8HG7
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![BU of 8hg7 by Molmil](/molmil-images/mine/8hg7) | Structure of human SGLT2-MAP17 complex with Sotagliflozin | 分子名称: | (2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[(4-ethoxyphenyl)methyl]phenyl]-6-methylsulfanyl-oxane-3,4,5-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose, PDZK1-interacting protein 1, ... | 著者 | Hiraizumi, M, Kishida, H, Miyaguchi, I, Nureki, O. | 登録日 | 2022-11-14 | 公開日 | 2023-11-15 | 最終更新日 | 2024-02-07 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter. Nat.Struct.Mol.Biol., 31, 2024
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8HEZ
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![BU of 8hez by Molmil](/molmil-images/mine/8hez) | Structure of human SGLT2-MAP17 complex with Dapagliflozin | 分子名称: | (2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[(4-ethoxyphenyl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose, PDZK1-interacting protein 1, ... | 著者 | Hiraizumi, M, Kishida, H, Miyaguchi, I, Nureki, O. | 登録日 | 2022-11-09 | 公開日 | 2023-11-15 | 最終更新日 | 2024-02-07 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter. Nat.Struct.Mol.Biol., 31, 2024
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8HDH
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![BU of 8hdh by Molmil](/molmil-images/mine/8hdh) | Structure of human SGLT2-MAP17 complex with Canagliflozin | 分子名称: | (2~{S},3~{R},4~{R},5~{S},6~{R})-2-[3-[[5-(4-fluorophenyl)thiophen-2-yl]methyl]-4-methyl-phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose, PDZK1-interacting protein 1, ... | 著者 | Hiraizumi, M, Kishida, H, Miyaguchi, I, Nureki, O. | 登録日 | 2022-11-04 | 公開日 | 2023-11-08 | 最終更新日 | 2024-02-07 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter. Nat.Struct.Mol.Biol., 31, 2024
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8HIN
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![BU of 8hin by Molmil](/molmil-images/mine/8hin) | Structure of human SGLT2-MAP17 complex with Phlorizin | 分子名称: | 1-[2-[(2S,3R,4S,5S,6R)-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-4,6-bis(oxidanyl)phenyl]-3-(4-hydroxyphenyl)propan-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, PDZK1-interacting protein 1, ... | 著者 | Hiraizumi, M, Kishida, H, Miyaguchi, I, Nureki, O. | 登録日 | 2022-11-21 | 公開日 | 2023-11-22 | 最終更新日 | 2024-02-07 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter. Nat.Struct.Mol.Biol., 31, 2024
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5TYR
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![BU of 5tyr by Molmil](/molmil-images/mine/5tyr) | X-ray crystal structure of wild type HIV-1 protease in complex with GRL-121 | 分子名称: | (3S,3aR,5R,7aS,8S)-hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-yl {(2S,3R)-4-[{[2-(cyclopropylamino)-1,3-benzothiazol-6-yl]sulfonyl}(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl}carbamate, Protease | 著者 | Yedidi, R.S, Hayashi, H, Aoki, M, Das, D, Ghosh, A.K, Mitsuya, H. | 登録日 | 2016-11-21 | 公開日 | 2017-10-18 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency. Elife, 6, 2017
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5TYS
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![BU of 5tys by Molmil](/molmil-images/mine/5tys) | X-ray crystal structure of wild type HIV-1 protease in complex with GRL-142 | 分子名称: | (3S,3aR,5R,7aS,8S)-hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-yl [(2S,3R)-4-[{[2-(cyclopropylamino)-1,3-benzothiazol-6-yl]sulfonyl}(2-methylpropyl)amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]carbamate, Protease | 著者 | Yedidi, R.S, Hayashi, H, Aoki, M, Das, D, Ghosh, A.K, Mitsuya, H. | 登録日 | 2016-11-21 | 公開日 | 2017-10-18 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.007 Å) | 主引用文献 | A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency. Elife, 6, 2017
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1IWJ
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![BU of 1iwj by Molmil](/molmil-images/mine/1iwj) | Putidaredoxin-Binding Stablilizes an Active Conformer of Cytochrome P450cam in its Reduced State; Crystal Structure of Mutant(109K) Cytochrome P450cam | 分子名称: | CAMPHOR, CYTOCHROME P450-CAM, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Nagano, S, Shimada, H, Tarumi, A, Hishiki, T, Kimata-Ariga, Y, Egawa, T, Park, S.-Y, Adachi, S, Shiro, Y, Ishimura, Y, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2002-05-15 | 公開日 | 2002-06-05 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Infrared spectroscopic and mutational studies on putidaredoxin-induced conformational changes in ferrous CO-P450cam Biochemistry, 42, 2003
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7XZR
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![BU of 7xzr by Molmil](/molmil-images/mine/7xzr) | Crystal structure of TNIK-AMPPNP-thiopeptide TP15 complex | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SULFATE ION, ... | 著者 | Hamada, K, Vinogradov, A.A, Zhang, Y, Chang, J.S, Nishimura, H, Goto, Y, Onaka, H, Suga, H, Ogata, K, Sengoku, T. | 登録日 | 2022-06-03 | 公開日 | 2022-10-26 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | De Novo Discovery of Thiopeptide Pseudo-natural Products Acting as Potent and Selective TNIK Kinase Inhibitors. J.Am.Chem.Soc., 144, 2022
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7XZQ
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![BU of 7xzq by Molmil](/molmil-images/mine/7xzq) | Crystal structure of TNIK-thiopeptide TP1 complex | 分子名称: | 1,4-BUTANEDIOL, TRAF2 and NCK-interacting protein kinase, thiopeptide TP1 | 著者 | Hamada, K, Vinogradov, A.A, Zhang, Y, Chang, J.S, Nishimura, H, Goto, Y, Onaka, H, Suga, H, Ogata, K, Sengoku, T. | 登録日 | 2022-06-03 | 公開日 | 2022-10-26 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | De Novo Discovery of Thiopeptide Pseudo-natural Products Acting as Potent and Selective TNIK Kinase Inhibitors. J.Am.Chem.Soc., 144, 2022
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4M6R
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![BU of 4m6r by Molmil](/molmil-images/mine/4m6r) | Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme | 分子名称: | Methylthioribulose-1-phosphate dehydratase, ZINC ION | 著者 | Kang, W, Hong, S.H, Lee, H.M, Kim, N.Y, Lim, Y.C, Le, L.T.M, Lim, B, Kim, H.C, Kim, T.Y, Ashida, H, Yokota, A, Hah, S.S, Chun, K.H, Jung, Y.K, Yang, J.K. | 登録日 | 2013-08-10 | 公開日 | 2014-01-29 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme. Proc.Natl.Acad.Sci.USA, 111, 2014
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5ZCZ
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![BU of 5zcz by Molmil](/molmil-images/mine/5zcz) | Solution structure of the T. Thermophilus HB8 TTHA1718 protein in living eukaryotic cells by in-cell NMR spectroscopy | 分子名称: | Heavy metal binding protein | 著者 | Tanaka, T, Teppei, I, Kamoshida, H, Mishima, M, Shirakawa, M, Guentert, P, Ito, Y. | 登録日 | 2018-02-22 | 公開日 | 2019-08-21 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | High-Resolution Protein 3D Structure Determination in Living Eukaryotic Cells. Angew.Chem.Int.Ed.Engl., 58, 2019
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5ZD0
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![BU of 5zd0 by Molmil](/molmil-images/mine/5zd0) | Solution structure of human ubiquitin with three alanine mutations in living eukaryotic cells by in-cell NMR spectroscopy | 分子名称: | ubiquitin | 著者 | Tanaka, T, Ikeya, T, Kamoshida, H, Mishima, M, Shirakawa, M, Guentert, P, Ito, Y. | 登録日 | 2018-02-22 | 公開日 | 2019-08-21 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | High-Resolution Protein 3D Structure Determination in Living Eukaryotic Cells. Angew.Chem.Int.Ed.Engl., 58, 2019
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5Z4B
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![BU of 5z4b by Molmil](/molmil-images/mine/5z4b) | GB1 structure determination in living eukaryotic cells by in-cell NMR spectroscopy | 分子名称: | Protein LG | 著者 | Tanaka, T, Teppei, I, Kamoshida, H, Mishima, M, Shirakawa, M, Guentert, P, Ito, Y. | 登録日 | 2018-01-10 | 公開日 | 2019-01-23 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | High-Resolution Protein 3D Structure Determination in Living Eukaryotic Cells. Angew.Chem.Int.Ed.Engl., 58, 2019
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1IWK
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![BU of 1iwk by Molmil](/molmil-images/mine/1iwk) | Putidaredoxin-Binding Stablilizes an Active Conformer of Cytochrome P450cam in its Reduced State; Crystal Structure of Mutant(112K) Cytochrome P450cam | 分子名称: | CYTOCHROME P450-CAM, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Nagano, S, Shimada, H, Tarumi, A, Hishiki, T, Kimata-Ariga, Y, Egawa, T, Park, S.-Y, Adachi, S, Shiro, Y, Ishimura, Y, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2002-05-15 | 公開日 | 2002-06-05 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Infrared spectroscopic and mutational studies on putidaredoxin-induced conformational changes in ferrous CO-P450cam Biochemistry, 42, 2003
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1GEB
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![BU of 1geb by Molmil](/molmil-images/mine/1geb) | X-RAY CRYSTAL STRUCTURE AND CATALYTIC PROPERTIES OF THR252ILE MUTANT OF CYTOCHROME P450CAM | 分子名称: | CAMPHOR, CYTOCHROME P450-CAM, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Hishiki, T, Shimada, H, Nagano, S, Park, S.-Y, Ishimura, Y. | 登録日 | 2000-11-01 | 公開日 | 2000-11-15 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | X-ray crystal structure and catalytic properties of Thr252Ile mutant of cytochrome P450cam: roles of Thr252 and water in the active center. J.Biochem., 128, 2000
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1IWI
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![BU of 1iwi by Molmil](/molmil-images/mine/1iwi) | Putidaredoxin-Binding Stablilizes an Active Conformer of Cytochrome P450cam in its Reduced State; Crystal Structure of Cytochrome P450cam | 分子名称: | CAMPHOR, CYTOCHROME P450-CAM, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Nagano, S, Shimada, H, Tarumi, A, Hishiki, T, Kimata-Ariga, Y, Egawa, T, Park, S.-Y, Adachi, S, Shiro, Y, Ishimura, Y, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2002-05-15 | 公開日 | 2002-06-05 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Infrared spectroscopic and mutational studies on putidaredoxin-induced conformational changes in ferrous CO-P450cam Biochemistry, 42, 2003
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7XK7
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![BU of 7xk7 by Molmil](/molmil-images/mine/7xk7) | Cryo-EM structure of Na+-pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae, with korormicin | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, CALCIUM ION, DODECYL-BETA-D-MALTOSIDE, ... | 著者 | Kishikawa, J, Ishikawa, M, Masuya, T, Murai, M, Barquera, B, Miyoshi, H. | 登録日 | 2022-04-19 | 公開日 | 2022-07-20 | 最終更新日 | 2022-08-10 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Cryo-EM structures of Na + -pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae. Nat Commun, 13, 2022
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7XK4
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![BU of 7xk4 by Molmil](/molmil-images/mine/7xk4) | Cryo-EM structure of Na+-pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae, state 2 | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, CALCIUM ION, DODECYL-BETA-D-MALTOSIDE, ... | 著者 | Kishikawa, J, Ishikawa, M, Masuya, T, Murai, M, Barquera, B, Miyoshi, H. | 登録日 | 2022-04-19 | 公開日 | 2022-07-20 | 最終更新日 | 2022-08-10 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Cryo-EM structures of Na + -pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae. Nat Commun, 13, 2022
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7XK5
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![BU of 7xk5 by Molmil](/molmil-images/mine/7xk5) | Cryo-EM structure of Na+-pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae, state 3 | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, CALCIUM ION, DODECYL-BETA-D-MALTOSIDE, ... | 著者 | Kishikawa, J, Ishikawa, M, Masuya, T, Murai, M, Barquera, B, Miyoshi, H. | 登録日 | 2022-04-19 | 公開日 | 2022-07-20 | 最終更新日 | 2022-08-10 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Cryo-EM structures of Na + -pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae. Nat Commun, 13, 2022
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7XK3
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![BU of 7xk3 by Molmil](/molmil-images/mine/7xk3) | Cryo-EM structure of Na+-pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae, state 1 | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, CALCIUM ION, DODECYL-BETA-D-MALTOSIDE, ... | 著者 | Kishikawa, J, Ishikawa, M, Masuya, T, Murai, M, Barquera, B, Miyoshi, H. | 登録日 | 2022-04-19 | 公開日 | 2022-07-20 | 最終更新日 | 2022-08-10 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Cryo-EM structures of Na + -pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae. Nat Commun, 13, 2022
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7XK6
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![BU of 7xk6 by Molmil](/molmil-images/mine/7xk6) | Cryo-EM structure of Na+-pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae, with aurachin D-42 | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Aurachin D, CALCIUM ION, ... | 著者 | Kishikawa, J, Ishikawa, M, Masuya, T, Murai, M, Barquera, B, Miyoshi, H. | 登録日 | 2022-04-19 | 公開日 | 2022-07-20 | 最終更新日 | 2022-08-10 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Cryo-EM structures of Na + -pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae. Nat Commun, 13, 2022
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2RNN
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![BU of 2rnn by Molmil](/molmil-images/mine/2rnn) | |
6LMW
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![BU of 6lmw by Molmil](/molmil-images/mine/6lmw) | Cryo-EM structure of the CALHM chimeric construct (8-mer) | 分子名称: | Calcium homeostasis modulator 1,Calcium homeostasis modulator protein 2 | 著者 | Demura, K, Kusakizako, T, Shihoya, W, Hiraizumi, M, Shimada, H, Yamashita, K, Nishizawa, T, Nureki, O. | 登録日 | 2019-12-26 | 公開日 | 2020-07-29 | 最終更新日 | 2020-09-09 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Cryo-EM structures of calcium homeostasis modulator channels in diverse oligomeric assemblies. Sci Adv, 6, 2020
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6MCS
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![BU of 6mcs by Molmil](/molmil-images/mine/6mcs) | X-ray crystal structure of wild type HIV-1 protease in complex with GRL-003 | 分子名称: | (3S,3aR,5R,7aS,8S)-hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-yl [(2S,3R)-4-[{[2-(cyclopropylamino)-1,3-benzothiazol-6-yl]sulfonyl}(2-methylpropyl)amino]-1-(4-fluorophenyl)-3-hydroxybutan-2-yl]carbamate, Protease | 著者 | Bulut, H, Hayashi, H, Hattori, S.I, Aoki, M, Das, D, Ghosh, A.K, Mitsuya, H. | 登録日 | 2018-09-02 | 公開日 | 2019-04-24 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | 主引用文献 | Halogen Bond Interactions of Novel HIV-1 Protease Inhibitors (PI) (GRL-001-15 and GRL-003-15) with the Flap of Protease Are Critical for Their Potent Activity against Wild-Type HIV-1 and Multi-PI-Resistant Variants. Antimicrob.Agents Chemother., 63, 2019
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6LMT
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![BU of 6lmt by Molmil](/molmil-images/mine/6lmt) | Cryo-EM structure of the killifish CALHM1 | 分子名称: | CHOLESTEROL HEMISUCCINATE, Calcium homeostasis modulator 1 | 著者 | Demura, K, Kusakizako, T, Shihoya, W, Hiraizumi, M, Shimada, H, Yamashita, K, Nishizawa, T, Nureki, O. | 登録日 | 2019-12-26 | 公開日 | 2020-07-29 | 最終更新日 | 2020-09-09 | 実験手法 | ELECTRON MICROSCOPY (2.66 Å) | 主引用文献 | Cryo-EM structures of calcium homeostasis modulator channels in diverse oligomeric assemblies. Sci Adv, 6, 2020
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