6BHZ
 
 | | Trastuzumab Fab D185A (Light Chain) Mutant. | | 分子名称: | 1,2-ETHANEDIOL, Trastuzumab Anti-HER2 Fab Heavy Chain, Trastuzumab Anti-HER2 Fab Light Chain D185A | | 著者 | DiDonato, M, Spraggon, G. | | 登録日 | 2017-10-31 | | 公開日 | 2018-02-14 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Tuning a Protein-Labeling Reaction to Achieve Highly Site Selective Lysine Conjugation.
Chembiochem, 19, 2018
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6BI0
 | | Trastuzumab Fab N158A, D185A, K190A (Light Chain) Triple Mutant. | | 分子名称: | 1,2-ETHANEDIOL, Trastuzumab anti-HER2 Fab Heavy Chain, Trastuzumab anti-HER2 Fab Light Chain | | 著者 | DiDonato, M, Spraggon, G. | | 登録日 | 2017-10-31 | | 公開日 | 2018-02-14 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.057 Å) | | 主引用文献 | Tuning a Protein-Labeling Reaction to Achieve Highly Site Selective Lysine Conjugation.
Chembiochem, 19, 2018
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3JXO
 | | Crystal Structure of an Octomeric Two-Subunit TrkA K+ Channel Ring Gating Assembly, TM1088A:TM1088B, from Thermotoga maritima | | 分子名称: | TrkA-N domain protein | | 著者 | Deller, M.C, Johnson, H.A, Miller, M, Spraggon, G, Wilson, I.A, Lesley, S.A, Joint Center for Structural Genomics (JCSG) | | 登録日 | 2009-09-20 | | 公開日 | 2009-10-06 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Crystal Structure of an Octomeric Two-Subunit TrkA K+ Channel Ring Gating Assembly, TM1088A:TM1088B, from Thermotoga maritima
To be Published
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4CJD
 | | Crystal structure of Neisseria meningitidis trimeric autotransporter and vaccine antigen NadA | | 分子名称: | IODIDE ION, NADA | | 著者 | Malito, E, Biancucci, M, Spraggon, G, Bottomley, M.J. | | 登録日 | 2013-12-19 | | 公開日 | 2014-11-26 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.056 Å) | | 主引用文献 | Structure of the Meningococcal Vaccine Antigen Nada and Epitope Mapping of a Bactericidal Antibody.
Proc.Natl.Acad.Sci.USA, 111, 2014
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2VP8
 | | Structure of Mycobacterium tuberculosis Rv1207 | | 分子名称: | 1,2-ETHANEDIOL, DIHYDROPTEROATE SYNTHASE 2 | | 著者 | Gengenbacher, M, Xu, T, Niyomwattanakit, P, Spraggon, G, Dick, T. | | 登録日 | 2008-02-27 | | 公開日 | 2008-08-12 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | | 主引用文献 | Biochemical and Structural Characterization of the Putative Dihydropteroate Synthase Ortholog Rv1207 of Mycobacterium Tuberculosis.
Fems Microbiol.Lett., 287, 2008
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4B8Y
 | | Ferrichrome-bound FhuD2 | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, FE (III) ION, ... | | 著者 | Malito, E, Bottomley, M.J, Spraggon, G. | | 登録日 | 2012-08-31 | | 公開日 | 2012-11-21 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural and Functional Characterization of the Staphylococcus Aureus Virulence Factor and Vaccine Candidate Fhud2.
Biochem.J., 449, 2013
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4BIH
 | | Crystal structure of the conserved staphylococcal antigen 1A, Csa1A | | 分子名称: | CALCIUM ION, UNCHARACTERIZED LIPOPROTEIN SAOUHSC_00053 | | 著者 | Malito, E, Bottomley, M.J, Spraggon, G, Schluepen, C, Liberatori, S. | | 登録日 | 2013-04-10 | | 公開日 | 2013-08-07 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.459 Å) | | 主引用文献 | Mining the Bacterial Unknown Proteome: Identification and Characterization of a Novel Family of Highly Conserved Protective Antigens in Staphylococcus Aureus
Biochem.J., 455, 2013
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3L4B
 | | Crystal Structure of an Octomeric Two-Subunit TrkA K+ Channel Ring Gating Assembly, TM1088A:TM1088B, from Thermotoga maritima | | 分子名称: | ADENOSINE MONOPHOSPHATE, TrkA K+ Channel protein TM1088A, TrkA K+ Channel protein TM1088B, ... | | 著者 | Deller, M.C, Johnson, H.A, Miller, M, Spraggon, G, Wilson, I.A, Lesley, S.A, Joint Center for Structural Genomics (JCSG) | | 登録日 | 2009-12-18 | | 公開日 | 2010-02-16 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (3.45 Å) | | 主引用文献 | Crystal Structure of an Octomeric Two-Subunit TrkA K+ Channel Ring Gating Assembly, TM1088A:TM1088B, from Thermotoga maritima
To be Published
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3FCA
 | | Genetic Incorporation of a Metal-ion Chelating Amino Acid into proteins as biophysical probe | | 分子名称: | Cysteine synthase, ZINC ION | | 著者 | Wang, F, Lee, H, Spraggon, G, Schultz, P.G. | | 登録日 | 2008-11-21 | | 公開日 | 2009-02-17 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.149 Å) | | 主引用文献 | Genetic incorporation of a metal-ion chelating amino acid into proteins as a biophysical probe.
J.Am.Chem.Soc., 131, 2009
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2PIS
 | | Efforts toward Expansion of the Genetic Alphabet: Structure and Replication of Unnatural Base Pairs | | 分子名称: | DNA (5'-D(*CP*GP*(CBR)P*GP*AP*AP*(FFD)P*TP*TP*CP*GP*CP*G)-3'), MAGNESIUM ION | | 著者 | Matsuda, S, Fillo, J.D, Henry, A.A, Wilkins, S.J, Rai, P, Dwyer, T.J, Geierstanger, B.H, Wemmer, D.E, Schultz, P.G, Spraggon, G, Romesberg, F.E. | | 登録日 | 2007-04-13 | | 公開日 | 2007-10-30 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Efforts toward expansion of the genetic alphabet: structure and replication of unnatural base pairs.
J.Am.Chem.Soc., 129, 2007
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2QTW
 | | The Crystal Structure of PCSK9 at 1.9 Angstroms Resolution Reveals structural homology to Resistin within the C-terminal domain | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Proprotein convertase subtilisin/kexin type 9, ... | | 著者 | Hampton, E.N, Knuth, M.W, Li, J, Harris, J.L, Lesley, S.A, Spraggon, G. | | 登録日 | 2007-08-02 | | 公開日 | 2007-09-18 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The self-inhibited structure of full-length PCSK9 at 1.9 A reveals structural homology with resistin within the C-terminal domain.
Proc.Natl.Acad.Sci.Usa, 104, 2007
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2QB5
 | | Crystal Structure of Human Inositol 1,3,4-Trisphosphate 5/6-Kinase (ITPK1) in Complex with ADP and Mn2+ | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Inositol-tetrakisphosphate 1-kinase, MANGANESE (II) ION, ... | | 著者 | Chamberlain, P.P, Lesley, S.A, Spraggon, G. | | 登録日 | 2007-06-15 | | 公開日 | 2007-07-03 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Integration of inositol phosphate signaling pathways via human ITPK1.
J.Biol.Chem., 282, 2007
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2Q7D
 | | Crystal Structure of Human Inositol 1,3,4-Trisphosphate 5/6-kinase (ITPK1) in complex with AMPPNP and Mn2+ | | 分子名称: | Inositol-tetrakisphosphate 1-kinase, MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | 著者 | Chamberlain, P.P, Lesley, S.A, Spraggon, G. | | 登録日 | 2007-06-06 | | 公開日 | 2007-07-03 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Integration of inositol phosphate signaling pathways via human ITPK1.
J.Biol.Chem., 282, 2007
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2V9K
 | | Crystal structure of human PUS10, a novel pseudouridine synthase. | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, GLYCEROL, ... | | 著者 | McCleverty, C.J, Hornsby, M, Spraggon, G, Kreusch, A. | | 登録日 | 2007-08-23 | | 公開日 | 2007-10-09 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal Structure of Human Pus10, a Novel Pseudouridine Synthase.
J.Mol.Biol., 373, 2007
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4AE1
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4AE0
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1J7J
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1S96
 | | The 2.0 A X-ray structure of Guanylate Kinase from E.coli | | 分子名称: | Guanylate kinase, PHOSPHATE ION, UNKNOWN ATOM OR ION | | 著者 | Kreusch, A, Spraggon, G, Klock, H.E, McMullan, D, Vincent, J, Rodrigues, K, Lesley, S.A. | | 登録日 | 2004-02-03 | | 公開日 | 2004-02-10 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The Structure of Guanylate Kinase from Escherichia coli at 2.0 A resolution
To be Published
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1JES
 | | Crystal Structure of a Copper-Mediated Base Pair in DNA | | 分子名称: | 5'-D(*CP*GP*CP*GP*(DPY)P*AP*TP*(DRP)P*CP*GP*CP*G)-3', COPPER (II) ION | | 著者 | Atwell, S, Meggers, E, Spraggon, G, Schultz, P.G. | | 登録日 | 2001-06-18 | | 公開日 | 2001-11-23 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structure of a Copper-Mediated Base Pair in DNA
J.Am.Chem.Soc., 123, 2001
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2AG6
 | | Crystal structure of p-bromo-l-phenylalanine-tRNA sythetase in complex with p-bromo-l-phenylalanine | | 分子名称: | 4-BROMO-L-PHENYLALANINE, Tyrosyl-tRNA synthetase | | 著者 | Turner, J.M, Graziano, J, Spraggon, G, Schultz, P.G. | | 登録日 | 2005-07-26 | | 公開日 | 2006-04-04 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural plasticity of an aminoacyl-tRNA synthetase active site
Proc.Natl.Acad.Sci.Usa, 103, 2006
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2AQX
 | | Crystal Structure of the Catalytic and CaM-Binding domains of Inositol 1,4,5-Trisphosphate 3-Kinase B | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PREDICTED: inositol 1,4,5-trisphosphate 3-kinase B | | 著者 | Chamberlain, P.P, Sandberg, M.L, Sauer, K, Cooke, M.P, Lesley, S.A, Spraggon, G. | | 登録日 | 2005-08-18 | | 公開日 | 2005-12-06 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural insights into enzyme regulation for inositol 1,4,5-trisphosphate 3-kinase B
Biochemistry, 44, 2005
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1ZLT
 | | Crystal Structure of Chk1 Complexed with a Hymenaldisine Analog | | 分子名称: | (4Z)-4-(2-AMINO-5-OXO-3,5-DIHYDRO-4H-IMIDAZOL-4-YLIDENE)-2,3-DICHLORO-4,5,6,7-TETRAHYDROPYRROLO[2,3-C]AZEPIN-8(1H)-ONE, SULFATE ION, Serine/threonine-protein kinase Chk1 | | 著者 | Lee, C.C, Ng, K, Wan, Y, Gray, N, Spraggon, G. | | 登録日 | 2005-05-09 | | 公開日 | 2006-06-27 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | | 主引用文献 | Crystal Structure of Chk1 Complexed with a Hymenaldisine Analog
To be Published
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1ZH6
 | | Crystal Structure of p-acetylphenylalanine-tRNA synthetase in complex with p-acetylphenylalanine | | 分子名称: | 4-ACETYL-L-PHENYLALANINE, BETA-MERCAPTOETHANOL, Tyrosyl-tRNA synthetase | | 著者 | Turner, J.M, Graziano, J, Spraggon, G, Schultz, P.G. | | 登録日 | 2005-04-22 | | 公開日 | 2006-04-04 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural characterization of a p-acetylphenylalanyl aminoacyl-tRNA synthetase.
J.Am.Chem.Soc., 127, 2005
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1ZH0
 | | Crystal Structure of L-3-(2-napthyl)alanine-tRNA synthetase in complex with L-3-(2-napthyl)alanine | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BETA-(2-NAPHTHYL)-ALANINE, Tyrosyl-tRNA synthetase | | 著者 | Turner, J.M, Graziano, J, Spraggon, G, Schultz, P.G. | | 登録日 | 2005-04-22 | | 公開日 | 2006-04-04 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural plasticity of an aminoacyl-tRNA synthetase active site
Proc.Natl.Acad.Sci.Usa, 103, 2006
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1FZF
 | | CRYSTAL STRUCTURE OF FRAGMENT DOUBLE-D FROM HUMAN FIBRIN WITH THE PEPTIDE LIGAND GLY-HIS-ARG-PRO-AMIDE | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, FIBRINOGEN | | 著者 | Everse, S.J, Spraggon, G, Veerapandian, L, Doolittle, R.F. | | 登録日 | 1998-12-28 | | 公開日 | 1999-06-08 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Conformational changes in fragments D and double-D from human fibrin(ogen) upon binding the peptide ligand Gly-His-Arg-Pro-amide.
Biochemistry, 38, 1999
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