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4FQN
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BU of 4fqn by Molmil
Crystal structure of the CCM2 C-terminal Harmonin Homology Domain (HHD)
分子名称: Malcavernin
著者Fisher, O.S, Zhang, R, Li, X, Murphy, J.W, Boggon, T.J.
登録日2012-06-25
公開日2012-12-19
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural studies of cerebral cavernous malformations 2 (CCM2) reveal a folded helical domain at its C-terminus.
Febs Lett., 587, 2013
4GZM
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BU of 4gzm by Molmil
Crystal structure of RAC1 F28L mutant
分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, Ras-related C3 botulinum toxin substrate 1
著者Ha, B.H, Boggon, T.J.
登録日2012-09-06
公開日2012-12-12
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献RAC1P29S is a spontaneously activating cancer-associated GTPase.
Proc.Natl.Acad.Sci.USA, 110, 2013
4GRZ
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BU of 4grz by Molmil
Crystal structure of SHP1 catalytic domain with PO4
分子名称: PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 6
著者Alicea-Velazquez, N.L, Jakoncic, J, Boggon, T.J.
登録日2012-08-27
公開日2012-12-19
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.3732 Å)
主引用文献Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition.
J.Struct.Biol., 181, 2013
4GS0
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BU of 4gs0 by Molmil
Crystal structure of SHP1 catalytic domain with JAK1 activation loop peptide
分子名称: Tyrosine-protein kinase JAK1, Tyrosine-protein phosphatase non-receptor type 6
著者Alicea-Velazquez, N.L, Jakoncic, J, Boggon, T.J.
登録日2012-08-27
公開日2012-12-19
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.7961 Å)
主引用文献Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition.
J.Struct.Biol., 181, 2013
4GZL
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BU of 4gzl by Molmil
Crystal structure of RAC1 Q61L mutant
分子名称: ISOPROPYL ALCOHOL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Ha, B.H, Boggon, T.J.
登録日2012-09-06
公開日2012-12-12
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献RAC1P29S is a spontaneously activating cancer-associated GTPase.
Proc.Natl.Acad.Sci.USA, 110, 2013
4GRY
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BU of 4gry by Molmil
Crystal structure of SHP1 catalytic domain with SO4
分子名称: SULFATE ION, Tyrosine-protein phosphatase non-receptor type 6
著者Alicea-Velazquez, N.L, Jakoncic, J, Boggon, T.J.
登録日2012-08-27
公開日2012-12-19
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.6998 Å)
主引用文献Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition.
J.Struct.Biol., 181, 2013
4HJQ
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BU of 4hjq by Molmil
SHP-1 catalytic domain WPD loop closed
分子名称: PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 6
著者Alicea-Velazquez, N.L, Boggon, T.J.
登録日2012-10-13
公開日2013-04-03
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.8013 Å)
主引用文献SHP Family Protein Tyrosine Phosphatases Adopt Canonical Active-Site Conformations in the Apo and Phosphate-Bound States.
Protein Pept.Lett., 20, 2013
4HI9
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BU of 4hi9 by Molmil
1.2 structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at wavelength 0.91974
分子名称: IODIDE ION, Integrin-linked protein kinase, LIM and senescent cell antigen-like-containing domain protein 1, ...
著者Stiegler, A.L, Jakoncic, J, Stojanoff, V, Chiswell, B.P, Calderwood, D.A, Boggon, T.J.
登録日2012-10-11
公開日2013-12-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.203 Å)
主引用文献1.2 structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at wavelength 0.91974
To be Published
4HI8
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BU of 4hi8 by Molmil
Structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at high energy, wavelength 0.32800
分子名称: Integrin-linked protein kinase, LIM and senescent cell antigen-like-containing domain protein 1, PHOSPHATE ION, ...
著者Stiegler, A.L, Jakoncic, J, Stojanoff, V, Chiswell, B.P, Calderwood, D.A, Boggon, T.J.
登録日2012-10-11
公開日2013-12-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.203 Å)
主引用文献Structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at high energy, wavelength 0.32800
To be Published
4HJP
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BU of 4hjp by Molmil
SHP-1 catalytic domain WPD loop open
分子名称: Tyrosine-protein phosphatase non-receptor type 6
著者Alicea-Velazquez, N.L, Boggon, T.J.
登録日2012-10-13
公開日2013-04-03
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.3994 Å)
主引用文献SHP Family Protein Tyrosine Phosphatases Adopt Canonical Active-Site Conformations in the Apo and Phosphate-Bound States.
Protein Pept.Lett., 20, 2013
4JDI
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BU of 4jdi by Molmil
Crystal structure of Serine/threonine-protein kinase PAK 4 in complex with Paktide S peptide substrate
分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Paktide S, ...
著者Ha, B.H, Boggon, T.J.
登録日2013-02-25
公開日2014-01-29
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Identification of a major determinant for serine-threonine kinase phosphoacceptor specificity.
Mol.Cell, 53, 2014
4JDJ
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BU of 4jdj by Molmil
Crystal structure of Serine/threonine-protein kinase PAK 4 F461V mutant in complex with Paktide T peptide substrate
分子名称: Paktide T, Serine/threonine-protein kinase PAK 4
著者Ha, B.H, Boggon, T.J.
登録日2013-02-25
公開日2014-01-29
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Identification of a major determinant for serine-threonine kinase phosphoacceptor specificity.
Mol.Cell, 53, 2014
4JDH
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BU of 4jdh by Molmil
Crystal structure of Serine/threonine-protein kinase PAK 4 in complex with Paktide T peptide substrate
分子名称: Paktide T, Serine/threonine-protein kinase PAK 4
著者Ha, B.H, Boggon, T.J.
登録日2013-02-25
公開日2014-01-29
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Identification of a major determinant for serine-threonine kinase phosphoacceptor specificity.
Mol.Cell, 53, 2014
4JDK
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BU of 4jdk by Molmil
Crystal structure of Serine/threonine-protein kinase PAK 4 F461V mutant in complex with Paktide S peptide substrate
分子名称: Paktide S, Serine/threonine-protein kinase PAK 4
著者Ha, B.H, Boggon, T.J.
登録日2013-02-25
公開日2014-01-29
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Identification of a major determinant for serine-threonine kinase phosphoacceptor specificity.
Mol.Cell, 53, 2014
4JIF
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BU of 4jif by Molmil
Co-crystal structure of ICAP1 PTB domain in complex with a KRIT1 peptide
分子名称: Integrin beta-1-binding protein 1, Krev interaction trapped protein 1
著者Liu, W, Boggon, T.J.
登録日2013-03-05
公開日2013-05-01
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.701 Å)
主引用文献Cocrystal structure of the ICAP1 PTB domain in complex with a KRIT1 peptide.
Acta Crystallogr.,Sect.F, 69, 2013
4K94
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BU of 4k94 by Molmil
Crystal structure of KIT D4D5 fragment in complex with anti-Kit antibody Fab19
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab19 heavy chain, Fab19 light chain, ...
著者Resheynyak, A.V, Boggon, T.J, Lax, I, Schlessinger, J.
登録日2013-04-19
公開日2013-10-16
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region.
Proc.Natl.Acad.Sci.USA, 110, 2013
4K9E
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BU of 4k9e by Molmil
Crystal structure of KIT D4D5 fragment in complex with anti-Kit antibodies Fab79D
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Mast/stem cell growth factor receptor Kit, heavy chain, ...
著者Resheynyak, A.V, Boggon, T.J, Lax, I, Schlessinger, J.
登録日2013-04-19
公開日2013-10-16
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region.
Proc.Natl.Acad.Sci.USA, 110, 2013
4KS8
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BU of 4ks8 by Molmil
PAK6 kinase domain in complex with sunitinib
分子名称: N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide, Serine/threonine-protein kinase PAK 6
著者Gao, J, Boggon, T.J.
登録日2013-05-17
公開日2013-09-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Substrate and Inhibitor Specificity of the Type II p21-Activated Kinase, PAK6.
Plos One, 8, 2013
4KS7
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BU of 4ks7 by Molmil
PAK6 kinase domain in complex with PF-3758309
分子名称: ISOPROPYL ALCOHOL, PF-3758309, Serine/threonine-protein kinase PAK 6
著者Gao, J, Boggon, T.J.
登録日2013-05-17
公開日2013-09-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Substrate and Inhibitor Specificity of the Type II p21-Activated Kinase, PAK6.
Plos One, 8, 2013
5U4U
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BU of 5u4u by Molmil
pseudoGTPase domain (pG1) of p190RhoGAP-A
分子名称: MALONATE ION, MGC81300 protein, SODIUM ION
著者Stiegler, A.L, Boggon, T.J.
登録日2016-12-06
公開日2017-09-20
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献p190RhoGAP proteins contain pseudoGTPase domains.
Nat Commun, 8, 2017
5U4V
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BU of 5u4v by Molmil
pseudoGTPase domain (pG1) of p190RhoGAP-B
分子名称: Rho GTPase-activating protein 5
著者Stiegler, A.L, Boggon, T.J.
登録日2016-12-06
公開日2017-09-20
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献p190RhoGAP proteins contain pseudoGTPase domains.
Nat Commun, 8, 2017
5UPL
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BU of 5upl by Molmil
CDC42 binds PAK4 via an extended GTPase-effector inteface - 2 peptide: PAK4FL, CDC42 - UNREFINED
分子名称: Cell division control protein 42 homolog, Serine/threonine-protein kinase PAK 4
著者Ha, B.H, Boggon, T.J.
登録日2017-02-03
公開日2017-12-27
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.003 Å)
主引用文献CDC42 binds PAK4 via an extended GTPase-effector interface.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5UPK
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BU of 5upk by Molmil
CDC42 binds PAK4 via an extended GTPase-effector interface - 3 peptide: PAK4cat, PAK4-N45, CDC42
分子名称: Cell division control protein 42 homolog, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Ha, B.H, Boggon, T.J.
登録日2017-02-03
公開日2017-12-27
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献CDC42 binds PAK4 via an extended GTPase-effector interface.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5VEF
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BU of 5vef by Molmil
PAK4 kinase domain in complex with fasudil
分子名称: 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE, ACETATE ION, Serine/threonine-protein kinase PAK 4
著者Zhang, E.Y, Ha, B.H, Boggon, T.J.
登録日2017-04-04
公開日2017-10-18
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.752 Å)
主引用文献PAK4 crystal structures suggest unusual kinase conformational movements.
Biochim. Biophys. Acta, 1866, 2018
5VEE
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BU of 5vee by Molmil
PAK4 kinase domain in complex with FRAX486
分子名称: 6-(2,4-dichlorophenyl)-8-ethyl-2-{[3-fluoro-4-(piperazin-1-yl)phenyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one, Serine/threonine-protein kinase PAK 4
著者Zhang, E.Y, Ha, B.H, Boggon, T.J.
登録日2017-04-04
公開日2017-10-18
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献PAK4 crystal structures suggest unusual kinase conformational movements.
Biochim. Biophys. Acta, 1866, 2018

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