7K4X
 
 | Crystal structure of Kemp Eliminase HG3.7 in complex with the transition state analog 6-nitrobenzotriazole | 分子名称: | 6-NITROBENZOTRIAZOLE, ACETATE ION, Endo-1,4-beta-xylanase, ... | 著者 | Padua, R.A.P, Otten, R, Bunzel, A, Nguyen, V, Pitsawong, W, Patterson, M, Sui, S, Perry, S.L, Cohen, A.E, Hilvert, D, Kern, D. | 登録日 | 2020-09-16 | 公開日 | 2020-12-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | How directed evolution reshapes the energy landscape in an enzyme to boost catalysis. Science, 370, 2020
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7K4Z
 
 | Crystal structure of Kemp Eliminase HG3.17 in complex with the transition state analog 6-nitrobenzotriazole | 分子名称: | 6-NITROBENZOTRIAZOLE, Endo-1,4-beta-xylanase, PENTAETHYLENE GLYCOL | 著者 | Padua, R.A.P, Otten, R, Bunzel, A, Nguyen, V, Pitsawong, W, Patterson, M, Sui, S, Perry, S.L, Cohen, A.E, Hilvert, D, Kern, D. | 登録日 | 2020-09-16 | 公開日 | 2020-12-02 | 最終更新日 | 2024-11-13 | 実験手法 | X-RAY DIFFRACTION (1.08 Å) | 主引用文献 | How directed evolution reshapes the energy landscape in an enzyme to boost catalysis. Science, 370, 2020
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7K4Q
 
 | Crystal structure of Kemp Eliminase HG3 in complex with the transition state analog 6-nitrobenzotriazole | 分子名称: | 6-NITROBENZOTRIAZOLE, Endo-1,4-beta-xylanase, SULFATE ION | 著者 | Padua, R.A.P, Otten, R, Bunzel, A, Nguyen, V, Pitsawong, W, Patterson, M, Sui, S, Perry, S.L, Cohen, A.E, Hilvert, D, Kern, D. | 登録日 | 2020-09-16 | 公開日 | 2020-12-02 | 最終更新日 | 2024-11-20 | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | 主引用文献 | How directed evolution reshapes the energy landscape in an enzyme to boost catalysis. Science, 370, 2020
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7K4V
 
 | Crystal structure of Kemp Eliminase HG3.17 | 分子名称: | Endo-1,4-beta-xylanase, TETRAETHYLENE GLYCOL | 著者 | Padua, R.A.P, Otten, R, Bunzel, A, Nguyen, V, Pitsawong, W, Patterson, M, Sui, S, Perry, S.L, Cohen, A.E, Hilvert, D, Kern, D. | 登録日 | 2020-09-16 | 公開日 | 2020-12-02 | 最終更新日 | 2024-10-30 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | How directed evolution reshapes the energy landscape in an enzyme to boost catalysis. Science, 370, 2020
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7K4W
 
 | Crystal structure of Kemp Eliminase HG3.17 in the inactive state | 分子名称: | CALCIUM ION, Endo-1,4-beta-xylanase | 著者 | Padua, R.A.P, Otten, R, Bunzel, A, Nguyen, V, Pitsawong, W, Patterson, M, Sui, S, Perry, S.L, Cohen, A.E, Hilvert, D, Kern, D. | 登録日 | 2020-09-16 | 公開日 | 2020-12-02 | 最終更新日 | 2024-10-23 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | How directed evolution reshapes the energy landscape in an enzyme to boost catalysis. Science, 370, 2020
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5G15
 
 | Structure Aurora A (122-403) bound to activating monobody Mb1 and AMPPCP | 分子名称: | AURORA A KINASE, MAGNESIUM ION, MB1 MONOBODY, ... | 著者 | Zorba, A, Kutter, S, Kern, D, Koide, S, Koide, A. | 登録日 | 2016-03-23 | 公開日 | 2018-03-14 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | Allosteric modulation of a human protein kinase with monobodies. Proc.Natl.Acad.Sci.USA, 116, 2019
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5G3Y
 
 | Crystal structure of adenylate kinase ancestor 1 with Zn and ADP bound | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENYLATE KINSE, ZINC ION | 著者 | Nguyen, V, Kutter, S, English, J, Kern, D. | 登録日 | 2016-05-03 | 公開日 | 2016-12-28 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.18 Å) | 主引用文献 | Evolutionary drivers of thermoadaptation in enzyme catalysis. Science, 355, 2017
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5G41
 
 | Crystal structure of adenylate kinase ancestor 4 with Zn, Mg and Ap5A bound | 分子名称: | ADENYLATE KINSE, BIS(ADENOSINE)-5'-PENTAPHOSPHATE, MAGNESIUM ION, ... | 著者 | Nguyen, V, Kutter, S, English, J, Kern, D. | 登録日 | 2016-05-03 | 公開日 | 2016-12-28 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Evolutionary drivers of thermoadaptation in enzyme catalysis. Science, 355, 2017
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5G40
 
 | Crystal structure of adenylate kinase ancestor 4 with Zn and AMP-ADP bound | 分子名称: | ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ADENYLATE KINSE, ... | 著者 | Nguyen, V, Kutter, S, English, J, Kern, D. | 登録日 | 2016-05-03 | 公開日 | 2016-12-28 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Evolutionary drivers of thermoadaptation in enzyme catalysis. Science, 355, 2017
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7K4U
 
 | Crystal structure of Kemp Eliminase HG3 K50Q in complex with the transition state analog 6-nitrobenzotriazole | 分子名称: | 6-NITROBENZOTRIAZOLE, Endo-1,4-beta-xylanase | 著者 | Padua, R.A.P, Otten, R, Bunzel, A, Nguyen, V, Pitsawong, W, Patterson, M, Sui, S, Perry, S.L, Cohen, A.E, Hilvert, D, Kern, D. | 登録日 | 2020-09-16 | 公開日 | 2020-12-02 | 最終更新日 | 2024-11-06 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | How directed evolution reshapes the energy landscape in an enzyme to boost catalysis. Science, 370, 2020
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7K4R
 
 | Crystal structure of Kemp Eliminase HG3 K50Q | 分子名称: | Endo-1,4-beta-xylanase | 著者 | Padua, R.A.P, Otten, R, Bunzel, A, Nguyen, V, Pitsawong, W, Patterson, M, Sui, S, Perry, S.L, Cohen, A.E, Hilvert, D, Kern, D. | 登録日 | 2020-09-16 | 公開日 | 2020-12-02 | 最終更新日 | 2024-10-23 | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | 主引用文献 | How directed evolution reshapes the energy landscape in an enzyme to boost catalysis. Science, 370, 2020
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7K4T
 
 | Crystal structure of Kemp Eliminase HG3.17 | 分子名称: | Endo-1,4-beta-xylanase | 著者 | Padua, R.A.P, Otten, R, Bunzel, A, Nguyen, V, Pitsawong, W, Patterson, M, Sui, S, Perry, S.L, Cohen, A.E, Hilvert, D, Kern, D. | 登録日 | 2020-09-16 | 公開日 | 2020-12-02 | 最終更新日 | 2024-11-13 | 実験手法 | X-RAY DIFFRACTION (0.999 Å) | 主引用文献 | How directed evolution reshapes the energy landscape in an enzyme to boost catalysis. Science, 370, 2020
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7K4P
 
 | Crystal structure of Kemp Eliminase HG3 | 分子名称: | Endo-1,4-beta-xylanase | 著者 | Padua, R.A.P, Otten, R, Bunzel, A, Nguyen, V, Pitsawong, W, Patterson, M, Sui, S, Perry, S.L, Cohen, A.E, Hilvert, D, Kern, D. | 登録日 | 2020-09-16 | 公開日 | 2020-12-02 | 最終更新日 | 2024-11-06 | 実験手法 | X-RAY DIFFRACTION (1.08 Å) | 主引用文献 | How directed evolution reshapes the energy landscape in an enzyme to boost catalysis. Science, 370, 2020
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7K4S
 
 | Crystal structure of Kemp Eliminase HG3.7 | 分子名称: | Endo-1,4-beta-xylanase, SULFATE ION | 著者 | Padua, R.A.P, Otten, R, Bunzel, A, Nguyen, V, Pitsawong, W, Patterson, M, Sui, S, Perry, S.L, Cohen, A.E, Hilvert, D, Kern, D. | 登録日 | 2020-09-16 | 公開日 | 2020-12-02 | 最終更新日 | 2024-11-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | How directed evolution reshapes the energy landscape in an enzyme to boost catalysis. Science, 370, 2020
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6CMP
 
 | Closed structure of inactive SHP2 mutant C459E | 分子名称: | Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Padua, R.A.P, Sun, Y, Marko, I, Pitsawong, W, Kern, D. | 登録日 | 2018-03-06 | 公開日 | 2018-11-14 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2. Nat Commun, 9, 2018
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6CMQ
 
 | Structure of human SHP2 without N-SH2 domain | 分子名称: | Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Padua, R.A.P, Sun, Y, Marko, I, Pitsawong, W, Kern, D. | 登録日 | 2018-03-06 | 公開日 | 2018-11-14 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2. Nat Commun, 9, 2018
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6C83
 
 | Structure of Aurora A (122-403) bound to inhibitory Monobody Mb2 and AMPPCP | 分子名称: | Aurora kinase A, Mb2 Monobody, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | 著者 | Hoemberger, M, Kutter, S, Zorba, A, Nguyen, V, Shohei, A, Shohei, K, Kern, D. | 登録日 | 2018-01-24 | 公開日 | 2019-02-27 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Allosteric modulation of a human protein kinase with monobodies. Proc.Natl.Acad.Sci.USA, 116, 2019
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6CMR
 
 | Closed structure of active SHP2 mutant E76D bound to SHP099 inhibitor | 分子名称: | 6-(4-azanyl-4-methyl-piperidin-1-yl)-3-[2,3-bis(chloranyl)phenyl]pyrazin-2-amine, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Padua, R.A.P, Sun, Y, Marko, I, Pitsawong, W, Kern, D. | 登録日 | 2018-03-06 | 公開日 | 2018-11-14 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2. Nat Commun, 9, 2018
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6CMS
 
 | Closed structure of active SHP2 mutant E76K bound to SHP099 inhibitor | 分子名称: | 6-(4-azanyl-4-methyl-piperidin-1-yl)-3-[2,3-bis(chloranyl)phenyl]pyrazin-2-amine, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Padua, R.A.P, Sun, Y, Marko, I, Pitsawong, W, Kern, D. | 登録日 | 2018-03-06 | 公開日 | 2018-11-14 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | 主引用文献 | Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2. Nat Commun, 9, 2018
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8DB3
 
 | Crystal structure of KaiC with truncated C-terminal coiled-coil domain | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Circadian clock protein KaiC | 著者 | Padua, R.A.P, Grant, T, Pitsawong, W, Hoemberger, M.S, Otten, R, Bradshaw, N, Grigorieff, N, Kern, D. | 登録日 | 2022-06-14 | 公開日 | 2023-03-22 | 最終更新日 | 2024-11-06 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | From primordial clocks to circadian oscillators. Nature, 616, 2023
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8DBA
 
 | Crystal structure of dodecameric KaiC | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Circadian clock protein KaiC, MAGNESIUM ION | 著者 | Padua, R.A.P, Grant, T, Pitsawong, W, Hoemberger, M.S, Otten, R, Bradshaw, N, Grigorieff, N, Kern, D. | 登録日 | 2022-06-14 | 公開日 | 2023-03-22 | 最終更新日 | 2024-12-25 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | From primordial clocks to circadian oscillators. Nature, 616, 2023
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2MSL
 
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2MSK
 
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4JZK
 
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4IKE
 
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