2YEX
| Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors | 分子名称: | 5-METHYL-8-(1H-PYRROL-2-YL)[1,2,4]TRIAZOLO[4,3-A]QUINOLIN-1(2H)-ONE, GLYCEROL, SERINE/THREONINE-PROTEIN KINASE CHK1, ... | 著者 | Read, J.A, Breed, J, Haye, H, McCall, E, Vallentine, A, White, A. | 登録日 | 2011-03-31 | 公開日 | 2012-03-14 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Synthesis and Evaluation of Triazolones as Checkpoint Kinase 1 Inhibitors. Bioorg.Med.Chem.Lett., 22, 2012
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3H70
| Crystal structure of o-succinylbenzoic acid synthetase from staphylococcus aureus Complexed with mg in the active site | 分子名称: | MAGNESIUM ION, O-succinylbenzoic acid (OSB) synthetase | 著者 | Fedorov, A.A, Fedorov, E.V, Sauder, J.M, Burley, S.K, Gerlt, J.A, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | 登録日 | 2009-04-24 | 公開日 | 2009-05-05 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Loss of quaternary structure is associated with rapid sequence divergence in the OSBS family. Proc.Natl.Acad.Sci.USA, 111, 2014
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3EG0
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3EQB
| X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... | 著者 | Ohren, J.F, Pavlovsky, A, Zhang, E. | 登録日 | 2008-09-30 | 公開日 | 2008-11-11 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | 2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles-O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase). Bioorg.Med.Chem.Lett., 18, 2008
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3HG6
| Crystal Structure of the Recombinant Onconase from Rana pipiens | 分子名称: | GLYCEROL, Onconase, SULFATE ION | 著者 | Camara-Artigas, A, Gavira, J.A, Casares-Atienza, S, Weininger, U, Balbach, J, Garcia-Mira, M.M. | 登録日 | 2009-05-13 | 公開日 | 2010-05-19 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Three-state thermal unfolding of onconase. Biophys.Chem., 159, 2011
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3MJI
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1EVQ
| THE CRYSTAL STRUCTURE OF THE THERMOPHILIC CARBOXYLESTERASE EST2 FROM ALICYCLOBACILLUS ACIDOCALDARIUS | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, SERINE HYDROLASE | 著者 | De Simone, G, Galdiero, S, Manco, G, Lang, D, Rossi, M, Pedone, C. | 登録日 | 2000-04-20 | 公開日 | 2000-11-22 | 最終更新日 | 2018-01-31 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | A snapshot of a transition state analogue of a novel thermophilic esterase belonging to the subfamily of mammalian hormone-sensitive lipase. J.Mol.Biol., 303, 2000
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1ETG
| REV RESPONSE ELEMENT (RRE) RNA COMPLEXED WITH REV PEPTIDE, NMR, 19 STRUCTURES | 分子名称: | REV PEPTIDE, REV RESPONSIVE ELEMENT RNA | 著者 | Battiste, J.L, Mao, H, Rao, N.S, Tan, R, Muhandiram, D.R, Kay, L.E, Frankel, A.D, Willamson, J.R. | 登録日 | 1996-08-28 | 公開日 | 1997-03-12 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Alpha helix-RNA major groove recognition in an HIV-1 rev peptide-RRE RNA complex. Science, 273, 1996
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1ETF
| REV RESPONSE ELEMENT (RRE) RNA COMPLEXED WITH REV PEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE | 分子名称: | REV PEPTIDE, REV RESPONSE ELEMENT RNA | 著者 | Battiste, J.L, Mao, H, Rao, N.S, Tan, R, Muhandiram, D.R, Kay, L.E, Frankel, A.D, Willamson, J.R. | 登録日 | 1996-08-28 | 公開日 | 1997-03-12 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Alpha helix-RNA major groove recognition in an HIV-1 rev peptide-RRE RNA complex. Science, 273, 1996
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1THX
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1EZN
| SOLUTION STRUCTURE OF A DNA THREE-WAY JUNCTION | 分子名称: | DNA THREE-WAY JUNCTION | 著者 | van Buuren, B.N.M, Overmars, F.J, Ippel, J.H, Altona, C, Wijmenga, S.S. | 登録日 | 2000-05-11 | 公開日 | 2001-04-21 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of a DNA three-way junction containing two unpaired thymidine bases. Identification of sequence features that decide conformer selection. J.Mol.Biol., 304, 2000
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1U0X
| Crystal structure of nitrophorin 4 under pressure of xenon (200 psi) | 分子名称: | AMMONIA, Nitrophorin 4, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Nienhaus, K, Maes, E.M, Weichsel, A, Montfort, W.R, Nienhaus, G.U. | 登録日 | 2004-07-14 | 公開日 | 2004-07-20 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Structural dynamics controls nitric oxide affinity in nitrophorin 4 J.Biol.Chem., 279, 2004
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1FOL
| REDUCED BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH L-ARG(H4B-FREE) | 分子名称: | ACETATE ION, ARGININE, CACODYLATE ION, ... | 著者 | Raman, C.S, Li, H, Martasek, P, Masters, B.S, Poulos, T.L. | 登録日 | 2000-08-28 | 公開日 | 2001-07-20 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystallographic studies on endothelial nitric oxide synthase complexed with nitric oxide and mechanism-based inhibitors Biochemistry, 40, 2001
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1FAH
| STRUCTURE OF CYTOCHROME P450 | 分子名称: | CYTOCHROME P450 BM-3, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Li, H.Y, Poulos, T.L. | 登録日 | 1996-08-01 | 公開日 | 1997-02-12 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The role of Thr268 in oxygen activation of cytochrome P450BM-3. Biochemistry, 34, 1995
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1UT3
| Solution Structure of Spheniscin-2, a beta-Defensin from Penguin Stomach Preserving Food | 分子名称: | SPHENISCIN-2 | 著者 | Landon, C, Labbe, H, Thouzeau, C, Bulet, P, Vovelle, F. | 登録日 | 2003-12-02 | 公開日 | 2004-05-06 | 最終更新日 | 2011-07-13 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution Structure of Spheniscin, a {Beta}-Defensin from the Penguin Stomach J.Biol.Chem., 279, 2004
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3M6F
| CD11A I-domain complexed with 6-((5S,9R)-9-(4-CYANOPHENYL)-3-(3,5-DICHLOROPHENYL)-1-METHYL-2,4-DIOXO-1,3,7- TRIAZASPIRO[4.4]NON-7-YL)NICOTINIC ACID | 分子名称: | 6-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl]pyridine-3-carboxylic acid, Integrin alpha-L, NITRATE ION | 著者 | Sheriff, S. | 登録日 | 2010-03-15 | 公開日 | 2010-05-12 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic acid (BMS-688521). J.Med.Chem., 53, 2010
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1GJR
| Ferredoxin-NADP+ Reductase complexed with NADP+ by COCRYSTALLIZATION | 分子名称: | FERREDOXIN-NADP REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Hermoso, J.A, Mayoral, T, Medina, M, Sanz-Aparicio, J, Gomez-Moreno, C. | 登録日 | 2001-08-01 | 公開日 | 2002-06-27 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Mechanism of Coenzyme Recognition and Binding Revealed by Crystal Structure Analysis of Ferredoxin-Nadp(+) Reductase Complexed with Nadp(+) J.Mol.Biol., 319, 2002
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1H8D
| X-ray structure of the human alpha-thrombin complex with a tripeptide phosphonate inhibitor. | 分子名称: | HIRUDIN I, N-[(benzyloxy)carbonyl]-beta-phenyl-D-phenylalanyl-N-{(1S,3E)-1-[dihydroxy(diphenoxy)-lambda~5~-phosphanyl]-4-methoxybut-3-en-1-yl}-L-prolinamide, THROMBIN | 著者 | Skordalakes, E, Dodson, G.G, Green, D, Deadman, J. | 登録日 | 2001-02-01 | 公開日 | 2001-02-26 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Inhibition of Human Alpha-Thrombin by a Phosphonate Tripeptide Proceeds Via a Metastable Pentacoordinated Phosphorus Intermediate J.Mol.Biol., 311, 2001
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1GY3
| pCDK2/cyclin A in complex with MgADP, nitrate and peptide substrate | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, ... | 著者 | Cook, A, Lowe, E.D, Chrysina, E.D, Skamnaki, V.T, Oikonomakos, N.G, Johnson, L.N. | 登録日 | 2002-04-19 | 公開日 | 2002-04-29 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural Studies on Phospho-Cdk2/Cyclin a Bound to Nitrate, a Transition State Analogue: Implications for the Protein Kinase Mechanism Biochemistry, 41, 2002
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1H25
| CDK2/Cyclin A in complex with an 11-residue recruitment peptide from retinoblastoma-associated protein | 分子名称: | CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, RETINOBLASTOMA-ASSOCIATED PROTEIN | 著者 | Tews, I, Cheng, K.Y, Lowe, E.D, Noble, M.E.M, Brown, N.R, Gul, S, Gamblin, S, Johnson, L.N. | 登録日 | 2002-07-31 | 公開日 | 2003-02-01 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A Biochemistry, 41, 2002
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3OYR
| Crystal structure of polyprenyl synthase from Caulobacter crescentus CB15 complexed with calcium and isoprenyl diphosphate | 分子名称: | CALCIUM ION, DIMETHYLALLYL DIPHOSPHATE, PYROPHOSPHATE 2-, ... | 著者 | Patskovsky, Y, Toro, R, Rutter, M, Sauder, J.M, Burley, S.K, Poulter, C.D, Gerlt, J.A, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | 登録日 | 2010-09-23 | 公開日 | 2010-10-13 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily. Proc.Natl.Acad.Sci.USA, 110, 2013
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1UP8
| Recombinant vanadium-dependent bromoperoxidase from red algae Corallina pilulifera | 分子名称: | CALCIUM ION, PHOSPHATE ION, VANADIUM-DEPENDENT BROMOPEROXIDASE 1 | 著者 | Garcia-Rodriguez, E, Isupov, M, Ohshiro, T, Izumi, Y, Littlechild, J.A. | 登録日 | 2003-09-29 | 公開日 | 2003-09-30 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Enhancing Effect of Calcium and Vanadium Ions on Thermal Stability of Bromoperoxidase from Corallina Pilulifera. J.Biol.Inorg.Chem., 10, 2005
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1UVZ
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1H8I
| X-ray crystal structure of human alpha-thrombin with a tripeptide phosphonate inhibitor. | 分子名称: | HIRUDIN I, N-[(benzyloxy)carbonyl]-beta-phenyl-D-phenylalanyl-N-[(1S)-4-methoxy-1-phosphonobutyl]-L-prolinamide, THROMBIN | 著者 | Skordalakes, E, Dodson, G.G, Green, D, Deadman, J. | 登録日 | 2001-02-08 | 公開日 | 2001-03-02 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Inhibition of Human Alpha-Thrombin by a Phosphonate Tripeptide Proceeds Via a Metastable Pentacoordinated Phosphorus Intermediate J.Mol.Biol., 311, 2001
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1H24
| CDK2/CyclinA in complex with a 9 residue recruitment peptide from E2F | 分子名称: | CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, TRANSCRIPTION FACTOR E2F1 | 著者 | Tews, I, Cheng, K.Y, Lowe, E.D, Noble, M.E.M, Brown, N.R, Gul, S, Gamblin, S, Johnson, L.N. | 登録日 | 2002-07-31 | 公開日 | 2003-02-01 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A Biochemistry, 41, 2002
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