6QV7
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6QVA
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3ZKE
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![BU of 3zke by Molmil](/molmil-images/mine/3zke) | Structure of LC8 in complex with Nek9 peptide | 分子名称: | DYNEIN LIGHT CHAIN 1, CYTOPLASMIC, NEK9 PROTEIN | 著者 | Gallego, P, Velazquez-Campoy, A, Regue, L, Roig, J, Reverter, D. | 登録日 | 2013-01-22 | 公開日 | 2013-03-20 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural Analysis of the Regulation of the Dynll/Lc8 Binding to Nek9 by Phosphorylation J.Biol.Chem., 288, 2013
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8F46
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![BU of 8f46 by Molmil](/molmil-images/mine/8f46) | Crystal structure of SARS-CoV-2 3CL protease in complex with a dimethyl phenyl sulfane inhibitor (cyano warhead) | 分子名称: | 3C-like proteinase, N-{(1Z,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-N~2~-{[2-methyl-2-(phenylsulfanyl)propoxy]carbonyl}-L-leucinamide, TETRAETHYLENE GLYCOL | 著者 | Liu, L, Lovell, S, Cooper, A, Battaile, K.P, Dampalla, C.S, Groutas, W.C. | 登録日 | 2022-11-10 | 公開日 | 2022-11-23 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structure-guided design of direct-acting antivirals that exploit the gem-dimethyl effect and potently inhibit 3CL proteases of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) and middle east respiratory syndrome coronavirus (MERS-CoV). Eur.J.Med.Chem., 254, 2023
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8F44
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![BU of 8f44 by Molmil](/molmil-images/mine/8f44) | Crystal structure of SARS-CoV-2 3CL protease in complex with a dimethyl phenyl sulfane inhibitor | 分子名称: | (1R,2S)-1-hydroxy-2-[(N-{[2-methyl-2-(phenylsulfanyl)propoxy]carbonyl}-L-leucyl)amino]-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, (2-methyl-2-phenylsulfanyl-propyl) ~{N}-[(2~{S})-1-[[(1~{S},2~{S})-1-[bis(oxidanyl)-oxidanylidene-$l^{5}-sulfanyl]-1-oxidanyl-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]carbamate, 3C-like proteinase, ... | 著者 | Liu, L, Lovell, S, Cooper, A, Battaile, K.P, Dampalla, C.S, Groutas, W.C. | 登録日 | 2022-11-10 | 公開日 | 2022-11-23 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structure-guided design of direct-acting antivirals that exploit the gem-dimethyl effect and potently inhibit 3CL proteases of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) and middle east respiratory syndrome coronavirus (MERS-CoV). Eur.J.Med.Chem., 254, 2023
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3ZX7
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![BU of 3zx7 by Molmil](/molmil-images/mine/3zx7) | Complex of lysenin with phosphocholine | 分子名称: | LYSENIN, PHOSPHATE ION, PHOSPHOCHOLINE, ... | 著者 | De Colibus, L, Sonnen, A.F.P, Morris, K.J, Siebert, C.A, Abrusci, P, Plitzko, J, Hodnik, V, Leippe, M, Volpi, E, Anderluh, G, Gilbert, R.J.C. | 登録日 | 2011-08-08 | 公開日 | 2012-09-19 | 最終更新日 | 2012-10-03 | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | 主引用文献 | Structures of Lysenin Reveal a Shared Evolutionary Origin for Pore-Forming Proteins and its Mode of Sphingomyelin Recognition. Structure, 20, 2012
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8EYZ
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![BU of 8eyz by Molmil](/molmil-images/mine/8eyz) | Engineered glutamine binding protein bound to GLN and a cobaloxime ligand | 分子名称: | AZIDOBIS (DIMETHYLGLYOXIMATO) PYRIDINECOBALT, Amino acid ABC transporter substrate-binding protein, GLUTAMINE, ... | 著者 | Bridwell-Rabb, J, Boggs, D.G, Olshansky, L, Fatima, S, Thompson, P. | 登録日 | 2022-10-29 | 公開日 | 2022-11-23 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | 主引用文献 | Engineering a Conformationally Switchable Artificial Metalloprotein. J.Am.Chem.Soc., 144, 2022
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4B82
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![BU of 4b82 by Molmil](/molmil-images/mine/4b82) | Mus musculus Acetylcholinesterase in complex with N-(2-Diethylamino- ethyl)-2-fluoranyl-benzenesulfonamide | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINESTERASE, DI(HYDROXYETHYL)ETHER, ... | 著者 | Andersson, C.D, Forsgren, N, Akfur, C, Allgardsson, A, Berg, L, Qian, W, Ekstrom, F, Linusson, A. | 登録日 | 2012-08-24 | 公開日 | 2013-09-04 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Divergent Structure-Activity Relationships of Structurally Similar Acetylcholinesterase Inhibitors. J.Med.Chem., 56, 2013
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6QWU
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![BU of 6qwu by Molmil](/molmil-images/mine/6qwu) | 4'-phosphopantetheinyl transferase PptAb from Mycobacterium abscessus at pH 5.5 with Mn2+ and CoA. | 分子名称: | COENZYME A, DI(HYDROXYETHYL)ETHER, MANGANESE (II) ION, ... | 著者 | Nguyen, M.C, Mourey, L, Pedelacq, J.D. | 登録日 | 2019-03-06 | 公開日 | 2020-03-25 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Conformational flexibility of coenzyme A and its impact on the post-translational modification of acyl carrier proteins by 4'-phosphopantetheinyl transferases. Febs J., 287, 2020
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8F8O
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![BU of 8f8o by Molmil](/molmil-images/mine/8f8o) | Crystal Structure of the Succinyl-diaminopimelate Desuccinylase (DapE) from Acinetobacter baumannii in complex with Succinic and L-Lactic Acids | 分子名称: | (2S)-2-HYDROXYPROPANOIC ACID, CITRIC ACID, SUCCINIC ACID, ... | 著者 | Minasov, G, Shuvalova, L, Brunzelle, J.S, Dubrovska, I, Pshenychnyi, S, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID), Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2022-11-22 | 公開日 | 2022-11-30 | 最終更新日 | 2023-02-22 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal Structure of the Succinyl-diaminopimelate Desuccinylase (DapE) from Acinetobacter baumannii in complex with Succinic and L-Lactic Acids To Be Published
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6QYI
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![BU of 6qyi by Molmil](/molmil-images/mine/6qyi) | Structure of HPAB from E.coli in complex with FAD | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-hydroxyphenylacetate 3-monooxygenase oxygenase component, DI(HYDROXYETHYL)ETHER, ... | 著者 | Pecqueur, L, Lombard, M, Deng, Y, Fontecave, M. | 登録日 | 2019-03-09 | 公開日 | 2019-06-12 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural and Functional Characterization of 4-Hydroxyphenylacetate 3-Hydroxylase from Escherichia coli. Chembiochem, 21, 2020
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6QLZ
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![BU of 6qlz by Molmil](/molmil-images/mine/6qlz) | IDOL F3ab subdomain | 分子名称: | E3 ubiquitin-protein ligase MYLIP | 著者 | Martinelli, L, Johansson, P, Wan, P.T, Gunnarsson, J, Guo, H, Boyd, H. | 登録日 | 2019-02-01 | 公開日 | 2020-02-19 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.343 Å) | 主引用文献 | Structural analysis of the LDL receptor-interacting FERM domain in the E3 ubiquitin ligase IDOL reveals an obscured substrate-binding site. J.Biol.Chem., 295, 2020
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6QM5
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![BU of 6qm5 by Molmil](/molmil-images/mine/6qm5) | Cryo-EM structure of calcium-bound nhTMEM16 lipid scramblase in DDM | 分子名称: | CALCIUM ION, Predicted protein | 著者 | Kalienkova, V, Clerico Mosina, V, Bryner, L, Oostergetel, G.T, Dutzler, R, Paulino, C. | 登録日 | 2019-02-01 | 公開日 | 2019-03-06 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM. Elife, 8, 2019
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6QXQ
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4BBK
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![BU of 4bbk by Molmil](/molmil-images/mine/4bbk) | Structural and functional characterisation of the kindlin-1 pleckstrin homology domain | 分子名称: | FERMITIN FAMILY HOMOLOG 1, GLYCEROL | 著者 | Yates, L.A, Lumb, C.N, Brahme, N.N, Zalyte, R, Bird, L.E, De Colibus, L, Owens, R.J, Calderwood, D.A, Sansom, M.S.P, Gilbert, R.J.C. | 登録日 | 2012-09-25 | 公開日 | 2012-11-14 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural and Functional Characterisation of the Kindlin-1 Pleckstrin Homology Domain J.Biol.Chem., 287, 2012
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4BDS
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![BU of 4bds by Molmil](/molmil-images/mine/4bds) | Human butyrylcholinesterase in complex with tacrine | 分子名称: | 1-formyl-L-proline, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Nachon, F, Carletti, E, Ronco, C, Trovaslet, M, Nicolet, Y, Jean, L, Renard, P.-Y. | 登録日 | 2012-10-06 | 公開日 | 2013-05-29 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal Structures of Human Cholinesterases in Complex with Huprine W and Tacrine: Elements of Specificity for Anti-Alzheimer'S Drugs Targeting Acetyl- and Butyrylcholinesterase. Biochem.J., 453, 2013
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4B81
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![BU of 4b81 by Molmil](/molmil-images/mine/4b81) | Mus musculus Acetylcholinesterase in complex with 1-(4-Chloro-phenyl)- N-(2-diethylamino-ethyl)-methanesulfonamide | 分子名称: | 1-(4-chlorophenyl)-N-[2-(diethylamino)ethyl]methanesulfonamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINESTERASE, ... | 著者 | Andersson, C.D, Forsgren, N, Akfur, C, Allgardsson, A, Berg, L, Qian, W, Ekstrom, F, Linusson, A. | 登録日 | 2012-08-24 | 公開日 | 2013-09-04 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Divergent Structure-Activity Relationships of Structurally Similar Acetylcholinesterase Inhibitors. J.Med.Chem., 56, 2013
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4B4C
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![BU of 4b4c by Molmil](/molmil-images/mine/4b4c) | Crystal structure of the DNA-binding domain of human CHD1. | 分子名称: | 1,2-ETHANEDIOL, CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1, GLYCEROL, ... | 著者 | Allerston, C.K, Cooper, C.D.O, Shrestha, L, Vollmar, M, Burgess-Brown, N, Yue, W.W, Carpenter, E.P, Arrowsmith, C.H, Edwards, A, Bountra, C, von Delft, F, Gileadi, O. | 登録日 | 2012-07-30 | 公開日 | 2012-08-15 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Crystal Structure of the DNA-Binding Domain of Human Chd1. To be Published
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4AYG
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![BU of 4ayg by Molmil](/molmil-images/mine/4ayg) | Lactobacillus reuteri N-terminally truncated glucansucrase GTF180 in orthorhombic apo-form | 分子名称: | ACETIC ACID, CALCIUM ION, GLUCANSUCRASE, ... | 著者 | Pijning, T, Vujicic-Zagar, A, Kralj, S, Dijkhuizen, L, Dijkstra, B.W. | 登録日 | 2012-06-21 | 公開日 | 2013-07-03 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Flexibility of Truncated and Full-Length Glucansucrase Gtf180 Enzymes from Lactobacillus Reuteri 180. FEBS J., 281, 2014
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6QPP
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![BU of 6qpp by Molmil](/molmil-images/mine/6qpp) | Rhizomucor miehei lipase propeptide complex, native | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Lipase | 著者 | Moroz, O.V, Blagova, E, Reiser, V, Saikia, R, Dalal, S, Jorgensen, C.I, Baunsgaard, L, Andersen, B, Svendsen, A, Wilson, K.S. | 登録日 | 2019-02-14 | 公開日 | 2019-03-13 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Novel Inhibitory Function of theRhizomucor mieheiLipase Propeptide and Three-Dimensional Structures of Its Complexes with the Enzyme. Acs Omega, 4, 2019
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6QPR
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![BU of 6qpr by Molmil](/molmil-images/mine/6qpr) | Rhizomucor miehei lipase propeptide complex, Ser95/Ile96 deletion mutant | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Lipase | 著者 | Moroz, O.V, Blagova, E, Reiser, V, Saikia, R, Dalal, S, Jorgensen, C.I, Baunsgaard, L, Andersen, B, Svendsen, A, Wilson, K.S. | 登録日 | 2019-02-14 | 公開日 | 2019-03-13 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Novel Inhibitory Function of theRhizomucor mieheiLipase Propeptide and Three-Dimensional Structures of Its Complexes with the Enzyme. Acs Omega, 4, 2019
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6QQ4
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![BU of 6qq4 by Molmil](/molmil-images/mine/6qq4) | Odorant-binding protein dmelOBP28a from Drosophila melanogaster | 分子名称: | General odorant-binding protein 28a, MALONIC ACID, PENTAETHYLENE GLYCOL | 著者 | Gonzalez, D, Neiers, F, Gotthard, G, Briand, L. | 登録日 | 2019-02-17 | 公開日 | 2020-03-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.998 Å) | 主引用文献 | The Drosophila odorant-binding protein 28a is involved in the detection of the floral odour ss-ionone. Cell.Mol.Life Sci., 77, 2020
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6QVO
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![BU of 6qvo by Molmil](/molmil-images/mine/6qvo) | Crystal structure of human MTH1 in complex with N6-methyl-dAMP | 分子名称: | 7,8-dihydro-8-oxoguanine triphosphatase, GLYCEROL, N6-METHYL-DEOXY-ADENOSINE-5'-MONOPHOSPHATE, ... | 著者 | Scaletti, E, Vallin, K.S, Brautigam, L, Sarno, A, Warpman Berglund, U, Helleday, T, Stenmark, P, Jemth, A.S. | 登録日 | 2019-03-04 | 公開日 | 2020-03-18 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool. J.Biol.Chem., 295, 2020
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4BEC
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![BU of 4bec by Molmil](/molmil-images/mine/4bec) | MUTANT (K220A) OF THE HSDR SUBUNIT OF THE ECOR124I RESTRICTION ENZYME IN COMPLEX WITH ATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, TYPE I RESTRICTION ENZYME HSDR | 著者 | Csefalvay, E, Lapkouski, M, Guzanova, A, Csefalvay, L, Baikova, T, Shevelev, I, Janscak, P, Smatanova, I.K, Panjikar, S, Carey, J, Weiserova, M, Ettrich, R. | 登録日 | 2013-03-07 | 公開日 | 2014-03-26 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | 主引用文献 | Functional Coupling of Duplex Translocation to DNA Cleavage in a Type I Restriction Enzyme. Plos One, 10, 2015
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4B84
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![BU of 4b84 by Molmil](/molmil-images/mine/4b84) | Mus musculus Acetylcholinesterase in complex with N-(2-Diethylamino- ethyl)-3-trifluoromethyl-benzenesulfonamide | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,6,9,12,15-PENTAOXAHEPTADECANE, ACETYLCHOLINESTERASE, ... | 著者 | Andersson, C.D, Forsgren, N, Akfur, C, Allgardsson, A, Berg, L, Qian, W, Ekstrom, F, Linusson, A. | 登録日 | 2012-08-24 | 公開日 | 2013-09-04 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Divergent Structure-Activity Relationships of Structurally Similar Acetylcholinesterase Inhibitors. J.Med.Chem., 56, 2013
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