8B64
| Cryo-EM structure of RC-LH1-PufX photosynthetic core complex from Rba. capsulatus | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, BACTERIOCHLOROPHYLL A, BACTERIOPHEOPHYTIN A, ... | 著者 | Bracun, L, Yamagata, A, Shirouzu, M, Liu, L.N. | 登録日 | 2022-09-26 | 公開日 | 2023-02-01 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (2.589 Å) | 主引用文献 | Cryo-EM structure of a monomeric RC-LH1-PufX supercomplex with high-carotenoid content from Rhodobacter capsulatus. Structure, 31, 2023
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4LMU
| Crystal structure of Pim1 in complex with the inhibitor Quercetin (resulting from displacement of SKF86002) | 分子名称: | 3,5,7,3',4'-PENTAHYDROXYFLAVONE, GLYCEROL, Serine/threonine-protein kinase pim-1 | 著者 | Parker, L.J, Tanaka, A, Handa, N, Honda, K, Tomabechi, Y, Shirouzu, M, Yokoyama, S. | 登録日 | 2013-07-11 | 公開日 | 2014-02-12 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | 主引用文献 | Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002. Acta Crystallogr.,Sect.D, 70, 2014
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4LUD
| Crystal Structure of HCK in complex with the fluorescent compound SKF86002 | 分子名称: | 6-(4-fluorophenyl)-5-(pyridin-4-yl)-2,3-dihydroimidazo[2,1-b][1,3]thiazole, CALCIUM ION, CHLORIDE ION, ... | 著者 | Parker, L.J, Tanaka, A, Handa, N, Honda, K, Tomabechi, Y, Shirouzu, M, Yokoyama, S. | 登録日 | 2013-07-25 | 公開日 | 2014-02-12 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002. Acta Crystallogr.,Sect.D, 70, 2014
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4LM5
| Crystal structure of Pim1 in complex with 2-{4-[(3-aminopropyl)amino]quinazolin-2-yl}phenol (resulting from displacement of SKF86002) | 分子名称: | 2-{4-[(3-aminopropyl)amino]quinazolin-2-yl}phenol, GLYCEROL, Serine/threonine-protein kinase pim-1 | 著者 | Parker, L.J, Tanaka, A, Handa, N, Honda, K, Tomabechi, Y, Shirouzu, M, Yokoyama, S. | 登録日 | 2013-07-10 | 公開日 | 2014-02-12 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002. Acta Crystallogr.,Sect.D, 70, 2014
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4LL5
| Crystal Structure of Pim-1 in complex with the fluorescent compound SKF86002 | 分子名称: | 6-(4-fluorophenyl)-5-(pyridin-4-yl)-2,3-dihydroimidazo[2,1-b][1,3]thiazole, CALCIUM ION, GLYCEROL, ... | 著者 | Parker, L.J, Tanaka, A, Handa, N, Honda, K, Tomabechi, Y, Shirouzu, M, Yokoyama, S. | 登録日 | 2013-07-09 | 公開日 | 2014-02-12 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002. Acta Crystallogr.,Sect.D, 70, 2014
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4LUE
| Crystal Structure of HCK in complex with 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (resulting from displacement of SKF86002) | 分子名称: | 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, CALCIUM ION, CHLORIDE ION, ... | 著者 | Parker, L.J, Tanaka, A, Handa, N, Honda, K, Tomabechi, Y, Shirouzu, M, Yokoyama, S. | 登録日 | 2013-07-25 | 公開日 | 2014-02-12 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (3.04 Å) | 主引用文献 | Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002. Acta Crystallogr.,Sect.D, 70, 2014
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5ZQQ
| Tankyrase-2 in complex with compound 52 | 分子名称: | 1-methyl-1'-(4-oxo-3,4,5,6,7,8-hexahydroquinazolin-2-yl)spiro[indole-3,4'-piperidin]-2(1H)-one, GLYCEROL, PHOSPHATE ION, ... | 著者 | Niwa, H, Shirai, F, Sato, S, Yoshimoto, N, Tsumura, T, Okue, M, Shirouzu, M, Seimiya, H, Umehara, T. | 登録日 | 2018-04-19 | 公開日 | 2019-04-03 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors. J. Med. Chem., 62, 2019
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5ZQO
| Tankyrase-2 in complex with compound 1a | 分子名称: | 2-[4-(2-methoxyphenyl)piperazin-1-yl]-5,6,7,8-tetrahydroquinazolin-4(3H)-one, GLYCEROL, SULFATE ION, ... | 著者 | Niwa, H, Shirai, F, Sato, S, Yoshimoto, N, Tsumura, T, Okue, M, Shirouzu, M, Seimiya, H, Umehara, T. | 登録日 | 2018-04-19 | 公開日 | 2019-04-03 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors. J. Med. Chem., 62, 2019
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5ZSU
| Structure of the human homo-hexameric LRRC8A channel at 4.25 Angstroms | 分子名称: | Volume-regulated anion channel subunit LRRC8A | 著者 | Kasuya, G, Nakane, T, Yokoyama, T, Shirouzu, M, Ishitani, R, Nureki, O. | 登録日 | 2018-04-29 | 公開日 | 2018-08-15 | 最終更新日 | 2018-09-26 | 実験手法 | ELECTRON MICROSCOPY (4.25 Å) | 主引用文献 | Cryo-EM structures of the human volume-regulated anion channel LRRC8. Nat. Struct. Mol. Biol., 25, 2018
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5ZQP
| Tankyrase-2 in complex with compound 12 | 分子名称: | 1'-(4-oxo-3,4,5,6,7,8-hexahydroquinazolin-2-yl)-2H-spiro[1-benzofuran-3,4'-piperidin]-2-one, GLYCEROL, PHOSPHATE ION, ... | 著者 | Niwa, H, Shirai, F, Sato, S, Yoshimoto, N, Tsumura, T, Okue, M, Shirouzu, M, Seimiya, H, Umehara, T. | 登録日 | 2018-04-19 | 公開日 | 2019-04-03 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors. J. Med. Chem., 62, 2019
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5ZQR
| Tankyrase-2 in complex with compound 40c | 分子名称: | 2-[4,6-difluoro-1-(2-hydroxyethyl)-1,2-dihydro-1'H-spiro[indole-3,4'-piperidin]-1'-yl]-5,6,7,8-tetrahydroquinazolin-4(3H)-one, GLYCEROL, PHOSPHATE ION, ... | 著者 | Niwa, H, Shirai, F, Sato, S, Yoshimoto, N, Tsumura, T, Okue, M, Shirouzu, M, Seimiya, H, Umehara, T. | 登録日 | 2018-04-19 | 公開日 | 2019-04-03 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors. J. Med. Chem., 62, 2019
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6A84
| Tankyrase-2 in complex with compound 15d | 分子名称: | 2-(4-chloro-1,2-dihydro-1'H-spiro[indole-3,4'-piperidin]-1'-yl)-5,6,7,8-tetrahydroquinazolin-4(3H)-one, GLYCEROL, PHOSPHATE ION, ... | 著者 | Niwa, H, Shirai, F, Sato, S, Yoshimoto, N, Tsumura, T, Okue, M, Shirouzu, M, Seimiya, H, Umehara, T. | 登録日 | 2018-07-06 | 公開日 | 2019-04-03 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors. J. Med. Chem., 62, 2019
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8H7X
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8JHK
| Cryo-EM structure of the DOCK5/ELMO1 complex, focused on one protomer | 分子名称: | Dedicator of cytokinesis protein 5, Engulfment and cell motility protein 1 | 著者 | Kukimoto-Niino, M, Katsura, K, Ishizuka-Katsura, Y, Mishima-Tsumagari, C, Yonemochi, M, Inoue, M, Nakagawa, R, Kaushik, R, Zhang, K.Y.J, Shirouzu, M. | 登録日 | 2023-05-23 | 公開日 | 2024-05-29 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (4.76 Å) | 主引用文献 | RhoG facilitates a conformational transition in the guanine nucleotide exchange factor complex DOCK5/ELMO1 to an open state. J.Biol.Chem., 300, 2024
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6AJ4
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6AJL
| DOCK7 mutant I1836Y complexed with Cdc42 | 分子名称: | Cell division control protein 42 homolog, Dedicator of cytokinesis protein 7 | 著者 | Kukimoto-Niino, M, Shirouzu, M. | 登録日 | 2018-08-28 | 公開日 | 2019-03-20 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.23 Å) | 主引用文献 | Structural Basis for the Dual Substrate Specificity of DOCK7 Guanine Nucleotide Exchange Factor. Structure, 27, 2019
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8I5W
| Crystal structure of the DHR-2 domain of DOCK10 in complex with Rac1 | 分子名称: | Dedicator of cytokinesis protein 10, Ras-related C3 botulinum toxin substrate 1, SULFATE ION | 著者 | Kukimoto-Niino, M, Mishima-Tsumagari, C, Ihara, K, Fukui, Y, Yokoyama, S, Shirouzu, M. | 登録日 | 2023-01-26 | 公開日 | 2023-03-15 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.432 Å) | 主引用文献 | Structural basis for the dual GTPase specificity of the DOCK10 guanine nucleotide exchange factor. Biochem.Biophys.Res.Commun., 653, 2023
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8I5F
| Crystal structure of the DHR-2 domain of DOCK10 in complex with Cdc42 (T17N mutant) | 分子名称: | Cell division control protein 42 homolog, Dedicator of cytokinesis protein 10 | 著者 | Kukimoto-Niino, M, Mishima-Tsumagari, C, Fukui, Y, Yokoyama, S, Shirouzu, M. | 登録日 | 2023-01-25 | 公開日 | 2023-03-15 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural basis for the dual GTPase specificity of the DOCK10 guanine nucleotide exchange factor. Biochem.Biophys.Res.Commun., 653, 2023
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8I5V
| DOCK10 mutant L1903Y complexed with Rac1 | 分子名称: | Dedicator of cytokinesis protein 10, Ras-related C3 botulinum toxin substrate 1, SULFATE ION | 著者 | Kukimoto-Niino, M, Mishima-Tsumagari, C, Ihara, K, Fukui, Y, Yokoyama, S, Shirouzu, M. | 登録日 | 2023-01-26 | 公開日 | 2023-03-15 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.726 Å) | 主引用文献 | Structural basis for the dual GTPase specificity of the DOCK10 guanine nucleotide exchange factor. Biochem.Biophys.Res.Commun., 653, 2023
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8I5L
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5ZEA
| Crystal structure of the nucleotide-free mutant A3B3 | 分子名称: | GLYCEROL, V-type sodium ATPase catalytic subunit A, V-type sodium ATPase subunit B | 著者 | Maruyama, S, Suzuki, K, Mizutani, K, Saito, Y, Imai, F.L, Ishizuka-Katsura, Y, Shirouzu, M, Ichiro, Y, Murata, T. | 登録日 | 2018-02-27 | 公開日 | 2019-02-06 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.384 Å) | 主引用文献 | Metastable asymmetrical structure of a shaftless V1motor. Sci Adv, 5, 2019
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7DPA
| Cryo-EM structure of the human ELMO1-DOCK5-Rac1 complex | 分子名称: | Dedicator of cytokinesis protein 5, Engulfment and cell motility protein 1, Ras-related C3 botulinum toxin substrate 1 | 著者 | Kukimoto-Niino, M, Katsura, K, Kaushik, R, Ehara, H, Yokoyama, T, Uchikubo-Kamo, T, Mishima-Tsumagari, C, Yonemochi, M, Ikeda, M, Hanada, K, Zhang, K.Y.J, Shirouzu, M. | 登録日 | 2020-12-18 | 公開日 | 2021-08-04 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Cryo-EM structure of the human ELMO1-DOCK5-Rac1 complex. Sci Adv, 7, 2021
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8H79
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7FCI
| human NTCP in complex with YN69083 Fab | 分子名称: | Fab Heavy chain, Fab Light chain, Sodium/bile acid cotransporter | 著者 | Park, J.H, Iwamoto, M, Yun, J.H, Uchikubo-Kamo, T, Son, D, Jin, Z, Yoshida, H, Ohki, M, Ishimoto, N, Mizutani, K, Oshima, M, Muramatsu, M, Wakita, T, Shirouzu, M, Liu, K, Uemura, T, Nomura, N, Iwata, S, Watashi, K, Tame, J.R.H, Nishizawa, T, Lee, W, Park, S.Y. | 登録日 | 2021-07-14 | 公開日 | 2022-05-25 | 最終更新日 | 2022-07-13 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural insights into the HBV receptor and bile acid transporter NTCP. Nature, 606, 2022
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8JG5
| Cryo-EM structure of the GI.4 Chiba VLP complexed with the CV-1A1 Fv-clasp | 分子名称: | VH,SARAH, VL,SARAH, VP1 | 著者 | Hosaka, T, Katsura, K, Kimura-Someya, T, Someya, Y, Shirouzu, M. | 登録日 | 2023-05-19 | 公開日 | 2024-04-17 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | 主引用文献 | Structural analyses of the GI.4 norovirus by cryo-electron microscopy and X-ray crystallography revealing binding sites for human monoclonal antibodies. J.Virol., 98, 2024
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