5O1B
| p53 cancer mutant Y220C in complex with compound MB84 | 分子名称: | 6-(hydroxymethyl)-2,4-bis(iodanyl)-3-pyrrol-1-yl-phenol, Cellular tumor antigen p53, GLYCEROL, ... | 著者 | Joerger, A.C, Bauer, M.R, Baud, M.G.J, Fersht, A.R. | 登録日 | 2017-05-18 | 公開日 | 2018-05-09 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | 主引用文献 | Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines. Eur J Med Chem, 152, 2018
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5O1G
| p53 cancer mutant Y220C in complex with compound MB487 | 分子名称: | 3-iodanyl-2-oxidanyl-5-(2-phenylethoxy)-4-pyrrol-1-yl-benzoic acid, Cellular tumor antigen p53, GLYCEROL, ... | 著者 | Joerger, A.C, Baud, M.G.J, Bauer, M.R, Fersht, A.R. | 登録日 | 2017-05-18 | 公開日 | 2018-05-09 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines. Eur J Med Chem, 152, 2018
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2WGX
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2X0W
| STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO 5,6-dimethoxy- 2-methylbenzothiazole | 分子名称: | 5,6-DIMETHOXY-2-METHYL-1,3-BENZOTHIAZOLE, CELLULAR TUMOR ANTIGEN P53, ZINC ION | 著者 | Kaar, J.L, Basse, N, Joerger, A.C, Fersht, A.R. | 登録日 | 2009-12-17 | 公開日 | 2010-01-26 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Toward the Rational Design of P53-Stabilizing Drugs: Probing the Surface of the Oncogenic Y220C Mutant. Chem.Biol., 17, 2010
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2VUK
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2X0U
| STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO A 2-amino substituted benzothiazole scaffold | 分子名称: | 6,7-DIHYDRO[1,4]DIOXINO[2,3-F][1,3]BENZOTHIAZOL-2-AMINE, CELLULAR TUMOR ANTIGEN P53, ZINC ION | 著者 | Joerger, A.C, Kaar, J.L, Basse, N, Fersht, A.R. | 登録日 | 2009-12-17 | 公開日 | 2010-01-26 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Toward the Rational Design of P53-Stabilizing Drugs: Probing the Surface of the Oncogenic Y220C Mutant. Chem.Biol., 17, 2010
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2X0V
| STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO 4-(trifluoromethyl)benzene-1,2-diamine | 分子名称: | 4-(TRIFLUOROMETHYL)BENZENE-1,2-DIAMINE, CELLULAR TUMOR ANTIGEN P53, ZINC ION | 著者 | Basse, N, Kaar, J.L, Joerger, A.C, Fersht, A.R. | 登録日 | 2009-12-17 | 公開日 | 2010-01-26 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Toward the Rational Design of P53-Stabilizing Drugs: Probing the Surface of the Oncogenic Y220C Mutant. Chem.Biol., 17, 2010
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1SS1
| STAPHYLOCOCCAL PROTEIN A, B-DOMAIN, Y15W MUTANT, NMR, 25 STRUCTURES | 分子名称: | Immunoglobulin G binding protein A | 著者 | Sato, S, Religa, T.L, Daggett, V, Fersht, A.R. | 登録日 | 2004-03-23 | 公開日 | 2004-04-06 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | From The Cover: Testing protein-folding simulations by experiment: B domain of protein A. Proc.Natl.Acad.Sci.USA, 101, 2004
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1W4H
| Peripheral-subunit from mesophilic, thermophilic and hyperthermophilic bacteria fold by ultrafast, apparently two-state transitions | 分子名称: | DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE | 著者 | Ferguson, N, Sharpe, T.D, Schartau, P.J, Allen, M.D, Johnson, C.M, Fersht, A.R. | 登録日 | 2004-07-23 | 公開日 | 2005-07-20 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Ultra-Fast Barrier-Limited Folding in the Peripheral Subunit-Binding Domain Family. J.Mol.Biol., 353, 2005
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2KZG
| A Transient and Low Populated Protein Folding Intermediate at Atomic Resolution | 分子名称: | Pre-mRNA-processing factor 40 homolog A | 著者 | Korzhnev, D.M, Religa, T.L, Banachewicz, W, Fersht, A.R, Kay, L.E. | 登録日 | 2010-06-17 | 公開日 | 2010-09-29 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | A transient and low-populated protein-folding intermediate at atomic resolution. Science, 329, 2010
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1W4G
| Peripheral-subunit binding domains from mesophilic, thermophilic, and hyperthermophilic bacteria fold by ultrafast, apparently two-state folding transitions | 分子名称: | DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE | 著者 | Ferguson, N, Sharpe, T.D, Schartau, P.J, Allen, M.D, Johnson, C.M, Sato, S, Fersht, A.R. | 登録日 | 2004-07-23 | 公開日 | 2005-07-20 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Ultra-Fast Barrier-Limited Folding in the Peripheral Subunit-Binding Domain Family. J.Mol.Biol., 353, 2005
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1W4J
| Peripheral-subunit binding domains from mesophilic, thermophilic, and hyperthermophilic bacteria fold by ultrafast, apparently two-state transitions | 分子名称: | PYRUVATE DEHYDROGENASE E2 | 著者 | Ferguson, N, Sharpe, T.D, Schartau, P.J, Allen, M.D, Johnson, C.M, Sato, S, Fersht, A.R. | 登録日 | 2004-07-23 | 公開日 | 2005-07-20 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Ultra-fast barrier-limited folding in the peripheral subunit-binding domain family. J. Mol. Biol., 353, 2005
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1JON
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1HL2
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1KCQ
| Human Gelsolin Domain 2 with a Cd2+ bound | 分子名称: | CADMIUM ION, GELSOLIN | 著者 | Kazmirski, S.L, Isaacson, R.L, An, C, Buckle, A, Johnson, C.M, Daggett, V, Fersht, A.R. | 登録日 | 2001-11-09 | 公開日 | 2002-01-04 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Loss of a metal-binding site in gelsolin leads to familial amyloidosis-Finnish type. Nat.Struct.Biol., 9, 2002
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1KID
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1B3S
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1B2S
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1B27
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1B2U
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1CIQ
| COMPLEX OF TWO FRAGMENTS OF CI2, RESIDUES 1-40 AND 41-64 | 分子名称: | CHYMOTRYPSIN INHIBITOR 2 | 著者 | Buckle, A.M, Fersht, A.R. | 登録日 | 1995-10-02 | 公開日 | 1996-03-08 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Towards the complete structural characterization of a protein folding pathway: the structures of the denatured, transition and native states for the association/folding of two complementary fragments of cleaved chymotrypsin inhibitor 2. Direct evidence for a nucleation-condensation mechanism Structure Fold.Des., 1, 1996
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1CIR
| COMPLEX OF TWO FRAGMENTS OF CI2 [(1-40)(DOT)(41-64)] | 分子名称: | CHYMOTRYPSIN INHIBITOR 2 | 著者 | Davis, B.J, Fersht, A.R. | 登録日 | 1995-10-02 | 公開日 | 1996-01-29 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Towards the complete structural characterization of a protein folding pathway: the structures of the denatured, transition and native states for the association/folding of two complementary fragments of cleaved chymotrypsin inhibitor 2. Direct evidence for a nucleation-condensation mechanism Structure Fold.Des., 1, 1996
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1BRS
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2VYR
| Structure of human MDM4 N-terminal domain bound to a single domain antibody | 分子名称: | HUMAN SINGLE DOMAIN ANTIBODY, MDM4 PROTEIN, SULFATE ION | 著者 | Yu, G.W, Vaysburd, M, Allen, M.D, Settanni, G, Fersht, A.R. | 登録日 | 2008-07-28 | 公開日 | 2008-11-25 | 最終更新日 | 2013-03-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of Human Mdm4 N-Terminal Domain Bound to a Single-Domain Antibody. J.Mol.Biol., 385, 2009
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2VY4
| U11-48K CHHC ZN-FINGER DOMAIN | 分子名称: | U11/U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 48 KDA PROTEIN, ZINC ION | 著者 | Tidow, H, Andreeva, A, Rutherford, T.J, Fersht, A.R. | 登録日 | 2008-07-17 | 公開日 | 2009-02-17 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the U11-48K CHHC zinc-finger domain that specifically binds the 5' splice site of U12-type introns. Structure, 17, 2009
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