7M0W
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![BU of 7m0w by Molmil](/molmil-images/mine/7m0w) | Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and Pimasertib | 分子名称: | Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, N-[(2S)-2,3-dihydroxypropyl]-3-[(2-fluoro-4-iodophenyl)amino]pyridine-4-carboxamide, ... | 著者 | Li, K, Gonzalez Del-Pino, G, Ha, B.H, Park, E, Eck, M.J. | 登録日 | 2021-03-11 | 公開日 | 2021-04-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.09 Å) | 主引用文献 | Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation. Proc.Natl.Acad.Sci.USA, 118, 2021
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7M0U
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![BU of 7m0u by Molmil](/molmil-images/mine/7m0u) | Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and Binimetinib | 分子名称: | 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... | 著者 | Li, K, Gonzalez Del-Pino, G, Ha, B.H, Park, E, Eck, M.J. | 登録日 | 2021-03-11 | 公開日 | 2021-04-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.09 Å) | 主引用文献 | Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation. Proc.Natl.Acad.Sci.USA, 118, 2021
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7M0Y
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![BU of 7m0y by Molmil](/molmil-images/mine/7m0y) | Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and Trametinib | 分子名称: | Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Li, K, Gonzalez Del-Pino, G, Ha, B.H, Park, E, Eck, M.J. | 登録日 | 2021-03-11 | 公開日 | 2021-04-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.45 Å) | 主引用文献 | Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation. Proc.Natl.Acad.Sci.USA, 118, 2021
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7M0T
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![BU of 7m0t by Molmil](/molmil-images/mine/7m0t) | Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and Selumetinib | 分子名称: | 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... | 著者 | Li, K, Gonzalez Del-Pino, G, Ha, B.H, Park, E, Eck, M.J. | 登録日 | 2021-03-11 | 公開日 | 2021-04-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.19 Å) | 主引用文献 | Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation. Proc.Natl.Acad.Sci.USA, 118, 2021
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7N70
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![BU of 7n70 by Molmil](/molmil-images/mine/7n70) | |
7N77
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![BU of 7n77 by Molmil](/molmil-images/mine/7n77) | |
7N72
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![BU of 7n72 by Molmil](/molmil-images/mine/7n72) | |
7N78
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![BU of 7n78 by Molmil](/molmil-images/mine/7n78) | Cryo-EM structure of ATP13A2 in the E2-Pi state | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL HEMISUCCINATE, DODECYL-BETA-D-MALTOSIDE, ... | 著者 | Sim, S.I, Park, E. | 登録日 | 2021-06-09 | 公開日 | 2021-11-10 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis of polyamine transport by human ATP13A2 (PARK9). Mol.Cell, 81, 2021
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7N74
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![BU of 7n74 by Molmil](/molmil-images/mine/7n74) | |
7N76
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![BU of 7n76 by Molmil](/molmil-images/mine/7n76) | |
7N75
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![BU of 7n75 by Molmil](/molmil-images/mine/7n75) | |
7N73
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![BU of 7n73 by Molmil](/molmil-images/mine/7n73) | |
7MYX
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![BU of 7myx by Molmil](/molmil-images/mine/7myx) | |
5D41
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![BU of 5d41 by Molmil](/molmil-images/mine/5d41) | EGFR kinase domain in complex with mutant selective allosteric inhibitor | 分子名称: | (2R)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-2-phenyl-N-(1,3-thiazol-2-yl)acetamide, Epidermal growth factor receptor, MAGNESIUM ION, ... | 著者 | Yun, C.-H, Park, E, Eck, M.J. | 登録日 | 2015-08-07 | 公開日 | 2016-06-08 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors. Nature, 534, 2016
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5EUL
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![BU of 5eul by Molmil](/molmil-images/mine/5eul) | Structure of the SecA-SecY complex with a translocating polypeptide substrate | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, AYC08, BERYLLIUM TRIFLUORIDE ION, ... | 著者 | Li, L, Park, E, Ling, J, Ingram, J, Ploegh, H, Rapoport, T.A. | 登録日 | 2015-11-18 | 公開日 | 2016-03-09 | 最終更新日 | 2019-12-25 | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | 主引用文献 | Crystal structure of a substrate-engaged SecY protein-translocation channel. Nature, 531, 2016
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7KAO
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![BU of 7kao by Molmil](/molmil-images/mine/7kao) | Cryo-EM structure of the Sec complex from S. cerevisiae, Sec61 pore mutant, class without Sec62 | 分子名称: | Protein translocation protein SEC63, Protein transport protein SBH1, Protein transport protein SEC61, ... | 著者 | Itskanov, S, Park, E. | 登録日 | 2020-10-01 | 公開日 | 2021-02-03 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62. Nat.Struct.Mol.Biol., 28, 2021
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7KAM
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![BU of 7kam by Molmil](/molmil-images/mine/7kam) | Cryo-EM structure of the Sec complex from T. lanuginosus, wild-type, class with Sec62, plug-closed conformation | 分子名称: | Protein transport channel Sec61 complex, alpha subunit (Sec61), beta subunit (Sbh1), ... | 著者 | Itskanov, S, Park, E. | 登録日 | 2020-10-01 | 公開日 | 2021-01-06 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62. Nat.Struct.Mol.Biol., 28, 2021
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7KAS
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![BU of 7kas by Molmil](/molmil-images/mine/7kas) | Cryo-EM structure of the Sec complex from S. cerevisiae, Sec63 FN3 mutant, class with Sec62 | 分子名称: | Protein translocation protein SEC63, Protein transport protein SBH1, Protein transport protein SEC61, ... | 著者 | Itskanov, S, Park, E. | 登録日 | 2020-10-01 | 公開日 | 2021-01-06 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62. Nat.Struct.Mol.Biol., 28, 2021
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7KAL
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![BU of 7kal by Molmil](/molmil-images/mine/7kal) | Cryo-EM structure of the Sec complex from T. lanuginosus, wild-type, class with Sec62, plug-open conformation | 分子名称: | Protein transport channel Sec61 complex, alpha subunit (Sec61), beta subunit (Sbh1), ... | 著者 | Itskanov, S, Park, E. | 登録日 | 2020-10-01 | 公開日 | 2021-01-06 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62. Nat.Struct.Mol.Biol., 28, 2021
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7KAH
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![BU of 7kah by Molmil](/molmil-images/mine/7kah) | Cryo-EM structure of the Sec complex from S. cerevisiae, wild-type, class without Sec62 | 分子名称: | Protein translocation protein SEC63, Protein transport protein SBH1, Protein transport protein SEC61, ... | 著者 | Itskanov, S, Park, E. | 登録日 | 2020-10-01 | 公開日 | 2021-02-03 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62. Nat.Struct.Mol.Biol., 28, 2021
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7KAT
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![BU of 7kat by Molmil](/molmil-images/mine/7kat) | Cryo-EM structure of the Sec complex from S. cerevisiae, Sec61 pore ring and Sec63 FN3 double mutant, class without Sec62 | 分子名称: | Protein translocation protein SEC63, Protein transport protein SBH1, Protein transport protein SEC61, ... | 著者 | Itskanov, S, Park, E. | 登録日 | 2020-10-01 | 公開日 | 2021-01-06 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62. Nat.Struct.Mol.Biol., 28, 2021
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7KAK
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![BU of 7kak by Molmil](/molmil-images/mine/7kak) | Cryo-EM structure of the Sec complex from T. lanuginosus, wild-type, class without Sec62 | 分子名称: | Protein transport channel Sec61 complex, alpha subunit (Sec61), beta subunit (Sbh1), ... | 著者 | Itskanov, S, Park, E. | 登録日 | 2020-10-01 | 公開日 | 2021-02-03 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62. Nat.Struct.Mol.Biol., 28, 2021
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7KAN
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![BU of 7kan by Molmil](/molmil-images/mine/7kan) | Cryo-EM structure of the Sec complex from T. lanuginosus, Sec62-lacking mutant (Delta Sec62) | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Protein transport channel Sec61 complex, alpha subunit (Sec61), ... | 著者 | Itskanov, S, Park, E. | 登録日 | 2020-10-01 | 公開日 | 2021-02-03 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62. Nat.Struct.Mol.Biol., 28, 2021
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7KAQ
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![BU of 7kaq by Molmil](/molmil-images/mine/7kaq) | Cryo-EM structure of the Sec complex from S. cerevisiae, Sec61 pore mutant, class with Sec62, conformation 2 (C2) | 分子名称: | Protein translocation protein SEC63, Protein transport protein SBH1, Protein transport protein SEC61, ... | 著者 | Itskanov, S, Park, E. | 登録日 | 2020-10-01 | 公開日 | 2021-01-06 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62. Nat.Struct.Mol.Biol., 28, 2021
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7KAJ
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![BU of 7kaj by Molmil](/molmil-images/mine/7kaj) | Cryo-EM structure of the Sec complex from S. cerevisiae, wild-type, class with Sec62, conformation 2 (C2) | 分子名称: | Protein translocation protein SEC63, Protein transport protein SBH1, Protein transport protein SEC61, ... | 著者 | Itskanov, S, Park, E. | 登録日 | 2020-10-01 | 公開日 | 2021-01-06 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62. Nat.Struct.Mol.Biol., 28, 2021
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