3ZDI
| Glycogen Synthase Kinase 3 Beta complexed with Axin Peptide and Inhibitor 7d | 分子名称: | 3,6-Diamino-4-(2-chlorophenyl)thieno[2,3-b]pyridine-2,5-dicarbonitrile, AXIN-1, GLYCOGEN SYNTHASE KINASE-3 BETA, ... | 著者 | Oberholzer, A.E, Pearl, L.H. | 登録日 | 2012-11-27 | 公開日 | 2012-12-26 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.645 Å) | 主引用文献 | 3,6-Diamino-4-(2-Halophenyl)-2-Benzoylthieno(2,3-B) Pyridine-5-Carbonitriles are Selective Inhibitors of Plasmodium Falciparum Glycogen Synthase Kinase-3 (Pfgsk-3) J.Med.Chem., 56, 2013
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2CGF
| A RADICICOL ANALOGUE BOUND TO THE ATP BINDING SITE OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE | 分子名称: | (5Z)-13-CHLORO-14,16-DIHYDROXY-3,4,7,8,9,10-HEXAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,11(12H)-DIONE, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82 | 著者 | Roe, S.M, Prodromou, C, Pearl, L.H, Moody, C.J. | 登録日 | 2006-03-02 | 公開日 | 2006-11-29 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol. Chem.Biol., 13, 2006
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4B7T
| Glycogen Synthase Kinase 3 Beta complexed with Axin Peptide and Leucettine L4 | 分子名称: | (5Z)-5-(1,3-benzodioxol-5-ylmethylidene)-3-methyl-2-(propan-2-ylamino)imidazol-4-one, AXIN-1, GLYCOGEN SYNTHASE KINASE-3 BETA | 著者 | Oberholzer, A.E, Pearl, L.H. | 登録日 | 2012-08-22 | 公開日 | 2013-01-30 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.772 Å) | 主引用文献 | Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B. J.Med.Chem., 55, 2012
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2IWU
| Analogues of radicicol bound to the ATP-binding site of Hsp90 | 分子名称: | (5E)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82 | 著者 | Roe, S.M, Prodromou, C, Pearl, L.H. | 登録日 | 2006-07-04 | 公開日 | 2006-11-30 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol. Chem.Biol., 13, 2006
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2IWS
| Radicicol analogues bound to the ATP site of HSP90 | 分子名称: | (5Z)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82 | 著者 | Roe, S.M, Prodromou, C, Pearl, L.H. | 登録日 | 2006-07-04 | 公開日 | 2006-11-30 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol. Chem.Biol., 13, 2006
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2IZO
| Structure of an Archaeal PCNA1-PCNA2-FEN1 Complex | 分子名称: | DNA POLYMERASE SLIDING CLAMP B, DNA POLYMERASE SLIDING CLAMP C, FLAP STRUCTURE-SPECIFIC ENDONUCLEASE, ... | 著者 | Dore, A.S, Kilkenny, M.L, Roe, S.M, Pearl, L.H. | 登録日 | 2006-07-25 | 公開日 | 2006-09-06 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structure of an Archaeal PCNA1-PCNA2-Fen1 Complex: Elucidating PCNA Subunit and Client Enzyme Specificity. Nucleic Acids Res., 34, 2006
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2IWX
| Analogues of radicicol bound to the ATP-binding site of Hsp90. | 分子名称: | (5E)-14-CHLORO-15,17-DIHYDROXY-4,7,8,9,10,11-HEXAHYDRO-2-BENZOXACYCLOPENTADECINE-1,12(3H,13H)-DIONE, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82 | 著者 | Roe, S.M, Prodromou, C, Pearl, L.H. | 登録日 | 2006-07-05 | 公開日 | 2006-11-30 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol. Chem.Biol., 13, 2006
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2JKI
| Complex of Hsp90 N-terminal and Sgt1 CS domain | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CYTOSOLIC HEAT SHOCK PROTEIN 90, SGT1-LIKE PROTEIN | 著者 | Zhang, M, Pearl, L.H. | 登録日 | 2008-08-28 | 公開日 | 2008-10-07 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structural and Functional Coupling of Hsp90- and Sgt1-Centred Multi-Protein Complexes. Embo J., 27, 2008
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1KCF
| Crystal Structure of the Yeast Mitochondrial Holliday Junction Resolvase, Ydc2 | 分子名称: | HYPOTHETICAL 30.2 KD PROTEIN C25G10.02 IN CHROMOSOME I, SULFATE ION | 著者 | Ceschini, S, Keeley, A, McAlister, M.S.B, Oram, M, Phelan, J, Pearl, L.H, Tsaneva, I.R, Barrett, T.E. | 登録日 | 2001-11-08 | 公開日 | 2001-11-28 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of the fission yeast mitochondrial Holliday junction resolvase Ydc2. EMBO J., 20, 2001
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1KO9
| Native Structure of the Human 8-oxoguanine DNA Glycosylase hOGG1 | 分子名称: | 8-oxoguanine DNA glycosylase, SULFATE ION | 著者 | Bjoras, M, Seeberg, E, Luna, L, Pearl, L.H, Barrett, T.E. | 登録日 | 2001-12-20 | 公開日 | 2002-01-09 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Reciprocal "flipping" underlies substrate recognition and catalytic activation by the human 8-oxo-guanine DNA glycosylase. J.Mol.Biol., 317, 2002
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1OE6
| Xenopus SMUG1, an anti-mutator uracil-DNA Glycosylase | 分子名称: | 5'-D(*CP*CP*CP*GP*TP*GP*AP*GP*TP*CP*CP*G)-3', 5'-D(*CP*GP*GP*AP*CP*TP*3DRP*AP*CP*GP*GP*G)-3', 5-HYDROXYMETHYL URACIL, ... | 著者 | Wibley, J.E.A, Pearl, L.H. | 登録日 | 2003-03-19 | 公開日 | 2003-07-11 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Structure and Specificity of the Vertebrate Anti-Mutator Uracil-DNA Glycosylase Smug1 Mol.Cell, 11, 2003
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1OE5
| Xenopus SMUG1, an anti-mutator uracil-DNA Glycosylase | 分子名称: | 2'-DEOXYURIDINE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-D(*CP*3DRP*GP*GP*AP*CP*TP*3DRP*AP*CP*GP*GP*GP)-3', ... | 著者 | Wibley, J.E.A, Pearl, L.H. | 登録日 | 2003-03-19 | 公開日 | 2003-07-11 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure and Specificity of the Vertebrate Anti-Mutator Uracil-DNA Glycosylase Smug1 Mol.Cell, 11, 2003
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1O9U
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1ODG
| Very-short-patch DNA repair endonuclease bound to its reaction product site | 分子名称: | 5'-D(*TP*AP*GP*GP*CP*5CM*TP*GP*GP*AP*TP*CP)-3', DNA MISMATCH ENDONUCLEASE, ZINC ION | 著者 | Bunting, K.A, Roe, S.M, Headley, A, Brown, T, Savva, R, Pearl, L.H. | 登録日 | 2003-02-19 | 公開日 | 2003-03-13 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal Structure of the Escherichia Coli Dcm Very-Short-Patch DNA Repair Endonuclease Bound to its Reaction Product-Site in a DNA Superhelix Nucleic Acids Res., 31, 2003
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1OE4
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1MUG
| G:T/U MISMATCH-SPECIFIC DNA GLYCOSYLASE FROM E.COLI | 分子名称: | PROTEIN (G:T/U SPECIFIC DNA GLYCOSYLASE), SULFATE ION | 著者 | Barrett, T.E, Savva, R, Panayotou, G, Brown, T, Barlow, T, Jiricny, J, Pearl, L.H. | 登録日 | 1998-07-10 | 公開日 | 1998-07-15 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions. Cell(Cambridge,Mass.), 92, 1998
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1MWJ
| Crystal Structure of a MUG-DNA pseudo substrate complex | 分子名称: | 5'-D(*CP*GP*CP*GP*A*GP*(DU)P*TP*CP*GP*CP*G)-3', G/U mismatch-specific DNA glycosylase | 著者 | Barrett, T.E, Scharer, O, Savva, R, Brown, T, Jiricny, J, Verdine, G.L, Pearl, L.H. | 登録日 | 2002-09-30 | 公開日 | 2002-10-11 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Crystal Structure of a thwarted mismatch glycosylase DNA repair complex Embo J., 18, 1999
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1Q2Z
| The 3D solution structure of the C-terminal region of Ku86 | 分子名称: | ATP-dependent DNA helicase II, 80 kDa subunit | 著者 | Harris, R, Esposito, D, Sankar, A, Maman, J.D, Hinks, J.A, Pearl, L.H, Driscoll, P.C. | 登録日 | 2003-07-28 | 公開日 | 2004-01-13 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | The 3D Solution Structure of the C-terminal Region of Ku86 (Ku86CTR) J.Mol.Biol., 335, 2004
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1MTL
| Non-productive MUG-DNA complex | 分子名称: | 5'-D(*CP*GP*CP*GP*AP*GP*(AAB)P*TP*CP*GP*CP*G)-3', G/U mismatch-specific DNA glycosylase | 著者 | Barrett, T.E, Savva, R, Barlow, T, Brown, T, Jiricny, J, Pearl, L.H. | 登録日 | 2002-09-21 | 公開日 | 2002-09-27 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure of a DNA base-excision product resembling a cisplatin inter-strand adduct. Nat.Struct.Biol., 5, 1998
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1MWI
| Crystal structure of a MUG-DNA product complex | 分子名称: | 5'-D(*CP*GP*CP*GP*AP*GP*(AAB)P*TP*CP*GP*CP*G)-3', G/U mismatch-specific DNA glycosylase | 著者 | Barrett, T.E, Savva, R, Panayotou, G, Brown, T, Barlow, T, Jiricny, J, Pearl, L.H. | 登録日 | 2002-09-30 | 公開日 | 2002-10-04 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions. Cell(Cambridge,Mass.), 92, 1998
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4BU1
| Crystal structure of Rad4 BRCT1,2 in complex with a Crb2 phosphopeptide | 分子名称: | 1,2-ETHANEDIOL, DNA REPAIR PROTEIN RHP9, GLYCEROL, ... | 著者 | Qu, M, Rappas, M, Wardlaw, C.P, Garcia, V, Carr, A.M, Oliver, A.W, Du, L.L, Pearl, L.H. | 登録日 | 2013-06-19 | 公開日 | 2013-10-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Phosphorylation-Dependent Assembly and Coordination of the DNA Damage Checkpoint Apparatus by Rad4(Topbp1.). Mol.Cell, 51, 2013
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4BMC
| Crystal structure of s.pombe Rad4 BRCT1,2 | 分子名称: | CHLORIDE ION, S-M CHECKPOINT CONTROL PROTEIN RAD4 | 著者 | Meng, Q, Rappas, M, Wardlaw, C.P, Garcia, V, Carr, A.M, Oliver, A.W, Du, L.L, Pearl, L.H. | 登録日 | 2013-05-07 | 公開日 | 2013-10-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.982 Å) | 主引用文献 | Phosphorylation-Dependent Assembly and Coordination of the DNA Damage Checkpoint Apparatus by Rad4(Topbp1.). Mol.Cell, 51, 2013
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4BMD
| Crystal structure of S.pombe Rad4 BRCT3,4 | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, S-M CHECKPOINT CONTROL PROTEIN RAD4 | 著者 | Meng, Q, Rappas, M, Wardlaw, C.P, Garcia, V, Carr, A.M, Oliver, A.W, Du, L.L, Pearl, L.H. | 登録日 | 2013-05-07 | 公開日 | 2013-10-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Phosphorylation-Dependent Assembly and Coordination of the DNA Damage Checkpoint Apparatus by Rad4(Topbp1.). Mol.Cell, 51, 2013
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4BU0
| Crystal structure of Rad4 BRCT1,2 in complex with a Crb2 phosphopeptide | 分子名称: | ACETATE ION, DNA REPAIR PROTEIN RHP9, GLYCEROL, ... | 著者 | Qu, M, Rappas, M, Wardlaw, C.P, Garcia, V, Carr, A.M, Oliver, A.W, Du, L.L, Pearl, L.H. | 登録日 | 2013-06-19 | 公開日 | 2013-10-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Phosphorylation-Dependent Assembly and Coordination of the DNA Damage Checkpoint Apparatus by Rad4(Topbp1.). Mol.Cell, 51, 2013
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1H0C
| The crystal structure of human alanine:glyoxylate aminotransferase | 分子名称: | (AMINOOXY)ACETIC ACID, GLYCEROL, PYRIDOXAL-5'-PHOSPHATE, ... | 著者 | Zhang, X, Danpure, C.J, Roe, S.M, Pearl, L.H. | 登録日 | 2002-06-17 | 公開日 | 2003-06-12 | 最終更新日 | 2019-05-08 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal Structure of Alanine:Glyoxylate Aminotransferase and the Relationship between Genotype and Enzymatic Phenotype in Primary Hyperoxaluria Type 1. J.Mol.Biol., 331, 2003
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