3V12
| Bovine trypsin variant X(tripleGlu217Phe227) in complex with small molecule inhibitor | 分子名称: | CALCIUM ION, Cationic trypsin, GLYCEROL, ... | 著者 | Tziridis, A, Neumann, P, Kolenko, P, Stubbs, M.T. | 登録日 | 2011-12-09 | 公開日 | 2012-12-12 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues. Biol.Chem., 395, 2014
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3UNQ
| Bovine trypsin variant X(triplePhe227) in complex with small molecule inhibitor | 分子名称: | 1,2-ETHANEDIOL, BENZAMIDINE, CALCIUM ION, ... | 著者 | Tziridis, A, Neumann, P, Kolenko, P, Stubbs, M.T. | 登録日 | 2011-11-16 | 公開日 | 2012-11-21 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues. Biol.Chem., 395, 2014
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6RHF
| Structure of Chloroflexus aggregans Cagg_3753 LOV domain C85A variant (CagFbFP) | 分子名称: | FLAVIN MONONUCLEOTIDE, GLYCEROL, Multi-sensor hybrid histidine kinase | 著者 | Nazarenko, V.V, Remeeva, A, Yudenko, A, Kovalev, K, Gordeliy, V, Gushchin, I. | 登録日 | 2019-04-19 | 公開日 | 2019-05-15 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.07 Å) | 主引用文献 | A thermostable flavin-based fluorescent protein from Chloroflexus aggregans: a framework for ultra-high resolution structural studies. Photochem. Photobiol. Sci., 18, 2019
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3UUZ
| Bovine trypsin variant X(triplePhe227) in complex with small molecule inhibitor | 分子名称: | CALCIUM ION, Cationic trypsin, GLYCEROL, ... | 著者 | Tziridis, A, Neumann, P, Kolenko, P, Stubbs, M.T. | 登録日 | 2011-11-29 | 公開日 | 2012-12-05 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues. Biol.Chem., 395, 2014
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3UNS
| Bovine trypsin variant X(triplePhe227) in complex with small molecule inhibitor | 分子名称: | CALCIUM ION, Cationic trypsin, GLYCEROL, ... | 著者 | Tziridis, A, Neumann, P, Kolenko, P, Stubbs, M.T. | 登録日 | 2011-11-16 | 公開日 | 2012-11-21 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues. Biol.Chem., 395, 2014
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3UOP
| Bovine trypsin variant X(triplePhe227) in complex with small molecule inhibitor | 分子名称: | CALCIUM ION, CHLORIDE ION, Cationic trypsin, ... | 著者 | Tziridis, A, Neumann, P, Kolenko, P, Stubbs, M.T. | 登録日 | 2011-11-17 | 公開日 | 2012-11-21 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues. Biol.Chem., 395, 2014
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3V13
| Bovine trypsin variant X(tripleGlu217Phe227) in complex with small molecule inhibitor | 分子名称: | 3-(3-carbamimidoylphenyl)-N-(2'-sulfamoylbiphenyl-4-yl)-1,2-oxazole-4-carboxamide, CALCIUM ION, CHLORIDE ION, ... | 著者 | Tziridis, A, Neumann, P, Kolenko, P, Stubbs, M.T. | 登録日 | 2011-12-09 | 公開日 | 2012-12-12 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues. Biol.Chem., 395, 2014
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6RHG
| Structure of Chloroflexus aggregans Cagg_3753 LOV domain | 分子名称: | FLAVIN MONONUCLEOTIDE, GLYCEROL, Multi-sensor hybrid histidine kinase | 著者 | Nazarenko, V.V, Remeeva, A, Yudenko, A, Kovalev, K, Gordeliy, V, Gushchin, I. | 登録日 | 2019-04-19 | 公開日 | 2019-05-15 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.22 Å) | 主引用文献 | A thermostable flavin-based fluorescent protein from Chloroflexus aggregans: a framework for ultra-high resolution structural studies. Photochem. Photobiol. Sci., 18, 2019
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7R4S
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7R56
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7R5N
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5LDH
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7YX0
| Crystal structure of the full-length short LOV protein SBW25-LOV from Pseudomonas fluorescens (light state) | 分子名称: | ACETATE ION, FLAVIN MONONUCLEOTIDE, Flavin mononucleotide (semi-quinone intermediate), ... | 著者 | Arinkin, V, Batra-Safferling, R, Granzin, J. | 登録日 | 2022-02-15 | 公開日 | 2023-05-24 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Conserved Signal Transduction Mechanisms and Dark Recovery Kinetic Tuning in the Pseudomonadaceae Short Light, Oxygen, Voltage (LOV) Protein Family. J.Mol.Biol., 2024
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8A36
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8A37
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8A3U
| Crystal structure of a chimeric LOV-Histidine kinase SB2F1 (symmetrical variant, trigonal form with short c-axis) | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, FLAVIN MONONUCLEOTIDE, Putative Sensory box protein,Sensor protein FixL | 著者 | Arinkin, V, Batra-Safferling, R, Granzin, J. | 登録日 | 2022-06-09 | 公開日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | Crystal structure of a chimeric LOV-Histidine kinase SB2F1 (symmetrical variant, trigonal form
with short c-axis) To Be Published
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8A52
| Crystal structure of a chimeric LOV-Histidine kinase SB2F1 (asymmetrical variant, trigonal form with long c-axis) | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, FLAVIN MONONUCLEOTIDE, Putative Sensory box protein,Putative Sensory box protein,Sensor protein FixL | 著者 | Batra-Safferling, R, Arinkin, V, Granzin, J. | 登録日 | 2022-06-14 | 公開日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.461 Å) | 主引用文献 | Crystal structure of a chimeric LOV-Histidine kinase SB2F1 (asymmetrical variant, trigonal form with long c axis) To Be Published
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8A7H
| Crystal structure of a chimeric LOV-Histidine kinase SB2F1-I66R mutant (light state; asymmetrical variant, trigonal form with long c axis) | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Flavin mononucleotide (semi-quinone intermediate), Putative Sensory box protein,Sensor protein FixL | 著者 | Arinkin, V, Granzin, J, Batra-Safferling, R. | 登録日 | 2022-06-21 | 公開日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.145 Å) | 主引用文献 | Crystal structure of a chimeric LOV-Histidine kinase SB2F1-I66R mutant (light state; asymmetrical variant, trigonal form with long c axis) To Be Published
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7A6P
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5J3W
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5J4E
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2WU6
| Crystal Structure of the Human CLK3 in complex with DKI | 分子名称: | 1,2-ETHANEDIOL, 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE, CHLORIDE ION, ... | 著者 | Muniz, J.R.C, Fedorov, O, King, O, Filippakopoulos, P, Bullock, A.N, Philips, C, Heightman, T, Ugochukwu, E, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S. | 登録日 | 2009-09-30 | 公開日 | 2009-10-20 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Specific Clk Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing. Chem.Biol, 18, 2011
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2VAG
| Crystal structure of di-phosphorylated human CLK1 in complex with a novel substituted indole inhibitor | 分子名称: | DUAL SPECIFICITY PROTEIN KINASE CLK1, ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate | 著者 | Pike, A.C.W, Bullock, A.N, Fedorov, O, Pilka, E.S, Ugochukwu, E, von Delft, F, Edwards, A, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Huber, K, Bracher, F, Knapp, S. | 登録日 | 2007-08-31 | 公開日 | 2007-10-09 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Specific Clk Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing. Chem.Biol, 18, 2011
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2WU7
| Crystal Structure of the Human CLK3 in complex with V25 | 分子名称: | CHLORIDE ION, DUAL SPECIFICITY PROTEIN KINASE CLK3, SULFATE ION, ... | 著者 | Muniz, J.R.C, Fedorov, O, King, O, Filippakopoulos, P, Bullock, A.N, Phillips, C, Heightman, T, Ugochukwu, E, von Delft, F, Arrowsmith, C.H, Bracher, F, Huber, K, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S. | 登録日 | 2009-09-30 | 公開日 | 2009-10-20 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Specific Clk Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing. Chem.Biol, 18, 2011
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6GAY
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