日 | 2016-03-16 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | | 主引用文献 | Structure-Based Design of an Iminoheterocyclic beta-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central A beta in Nonhuman Primates.
J.Med.Chem., 59, 2016
|
|
9C9W
 | | Dimerized human TOP3B-TDRD3 core complex with a DNA mismatch bubble | | 分子名称: | DNA (38-MER), DNA (5'-D(*AP*TP*TP*GP*GP*AP*GP*TP*TP*CP*AP*TP*GP*TP*GP*AP*TP*GP*C)-3'), DNA (5'-D(P*CP*AP*GP*AP*TP*CP*AP*GP*AP*AP*TP*GP*AP*AP*TP*AP*TP*AP*CP*TP*AP*AP*A)-3'), ... | | 著者 | Yang, X. | | 登録日 | 2024-06-16 | | 公開日 | 2025-02-05 | | 実験手法 | ELECTRON MICROSCOPY (4.25 Å) | | 主引用文献 | Structural insights into human topoisomerase 3 beta DNA and RNA catalysis and nucleic acid gate dynamics.
Nat Commun, 16, 2025
|
|
7WI0
 | | SARS-CoV-2 Omicron variant spike in complex with three human neutralizing antibodies | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, IG c1437_light_IGLV1-40_IGLJ1, IG c934_light_IGKV1-5_IGKJ1, ... | | 著者 | Zheng, Q, Li, S, Sun, H, Zheng, Z, Wang, S. | | 登録日 | 2022-01-01 | | 公開日 | 2022-06-22 | | 最終更新日 | 2025-06-18 | | 実験手法 | ELECTRON MICROSCOPY (3.82 Å) | | 主引用文献 | Three SARS-CoV-2 antibodies provide broad and synergistic neutralization against variants of concern, including Omicron.
Cell Rep, 39, 2022
|
|
7WHZ
 | | SARS-CoV-2 spike protein in complex with three human neutralizing antibodies | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, IG c1437_light_IGLV1-40_IGLJ1, IG c934_light_IGKV1-5_IGKJ1, ... | | 著者 | Zheng, Q, Li, S, Sun, H, Zheng, Z, Wang, S. | | 登録日 | 2022-01-01 | | 公開日 | 2022-06-22 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (3.42 Å) | | 主引用文献 | Three SARS-CoV-2 antibodies provide broad and synergistic neutralization against variants of concern, including Omicron.
Cell Rep, 39, 2022
|
|
5HE7
 | | BACE-1 in complex with (4aR,7aS)-7a-(2,4-difluorophenyl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-2-imino-3-methyloctahydro-4H-pyrrolo[3,4-d]pyrimidin-4-one | | 分子名称: | (2E,4aR,7aS)-7a-(2,4-difluorophenyl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-2-imino-3-methyloctahydro-4H-pyrrolo[3,4-d]pyrimidin-4-one, Beta-secretase 1 | | 著者 | Orth, P. | | 登録日 | 2016-01-05 | | 公開日 | 2016-03-16 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | | 主引用文献 | Structure-Based Design of an Iminoheterocyclic beta-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central A beta in Nonhuman Primates.
J.Med.Chem., 59, 2016
|
|
4R95
 | | BACE-1 in complex with 2-(((1R,3S)-3-(((R)-4-(2-cyclohexylethyl)-2-iminio-1-methyl-5-oxoimidazolidin-4-yl)methyl)cyclohexyl)amino)quinolin-1-ium | | 分子名称: | (2E,5R)-5-(2-cyclohexylethyl)-2-imino-3-methyl-5-{[(1S,3R)-3-(quinolin-2-ylamino)cyclohexyl]methyl}imidazolidin-4-one, Beta-secretase 1, L(+)-TARTARIC ACID | | 著者 | Orth, P, Strickland, C, Caldwell, J.P. | | 登録日 | 2014-09-03 | | 公開日 | 2014-11-05 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | Discovery of potent iminoheterocycle BACE1 inhibitors.
Bioorg.Med.Chem.Lett., 24, 2014
|
|
5HDZ
 | |
