7MSM
 
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2JXN
 | | Solution Structure of S. cerevisiae PDCD5-like Protein Ymr074cp | | 分子名称: | S-[(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate, Uncharacterized protein YMR074C | | 著者 | Hong, J, Zhang, J, Liu, Z, Shi, Y, Wu, J. | | 登録日 | 2007-11-23 | | 公開日 | 2008-12-02 | | 最終更新日 | 2021-10-20 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution Structure and Dynamics of S. cerevisiae PDCD5-like Protein Ymr074cp Determined by Heteronuclear NMR Spectroscopy
To be Published
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8GXH
 | | The crystal structure of SARS-CoV-2 main protease in complex with 14b | | 分子名称: | 3C-like proteinase nsp5, N-[(2S)-3-cyclohexyl-1-oxidanylidene-1-[[(2S,3R)-3-oxidanyl-4-oxidanylidene-1-[(3S)-2-oxidanylidenepiperidin-3-yl]-4-[(phenylmethyl)amino]butan-2-yl]amino]propan-2-yl]-1-benzofuran-2-carboxamide | | 著者 | Zhao, Y, Zhao, J, Shao, M, Yang, H, Rao, Z. | | 登録日 | 2022-09-20 | | 公開日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | | 主引用文献 | The crystal structure of SARS-CoV-2 main protease in complex with 14b
To Be Published
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2L97
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8H91
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8HQG
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8HUW
 | | Crystal structure of SARS-Cov-2 main protease K90R mutant in complex with S217622 | | 分子名称: | 3C-like proteinase nsp5, 6-[(6-chloranyl-2-methyl-indazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazine-2,4-dione | | 著者 | Wang, J, Zhang, J, Li, J. | | 登録日 | 2022-12-24 | | 公開日 | 2023-06-21 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structural basis for the inhibition of coronaviral main proteases by ensitrelvir.
Structure, 31, 2023
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8HVM
 | | Crystal structure of SARS-Cov-2 main protease K90R mutant in complex with PF07321332 | | 分子名称: | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5 | | 著者 | Wang, J, Zhang, J, Li, J. | | 登録日 | 2022-12-27 | | 公開日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | | 主引用文献 | Crystal structure of SARS-Cov-2 main protease
K90R mutant in complex with PF07321332
To Be Published
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8HVU
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8HVV
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8HVX
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8HVY
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8IG4
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8IG5
 | | Crystal structure of SARS main protease in complex with GC376 | | 分子名称: | 3C-like proteinase nsp5, N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide | | 著者 | Lin, C, Zhang, J, Li, J. | | 登録日 | 2023-02-20 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | | 主引用文献 | Structural Basis for Coronaviral Main Proteases Inhibition by the 3CLpro Inhibitor GC376.
J.Mol.Biol., 436, 2024
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8IG6
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8IG8
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8IG7
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8IG9
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8IGA
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8IGB
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4MSU
 | | Human GKRP bound to AMG-6861 and Sorbitol-6-phosphate | | 分子名称: | 1,1,1,3,3,3-hexafluoro-2-{4-[4-(thiophen-2-ylsulfonyl)piperazin-1-yl]phenyl}propan-2-ol, D-SORBITOL-6-PHOSPHATE, GLYCEROL, ... | | 著者 | Ashton, K.S, Andrews, K.L, Bryan, M.C, Chen, J, Chen, K, Chen, M, Chmait, S, Croghan, M, Cupples, R, Fotsch, C, Helmering, J, Jordan, S.R, Kurzeja, R.J, Michelsen, K, Pennington, L.D, Poon, S.F, Sivits, G, Van, G, Vonderfecht, S.L, Wahl, R.C, Zhang, J, Lloyd, D.J, Hale, C, St Jean, D.J. | | 登録日 | 2013-09-18 | | 公開日 | 2014-03-12 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 1. Discovery of a Novel Tool Compound for in Vivo Proof-of-Concept.
J.Med.Chem., 57, 2014
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8GXI
 | | The crystal structure of SARS-CoV-2 main protease in complex with 14c | | 分子名称: | 3C-like proteinase nsp5, N-[(2S)-3-cyclohexyl-1-[[(2S,3R)-4-(cyclopropylamino)-3-oxidanyl-4-oxidanylidene-1-[(3S)-2-oxidanylidenepiperidin-3-yl]butan-2-yl]amino]-1-oxidanylidene-propan-2-yl]-1-benzofuran-2-carboxamide | | 著者 | Zhao, Y, Zhao, J, Shao, M, Yang, H, Rao, Z. | | 登録日 | 2022-09-20 | | 公開日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | | 主引用文献 | The crystal structure of SARS-CoV-2 main protease in complex with 14c
To Be Published
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8GXG
 | | The crystal structure of SARS-CoV-2 main protease in complex with 14a | | 分子名称: | 3C-like proteinase nsp5, N-[(2S)-3-(4-fluorophenyl)-1-oxidanylidene-1-[[(2S,3S)-3-oxidanyl-4-oxidanylidene-1-[(3S)-2-oxidanylidenepiperidin-3-yl]-4-[(phenylmethyl)amino]butan-2-yl]amino]propan-2-yl]-1-benzofuran-2-carboxamide | | 著者 | Zhao, Y, Zhao, J, Shao, M, Yang, H, Rao, Z. | | 登録日 | 2022-09-20 | | 公開日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | | 主引用文献 | The crystal structure of SARS-CoV-2 main protease in complex with 14a
To Be Published
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6JPD
 | | Mouse receptor-interacting protein kinase 3 (RIP3) amyloid structure by solid-state NMR | | 分子名称: | Receptor-interacting serine/threonine-protein kinase 3 | | 著者 | Wu, X.L, Hu, H, Zhang, J, Dong, X.Q, Wang, J, Schwieters, C, Wang, H.Y, Lu, J.X. | | 登録日 | 2019-03-26 | | 公開日 | 2020-10-28 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLID-STATE NMR | | 主引用文献 | The amyloid structure of mouse RIPK3 (receptor interacting protein kinase 3) in cell necroptosis.
Nat Commun, 12, 2021
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4DWT
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