8Y2C
 
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8Y2E
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8Y2G
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8WFJ
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8Y2F
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8Y2D
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8WMM
 | | Structure of CbCas9-PcrIIC1 complex bound to 28-bp DNA substrate (20-nt complementary) | | 分子名称: | MAGNESIUM ION, NTS, PcrIIC1, ... | | 著者 | Zhang, S, Lin, S, Liu, J.J.G. | | 登録日 | 2023-10-04 | | 公開日 | 2024-06-05 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | | 主引用文献 | Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity.
Nature, 630, 2024
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8WMN
 | | Structure of CbCas9-PcrIIC1 complex bound to 62-bp DNA substrate (symmetric 20-nt complementary) | | 分子名称: | DNA (62-MER), MAGNESIUM ION, PcrIIC1, ... | | 著者 | Zhang, S, Lin, S, Liu, J.J.G. | | 登録日 | 2023-10-04 | | 公開日 | 2024-06-05 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (2.82 Å) | | 主引用文献 | Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity.
Nature, 630, 2024
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8WR4
 | | Structure of CbCas9-PcrIIC1 complex bound to 62-bp DNA substrate (non-targeting complex) | | 分子名称: | CbCas9 effector-1, DNA (62-MER), MAGNESIUM ION, ... | | 著者 | Zhang, S, Lin, S, Liu, J.J.G. | | 登録日 | 2023-10-13 | | 公開日 | 2024-06-05 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | | 主引用文献 | Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity.
Nature, 630, 2024
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8WMH
 | | Structure of CbCas9 bound to 6-nucleotide complementary DNA substrate | | 分子名称: | NTS, TS, deadCbCas9, ... | | 著者 | Zhang, S, Lin, S, Liu, J.J.G. | | 登録日 | 2023-10-03 | | 公開日 | 2024-06-05 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity.
Nature, 630, 2024
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8WTW
 | | Cryo-EM structure of noradrenaline transporter in complex with a x-MrlA analogue | | 分子名称: | CHLORIDE ION, MrlA, SODIUM ION, ... | | 著者 | Zhao, Y, Hu, T, Yu, Z. | | 登録日 | 2023-10-19 | | 公開日 | 2024-08-07 | | 最終更新日 | 2024-10-02 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Transport and inhibition mechanisms of the human noradrenaline transporter.
Nature, 632, 2024
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8WTU
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8WTX
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8WTY
 | | Cryo-EM structure of noradrenaline transporter in complex with ziprasidone | | 分子名称: | 5-[2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl]-6-chloranyl-1,3-dihydroindol-2-one, Sodium-dependent noradrenaline transporter | | 著者 | Zhao, Y, Hu, T, Yu, Z. | | 登録日 | 2023-10-19 | | 公開日 | 2024-08-07 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Transport and inhibition mechanisms of the human noradrenaline transporter.
Nature, 632, 2024
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8WTV
 | | Cryo-EM structure of noradrenaline transporter in complex with noradrenaline | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Noradrenaline, ... | | 著者 | Zhao, Y, Hu, T, Yu, Z. | | 登録日 | 2023-10-19 | | 公開日 | 2024-08-07 | | 最終更新日 | 2024-09-04 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Transport and inhibition mechanisms of the human noradrenaline transporter.
Nature, 632, 2024
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9B3G
 | | Human Notch-1 EGFs 21-23 | | 分子名称: | BARIUM ION, Neurogenic locus notch homolog protein 1 | | 著者 | Johnson, S, Sheppard, D, Handford, P.A, Lea, S.M. | | 登録日 | 2024-03-19 | | 公開日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Structural and functional studies of the EGF20-27 region reveal new features of the human Notch receptor important for optimal activation
To Be Published
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9B3N
 | | Human Notch-1 EGFs 20-24 | | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, Neurogenic locus notch homolog protein 1, ... | | 著者 | Johnson, S, Suckling, R, Handford, P.A, Lea, S.M. | | 登録日 | 2024-03-19 | | 公開日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural and functional studies of the EGF20-27 region reveal new features of the human Notch receptor important for optimal activation
To Be Published
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7YJ3
 | | Cryo-EM structure of SARS-CoV-2 Omicron BA.2 RBD in complex with human ACE2 (local refinement) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike protein S1, ... | | 著者 | Zhao, Z.N, Xie, Y.F, Qi, J.X, Gao, G.F. | | 登録日 | 2022-07-19 | | 公開日 | 2023-07-19 | | 最終更新日 | 2023-08-02 | | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | | 主引用文献 | Structural basis for receptor binding and broader interspecies receptor recognition of currently circulating Omicron sub-variants.
Nat Commun, 14, 2023
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7YHW
 | | Cryo-EM structure of SARS-CoV-2 Omicron BA.2.12.1 RBD in complex with human ACE2 (local refinement) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhao, Z.N, Xie, Y.F, Qi, J.X, Gao, G.F. | | 登録日 | 2022-07-14 | | 公開日 | 2023-07-19 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | | 主引用文献 | Structural basis for receptor binding and broader interspecies receptor recognition of currently circulating Omicron sub-variants.
Nat Commun, 14, 2023
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7XEY
 | | EDS1-PAD4 complexed with pRib-ADP | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5-O-phosphono-beta-D-ribofuranose, ADENOSINE-5'-DIPHOSPHATE, ... | | 著者 | Huang, S, Jia, A, Xiao, Y. | | 登録日 | 2022-03-31 | | 公開日 | 2022-07-13 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | | 主引用文献 | Identification and receptor mechanism of TIR-catalyzed small molecules in plant immunity.
Science, 377, 2022
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7XDD
 | | Cryo-EM structure of EDS1 and PAD4 | | 分子名称: | Lipase-like PAD4, Protein EDS1 | | 著者 | Huang, S.J, Jia, A.L, Sun, Y, Han, Z.F, Chai, J.J. | | 登録日 | 2022-03-26 | | 公開日 | 2022-07-13 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | | 主引用文献 | Identification and receptor mechanism of TIR-catalyzed small molecules in plant immunity.
Science, 377, 2022
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7XOZ
 | | Crystal structure of RPPT-TIR | | 分子名称: | ADENOSINE-5-DIPHOSPHORIBOSE, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase | | 著者 | Song, W, Jia, A, Huang, S, Chai, J. | | 登録日 | 2022-05-02 | | 公開日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | | 主引用文献 | TIR-catalyzed ADP-ribosylation reactions produce signaling molecules for plant immunity.
Science, 377, 2022
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7XJP
 | | Cryo-EM structure of EDS1 and SAG101 with ATP-APDR | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, ADENOSINE-5-DIPHOSPHORIBOSE, ISOPROPYL ALCOHOL, ... | | 著者 | Huang, S.J, Jia, A.L, Han, Z.F, Chai, J.J. | | 登録日 | 2022-04-18 | | 公開日 | 2022-07-20 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (2.71 Å) | | 主引用文献 | TIR-catalyzed ADP-ribosylation reactions produce signaling molecules for plant immunity.
Science, 377, 2022
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3B2R
 | | Crystal Structure of PDE5A1 catalytic domain in complex with Vardenafil | | 分子名称: | 2-{2-ETHOXY-5-[(4-ETHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-5-METHYL-7-PROPYLIMIDAZO[5,1-F][1,2,4]TRIAZIN-4(1H)-ONE, cGMP-specific 3',5'-cyclic phosphodiesterase | | 著者 | Huanchen, W, Mengchun, Y, Howard, R, Sharron, H.F, Hengming, K. | | 登録日 | 2007-10-19 | | 公開日 | 2008-05-20 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | | 主引用文献 | Conformational variations of both phosphodiesterase-5 and inhibitors provide the structural basis for the physiological effects of vardenafil and sildenafil.
Mol.Pharmacol., 73, 2008
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