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5TTU

Jak3 with covalent inhibitor 7

Summary for 5TTU
Entry DOI10.2210/pdb5ttu/pdb
Related5TTS 5TTV
DescriptorTyrosine-protein kinase JAK3, 1-[(3aR,7aR)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)octahydro-6H-pyrrolo[2,3-c]pyridin-6-yl]propan-1-one, SULFATE ION, ... (4 entities in total)
Functional Keywordskinase, covalent, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationEndomembrane system ; Peripheral membrane protein : P52333
Total number of polymer chains1
Total formula weight37035.15
Authors
Vajdos, F.F. (deposition date: 2016-11-04, release date: 2017-02-22, Last modification date: 2017-03-22)
Primary citationThorarensen, A.,Dowty, M.E.,Banker, M.E.,Juba, B.,Jussif, J.,Lin, T.,Vincent, F.,Czerwinski, R.M.,Casimiro-Garcia, A.,Unwalla, R.,Trujillo, J.I.,Liang, S.,Balbo, P.,Che, Y.,Gilbert, A.M.,Brown, M.F.,Hayward, M.,Montgomery, J.,Leung, L.,Yang, X.,Soucy, S.,Hegen, M.,Coe, J.,Langille, J.,Vajdos, F.,Chrencik, J.,Telliez, J.B.
Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans.
J. Med. Chem., 60:1971-1993, 2017
Cited by
PubMed: 28139931
DOI: 10.1021/acs.jmedchem.6b01694
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.72 Å)
Structure validation

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