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8JWN
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Crystal structure of AKRtyl-NADPH complex
分子名称: Aldo/keto reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Lin, S, Dai, S, Xiao, Z.
登録日2023-06-29
公開日2024-04-10
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献A three-level regulatory mechanism of the aldo-keto reductase subfamily AKR12D.
Nat Commun, 15, 2024
8JWL
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BU of 8jwl by Molmil
The first purified state crystal structure of AKRtyl
分子名称: Aldo/keto reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Lin, S, Dai, S, Xiao, Z.
登録日2023-06-29
公開日2024-04-10
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献A three-level regulatory mechanism of the aldo-keto reductase subfamily AKR12D.
Nat Commun, 15, 2024
4E90
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Human phosphodiesterase 9 in complex with inhibitors
分子名称: 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ...
著者Liu, S.
登録日2012-03-20
公開日2013-02-27
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors.
J.Med.Chem., 55, 2012
4G2L
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BU of 4g2l by Molmil
Human PDE9 in complex with selective compound
分子名称: 1-cyclopentyl-6-{(1R)-1-[3-(pyrimidin-2-yl)azetidin-1-yl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ...
著者Liu, S.
登録日2012-07-12
公開日2013-05-29
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors.
J.Med.Chem., 55, 2012
4G2J
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BU of 4g2j by Molmil
Human pde9 in complex with selective compound
分子名称: 1-cyclopentyl-6-[(1R)-1-(3-phenoxyazetidin-1-yl)ethyl]-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ...
著者Liu, S.
登録日2012-07-12
公開日2013-05-29
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors.
J.Med.Chem., 55, 2012
8IAK
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BU of 8iak by Molmil
Cryo-EM structure of the yeast SPT-ORM2 (ORM2-S3A-N71A) complex
分子名称: PYRIDOXAL-5'-PHOSPHATE, Protein ORM2, Serine palmitoyltransferase 2, ...
著者Xie, T, Gong, X.
登録日2023-02-08
公開日2024-02-14
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Collaborative regulation of yeast SPT-Orm2 complex by phosphorylation and ceramide.
Cell Rep, 43, 2024
8IAM
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BU of 8iam by Molmil
Cryo-EM structure of the yeast SPT-ORM2 (ORM2-S3D) complex
分子名称: Chimera of Long chain base biosynthesis protein 1 and Serine palmitoyltransferase 1, N-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]tetracosanamide, PYRIDOXAL-5'-PHOSPHATE, ...
著者Xie, T, Gong, X.
登録日2023-02-08
公開日2024-02-14
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Collaborative regulation of yeast SPT-Orm2 complex by phosphorylation and ceramide.
Cell Rep, 43, 2024
8IAJ
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Cryo-EM structure of the yeast SPT-ORM2 (ORM2-S3A) complex
分子名称: N-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]tetracosanamide, PYRIDOXAL-5'-PHOSPHATE, Protein ORM2, ...
著者Xie, T, Gong, X.
登録日2023-02-08
公開日2024-02-14
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Collaborative regulation of yeast SPT-Orm2 complex by phosphorylation and ceramide.
Cell Rep, 43, 2024
8J0F
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BU of 8j0f by Molmil
GK tetramer with adjacent hooks at reaction state
分子名称: ADENOSINE-5'-DIPHOSPHATE, Delta-1-pyrroline-5-carboxylate synthase B, GAMMA-GLUTAMYL PHOSPHATE, ...
著者Zhang, T, Guo, C.J, Liu, J.L.
登録日2023-04-10
公開日2024-04-17
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Dynamic Arabidopsis P5CS filament facilitates substrate channelling.
Nat.Plants, 2024
8OK4
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BU of 8ok4 by Molmil
Variant Surface Glycoprotein VSG11wt-Oil
分子名称: Variant surface glycoprotein, alpha-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Zeelen, J.P, Stebbins, C.E, Aresta-Branco, F, Foti, K.
登録日2023-03-27
公開日2023-09-13
実験手法X-RAY DIFFRACTION (1.23 Å)
主引用文献A structural classification of the variant surface glycoproteins of the African trypanosomey.
Plos Negl Trop Dis, 17, 2023
8OK8
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BU of 8ok8 by Molmil
Variant Surface Glycoprotein VSG615
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Variant surface glycoprotein 615, ...
著者Zeelen, J.P, Stebbins, C.E, Chandra, M.
登録日2023-03-27
公開日2023-09-13
実験手法X-RAY DIFFRACTION (3.22 Å)
主引用文献A structural classification of the variant surface glycoproteins of the African trypanosomey.
Plos Negl Trop Dis, 17, 2023
8OK6
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BU of 8ok6 by Molmil
Variant Surface Glycoprotein VSG11 two monomers
分子名称: SULFATE ION, Variant surface glycoprotein, alpha-D-glucopyranose, ...
著者Gkeka, A, Vlachou, E.P, Zeelen, J.P, Stebbins, C.E.
登録日2023-03-27
公開日2023-09-13
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献A structural classification of the variant surface glycoproteins of the African trypanosomey.
Plos Negl Trop Dis, 17, 2023
8OK5
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BU of 8ok5 by Molmil
Variant Surface Glycoprotein VSG11 monomer with iodine
分子名称: IODIDE ION, Variant surface glycoprotein, alpha-D-glucopyranose, ...
著者Zeelen, J.P, Stebbins, C.E, Aresta-Branco, F.
登録日2023-03-27
公開日2023-09-13
実験手法X-RAY DIFFRACTION (1.27 Å)
主引用文献A structural classification of the variant surface glycoproteins of the African trypanosomey.
Plos Negl Trop Dis, 17, 2023
8ONH
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BU of 8onh by Molmil
Variant Surface Glycoprotein VSG11wt-Oil
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Variant surface glycoprotein, alpha-D-glucopyranose, ...
著者Zeelen, J.P, Stebbins, C.E, Foti, K, Gkeka, A, Vlachou, E.P.
登録日2023-04-03
公開日2023-09-13
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献A structural classification of the variant surface glycoproteins of the African trypanosomey.
Plos Negl Trop Dis, 17, 2023
8Q0E
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BU of 8q0e by Molmil
Crystal Structure of the N-terminal Domain of Variant Surface Glycoprotein 545 (VSG545) of Trypanosome brucei brucei Lister 427
分子名称: Variant surface glycoprotein 545
著者van Straaten, M, Stebbins, C.E.
登録日2023-07-28
公開日2023-09-13
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献A structural classification of the variant surface glycoproteins of the African trypanosomey.
Plos Negl Trop Dis, 17, 2023
8Q0P
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BU of 8q0p by Molmil
Crystal Structure of an N-terminal Domain of Variant Surface Glycoprotein 21 (VSG21) of Trypanosome brucei brucei Lister 427
分子名称: Variant surface glycoprotein MITat 1.21
著者Zeelen, J.P, Stebbins, C.E.
登録日2023-07-28
公開日2023-09-13
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献A structural classification of the variant surface glycoproteins of the African trypanosomey.
Plos Negl Trop Dis, 17, 2023
7CL1
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BU of 7cl1 by Molmil
Human SIRT6 in complex with allosteric activator MDL-801 (3.2A)
分子名称: 5-[[3,5-bis(chloranyl)phenyl]sulfonylamino]-2-[(5-bromanyl-4-fluoranyl-2-methyl-phenyl)sulfamoyl]benzoic acid, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
著者Song, K, Zhang, J.
登録日2020-07-20
公開日2021-02-24
最終更新日2021-05-12
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Reply to: Binding site for MDL-801 on SIRT6.
Nat.Chem.Biol., 17, 2021
7CL0
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BU of 7cl0 by Molmil
Crystal structure of human SIRT6
分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, NAD-dependent protein deacetylase sirtuin-6, ...
著者Song, K, Zhang, J.
登録日2020-07-20
公開日2021-02-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.53 Å)
主引用文献Reply to: Binding site for MDL-801 on SIRT6.
Nat.Chem.Biol., 17, 2021
7X4B
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BU of 7x4b by Molmil
Crystal Structure of An Anti-CRISPR Protein
分子名称: Anti-CRISPR protein (AcrIIC1), SULFATE ION
著者Hu, J, Zhang, S, Gao, J.Y, Liu, X, Liu, J.
登録日2022-03-02
公開日2022-10-26
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.61 Å)
主引用文献A redox switch regulates the assembly and anti-CRISPR activity of AcrIIC1.
Nat Commun, 13, 2022
7X31
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BU of 7x31 by Molmil
solution structure of an anti-CRISPR protein
分子名称: Anti-CRISPR protein (AcrIIC1)
著者Zhao, Y, Yang, F.
登録日2022-02-27
公開日2022-10-26
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献A redox switch regulates the assembly and anti-CRISPR activity of AcrIIC1.
Nat Commun, 13, 2022
7YES
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BU of 7yes by Molmil
The structure of EBOV L-VP35-RNA complex (state2)
分子名称: RNA-directed RNA polymerase L, VP35 of EBOV L-VP35 complex, ZINC ION
著者Shi, Y, Yuan, B, Peng, Q.
登録日2022-07-06
公開日2022-10-05
最終更新日2022-10-26
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structure of the Ebola virus polymerase complex.
Nature, 610, 2022
7YET
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BU of 7yet by Molmil
The structure of EBOV L-VP35 in complex with suramin
分子名称: 8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFON IC ACID, Polymerase cofactor VP35, RNA-directed RNA polymerase L
著者Shi, Y, Yuan, B, Peng, Q.
登録日2022-07-06
公開日2022-10-05
最終更新日2022-10-26
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structure of the Ebola virus polymerase complex.
Nature, 610, 2022
7YER
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BU of 7yer by Molmil
The structure of EBOV L-VP35 complex
分子名称: Polymerase cofactor VP35, RNA-directed RNA polymerase L, ZINC ION
著者Shi, Y, Yuan, B, Peng, Q.
登録日2022-07-06
公開日2022-10-05
最終更新日2022-10-26
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structure of the Ebola virus polymerase complex.
Nature, 610, 2022
7YFX
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BU of 7yfx by Molmil
Cryo-EM structure of Hili in complex with piRNA
分子名称: MAGNESIUM ION, Piwi-like protein 2, piRNA
著者Li, Z.Q, Liu, H.B, Wu, J.P, Shen, E.Z.
登録日2022-07-09
公開日2024-01-24
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Mammalian PIWI-piRNA-target complexes reveal features for broad and efficient target silencing.
Nat.Struct.Mol.Biol., 2024
7YG6
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BU of 7yg6 by Molmil
Cryo-EM structure of the EfPiwi(N959K) in complex with piRNA
分子名称: MAGNESIUM ION, Piwi, piRNA
著者Li, Z.Q, Liu, H.B, Wu, J.P, Shen, E.Z.
登録日2022-07-11
公開日2024-01-24
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Mammalian PIWI-piRNA-target complexes reveal features for broad and efficient target silencing.
Nat.Struct.Mol.Biol., 2024

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