1JL4
| CRYSTAL STRUCTURE OF THE HUMAN CD4 N-TERMINAL TWO DOMAIN FRAGMENT COMPLEXED TO A CLASS II MHC MOLECULE | 分子名称: | H-2 CLASS II HISTOCOMPATIBILITY ANTIGEN, A-K ALPHA CHAIN, A-K BETA CHAIN, ... | 著者 | Wang, J.-H, Meijers, R, Reinherz, E.L. | 登録日 | 2001-07-15 | 公開日 | 2001-09-19 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (4.3 Å) | 主引用文献 | Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule. Proc.Natl.Acad.Sci.USA, 98, 2001
|
|
7FJS
| Crystal structure of T6 Fab bound to theSARS-CoV-2 RBD of B.1.351 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, T6 heavy chain, ... | 著者 | Wang, X, Zhang, L, Zhang, S, Liang, Q. | 登録日 | 2021-08-04 | 公開日 | 2022-04-27 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | RBD trimer mRNA vaccine elicits broad and protective immune responses against SARS-CoV-2 variants. Iscience, 25, 2022
|
|
6B1B
| STRUCTURE OF 4-HYDROXYPHENYLACETATE 3-MONOOXYGENASE (HPAB), OXYGENASE COMPONENT FROM ESCHERICHIA COLI MUTANT XS6 (APO Enzyme) | 分子名称: | 4-hydroxyphenylacetate 3-monooxygenase, oxygenase subunit, trimethylamine oxide | 著者 | Zhou, D, Kandavelu, P, Wang, B.C, Yan, Y, Rose, J.P. | 登録日 | 2017-09-18 | 公開日 | 2019-05-22 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.944 Å) | 主引用文献 | Structural Insights into Catalytic Versatility of the Flavin-dependent Hydroxylase (HpaB) from Escherichia coli. Sci Rep, 9, 2019
|
|
5T4Z
| |
1A4F
| BAR-HEADED GOOSE HEMOGLOBIN (OXY FORM) | 分子名称: | HEMOGLOBIN (ALPHA CHAIN), HEMOGLOBIN (BETA CHAIN), OXYGEN MOLECULE, ... | 著者 | Zhang, J, Gu, X. | 登録日 | 1998-01-29 | 公開日 | 1998-04-29 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The crystal structure of a high oxygen affinity species of haemoglobin (bar-headed goose haemoglobin in the oxy form). J.Mol.Biol., 255, 1996
|
|
7WSF
| |
7WSE
| |
7WSG
| |
7WSH
| Cryo-EM structure of SARS-CoV-2 spike receptor-binding domain in complex with sea lion ACE2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, Spike protein S1, ... | 著者 | Li, S, Han, P, Qi, J. | 登録日 | 2022-01-29 | 公開日 | 2022-11-09 | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | 主引用文献 | Cross-species recognition and molecular basis of SARS-CoV-2 and SARS-CoV binding to ACE2s of marine animals. Natl Sci Rev, 9, 2022
|
|
6JRK
| The structure of co-crystals of 8r-B-EGFR WT complex | 分子名称: | 6-(2-chloranyl-3-fluoranyl-phenyl)-5-methyl-2-[[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]amino]-8-[(3S)-1-propanoylpiperidin-3-yl]pyrido[2,3-d]pyrimidin-7-one, Epidermal growth factor receptor | 著者 | Zhu, S.J, Yun, C.H. | 登録日 | 2019-04-04 | 公開日 | 2020-04-15 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.796 Å) | 主引用文献 | Structure-Based Design of 5-Methylpyrimidopyridone Derivatives as New Wild-Type Sparing Inhibitors of the Epidermal Growth Factor Receptor Triple Mutant (EGFRL858R/T790M/C797S). J.Med.Chem., 62, 2019
|
|
6JRJ
| The structure of co-crystals of 8r-B-EGFR T790M/C797S complex | 分子名称: | 6-(2-chloranyl-3-fluoranyl-phenyl)-5-methyl-2-[[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]amino]-8-[(3S)-1-propanoylpiperidin-3-yl]pyrido[2,3-d]pyrimidin-7-one, Epidermal growth factor receptor | 著者 | Zhu, S.J, Yun, C.H. | 登録日 | 2019-04-04 | 公開日 | 2020-04-15 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.943 Å) | 主引用文献 | Structure-Based Design of 5-Methylpyrimidopyridone Derivatives as New Wild-Type Sparing Inhibitors of the Epidermal Growth Factor Receptor Triple Mutant (EGFRL858R/T790M/C797S). J.Med.Chem., 62, 2019
|
|
5INW
| Structure of reaction loop cleaved lamprey angiotensinogen | 分子名称: | C-terminal peptide of Putative angiotensinogen, Putative angiotensinogen, SULFATE ION | 著者 | Wei, H, Zhou, A. | 登録日 | 2016-03-08 | 公開日 | 2016-10-05 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Heparin Binds Lamprey Angiotensinogen and Promotes Thrombin Inhibition through a Template Mechanism J.Biol.Chem., 291, 2016
|
|
5C45
| Selective Small Molecule Inhibition of the FMN Riboswitch | 分子名称: | (6M)-2-[(3S)-1-{[2-(methylamino)pyrimidin-5-yl]methyl}piperidin-3-yl]-6-(thiophen-2-yl)pyrimidin-4-ol, FMN Riboswitch, MAGNESIUM ION, ... | 著者 | Fischmann, T.O. | 登録日 | 2015-06-17 | 公開日 | 2015-10-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.93 Å) | 主引用文献 | Selective small-molecule inhibition of an RNA structural element. Nature, 526, 2015
|
|
5F6I
| |
5F6H
| |
5F6J
| |
2GTH
| crystal structure of the wildtype MHV coronavirus non-structural protein nsp15 | 分子名称: | Replicase polyprotein 1ab | 著者 | Xu, X, Zhai, Y, Sun, F, Lou, Z, Su, D, Rao, Z. | 登録日 | 2006-04-28 | 公開日 | 2006-08-15 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | New Antiviral Target Revealed by the Hexameric Structure of Mouse Hepatitis Virus Nonstructural Protein nsp15 J.Virol., 80, 2006
|
|
4FII
| |
6AFR
| Crystal Structure of the first bromodomain of human BRD4 in complex with 5-((4-fluoro-1H-imidazol-1-yl)methyl)quinolin-8-ol | 分子名称: | 5-[(4-fluoranylimidazol-1-yl)methyl]quinolin-8-ol, Bromodomain-containing protein 4 | 著者 | Xing, J, Zhang, R.K, Zheng, M.Y, Luo, C, Jiang, X.R. | 登録日 | 2018-08-08 | 公開日 | 2018-12-12 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.998 Å) | 主引用文献 | Rational design of 5-((1H-imidazol-1-yl)methyl)quinolin-8-ol derivatives as novel bromodomain-containing protein 4 inhibitors Eur J Med Chem, 163, 2018
|
|
5H65
| Crystal structure of human POT1 and TPP1 | 分子名称: | Adrenocortical dysplasia protein homolog, Protection of telomeres protein 1, ZINC ION | 著者 | Chen, C, Wu, J, Lei, M. | 登録日 | 2016-11-10 | 公開日 | 2017-05-31 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer. Nat Commun, 8, 2017
|
|
6T2E
| Multicomponent Peptide Stapling as a Diversity-Driven Tool for the Development of Inhibitors of Protein-Protein Interactions | 分子名称: | E3 ubiquitin-protein ligase Mdm2, Stapled peptide GAR300-Gm | 著者 | Groves, R.M, Ali, M.A, Atmaj, J, van Oosterwijk, N, Domling, A, Rivera, G.D, Ricardo, G.M. | 登録日 | 2019-10-08 | 公開日 | 2020-01-29 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Multicomponent Peptide Stapling as a Diversity-Driven Tool for the Development of Inhibitors of Protein-Protein Interactions. Angew.Chem.Int.Ed.Engl., 59, 2020
|
|
6T2F
| Multicomponent Peptide Stapling as a Diversity-Driven Tool for the Development of Inhibitors of Protein-Protein Interactions | 分子名称: | 2-(methylamino)-~{N}-[[3-[[2-(methylamino)ethanoylamino]methyl]phenyl]methyl]ethanamide, E3 ubiquitin-protein ligase Mdm2, MDM2 in complex with GAR300-Am | 著者 | Groves, R.M, Ali, M.A, Atmaj, J, van Oosterwijk, N, Domling, A, Rivera, G.D, Ricardo, G.M. | 登録日 | 2019-10-08 | 公開日 | 2020-01-29 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Multicomponent Peptide Stapling as a Diversity-Driven Tool for the Development of Inhibitors of Protein-Protein Interactions. Angew.Chem.Int.Ed.Engl., 59, 2020
|
|
6T2D
| Multicomponent Peptide Stapling as a Diversity-Driven Tool for the Development of Inhibitors of Protein-Protein Interactions | 分子名称: | 2-(methylamino)-~{N}-[[4-[[2-(methylamino)ethanoylamino]methyl]phenyl]methyl]ethanamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DIMETHYL SULFOXIDE, ... | 著者 | Groves, R.M, Ali, M.A, Atmaj, J, van Oosterwijk, N, Domling, A, Rivera, G.D, Ricardo, G.M. | 登録日 | 2019-10-08 | 公開日 | 2020-01-29 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Multicomponent Peptide Stapling as a Diversity-Driven Tool for the Development of Inhibitors of Protein-Protein Interactions. Angew.Chem.Int.Ed.Engl., 59, 2020
|
|
6FZY
| PPAR mutant | 分子名称: | Peroxisome proliferator-activated receptor gamma | 著者 | Rochel, N. | 登録日 | 2018-03-15 | 公開日 | 2019-02-13 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Recurrent activating mutations of PPAR gamma associated with luminal bladder tumors. Nat Commun, 10, 2019
|
|
6FZF
| PPAR mutant complex | 分子名称: | (2~{S})-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]-2-[[2-(phenylcarbonyl)phenyl]amino]propanoic acid, Peroxisome proliferator-activated receptor gamma, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha | 著者 | Rochel, N. | 登録日 | 2018-03-14 | 公開日 | 2019-02-13 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Recurrent activating mutations of PPAR gamma associated with luminal bladder tumors. Nat Commun, 10, 2019
|
|