5H7Z
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5H7Y
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6J7O
| Crystal structure of toxin TglT (unusual type guanylyltransferase-like toxin, Rv1045) mutant E146Q from Mycobacterium tuberculosis | 分子名称: | MAGNESIUM ION, guanylyltransferase-like toxin | 著者 | Yu, X, Gao, X, Zhu, K, Wojdyla, J.A, Wang, M, Cui, S. | 登録日 | 2019-01-18 | 公開日 | 2020-05-13 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism. Commun Biol, 3, 2020
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6J7T
| Crystal structure of toxin TglT (unusual type guanylyltransferase-like toxin, Rv1045) mutant D82A from Mycobacterium tuberculosis | 分子名称: | GLYCEROL, MAGNESIUM ION, guanylyltransferase-like toxin | 著者 | Yu, X, Gao, X, Zhu, K, Wojdyla, J.A, Wang, M, Cui, S. | 登録日 | 2019-01-18 | 公開日 | 2020-05-13 | 最終更新日 | 2020-05-20 | 実験手法 | X-RAY DIFFRACTION (1.903 Å) | 主引用文献 | Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism. Commun Biol, 3, 2020
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6J7R
| Crystal structure of toxin TglT (unusual type guanylyltransferase-like toxin, Rv1045) mutant S78A co-expressed with TakA from Mycobacterium tuberculosis | 分子名称: | MAGNESIUM ION, guanylyltransferase-like toxin | 著者 | Yu, X, Gao, X, Zhu, K, Wojdyla, J.A, Wang, M, Cui, S. | 登録日 | 2019-01-18 | 公開日 | 2020-05-13 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.299 Å) | 主引用文献 | Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism. Commun Biol, 3, 2020
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6J7N
| Crystal structure of toxin TglT (unusual type guanylyltransferase-like toxin, Rv1045) mutant D82A co-expressed with TakA from Mycobacterium tuberculosis | 分子名称: | MAGNESIUM ION, guanylyltransferase-like toxin | 著者 | Yu, X, Gao, X, Zhu, K, Wojdyla, J.A, Wang, M, Cui, S. | 登録日 | 2019-01-18 | 公開日 | 2020-05-13 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.294 Å) | 主引用文献 | Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism. Commun Biol, 3, 2020
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6J7S
| Crystal structure of toxin TglT (unusual type guanylyltransferase-like toxin, Rv1045) wild type protein from Mycobacterium tuberculosis | 分子名称: | MAGNESIUM ION, guanylyltransferase-like toxin | 著者 | Yu, X, Gao, X, Zhu, K, Wojdyla, J.A, Wang, M, Cui, S. | 登録日 | 2019-01-18 | 公開日 | 2020-05-13 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.102 Å) | 主引用文献 | Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism. Commun Biol, 3, 2020
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6J7P
| Crystal structure of toxin TglT (unusual type guanylyltransferase-like toxin, Rv1045) mutant E146Q co-expressed with TakA from Mycobacterium tuberculosis | 分子名称: | MAGNESIUM ION, guanylyltransferase-like toxin | 著者 | Yu, X, Gao, X, Zhu, K, Wojdyla, J.A, Wang, M, Cui, S. | 登録日 | 2019-01-18 | 公開日 | 2020-05-13 | 最終更新日 | 2020-05-20 | 実験手法 | X-RAY DIFFRACTION (2.629 Å) | 主引用文献 | Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism. Commun Biol, 3, 2020
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6J7Q
| Crystal structure of toxin TglT (unusual type guanylyltransferase-like toxin, Rv1045) mutant S78A from Mycobacterium tuberculosis | 分子名称: | CALCIUM ION, MAGNESIUM ION, guanylyltransferase-like toxin | 著者 | Yu, X, Gao, X, Zhu, K, Wojdyla, J.A, Wang, M, Cui, S. | 登録日 | 2019-01-18 | 公開日 | 2020-05-13 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism. Commun Biol, 3, 2020
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7CDW
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7EO7
| Crystal structure of HCoV-NL63 3C-like protease in complex with an inhibitor Shikonin | 分子名称: | 2-[(1R)-4-methyl-1-oxidanyl-pent-3-enyl]-5,8-bis(oxidanyl)naphthalene-1,4-dione, 3C-like proteinase | 著者 | Gao, H.X, Zhang, Y.T, Zhou, X.L, Zhong, F.L, Li, J, Zhang, J. | 登録日 | 2021-04-21 | 公開日 | 2021-10-20 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.24916625 Å) | 主引用文献 | Structure-Based Discovery and Structural Basis of a Novel Broad-Spectrum Natural Product against the Main Protease of Coronavirus. J.Virol., 96, 2022
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7BL2
| pre-50S-ObgE particle state 1 | 分子名称: | 23S ribosomal RNA, 50S ribosomal protein L11, 50S ribosomal protein L13, ... | 著者 | Hilal, T, Nikolay, R, Schmidt, S, Spahn, C.M.T. | 登録日 | 2021-01-18 | 公開日 | 2021-05-12 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Snapshots of native pre-50S ribosomes reveal a biogenesis factor network and evolutionary specialization. Mol.Cell, 81, 2021
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7BL5
| pre-50S-ObgE particle | 分子名称: | 23S ribosomal RNA, 50S ribosomal protein L10, 50S ribosomal protein L11, ... | 著者 | Hilal, T, Nikolay, R, Spahn, C.M.T, Schmidt, S. | 登録日 | 2021-01-18 | 公開日 | 2021-05-12 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Snapshots of native pre-50S ribosomes reveal a biogenesis factor network and evolutionary specialization. Mol.Cell, 81, 2021
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7BL4
| in vitro reconstituted 50S-ObgE-GMPPNP-RsfS particle | 分子名称: | 23S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | 著者 | Hilal, T, Nikolay, R, Spahn, C.M.T. | 登録日 | 2021-01-18 | 公開日 | 2021-05-12 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Snapshots of native pre-50S ribosomes reveal a biogenesis factor network and evolutionary specialization. Mol.Cell, 81, 2021
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7BL6
| 50S-ObgE-GMPPNP particle | 分子名称: | 23S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | 著者 | Hilal, T, Nikolay, R, Schmidt, S, Spahn, C.M.T. | 登録日 | 2021-01-18 | 公開日 | 2021-05-12 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Snapshots of native pre-50S ribosomes reveal a biogenesis factor network and evolutionary specialization. Mol.Cell, 81, 2021
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7BL3
| pre-50S-ObgE particle state 2 | 分子名称: | 23S ribosomal RNA, 50S ribosomal protein L11, 50S ribosomal protein L13, ... | 著者 | Hilal, T, Nikolay, R, Spahn, C.M.T. | 登録日 | 2021-01-18 | 公開日 | 2021-05-12 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Snapshots of native pre-50S ribosomes reveal a biogenesis factor network and evolutionary specialization. Mol.Cell, 81, 2021
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7DV4
| Crystal structure of anti-CTLA-4 VH domain in complex with human CTLA-4 | 分子名称: | 1,2-ETHANEDIOL, 4003-1(VH), Cytotoxic T-lymphocyte protein 4 | 著者 | Li, H, Gan, X, He, Y. | 登録日 | 2021-01-12 | 公開日 | 2022-01-12 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | 主引用文献 | An anti-CTLA-4 heavy chain-only antibody with enhanced T reg depletion shows excellent preclinical efficacy and safety profile. Proc.Natl.Acad.Sci.USA, 119, 2022
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7XT3
| Crystal Structure of Hepatitis virus A 2C protein 128-335 aa | 分子名称: | Genome polyprotein, PHOSPHATE ION | 著者 | Chen, P, Wojdyla, J.A, Li, Z, Wang, M, Cui, S. | 登録日 | 2022-05-16 | 公開日 | 2022-07-27 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Biochemical and structural characterization of hepatitis A virus 2C reveals an unusual ribonuclease activity on single-stranded RNA. Nucleic Acids Res., 50, 2022
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7EO8
| Crystal structure of SARS coronavirus main protease in complex with an inhibitor Shikonin | 分子名称: | 2-[(1R)-4-methyl-1-oxidanyl-pent-3-enyl]-5,8-bis(oxidanyl)naphthalene-1,4-dione, 3C-like proteinase | 著者 | Zhang, Y.T, Gao, H.X, Zhou, H, Zhong, F.L, Hu, X.H, Zhou, X.L, Lin, C, Wang, Q.S, Li, J, Zhang, J. | 登録日 | 2021-04-21 | 公開日 | 2021-10-20 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.2808516 Å) | 主引用文献 | Structure-Based Discovery and Structural Basis of a Novel Broad-Spectrum Natural Product against the Main Protease of Coronavirus. J.Virol., 96, 2022
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7DQZ
| Crystal structure of SARS 3C-like protease in apo form | 分子名称: | 3C-like proteinase | 著者 | Zhang, Y.T, Gao, H.X, Zhou, H, Zhong, F.L, Hu, X.H, Zhou, X.L, Lin, C, Wang, Q.S, Li, J, Zhang, J. | 登録日 | 2020-12-24 | 公開日 | 2021-09-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Structure-Based Discovery and Structural Basis of a Novel Broad-Spectrum Natural Product against the Main Protease of Coronavirus. J.Virol., 96, 2022
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7CMD
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7CJD
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7F90
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7F60
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7FEX
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