4QYY
 
 | | Discovery of Novel, Dual Mechanism ERK Inhibitors by Affinity Selection Screening of an Inactive Kinase State | | 分子名称: | (3R)-1-{2-[4-(4-acetylphenyl)piperazin-1-yl]-2-oxoethyl}-N-(3-chloro-4-hydroxyphenyl)pyrrolidine-3-carboxamide, Mitogen-activated protein kinase 1, SULFATE ION | | 著者 | Deng, Y, Shipps, G.W, Cooper, A, English, J.M, Annis, D.A, Carr, D, Nan, Y, Wang, T, Zhu, Y.H, Chuang, C, Dayananth, P, Hruza, A.W, Xiao, L, Jin, W, Kirschmeier, P, Windsor, W.T, Samatar, A.A. | | 登録日 | 2014-07-26 | | 公開日 | 2014-11-12 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Discovery of Novel, Dual Mechanism ERK Inhibitors by Affinity Selection Screening of an Inactive Kinase.
J.Med.Chem., 57, 2014
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8HLT
 | | The co-crystal structure of DYRK2 with YK-2-99B | | 分子名称: | (6-{[(4P)-4-(1,3-benzothiazol-5-yl)-5-fluoropyrimidin-2-yl]amino}pyridin-3-yl)(piperazin-1-yl)methanone, Dual specificity tyrosine-phosphorylation-regulated kinase 2 | | 著者 | Shen, H.T, Xiao, Y.B, Yuan, K, Yang, P, Li, Q.N. | | 登録日 | 2022-12-01 | | 公開日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Discovery of Potent DYRK2 Inhibitors with High Selectivity, Great Solubility, and Excellent Safety Properties for the Treatment of Prostate Cancer.
J.Med.Chem., 66, 2023
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7CFW
 | | Crystal structure of the receiver domain of sensor histidine kinase PA1611 (PA1611REC) from Pseudomonas aeruginosa PAO1 with calcium ion coordinated in the active site cleft | | 分子名称: | CALCIUM ION, Histidine kinase | | 著者 | Chen, S.K, Guan, H.H, Wu, P.H, Lin, L.T, Wu, M.C, Chang, H.Y, Chen, N.C, Lin, C.C, Chuankhayan, P, Huang, Y.C, Lin, P.J, Chen, C.J. | | 登録日 | 2020-06-29 | | 公開日 | 2020-11-04 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.31 Å) | | 主引用文献 | Structural insights into the histidine-containing phospho-transfer protein and receiver domain of sensor histidine kinase suggest a complex model in the two-component regulatory system in Pseudomonas aeruginosa
Iucrj, 7, 2020
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5X45
 | | Crystal structure of 2A protease from Human rhinovirus C15 | | 分子名称: | ZINC ION, protease 2A | | 著者 | Ling, H, Yang, P, Shaw, N, Sun, Y, Wang, X. | | 登録日 | 2017-02-10 | | 公開日 | 2018-02-21 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.602 Å) | | 主引用文献 | Structural view of the 2A protease from human rhinovirus C15.
Acta Crystallogr.,Sect.F, 74, 2018
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5YWO
 | | Structure of JEV-2F2 Fab complex | | 分子名称: | 2F2 heavy chain, 2F2 light chain, JEV E protein, ... | | 著者 | Qiu, X, Lei, Y.F, Yang, P, Gao, Q, Wang, N, Cao, L, Yuan, S, Wang, X, Xu, Z.K, Rao, Z. | | 登録日 | 2017-11-29 | | 公開日 | 2018-03-21 | | 最終更新日 | 2018-09-12 | | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | | 主引用文献 | Structural basis for neutralization of Japanese encephalitis virus by two potent therapeutic antibodies
Nat Microbiol, 3, 2018
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5YWP
 | | JEV-2H4 Fab complex | | 分子名称: | 2H4 heavy chain, 2H4 light chain, JEV E protein, ... | | 著者 | Qiu, X.D, Lei, Y.F, Yang, P, Gao, Q, WANG, N, Cao, L, Yuan, S, Wang, X.X, Xu, Z.K, Rao, Z.H. | | 登録日 | 2017-11-29 | | 公開日 | 2018-05-02 | | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | | 主引用文献 | Structural basis for neutralization of Japanese encephalitis virus by two potent therapeutic antibodies
Nat Microbiol, 3, 2018
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5YWF
 | | Crystal structure of 2H4 Fab | | 分子名称: | 2H4 heavy chain, 2H4 light chain | | 著者 | Qiu, X, Lei, Y, Yang, P, Gao, Q, Wang, N, Cao, L, Wang, X, Xu, Z.K, Rao, Z. | | 登録日 | 2017-11-29 | | 公開日 | 2018-03-21 | | 実験手法 | X-RAY DIFFRACTION (2.206 Å) | | 主引用文献 | Structural basis for neutralization of Japanese encephalitis virus by two potent therapeutic antibodies
Nat Microbiol, 3, 2018
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5XBM
 | | Structure of SCARB2-JL2 complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Lysosome membrane protein 2, ... | | 著者 | Zhang, X, Yang, P, Wang, N, Zhang, J, Li, J, Guo, H, Yin, X, Rao, Z, Wang, X, Zhang, L. | | 登録日 | 2017-03-20 | | 公開日 | 2018-06-27 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.501 Å) | | 主引用文献 | The binding of a monoclonal antibody to the apical region of SCARB2 blocks EV71 infection.
Protein Cell, 8, 2017
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5YL0
 | | The crystal structure of Penaeus vannamei nodavirus P-domain (P212121) | | 分子名称: | Capsid protein | | 著者 | Chen, N.C, Yoshimura, M, Lin, C.C, Guan, H.H, Chuankhayan, P, Chen, C.J. | | 登録日 | 2017-10-16 | | 公開日 | 2018-10-24 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.22 Å) | | 主引用文献 | The atomic structures of shrimp nodaviruses reveal new dimeric spike structures and particle polymorphism.
Commun Biol, 2, 2019
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5YKX
 | | The crystal structure of Macrobrachium rosenbergii nodavirus P-domain with Cd ion | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CADMIUM ION, Capsid protein, ... | | 著者 | Chen, N.C, Yoshimura, M, Lin, C.C, Guan, H.H, Chuankhayan, P, Chen, C.J. | | 登録日 | 2017-10-16 | | 公開日 | 2018-10-24 | | 最終更新日 | 2019-03-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The atomic structures of shrimp nodaviruses reveal new dimeric spike structures and particle polymorphism.
Commun Biol, 2, 2019
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5YKZ
 | | The crystal structure of Penaeus vannamei nodavirus P-domain (P21) | | 分子名称: | Capsid protein | | 著者 | Chen, N.C, Yoshimura, M, Lin, C.C, Guan, H.H, Chuankhayan, P, Chen, C.J. | | 登録日 | 2017-10-16 | | 公開日 | 2018-10-24 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.17 Å) | | 主引用文献 | The atomic structures of shrimp nodaviruses reveal new dimeric spike structures and particle polymorphism.
Commun Biol, 2, 2019
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5YKV
 | | The crystal structure of Macrobrachium rosenbergii nodavirus P-domain | | 分子名称: | Capsid protein | | 著者 | Chen, N.C, Yoshimura, M, Lin, C.C, Guan, H.H, Chuankhayan, P, Chen, C.J. | | 登録日 | 2017-10-16 | | 公開日 | 2018-10-24 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | | 主引用文献 | The atomic structures of shrimp nodaviruses reveal new dimeric spike structures and particle polymorphism.
Commun Biol, 2, 2019
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5YKU
 | | The crystal structure of Macrobrachium rosenbergii nodavirus P-domain with Zn ions | | 分子名称: | Capsid protein, ZINC ION | | 著者 | Chen, N.C, Yoshimura, M, Lin, C.C, Guan, H.H, Chuankhayan, P, Chen, C.J. | | 登録日 | 2017-10-16 | | 公開日 | 2018-10-24 | | 最終更新日 | 2019-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.39 Å) | | 主引用文献 | The atomic structures of shrimp nodaviruses reveal new dimeric spike structures and particle polymorphism.
Commun Biol, 2, 2019
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5YL1
 | | T=1 subviral particle of Penaeus vannamei nodavirus capsid protein deletion mutant (delta 1-37 & 251-368) | | 分子名称: | CALCIUM ION, Capsid protein | | 著者 | Chen, N.C, Yoshimura, M, Lin, C.C, Guan, H.H, Chuankhayan, P, Chen, C.J. | | 登録日 | 2017-10-16 | | 公開日 | 2018-12-12 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (3.12 Å) | | 主引用文献 | The atomic structures of shrimp nodaviruses reveal new dimeric spike structures and particle polymorphism.
Commun Biol, 2, 2019
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7YUY
 | | Structure of a mutated membrane-bound glycosyltransferase | | 分子名称: | (11R,14S)-17-amino-14-hydroxy-8,14-dioxo-9,13,15-trioxa-14lambda~5~-phosphaheptadecan-11-yl decanoate, 1,3-beta-glucan synthase component FKS1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Hu, X.L, Yang, P, Zhang, M, Liu, X.T, Yu, H.J. | | 登録日 | 2022-08-18 | | 公開日 | 2023-03-29 | | 最終更新日 | 2023-04-19 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structural and mechanistic insights into fungal beta-1,3-glucan synthase FKS1.
Nature, 616, 2023
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7XPE
 | | Cryo-EM structure of the T=4 lake sinai virus 2 virus-like capsid at pH 8.5 | | 分子名称: | Capsid protein alpha | | 著者 | Chen, N.C, Wang, C.H, Chen, C.J, Yoshimura, M, Guan, H.H, Chuankhayan, P, Lin, C.C. | | 登録日 | 2022-05-04 | | 公開日 | 2023-02-08 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | | 主引用文献 | Structures of honeybee-infecting Lake Sinai virus reveal domain functions and capsid assembly with dynamic motions.
Nat Commun, 14, 2023
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7XGZ
 | | Cryo-EM structure of the T=4 lake sinai virus 2 virus-like capsid at pH 7.5 | | 分子名称: | Capsid protein alpha | | 著者 | Chen, N.C, Wang, C.H, Chen, C.J, Yoshimura, M, Guan, H.H, Chuankhayan, P, Lin, C.C. | | 登録日 | 2022-04-07 | | 公開日 | 2023-02-08 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | | 主引用文献 | Structures of honeybee-infecting Lake Sinai virus reveal domain functions and capsid assembly with dynamic motions
Nat Commun, 14, 2023
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7XPA
 | | Cryo-EM structure of the T=3 lake sinai virus 2 virus-like capsid at pH 7.5 | | 分子名称: | Capsid protein alpha | | 著者 | Chen, N.C, Wang, C.H, Chen, C.J, Yoshimura, M, Guan, H.H, Chuankhayan, P, Lin, C.C. | | 登録日 | 2022-05-04 | | 公開日 | 2023-02-08 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (3.33 Å) | | 主引用文献 | Structures of honeybee-infecting Lake Sinai virus reveal domain functions and capsid assembly with dynamic motions.
Nat Commun, 14, 2023
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7XPD
 | | Cryo-EM structure of the T=3 lake sinai virus 2 virus-like capsid at pH 6.5 | | 分子名称: | Capsid protein alpha | | 著者 | Chen, N.C, Wang, C.H, Chen, C.J, Yoshimura, M, Guan, H.H, Chuankhayan, P, Lin, C.C. | | 登録日 | 2022-05-04 | | 公開日 | 2023-02-08 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (3.74 Å) | | 主引用文献 | Structures of honeybee-infecting Lake Sinai virus reveal domain functions and capsid assembly with dynamic motions.
Nat Commun, 14, 2023
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7XPF
 | | Cryo-EM structure of the T=3 lake sinai virus 2 virus-like capsid at pH 8.5 | | 分子名称: | Capsid protein alpha | | 著者 | Chen, N.C, Wang, C.H, Chen, C.J, Yoshimura, M, Guan, H.H, Chuankhayan, P, Lin, C.C. | | 登録日 | 2022-05-04 | | 公開日 | 2023-02-08 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (3.13 Å) | | 主引用文献 | Structures of honeybee-infecting Lake Sinai virus reveal domain functions and capsid assembly with dynamic motions.
Nat Commun, 14, 2023
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7XPB
 | | Cryo-EM structure of the T=4 lake sinai virus 2 virus-like capsid at pH 6.5 | | 分子名称: | Capsid protein alpha | | 著者 | Chen, N.C, Wang, C.H, Chen, C.J, Yoshimura, M, Guan, H.H, Chuankhayan, P, Lin, C.C. | | 登録日 | 2022-05-04 | | 公開日 | 2023-02-08 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (3.91 Å) | | 主引用文献 | Structures of honeybee-infecting Lake Sinai virus reveal domain functions and capsid assembly with dynamic motions.
Nat Commun, 14, 2023
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7XPG
 | | Cryo-EM structure of the T=3 lake sinai virus 1 (delta-N48) virus-like capsid at pH 6.5 | | 分子名称: | Capsid protein alpha, RNA (5'-R(P*UP*G)-3') | | 著者 | Chen, N.C, Wang, C.H, Chen, C.J, Yoshimura, M, Guan, H.H, Chuankhayan, P, Lin, C.C. | | 登録日 | 2022-05-04 | | 公開日 | 2023-02-08 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (3.51 Å) | | 主引用文献 | Structures of honeybee-infecting Lake Sinai virus reveal domain functions and capsid assembly with dynamic motions.
Nat Commun, 14, 2023
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7VUN
 | | Design, modification, evaluation and cocrystal studies of novel phthalimides regulating PD-1/PD-L1 interaction | | 分子名称: | (2~{S},3~{S})-2-[[6-[(3-cyanophenyl)methoxy]-2-(2-methyl-3-phenyl-phenyl)-1,3-bis(oxidanylidene)isoindol-5-yl]methylamino]-3-oxidanyl-butanoic acid, Programmed cell death 1 ligand 1 | | 著者 | Cheng, Y, Sun, C.L, Chen, M.R, Yang, P, Xiao, Y.B. | | 登録日 | 2021-11-03 | | 公開日 | 2022-09-14 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.701 Å) | | 主引用文献 | Novel phthalimides regulating PD-1/PD-L1 interaction as potential immunotherapy agents.
Acta Pharm Sin B, 12, 2022
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7EJV
 | | The co-crystal structure of DYRK2 with YK-2-69 | | 分子名称: | Dual specificity tyrosine-phosphorylation-regulated kinase 2, [6-[[4-[2-(dimethylamino)-1,3-benzothiazol-6-yl]-5-fluoranyl-pyrimidin-2-yl]amino]pyridin-3-yl]-(4-ethylpiperazin-1-yl)methanone | | 著者 | Li, Z, Xiao, Y, Yuan, K, Kuang, W, Xiuquan, Y, Yang, P. | | 登録日 | 2021-04-02 | | 公開日 | 2022-04-06 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Targeting dual-specificity tyrosine phosphorylation-regulated kinase 2 with a highly selective inhibitor for the treatment of prostate cancer.
Nat Commun, 13, 2022
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7XE4
 | | structure of a membrane-bound glycosyltransferase | | 分子名称: | (11R,14S)-17-amino-14-hydroxy-8,14-dioxo-9,13,15-trioxa-14lambda~5~-phosphaheptadecan-11-yl decanoate, 1,3-beta-glucan synthase component FKS1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Hu, X.L, Yang, P, Zhang, M, Liu, X.T, Yu, H.J. | | 登録日 | 2022-03-29 | | 公開日 | 2023-03-29 | | 最終更新日 | 2023-04-19 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural and mechanistic insights into fungal beta-1,3-glucan synthase FKS1.
Nature, 616, 2023
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