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6BHZ
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BU of 6bhz by Molmil
Trastuzumab Fab D185A (Light Chain) Mutant.
分子名称: 1,2-ETHANEDIOL, Trastuzumab Anti-HER2 Fab Heavy Chain, Trastuzumab Anti-HER2 Fab Light Chain D185A
著者DiDonato, M, Spraggon, G.
登録日2017-10-31
公開日2018-02-14
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Tuning a Protein-Labeling Reaction to Achieve Highly Site Selective Lysine Conjugation.
Chembiochem, 19, 2018
2WGH
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BU of 2wgh by Molmil
Human Ribonucleotide reductase R1 subunit (RRM1) in complex with dATP and Mg.
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ...
著者Welin, R.M, Moche, M, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Karlberg, T, Kragh-Nielsen, T, Kotzsch, A, Kotenyova, T, Nyman, T, Persson, C, Sagemark, J, Schueler, H, Schutz, P, Siponen, M.I, Svensson, L, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Wisniewska, M, Nordlund, P.
登録日2009-04-19
公開日2009-05-05
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural Basis for Allosteric Regulation of Human Ribonucleotide Reductase by Nucleotide-Induced Oligomerization.
Nat.Struct.Mol.Biol., 18, 2011
3WAJ
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BU of 3waj by Molmil
Crystal structure of the Archaeoglobus fulgidus oligosaccharyltransferase (O29867_ARCFU) complex with Zn and sulfate
分子名称: SULFATE ION, Transmembrane oligosaccharyl transferase, ZINC ION
著者Matsumoto, S, Shimada, A, Kohda, D.
登録日2013-05-03
公開日2013-10-30
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.501 Å)
主引用文献Crystal structures of an archaeal oligosaccharyltransferase provide insights into the catalytic cycle of N-linked protein glycosylation
Proc.Natl.Acad.Sci.USA, 110, 2013
2RHS
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BU of 2rhs by Molmil
PheRS from Staphylococcus haemolyticus- rational protein engineering and inhibitor studies
分子名称: 1-{3-[(4-pyridin-2-ylpiperazin-1-yl)sulfonyl]phenyl}-3-(1,3-thiazol-2-yl)urea, Phenylalanyl-tRNA synthetase alpha chain, Phenylalanyl-tRNA synthetase beta chain, ...
著者Evdokimov, A.G, Mekel, M.
登録日2007-10-09
公開日2007-11-06
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Rational protein engineering in action: the first crystal structure of a phenylalanine tRNA synthetase from Staphylococcus haemolyticus.
J.Struct.Biol., 162, 2008
2RHQ
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BU of 2rhq by Molmil
PheRS from Staphylococcus haemolyticus- rational protein engineering and inhibitor studies
分子名称: 1-{3-[(4-pyridin-2-ylpiperazin-1-yl)sulfonyl]phenyl}-3-(1,3-thiazol-2-yl)urea, Phenylalanyl-tRNA synthetase alpha chain, Phenylalanyl-tRNA synthetase beta chain, ...
著者Evdokimov, A.G, Mekel, M.
登録日2007-10-09
公開日2007-11-06
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Rational protein engineering in action: the first crystal structure of a phenylalanine tRNA synthetase from Staphylococcus haemolyticus.
J.Struct.Biol., 162, 2008
2V59
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BU of 2v59 by Molmil
CRYSTAL STRUCTURE OF BIOTIN CARBOXYLASE FROM E.COLI IN COMPLEX WITH POTENT INHIBITOR 2
分子名称: 6-(2,6-DIMETHOXYPHENYL)PYRIDO[2,3-D]PYRIMIDINE-2,7-DIAMINE, BIOTIN CARBOXYLASE
著者Mochalkin, I, Miller, J.R.
登録日2008-10-02
公開日2009-01-13
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献A Class of Selective Antibacterials Derived from a Protein Kinase Inhibitor Pharmacophore.
Proc.Natl.Acad.Sci.USA, 106, 2009
1MAE
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BU of 1mae by Molmil
The Active Site Structure of Methylamine Dehydrogenase: Hydrazines Identify C6 as the Reactive Site of the Tryptophan Derived Quinone Cofactor
分子名称: METHYLAMINE DEHYDROGENASE (HEAVY SUBUNIT), METHYLAMINE DEHYDROGENASE (LIGHT SUBUNIT), NITROGEN MOLECULE
著者Huizinga, E.G, Vellieux, F.M.D, Hol, W.G.J.
登録日1992-05-20
公開日1994-01-31
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Active site structure of methylamine dehydrogenase: hydrazines identify C6 as the reactive site of the tryptophan-derived quinone cofactor.
Biochemistry, 31, 1992
2BBK
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BU of 2bbk by Molmil
CRYSTAL STRUCTURE OF THE QUINOPROTEIN METHYLAMINE DEHYDROGENASE FROM PARACOCCUS DENITRIFICANS AT 1.75 ANGSTROMS
分子名称: METHYLAMINE DEHYDROGENASE (HEAVY SUBUNIT), METHYLAMINE DEHYDROGENASE (LIGHT SUBUNIT)
著者Chen, L, Mathews, F.S.
登録日1993-12-17
公開日1994-01-31
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Refined crystal structure of methylamine dehydrogenase from Paracoccus denitrificans at 1.75 A resolution.
J.Mol.Biol., 276, 1998
2V58
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BU of 2v58 by Molmil
CRYSTAL STRUCTURE OF BIOTIN CARBOXYLASE FROM E.COLI IN COMPLEX WITH POTENT INHIBITOR 1
分子名称: 6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine, BIOTIN CARBOXYLASE, CHLORIDE ION
著者Mochalkin, I, Miller, J.R.
登録日2008-10-02
公開日2009-01-13
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献A Class of Selective Antibacterials Derived from a Protein Kinase Inhibitor Pharmacophore.
Proc.Natl.Acad.Sci.USA, 106, 2009
2V5A
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BU of 2v5a by Molmil
CRYSTAL STRUCTURE OF BIOTIN CARBOXYLASE FROM E.COLI IN COMPLEX WITH POTENT INHIBITOR 3
分子名称: 7-(2,5-dihydropyrrol-1-yl)-6-phenyl-pyrido[6,5-d]pyrimidin-2-amine, BIOTIN CARBOXYLASE, CHLORIDE ION
著者Mochalkin, I, Miller, J.R.
登録日2008-10-02
公開日2009-01-13
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献A Class of Selective Antibacterials Derived from a Protein Kinase Inhibitor Pharmacophore.
Proc.Natl.Acad.Sci.USA, 106, 2009
3PAW
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BU of 3paw by Molmil
Low resolution X-ray crystal structure of Yeast Rnr1p with dATP bound in the A-site
分子名称: Ribonucleoside-diphosphate reductase large chain 1
著者Fairman, J.W, Wijerathna, S.R, Dealwis, C.G.
登録日2010-10-19
公開日2011-02-23
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (6.61 Å)
主引用文献Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization.
Nat.Struct.Mol.Biol., 18, 2011
2F23
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BU of 2f23 by Molmil
Crystal structure of GreA factor homolog 1 (Gfh1) protein of Thermus thermophilus
分子名称: Anti-cleavage anti-greA transcription factor gfh1
著者Kong, X.P, Kim, S.-S.
登録日2005-11-15
公開日2006-05-30
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献pH-dependent conformational switch activates the inhibitor of transcription elongation.
Embo J., 25, 2006
3GRT
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BU of 3grt by Molmil
HUMAN GLUTATHIONE REDUCTASE A34E, R37W MUTANT, OXIDIZED TRYPANOTHIONE COMPLEX
分子名称: 2-AMINO-4-[4-(4-AMINO-4-CARBOXY-BUTYRYLAMINO)-5,8,19,22-TETRAOXO-1,2-DITHIA-6,9,13,18,21-PENTAAZA-CYCLOTETRACOS-23-YLCARBAMOYL]-BUTYRIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONE REDUCTASE
著者Stoll, V.S, Simpson, S.J, Krauth-Siegel, R.L, Walsh, C.T, Pai, E.F.
登録日1997-02-12
公開日1997-08-12
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity.
Biochemistry, 36, 1997
5TTV
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BU of 5ttv by Molmil
Jak3 with covalent inhibitor 6
分子名称: N-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]propanamide, Tyrosine-protein kinase JAK3
著者Vajdos, F.F.
登録日2016-11-04
公開日2017-02-22
最終更新日2017-03-22
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans.
J. Med. Chem., 60, 2017
1MDA
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BU of 1mda by Molmil
CRYSTAL STRUCTURE OF AN ELECTRON-TRANSFER COMPLEX BETWEEN METHYLAMINE DEHYDROGENASE AND AMICYANIN
分子名称: AMICYANIN, COPPER (II) ION, METHYLAMINE DEHYDROGENASE (HEAVY SUBUNIT), ...
著者Chen, L, Durley, R, Mathews, F.S.
登録日1992-03-02
公開日1993-10-31
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of an electron-transfer complex between methylamine dehydrogenase and amicyanin.
Biochemistry, 31, 1992
3HNF
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BU of 3hnf by Molmil
Crystal structure of human ribonucleotide reductase 1 bound to the effectors TTP and dATP
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, ...
著者Fairman, J.W, Wijerathna, S.R, Xu, H, Dealwis, C.G.
登録日2009-05-31
公開日2011-02-23
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.16 Å)
主引用文献Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization.
Nat.Struct.Mol.Biol., 18, 2011
3HNE
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BU of 3hne by Molmil
Crystal structure of human ribonucleotide reductase 1 bound to the effectors TTP and ATP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, ...
著者Fairman, J.W, Wijerathna, S.R, Xu, H, Dealwis, C.G.
登録日2009-05-31
公開日2011-02-23
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.11 Å)
主引用文献Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization.
Nat.Struct.Mol.Biol., 18, 2011
3HNC
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BU of 3hnc by Molmil
Crystal structure of human ribonucleotide reductase 1 bound to the effector TTP
分子名称: MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, SULFATE ION, ...
著者Fairman, J.W, Wijerathna, S.R, Xu, H, Dealwis, C.G.
登録日2009-05-31
公開日2011-02-23
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization.
Nat.Struct.Mol.Biol., 18, 2011
1PP2
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BU of 1pp2 by Molmil
THE REFINED CRYSTAL STRUCTURE OF DIMERIC PHOSPHOLIPASE A2 AT 2.5 ANGSTROMS. ACCESS TO A SHIELDED CATALYTIC CENTER
分子名称: CALCIUM-FREE PHOSPHOLIPASE A2
著者Brunie, S, Sigler, P.B.
登録日1986-03-10
公開日1986-05-07
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The refined crystal structure of dimeric phospholipase A2 at 2.5 A. Access to a shielded catalytic center.
J.Biol.Chem., 260, 1985
4EWN
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BU of 4ewn by Molmil
Structure of HisF-D130V+D176V with bound rCdRP
分子名称: 1-(O-carboxy-phenylamino)-1-deoxy-D-ribulose-5-phosphate, Imidazole glycerol phosphate synthase subunit HisF
著者Reisinger, B, Bocola, M, Rajendran, C, List, F, Sterner, R.
登録日2012-04-27
公開日2012-12-05
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.903 Å)
主引用文献A sugar isomerization reaction established on various (beta-alpha)8-barrel scaffolds is based on substrate-assisted catalysis
Protein Eng.Des.Sel., 25, 2012
5TTU
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BU of 5ttu by Molmil
Jak3 with covalent inhibitor 7
分子名称: 1-[(3aR,7aR)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)octahydro-6H-pyrrolo[2,3-c]pyridin-6-yl]propan-1-one, SULFATE ION, Tyrosine-protein kinase JAK3
著者Vajdos, F.F.
登録日2016-11-04
公開日2017-02-22
最終更新日2017-03-22
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans.
J. Med. Chem., 60, 2017
5TTS
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BU of 5tts by Molmil
Jak3 with covalent inhibitor 4
分子名称: 1-{(3R)-3-[(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}propan-1-one, Tyrosine-protein kinase JAK3
著者Vajdos, F.F.
登録日2016-11-04
公開日2017-02-22
最終更新日2017-03-22
実験手法X-RAY DIFFRACTION (2.34 Å)
主引用文献Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans.
J. Med. Chem., 60, 2017
1BCD
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BU of 1bcd by Molmil
X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A COMPLEX BETWEEN HUMAN CARBONIC ANHYDRASE II AND A NEW TOPICAL INHIBITOR, TRIFLUOROMETHANE SULPHONAMIDE
分子名称: CARBONIC ANHYDRASE II, TRIFLUOROMETHANE SULFONAMIDE, ZINC ION
著者Hakansson, K, Liljas, A.
登録日1993-08-31
公開日1993-10-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The structure of a complex between carbonic anhydrase II and a new inhibitor, trifluoromethane sulphonamide.
FEBS Lett., 350, 1994
8VLM
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BU of 8vlm by Molmil
Crystal structure of the yeast cytosine deaminase (yCD) E64V-M100W heterodimer
分子名称: 1,2-ETHANEDIOL, Cytosine deaminase, ZINC ION
著者Picard, M.-E, Grenier, G, Despres, P.C, Dube, A.K, Landry, C.R, Shi, R.
登録日2024-01-11
公開日2024-08-21
実験手法X-RAY DIFFRACTION (2.67 Å)
主引用文献Compensatory mutations potentiate constructive neutral evolution by gene duplication
Science, 2024
2XT0
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BU of 2xt0 by Molmil
Dehalogenase DPpA from Plesiocystis pacifica SIR-I
分子名称: HALOALKANE DEHALOGENASE, SULFATE ION
著者Bogdanovic, X, Palm, G.J, Hinrichs, W.
登録日2010-10-02
公開日2011-08-10
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Cloning, Functional Expression, Biochemical Characterization, and Structural Analysis of a Haloalkane Dehalogenase from Plesiocystis Pacifica Sir-1.
Appl.Microbiol.Biotechnol., 91, 2011

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