5GW1
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7KID
| PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 72 | 分子名称: | (1S,2R,3aR,4S,6aR)-4-[(2-amino-3,5-difluoroquinolin-7-yl)methyl]-2-(4-amino-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)hexahydropentalene-1,6a(1H)-diol, 1,2-ETHANEDIOL, Methylosome protein 50, ... | 著者 | Palte, R.L. | 登録日 | 2020-10-23 | 公開日 | 2021-04-21 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer. J.Med.Chem., 64, 2021
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7KIC
| PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 34 | 分子名称: | (2R,3R,3aS,6S,6aR)-6-[(2-amino-3-bromoquinolin-7-yl)oxy]-2-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)hexahydro-3aH-cyclopenta[b]furan-3,3a-diol, 1,2-ETHANEDIOL, Methylosome protein 50, ... | 著者 | Palte, R.L. | 登録日 | 2020-10-23 | 公開日 | 2021-04-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer. J.Med.Chem., 64, 2021
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7KIB
| PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 4 | 分子名称: | (2R,3R,3aS,6S,6aR)-6-[(2-amino-3-bromoquinolin-7-yl)oxy]-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)hexahydro-3aH-cyclopenta[b]furan-3,3a-diol, 1,2-ETHANEDIOL, CHLORIDE ION, ... | 著者 | Palte, R.L, Hayes, R.P. | 登録日 | 2020-10-23 | 公開日 | 2021-04-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | 主引用文献 | The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer. J.Med.Chem., 64, 2021
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7EU9
| Crystal structure of the selenomethionine(SeMet)-derived Cas12i1 R-loop complex before target DNA cleavage | 分子名称: | CITRIC ACID, Cas12i1 D647A mutant, DNA (24-MER), ... | 著者 | Zhang, B, Luo, D.Y, Li, Y, OuYang, S.Y. | 登録日 | 2021-05-16 | 公開日 | 2021-05-26 | 最終更新日 | 2021-06-23 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Mechanistic insights into the R-loop formation and cleavage in CRISPR-Cas12i1. Nat Commun, 12, 2021
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5KIW
| p97 ND1-L198W in complex with VIMP | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Selenoprotein S, ... | 著者 | Tang, W.K, Xia, D. | 登録日 | 2016-06-17 | 公開日 | 2018-03-07 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.41 Å) | 主引用文献 | Structural basis for nucleotide-modulated p97 association with the ER membrane. Cell Discov, 3, 2017
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3THB
| Structure of PLK1 kinase domain in complex with a benzolactam-derived inhibitor | 分子名称: | 9-chloro-2-({5-[3-(dimethylamino)propyl]-2-methylpyridin-3-yl}amino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepine-6-thi one, Serine/threonine-protein kinase PLK1, ZINC ION | 著者 | Sintchak, M.D. | 登録日 | 2011-08-18 | 公開日 | 2011-11-23 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Discovery of a Potent and Orally Bioavailable Benzolactam-Derived Inhibitor of Polo-Like Kinase 1 (MLN0905). J.Med.Chem., 55, 2012
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6UXY
| PRMT5:MEP50 Complexed with Allosteric Inhibitor Compound 8 | 分子名称: | (5R)-2-amino-5-(2-cyclohexylethyl)-3-methyl-5-phenyl-3,5-dihydro-4H-imidazol-4-one, 1,2-ETHANEDIOL, GLYCEROL, ... | 著者 | Palte, R.L, Schneider, S.E. | 登録日 | 2019-11-08 | 公開日 | 2020-08-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5). Acs Med.Chem.Lett., 11, 2020
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6UXX
| PRMT5:MEP50 Complexed with Allosteric Inhibitor Compound 1a | 分子名称: | (5R)-2-amino-5-(4-methoxyphenyl)-3-methyl-5-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]decan-1-yl]-3,5-dihydro-4H-imidazol-4-one, Methylosome protein 50, Protein arginine N-methyltransferase 5 | 著者 | Palte, R.L, Schneider, S.E. | 登録日 | 2019-11-08 | 公開日 | 2020-08-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5). Acs Med.Chem.Lett., 11, 2020
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6VYA
| Crystal structure of NotF in complex with brevianamide F and DMSPP | 分子名称: | (3S,8aS)-3-(1H-indol-3-ylmethyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione, DIMETHYLALLYL S-THIOLODIPHOSPHATE, Deoxybrevianamide E synthase notF | 著者 | Dan, Q, Smith, J.L. | 登録日 | 2020-02-25 | 公開日 | 2021-02-03 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Data Science-Driven Analysis of Substrate-Permissive Diketopiperazine Reverse Prenyltransferase NotF: Applications in Protein Engineering and Cascade Biocatalytic Synthesis of (-)-Eurotiumin A. J.Am.Chem.Soc., 144, 2022
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6VY9
| Crystal structure of NotF prenyltransferase | 分子名称: | Deoxybrevianamide E synthase notF | 著者 | Dan, Q, Smith, J.L. | 登録日 | 2020-02-25 | 公開日 | 2021-02-03 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.19 Å) | 主引用文献 | Data Science-Driven Analysis of Substrate-Permissive Diketopiperazine Reverse Prenyltransferase NotF: Applications in Protein Engineering and Cascade Biocatalytic Synthesis of (-)-Eurotiumin A. J.Am.Chem.Soc., 144, 2022
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2LKP
| solution structure of apo-NmtR | 分子名称: | HTH-type transcriptional regulator NmtR | 著者 | Lee, C, Giedroc, D. | 登録日 | 2011-10-18 | 公開日 | 2012-04-18 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution Structure of Mycobacterium tuberculosis NmtR in the Apo State: Insights into Ni(II)-Mediated Allostery. Biochemistry, 51, 2012
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6NKI
| Structure of PhqB Reductase Domain from Penicillium fellutanum | 分子名称: | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, NRPS | 著者 | Dan, Q, Newmister, S.A, Smith, J.L, Sherman, D.H. | 登録日 | 2019-01-07 | 公開日 | 2019-10-09 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Fungal indole alkaloid biogenesis through evolution of a bifunctional reductase/Diels-Alderase. Nat.Chem., 11, 2019
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6NKM
| Structure of PhqE D166N Reductase/Diels-Alderase from Penicillium fellutanum in complex with NADP+ and substrate | 分子名称: | 3-{[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]methyl}-8H-pyrrolo[1,2-a]pyrazin-5-ium-1-olate, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Short chain dehydrogenase | 著者 | Newmister, S.A, Dan, Q, Smith, J.L, Sherman, D.H. | 登録日 | 2019-01-07 | 公開日 | 2019-10-09 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.896 Å) | 主引用文献 | Fungal indole alkaloid biogenesis through evolution of a bifunctional reductase/Diels-Alderase. Nat.Chem., 11, 2019
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7B3E
| Crystal structure of myricetin covalently bound to the main protease (3CLpro/Mpro) of SARS-CoV-2 | 分子名称: | 1,2-ETHANEDIOL, 3,5,7-TRIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE, CHLORIDE ION, ... | 著者 | Costanzi, E, Demitri, N, Giabbai, B, Storici, P. | 登録日 | 2020-11-30 | 公開日 | 2021-01-13 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | Identification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen. Acs Pharmacol Transl Sci, 4, 2021
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8PO2
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8PO0
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8PO3
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8PO1
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8PO4
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8PNZ
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2QJ0
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4ON3
| Crystal structure of human sorting nexin 10 (SNX10) | 分子名称: | NITRATE ION, PENTAETHYLENE GLYCOL, SODIUM ION, ... | 著者 | Xu, T, Xu, J, Wang, Q, Liu, J. | 登録日 | 2014-01-28 | 公開日 | 2014-09-24 | 最終更新日 | 2014-12-03 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure of human SNX10 reveals insights into its role in human autosomal recessive osteopetrosis. Proteins, 82, 2014
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2QIZ
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3L59
| Structure of BACE Bound to SCH710413 | 分子名称: | (2Z)-3-(3-chlorobenzyl)-2-imino-5,5-dimethylimidazolidin-4-one, Beta-secretase 1, D(-)-TARTARIC ACID | 著者 | Strickland, C, Zhu, Z. | 登録日 | 2009-12-21 | 公開日 | 2010-02-16 | 最終更新日 | 2018-01-24 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation J.Med.Chem., 53, 2010
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