3ZUX
| Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBT. | 分子名称: | LAURYL DIMETHYLAMINE-N-OXIDE, MERCURY (II) ION, PHOSPHATIDYLETHANOLAMINE, ... | 著者 | Hu, N.-J, Iwata, S, Cameron, A.D, Drew, D. | 登録日 | 2011-07-21 | 公開日 | 2011-10-12 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal Structure of a Bacterial Homologue of the Bile Acid Sodium Symporter Asbt. Nature, 478, 2011
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3ZUY
| Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBT. | 分子名称: | LAURYL DIMETHYLAMINE-N-OXIDE, PHOSPHATIDYLETHANOLAMINE, SODIUM ION, ... | 著者 | Hu, N.-J, Iwata, S, Cameron, A.D, Drew, D. | 登録日 | 2011-07-21 | 公開日 | 2011-10-12 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal Structure of a Bacterial Homologue of the Bile Acid Sodium Symporter Asbt. Nature, 478, 2011
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2WIH
| STRUCTURE OF CDK2-CYCLIN A WITH PHA-848125 | 分子名称: | CELL DIVISION PROTEIN KINASE 2, CYCLIN-A2, N,1,4,4-TETRAMETHYL-8-{[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]AMINO}-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE, ... | 著者 | Brasca, M.G, Amboldi, N, Ballinari, D, Cameron, A.D, Casale, E, Cervi, G, Colombo, M, Colotta, F, Croci, V, Dalessio, R, Fiorentini, F, Isacchi, A, Mercurio, C, Moretti, W, Panzeri, A, Pastori, W, Pevarello, P, Quartieri, F, Roletto, F, Traquandi, G, Vianello, P, Vulpetti, A, Ciomei, M. | 登録日 | 2009-05-13 | 公開日 | 2009-07-28 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Identification of N,1,4,4-Tetramethyl-8-{[4-(4-Methylpiperazin-1-Yl)Phenyl]Amino}-4,5-Dihydro-1H-Pyrazolo[4,3-H]Quinazoline-3-Carboxamide (Pha-848125), a Potent, Orally Available Cyclin Dependent Kinase Inhibitor. J.Med.Chem., 52, 2009
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4APS
| Crystal structure of a POT family peptide transporter in an inward open conformation. | 分子名称: | CADMIUM ION, DI-OR TRIPEPTIDE H+ SYMPORTER | 著者 | Solcan, N, Kwok, J, Fowler, P.W, Cameron, A.D, Drew, D, Iwata, S, Newstead, S. | 登録日 | 2012-04-05 | 公開日 | 2012-06-13 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Alternating Access Mechanism in the Pot Family of Oligopeptide Transporters. Embo J., 31, 2012
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2XVA
| Crystal structure of the tellurite detoxification protein TehB from E. coli in complex with sinefungin | 分子名称: | SINEFUNGIN, TELLURITE RESISTANCE PROTEIN TEHB, ZINC ION | 著者 | Choudhury, H.G, Cameron, A.D, Iwata, S, Beis, K. | 登録日 | 2010-10-25 | 公開日 | 2011-02-16 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure and Mechanism of the Chalcogen Detoxifying Protein Tehb from Escherichia Coli. Biochem.J., 435, 2011
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2XRU
| AURORA-A T288E COMPLEXED WITH PHA-828300 | 分子名称: | 3-({[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]CARBONYL}AMINO)-N-[(1R)-1-PHENYLPROPYL]-1H-THIENO[3,2-C]PYRAZOLE-5-CARBOXAMIDE, SERINE/THREONINE-PROTEIN KINASE 6 | 著者 | Bindi, S, Fancelli, D, Alli, C, Berta, D, Bertrand, J.A, Cameron, A.D, Cappella, P, Carpinelli, P, Cervi, G, Croci, W, D'Anello, M, Forte, B, LauraGiorgini, M, Marsiglio, A, Moll, J, Pesenti, E, Pittala, V, Pulici, M, Riccardi-Sirtori, F, Roletto, F, Soncini, C, Storici, P, Varasi, M, Volpi, D, Zugnoni, P, Vianello, P. | 登録日 | 2010-09-22 | 公開日 | 2010-09-29 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Thieno[3,2-C]Pyrazoles: A Novel Class of Aurora Inhibitors with Favorable Antitumor Activity. Bioorg.Med.Chem., 18, 2010
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2XVM
| Crystal structure of the tellurite detoxification protein TehB from E. coli in complex with SAH | 分子名称: | S-ADENOSYL-L-HOMOCYSTEINE, TELLURITE RESISTANCE PROTEIN TEHB | 著者 | Choudhury, H.G, Cameron, A.D, Iwata, S, Beis, K. | 登録日 | 2010-10-26 | 公開日 | 2011-02-16 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | Structure and Mechanism of the Chalcogen Detoxifying Protein Tehb from Escherichia Coli. Biochem.J., 435, 2011
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4AU5
| Structure of the NhaA dimer, crystallised at low pH | 分子名称: | DODECYL-ALPHA-D-MALTOSIDE, NA(+)/H(+) ANTIPORTER NHAA, SULFATE ION | 著者 | Drew, D, Lee, C, Iwata, S, Cameron, A.D. | 登録日 | 2012-05-14 | 公開日 | 2013-07-10 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.696 Å) | 主引用文献 | Crystal structure of the sodium-proton antiporter NhaA dimer and new mechanistic insights. J. Gen. Physiol., 144, 2014
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7QEQ
| human Connexin 26 dodecamer at 90mmHg PCO2, pH7.4 | 分子名称: | DODECYL-BETA-D-MALTOSIDE, Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE | 著者 | Brotherton, D.H, Cameron, A.D, Savva, C.G, Ragan, T.J. | 登録日 | 2021-12-03 | 公開日 | 2022-03-30 | 最終更新日 | 2022-05-18 | 実験手法 | ELECTRON MICROSCOPY (1.9 Å) | 主引用文献 | Conformational changes and CO 2 -induced channel gating in connexin26. Structure, 30, 2022
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7QER
| human Connexin 26 dodecamer at 55mm Hg PCO2, pH7.4 | 分子名称: | DODECYL-BETA-D-MALTOSIDE, Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE | 著者 | Brotherton, D.H, Cameron, A.D, Savva, C.G, Ragan, T.J. | 登録日 | 2021-12-03 | 公開日 | 2022-03-30 | 最終更新日 | 2022-05-18 | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | 主引用文献 | Conformational changes and CO 2 -induced channel gating in connexin26. Structure, 30, 2022
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7QET
| human Connexin 26 dodecamer at 20mmHg PCO2, pH7.4 | 分子名称: | DODECYL-BETA-D-MALTOSIDE, Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE | 著者 | Brotherton, D.H, Cameron, A.D, Savva, C.G, Ragan, T.J. | 登録日 | 2021-12-03 | 公開日 | 2022-03-30 | 最終更新日 | 2022-05-18 | 実験手法 | ELECTRON MICROSCOPY (2.1 Å) | 主引用文献 | Conformational changes and CO 2 -induced channel gating in connexin26. Structure, 30, 2022
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7QEW
| human Connexin 26 class 2 hexamer at 90mmHg PCO2, pH7.4 | 分子名称: | DODECYL-BETA-D-MALTOSIDE, Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE | 著者 | Brotherton, D.H, Cameron, A.D, Savva, C.G, Ragan, T.J. | 登録日 | 2021-12-03 | 公開日 | 2022-03-30 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (2.1 Å) | 主引用文献 | Conformational changes and CO 2 -induced channel gating in connexin26. Structure, 30, 2022
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7QEY
| human Connexin 26 class 1 hexamer at 90mmHg PCO2, pH7.4 | 分子名称: | DODECYL-BETA-D-MALTOSIDE, Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE | 著者 | Brotherton, D.H, Cameron, A.D, Savva, C.G, Ragan, T.J. | 登録日 | 2021-12-03 | 公開日 | 2022-03-30 | 最終更新日 | 2022-11-09 | 実験手法 | ELECTRON MICROSCOPY (2 Å) | 主引用文献 | Conformational changes and CO 2 -induced channel gating in connexin26. Structure, 30, 2022
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7QEU
| human Connexin 26 at 55mmHg PCO2, pH7.4: two masked subunits, class B | 分子名称: | DODECYL-BETA-D-MALTOSIDE, Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE | 著者 | Brotherton, D.H, Cameron, A.D, Savva, C.G, Ragan, T.J. | 登録日 | 2021-12-03 | 公開日 | 2022-06-15 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Conformational changes and CO 2 -induced channel gating in connexin26. Structure, 30, 2022
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7QES
| human Connexin 26 at 55mm Hg PCO2, pH7.4: two masked subunits, class A | 分子名称: | DODECYL-BETA-D-MALTOSIDE, Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE | 著者 | Brotherton, D.H, Cameron, A.D, Savva, C.G, Ragan, T.J. | 登録日 | 2021-12-03 | 公開日 | 2022-06-15 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Conformational changes and CO 2 -induced channel gating in connexin26. Structure, 30, 2022
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7QEO
| human Connexin 26 at 55mm Hg PCO2, pH7.4: two masked subunits, class C | 分子名称: | DODECYL-BETA-D-MALTOSIDE, Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE | 著者 | Brotherton, D.H, Cameron, A.D, Savva, C.G, Ragan, T.J. | 登録日 | 2021-12-03 | 公開日 | 2022-06-22 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Conformational changes and CO 2 -induced channel gating in connexin26. Structure, 30, 2022
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7QEV
| human Connexin 26 at 55mm Hg PCO2, pH7.4:two masked subunits, class D | 分子名称: | DODECYL-BETA-D-MALTOSIDE, Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE | 著者 | Brotherton, D.H, Cameron, A.D, Savva, C.G, Ragan, T.J. | 登録日 | 2021-12-03 | 公開日 | 2022-06-15 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Conformational changes and CO 2 -induced channel gating in connexin26. Structure, 30, 2022
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7QOA
| Structure of CodB, a cytosine transporter in an outward-facing conformation | 分子名称: | 2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 6-AMINOPYRIMIDIN-2(1H)-ONE, Cytosine permease, ... | 著者 | Hatton, C.E, Cameron, A.D. | 登録日 | 2021-12-23 | 公開日 | 2022-07-13 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure of cytosine transport protein CodB provides insight into nucleobase-cation symporter 1 mechanism. Embo J., 41, 2022
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2BMC
| Aurora-2 T287D T288D complexed with PHA-680632 | 分子名称: | (3E)-N-(2,6-DIETHYLPHENYL)-3-{[4-(4-METHYLPIPERAZIN-1-YL)BENZOYL]IMINO}PYRROLO[3,4-C]PYRAZOLE-5(3H)-CARBOXAMIDE, SERINE THREONINE-PROTEIN KINASE 6 | 著者 | Cameron, A.D, Izzo, G, Sagliano, A, Rusconi, L, Storici, P, Fancelli, D, Berta, D, Bindi, S, Catana, C, Forte, B, Giordano, P, Mantegani, S, Meroni, M, Moll, J, Pittala, V, Severino, D, Tonani, R, Varasi, M, Vulpetti, A, Vianello, P. | 登録日 | 2005-03-11 | 公開日 | 2005-03-17 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Potent and Selective Aurora Inhibitors Identified by the Expansion of a Novel Scaffold for Protein Kinase Inhibition. J.Med.Chem., 48, 2005
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2J4Z
| Structure of Aurora-2 in complex with PHA-680626 | 分子名称: | 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE, ARSENIC, SERINE THREONINE-PROTEIN KINASE 6 | 著者 | Cameron, A.D, Izzo, G, Storici, P, Rusconi, L, Fancelli, D, Varasi, M, Berta, D, Bindi, S, Forte, B, Severino, D, Tonani, R, Vianello, P. | 登録日 | 2006-09-08 | 公開日 | 2006-11-06 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: identification of a potent Aurora kinase inhibitor with a favorable antitumor kinase inhibition profile. J. Med. Chem., 49, 2006
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6Y8S
| Crystal structure of the quaternary ammonium Rieske monooxygenase CntA in complex with substrate gamma-butyrobetaine | 分子名称: | 3-CARBOXY-N,N,N-TRIMETHYLPROPAN-1-AMINIUM, Carnitine monooxygenase oxygenase subunit, FE (III) ION, ... | 著者 | Quareshy, M, Shanmugam, M, Bugg, T.D, Cameron, A, Chen, Y. | 登録日 | 2020-03-05 | 公開日 | 2020-11-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.629 Å) | 主引用文献 | Structural basis of carnitine monooxygenase CntA substrate specificity, inhibition, and intersubunit electron transfer. J.Biol.Chem., 296, 2020
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6Y9C
| The structure of a quaternary ammonium Rieske monooxygenase reveals insights into carnitine oxidation by gut microbiota and inter-subunit electron transfer | 分子名称: | CARNITINE, Carnitine monooxygenase oxygenase subunit, FE (III) ION, ... | 著者 | Quareshy, M, Shanmugam, M, Bugg, T.D, Cameron, A, Chen, Y. | 登録日 | 2020-03-06 | 公開日 | 2021-03-31 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Characterisation of an unusual cysteine pair in the Rieske carnitine monooxygenase CntA catalytic site. Febs J., 2023
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6ZGP
| Crystal structure of the quaternary ammonium Rieske monooxygenase CntA in complex with inhibitor MMV12 (MMV020670) | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Carnitine monooxygenase oxygenase subunit, FE (III) ION, ... | 著者 | Quareshy, M, Shanmugam, M, Bugg, T.D.H, Cameron, A, Chen, Y. | 登録日 | 2020-06-19 | 公開日 | 2020-11-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Structural basis of carnitine monooxygenase CntA substrate specificity, inhibition, and intersubunit electron transfer. J.Biol.Chem., 296, 2020
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5BZ3
| CRYSTAL STRUCTURE OF SODIUM PROTON ANTIPORTER NAPA IN OUTWARD-FACING CONFORMATION. | 分子名称: | (2R)-2,3-DIHYDROXYPROPYL (7Z)-TETRADEC-7-ENOATE, Na(+)/H(+) antiporter | 著者 | Coincon, M, Uzdavinys, P, Emmanuel, N, Cameron, A, Drew, D. | 登録日 | 2015-06-11 | 公開日 | 2016-01-20 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structures reveal the molecular basis of ion translocation in sodium/proton antiporters. Nat.Struct.Mol.Biol., 23, 2016
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5BZ2
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