6IGC
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![BU of 6igc by Molmil](/molmil-images/mine/6igc) | Crystal structure of HPV58/33/52 chimeric L1 pentamer | 分子名称: | Major capsid protein L1 | 著者 | Li, Z.H, Song, S, He, M.Z, Gu, Y, Li, S.W. | 登録日 | 2018-09-25 | 公開日 | 2018-11-21 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity. Nat Commun, 9, 2018
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6IGD
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![BU of 6igd by Molmil](/molmil-images/mine/6igd) | Crystal structure of HPV58/33 chimeric L1 pentamer | 分子名称: | Major capsid protein L1 | 著者 | Li, Z.H, Song, S, He, M.Z, Gu, Y, Li, S.W. | 登録日 | 2018-09-25 | 公開日 | 2018-11-21 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity. Nat Commun, 9, 2018
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6IGF
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![BU of 6igf by Molmil](/molmil-images/mine/6igf) | Crystal structure of Human Papillomavirus type 52 pentamer | 分子名称: | Major capsid protein L1 | 著者 | Li, Z.H, Song, S, He, M.Z, Gu, Y, Li, S.W. | 登録日 | 2018-09-25 | 公開日 | 2018-11-28 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.751 Å) | 主引用文献 | Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity. Nat Commun, 9, 2018
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6IGE
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![BU of 6ige by Molmil](/molmil-images/mine/6ige) | Crystal structure of Human Papillomavirus type 33 pentamer | 分子名称: | Major capsid protein L1 | 著者 | Li, Z.H, Song, S, He, M.Z, Gu, Y, Li, S.W. | 登録日 | 2018-09-25 | 公開日 | 2018-12-05 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity. Nat Commun, 9, 2018
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5DX4
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![BU of 5dx4 by Molmil](/molmil-images/mine/5dx4) | Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand | 分子名称: | 1,2-ETHANEDIOL, 5-bromo-N-(1-ethyl-2-oxo-1,2-dihydrobenzo[cd]indol-6-yl)-2-methoxybenzenesulfonamide, Bromodomain-containing protein 4, ... | 著者 | Zhang, Y, Song, M, Liu, Z, Xue, X, Xu, Y. | 登録日 | 2015-09-23 | 公開日 | 2016-01-13 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation J.Med.Chem., 59, 2016
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5CM4
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![BU of 5cm4 by Molmil](/molmil-images/mine/5cm4) | Crystal structure of human Frizzled 4 Cysteine-Rich Domain (CRD) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Frizzled-4 | 著者 | Ke, J, Parker, N, Gu, X, Zhang, C, Melcher, K, Xu, H.E. | 登録日 | 2015-07-16 | 公開日 | 2015-08-12 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural basis of the Norrin-Frizzled 4 interaction. Cell Res., 25, 2015
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6XP9
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8I13
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![BU of 8i13 by Molmil](/molmil-images/mine/8i13) | Cryo-EM structure of 6-subunit Smc5/6 | 分子名称: | MMS21 isoform 1, NSE3 isoform 1, Non-structural maintenance of chromosomes element 1 homolog, ... | 著者 | Qian, L, Jun, Z, Xiang, Z, Cheng, T, Zhaoning, W, Duo, J, Zhenguo, C, Wang, L. | 登録日 | 2023-01-12 | 公開日 | 2024-06-26 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (6.9 Å) | 主引用文献 | Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms. Nat.Struct.Mol.Biol., 2024
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8I4V
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![BU of 8i4v by Molmil](/molmil-images/mine/8i4v) | Cryo-EM structure of 5-subunit Smc5/6 arm region | 分子名称: | DNA repair protein KRE29, E3 SUMO-protein ligase MMS21, Structural maintenance of chromosomes protein 5, ... | 著者 | Qian, L, Jun, Z, Xiang, Z, Cheng, T, Zhaoning, W, Zhenguo, C, Wang, L. | 登録日 | 2023-01-21 | 公開日 | 2024-06-26 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (5.97 Å) | 主引用文献 | Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms. Nat.Struct.Mol.Biol., 2024
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8I4W
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![BU of 8i4w by Molmil](/molmil-images/mine/8i4w) | Cryo-EM structure of 5-subunit Smc5/6 head region | 分子名称: | DNA repair protein KRE29, Non-structural maintenance of chromosome element 5, Structural maintenance of chromosomes protein 5, ... | 著者 | Qian, L, Jun, Z, Xiang, Z, Zhaoning, W, Cheng, T, Duo, J, Zhenguo, C, Wang, L. | 登録日 | 2023-01-21 | 公開日 | 2024-06-26 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (6.01 Å) | 主引用文献 | Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms. Nat.Struct.Mol.Biol., 2024
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8I4X
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![BU of 8i4x by Molmil](/molmil-images/mine/8i4x) | Cryo-EM structure of 5-subunit Smc5/6 | 分子名称: | E3 SUMO-protein ligase MMS21, Non-structural maintenance of chromosome element 5, Nse6, ... | 著者 | Qian, L, Jun, Z, Xiang, Z, Zhaoning, W, Tong, C, Duo, J, Zhenguo, C, Wang, L. | 登録日 | 2023-01-21 | 公開日 | 2024-06-26 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (8.5 Å) | 主引用文献 | Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms. Nat.Struct.Mol.Biol., 2024
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8I21
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![BU of 8i21 by Molmil](/molmil-images/mine/8i21) | Cryo-EM structure of 6-subunit Smc5/6 arm region | 分子名称: | E3 SUMO-protein ligase MMS21, Structural maintenance of chromosomes protein 5, Structural maintenance of chromosomes protein 6 | 著者 | Jun, Z, Qian, L, Xiang, Z, Tong, C, Zhaoning, W, Duo, J, Zhenguo, C, Lanfeng, W. | 登録日 | 2023-01-13 | 公開日 | 2024-06-26 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (6.02 Å) | 主引用文献 | Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms. Nat.Struct.Mol.Biol., 2024
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2DWU
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![BU of 2dwu by Molmil](/molmil-images/mine/2dwu) | Crystal Structure of Glutamate Racemase Isoform RacE1 from Bacillus anthracis | 分子名称: | D-GLUTAMIC ACID, GLYCEROL, Glutamate racemase, ... | 著者 | Mehboob, S, Santarsiero, B.D, Johnson, M.E. | 登録日 | 2006-08-17 | 公開日 | 2007-06-19 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structural and Functional Analysis of Two Glutamate Racemase Isozymes from Bacillus anthracis and Implications for Inhibitor Design J.Mol.Biol., 371, 2007
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1QUI
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![BU of 1qui by Molmil](/molmil-images/mine/1qui) | PHOSPHATE-BINDING PROTEIN MUTANT WITH ASP 137 REPLACED BY GLY COMPLEX WITH BROMINE AND PHOSPHATE | 分子名称: | BROMIDE ION, PHOSPHATE ION, PHOSPHATE-BINDING PROTEIN | 著者 | Yao, N, Choudhary, A, Ledvina, P.S, Quiocho, F.A. | 登録日 | 1995-11-11 | 公開日 | 1996-07-11 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Modulation of a salt link does not affect binding of phosphate to its specific active transport receptor. Biochemistry, 35, 1996
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5E6N
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![BU of 5e6n by Molmil](/molmil-images/mine/5e6n) | Crystal structure of C. elegans LGG-2 | 分子名称: | Protein lgg-2 | 著者 | Qi, X, Ren, J.Q, Wu, F, Zhang, H, Feng, W. | 登録日 | 2015-10-10 | 公開日 | 2016-01-06 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.102 Å) | 主引用文献 | Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy Mol.Cell, 60, 2015
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1QUJ
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![BU of 1quj by Molmil](/molmil-images/mine/1quj) | PHOSPHATE-BINDING PROTEIN MUTANT WITH ASP 137 REPLACED BY GLY COMPLEX WITH CHLORINE AND PHOSPHATE | 分子名称: | CHLORIDE ION, PHOSPHATE ION, PHOSPHATE-BINDING PROTEIN | 著者 | Yao, N, Choudhary, A, Ledvina, P.S, Quiocho, F.A. | 登録日 | 1995-11-11 | 公開日 | 1996-07-11 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Modulation of a salt link does not affect binding of phosphate to its specific active transport receptor. Biochemistry, 35, 1996
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1QUK
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![BU of 1quk by Molmil](/molmil-images/mine/1quk) | PHOSPHATE-BINDING PROTEIN MUTANT WITH ASP 137 REPLACED BY ASN COMPLEX WITH PHOSPHATE | 分子名称: | PHOSPHATE ION, PHOSPHATE-BINDING PROTEIN | 著者 | Yao, N, Choudhary, A, Ledvina, P.S, Quiocho, F.A. | 登録日 | 1995-11-11 | 公開日 | 1996-07-11 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Modulation of a salt link does not affect binding of phosphate to its specific active transport receptor. Biochemistry, 35, 1996
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1QUL
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![BU of 1qul by Molmil](/molmil-images/mine/1qul) | PHOSPHATE-BINDING PROTEIN MUTANT WITH ASP 137 REPLACED BY THR COMPLEX WITH CHLORINE AND PHOSPHATE | 分子名称: | CHLORIDE ION, PHOSPHATE ION, PHOSPHATE-BINDING PROTEIN | 著者 | Yao, N, Choudhary, A, Ledvina, P.S, Quiocho, F.A. | 登録日 | 1995-11-11 | 公開日 | 1996-07-11 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Modulation of a salt link does not affect binding of phosphate to its specific active transport receptor. Biochemistry, 35, 1996
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6UL5
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![BU of 6ul5 by Molmil](/molmil-images/mine/6ul5) | Crystal structure of HIV-1 reverse transcriptase (RT) in complex with 4-[(4-{4-[(E)-2-cyanoethenyl]-2,6-dimethylphenoxy}thieno[3,2-d]pyrimidin-2-yl)amino]-2-fluorobenzonitrile (24b), a non-nucleoside RT inhibitor | 分子名称: | 1,2-ETHANEDIOL, 4-[(4-{4-[(E)-2-cyanoethenyl]-2,6-dimethylphenoxy}thieno[3,2-d]pyrimidin-2-yl)amino]-2-fluorobenzonitrile, MAGNESIUM ION, ... | 著者 | Ruiz, F.X, Pilch, A, Arnold, E. | 登録日 | 2019-10-06 | 公開日 | 2020-02-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel. J.Med.Chem., 63, 2020
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7M9F
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![BU of 7m9f by Molmil](/molmil-images/mine/7m9f) | |
6V9C
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![BU of 6v9c by Molmil](/molmil-images/mine/6v9c) | Crystal structure of FGFR4 kinase domain in complex with covalent inhibitor | 分子名称: | Fibroblast growth factor receptor 4, N-[(3R,4S)-4-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino}oxolan-3-yl]prop-2-enamide, SULFATE ION | 著者 | Liu, J, Liu, H. | 登録日 | 2019-12-13 | 公開日 | 2020-03-25 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Discovery of Selective, Covalent FGFR4 Inhibitors with Antitumor Activity in Models of Hepatocellular Carcinoma. Acs Med.Chem.Lett., 11, 2020
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8HOG
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![BU of 8hog by Molmil](/molmil-images/mine/8hog) | Crystal structure of Bcl-2 in complex with sonrotoclax | 分子名称: | Apoptosis regulator Bcl-2, ~{N}-[4-[(4-methyl-4-oxidanyl-cyclohexyl)methylamino]-3-nitro-phenyl]sulfonyl-4-[2-[(2~{S})-2-(2-propan-2-ylphenyl)pyrrolidin-1-yl]-7-azaspiro[3.5]nonan-7-yl]-2-(1~{H}-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide | 著者 | Liu, J, Xu, M, Feng, Y, Hong, Y, Liu, Y. | 登録日 | 2022-12-10 | 公開日 | 2024-01-17 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy. Blood, 143, 2024
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8HOH
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![BU of 8hoh by Molmil](/molmil-images/mine/8hoh) | Crystal structure of Bcl-2 G101V in complex with sonrotoclax | 分子名称: | Apoptosis regulator Bcl-2, ~{N}-[4-[(4-methyl-4-oxidanyl-cyclohexyl)methylamino]-3-nitro-phenyl]sulfonyl-4-[2-[(2~{S})-2-(2-propan-2-ylphenyl)pyrrolidin-1-yl]-7-azaspiro[3.5]nonan-7-yl]-2-(1~{H}-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide | 著者 | Liu, J, Xu, M, Feng, Y, Hong, Y, Liu, Y. | 登録日 | 2022-12-10 | 公開日 | 2024-01-17 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy. Blood, 143, 2024
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8HOI
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![BU of 8hoi by Molmil](/molmil-images/mine/8hoi) | Crystal structure of Bcl-2 D103Y in complex with sonrotoclax | 分子名称: | Apoptosis regulator Bcl-2, FORMIC ACID, ~{N}-[4-[(4-methyl-4-oxidanyl-cyclohexyl)methylamino]-3-nitro-phenyl]sulfonyl-4-[2-[(2~{S})-2-(2-propan-2-ylphenyl)pyrrolidin-1-yl]-7-azaspiro[3.5]nonan-7-yl]-2-(1~{H}-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide | 著者 | Liu, J, Xu, M, Feng, Y, Hong, Y, Liu, Y. | 登録日 | 2022-12-10 | 公開日 | 2024-01-17 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy. Blood, 143, 2024
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6V4K
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![BU of 6v4k by Molmil](/molmil-images/mine/6v4k) | Structure of TrkH-TrkA in complex with ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Potassium transporter peripheral membrane component, Trk system potassium uptake protein | 著者 | Zhou, M, Zhang, H. | 登録日 | 2019-11-27 | 公開日 | 2020-02-12 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.53004146 Å) | 主引用文献 | TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential. Nat Commun, 11, 2020
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