8D0E
 
 | | Human SARM1 TIR domain bound to NB-7 | | 分子名称: | 3-(4-chlorophenyl)-N-[4-methyl-3-(pyridin-4-yl)-1H-pyrazol-5-yl]propanamide, NAD(+) hydrolase SARM1 | | 著者 | Bratkowski, M.A, Mathur, P. | | 登録日 | 2022-05-26 | | 公開日 | 2022-09-21 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | | 主引用文献 | Uncompetitive, adduct-forming SARM1 inhibitors are neuroprotective in preclinical models of nerve injury and disease.
Neuron, 110, 2022
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8D0J
 | | Apo Human SARM1 TIR domain | | 分子名称: | NAD(+) hydrolase SARM1 | | 著者 | Bratkowski, M.A, Mathur, P. | | 登録日 | 2022-05-26 | | 公開日 | 2022-09-21 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | Uncompetitive, adduct-forming SARM1 inhibitors are neuroprotective in preclinical models of nerve injury and disease.
Neuron, 110, 2022
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8DDG
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8DDH
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8DDF
 | | Quasi-racemic mixture of L-FWF and D-FYF peptide reveals rippled beta-sheet | | 分子名称: | 1,1,1,3,3,3-hexafluoropropan-2-ol, DPN-DTY-DPN, PHE-TRP-PHE | | 著者 | Sawaya, M.R, Hazari, A, Eisenberg, D.E. | | 登録日 | 2022-06-18 | | 公開日 | 2022-09-28 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | The rippled beta-sheet layer configuration-a novel supramolecular architecture based on predictions by Pauling and Corey.
Chem Sci, 13, 2022
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8F1G
 | | Crystal structure of human WDR5 in complex with compound WM662 | | 分子名称: | (2S)-2-({(2S)-3-(3'-chloro[1,1'-biphenyl]-4-yl)-1-oxo-1-[(1H-tetrazol-5-yl)amino]propan-2-yl}oxy)propanoic acid, GLYCEROL, SULFATE ION, ... | | 著者 | Liu, H. | | 登録日 | 2022-11-05 | | 公開日 | 2023-01-11 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | | 主引用文献 | Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction.
Acs Chem.Biol., 18, 2023
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8ELK
 | | HRAS R97F Crystal Form 1 | | 分子名称: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | | 著者 | Johnson, C.W, Mattos, C. | | 登録日 | 2022-09-26 | | 公開日 | 2023-09-06 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Allosteric site variants affect GTP hydrolysis on Ras.
Protein Sci., 32, 2023
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8ELX
 | | HRAS R97I Crystal Form 1 | | 分子名称: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | | 著者 | Johnson, C.W, Mattos, C. | | 登録日 | 2022-09-26 | | 公開日 | 2023-09-06 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.975 Å) | | 主引用文献 | Allosteric site variants affect GTP hydrolysis on Ras.
Protein Sci., 32, 2023
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8ELT
 | | HRAS R97G Crystal Form 2 | | 分子名称: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | | 著者 | Johnson, C.W, Mattos, C. | | 登録日 | 2022-09-26 | | 公開日 | 2023-09-06 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | | 主引用文献 | Allosteric site variants affect GTP hydrolysis on Ras.
Protein Sci., 32, 2023
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8ELV
 | | HRAS R97I Crystal Form 2 | | 分子名称: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | | 著者 | Johnson, C.W, Mattos, C. | | 登録日 | 2022-09-26 | | 公開日 | 2023-09-06 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.153 Å) | | 主引用文献 | Allosteric site variants affect GTP hydrolysis on Ras.
Protein Sci., 32, 2023
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8EM0
 | | HRAS R97V Crystal Form 1 | | 分子名称: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | | 著者 | Johnson, C.W, Mattos, C. | | 登録日 | 2022-09-26 | | 公開日 | 2023-09-06 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.109 Å) | | 主引用文献 | Allosteric site variants affect GTP hydrolysis on Ras.
Protein Sci., 32, 2023
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8ELR
 | | HRAS R97F Crystal Form 2 | | 分子名称: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | | 著者 | Johnson, C.W, Mattos, C. | | 登録日 | 2022-09-26 | | 公開日 | 2023-09-06 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Allosteric site variants affect GTP hydrolysis on Ras.
Protein Sci., 32, 2023
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8ELY
 | | HRAS R97M Crystal Form 2 | | 分子名称: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | | 著者 | Johnson, C.W, Mattos, C. | | 登録日 | 2022-09-26 | | 公開日 | 2023-09-06 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Allosteric site variants affect GTP hydrolysis on Ras.
Protein Sci., 32, 2023
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8ELW
 | | HRAS R97A Crystal Form 1 T-State | | 分子名称: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | | 著者 | Davis, K, Johnson, C.W, Mattos, C. | | 登録日 | 2022-09-26 | | 公開日 | 2023-09-06 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.699 Å) | | 主引用文献 | Allosteric site variants affect GTP hydrolysis on Ras.
Protein Sci., 32, 2023
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8DJT
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8DJW
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8DIP
 | | The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ001023030 | | 分子名称: | (2P)-5-hydroxy-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-oxo-2-[3-(trifluoromethyl)phenyl]-1,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... | | 著者 | Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W. | | 登録日 | 2022-06-29 | | 公開日 | 2023-03-29 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential.
Eur.J.Med.Chem., 247, 2023
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8ELZ
 | | HRAS R97M Crystal Form 1 | | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, CALCIUM ION, GTPase HRas, ... | | 著者 | Johnson, C.W, Mattos, C. | | 登録日 | 2022-09-26 | | 公開日 | 2023-09-06 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.961 Å) | | 主引用文献 | Allosteric site variants affect GTP hydrolysis on Ras.
Protein Sci., 32, 2023
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8ELS
 | | HRAS R97A Crystal Form 1 R-state | | 分子名称: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | | 著者 | Davis, D, Johnson, C.W, Mattos, C. | | 登録日 | 2022-09-26 | | 公開日 | 2023-09-06 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.267 Å) | | 主引用文献 | Allosteric site variants affect GTP hydrolysis on Ras.
Protein Sci., 32, 2023
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8EME
 | | EGFR(T790M/V948R) in complex with ZNL-0056 | | 分子名称: | Epidermal growth factor receptor, N-{7-methyl-1-[(3S)-1-(prop-2-enoyl)azepan-3-yl]-1H-benzimidazol-2-yl}-5-(prop-2-enamido)thiophene-3-carboxamide | | 著者 | Beyett, T.S, Eck, M.J. | | 登録日 | 2022-09-27 | | 公開日 | 2023-10-18 | | 最終更新日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (3.32 Å) | | 主引用文献 | Molecular Bidents with Two Electrophilic Warheads as a New Pharmacological Modality.
Acs Cent.Sci., 10, 2024
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8EQF
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8DJR
 | | Cytosolic ascorbate peroxidase from Sorghum bicolor | | 分子名称: | L-ascorbate peroxidase, PROTOPORPHYRIN IX CONTAINING FE, SODIUM ION, ... | | 著者 | Zhang, B, Kang, C. | | 登録日 | 2022-07-01 | | 公開日 | 2023-01-18 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | | 主引用文献 | A sorghum ascorbate peroxidase with four binding sites has activity against ascorbate and phenylpropanoids.
Plant Physiol., 192, 2023
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8DJX
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8DJS
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8DJU
 | | Cytosolic ascorbate peroxidase from Sorghum bicolor - bicyclic dehydroascorbic acid complex | | 分子名称: | (3aS,6S,6aR)-3,3,3a,6-tetrahydroxytetrahydrofuro[3,2-b]furan-2(3H)-one (non-preferred name), L-ascorbate peroxidase, PROTOPORPHYRIN IX CONTAINING FE, ... | | 著者 | Zhang, B, Kang, C. | | 登録日 | 2022-07-01 | | 公開日 | 2023-01-18 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | A sorghum ascorbate peroxidase with four binding sites has activity against ascorbate and phenylpropanoids.
Plant Physiol., 192, 2023
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