4APE
 
 | | THE ACTIVE SITE OF ASPARTIC PROTEINASES | | 分子名称: | ENDOTHIAPEPSIN | | 著者 | Pearl, L.H, Sewell, B.T, Jenkins, J.A, Cooper, J.B, Blundell, T.L. | | 登録日 | 1986-06-09 | | 公開日 | 1986-07-14 | | 最終更新日 | 2019-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | The Active Site of Aspartic Proteinases
FEBS Lett., 174, 1984
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7W72
 | | Structure of a human glycosylphosphatidylinositol (GPI) transamidase | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GPI transamidase component PIG-S, ... | | 著者 | Zhang, H, Su, J, Li, B, Gao, Y, Zhang, X.C, Zhao, Y. | | 登録日 | 2021-12-02 | | 公開日 | 2022-02-16 | | 最終更新日 | 2022-03-30 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structure of human glycosylphosphatidylinositol transamidase.
Nat.Struct.Mol.Biol., 29, 2022
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7WB4
 | | Cryo-EM structure of the NR subunit from X. laevis NPC | | 分子名称: | GATOR complex protein SEC13, MGC154553 protein, MGC83295 protein, ... | | 著者 | Huang, G, Zhan, X, Shi, Y. | | 登録日 | 2021-12-15 | | 公開日 | 2022-03-02 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (5.6 Å) | | 主引用文献 | Cryo-EM structure of the nuclear ring from Xenopus laevis nuclear pore complex.
Cell Res., 32, 2022
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7WKK
 | | Cryo-EM structure of the IR subunit from X. laevis NPC | | 分子名称: | Aaas-prov protein, IL4I1 protein, MGC83295 protein, ... | | 著者 | Huang, G, Zhan, X, Shi, Y. | | 登録日 | 2022-01-10 | | 公開日 | 2022-03-30 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Cryo-EM structure of the inner ring from the Xenopus laevis nuclear pore complex.
Cell Res., 32, 2022
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7W9N
 | | THE STRUCTURE OF OBA33-OTA COMPLEX | | 分子名称: | (2~{S})-2-[[(3~{R})-5-chloranyl-3-methyl-8-oxidanyl-1-oxidanylidene-3,4-dihydroisochromen-7-yl]carbonylamino]-3-phenyl-propanoic acid, OTA DNA APTAMER (33-MER) | | 著者 | Xu, G.H, Li, C.G. | | 登録日 | 2021-12-10 | | 公開日 | 2022-01-19 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural Insights into the Mechanism of High-Affinity Binding of Ochratoxin A by a DNA Aptamer.
J.Am.Chem.Soc., 144, 2022
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7X9E
 | | Crystal structure of the 76E1 Fab in complex with a SARS-CoV-2 spike peptide | | 分子名称: | 76E1 Fab Heavy Chain, 76E1 Fab Light Chain, Spike peptide | | 著者 | Chen, X, Zhang, T, Ding, J, Sun, X, Sun, B. | | 登録日 | 2022-03-15 | | 公開日 | 2022-05-11 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Neutralization mechanism of a human antibody with pan-coronavirus reactivity including SARS-CoV-2.
Nat Microbiol, 7, 2022
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4ER2
 | | The active site of aspartic proteinases | | 分子名称: | ENDOTHIAPEPSIN, PEPSTATIN, SULFATE ION | | 著者 | Bailey, D, Veerapandian, B, Cooper, J.B, Blundell, T.L. | | 登録日 | 1990-10-20 | | 公開日 | 1991-01-15 | | 最終更新日 | 2017-11-29 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The active site of aspartic proteinases
FEBS Lett., 174, 1984
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2ER9
 | | X-RAY STUDIES OF ASPARTIC PROTEINASE-STATINE INHIBITOR COMPLEXES. | | 分子名称: | ENDOTHIAPEPSIN, L363,564 | | 著者 | Cooper, J.B, Foundling, S.I, Boger, J, Blundell, T.L. | | 登録日 | 1990-10-20 | | 公開日 | 1991-01-15 | | 最終更新日 | 2017-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | X-ray studies of aspartic proteinase-statine inhibitor complexes.
Biochemistry, 28, 1989
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2ER0
 | | X-RAY STUDIES OF ASPARTIC PROTEINASE-STATINE INHIBITOR COMPLEXES | | 分子名称: | ENDOTHIAPEPSIN, L364,099 | | 著者 | Cooper, J.B, Foundling, S.I, Boger, J, Blundell, T.L. | | 登録日 | 1990-10-20 | | 公開日 | 1991-01-15 | | 最終更新日 | 2017-11-29 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | X-ray studies of aspartic proteinase-statine inhibitor complexes.
Biochemistry, 28, 1989
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7C8U
 | | The crystal structure of COVID-19 main protease in complex with GC376 | | 分子名称: | (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase | | 著者 | Luan, X, Shang, W, Wang, Y, Yin, W, Jiang, Y, Feng, S, Wang, Y, Liu, M, Zhou, R, Zhang, Z, Wang, F, Cheng, W, Gao, M, Wang, H, Wu, W, Tian, R, Tian, Z, Jin, Y, Jiang, H.W, Zhang, L, Xu, H.E, Zhang, S. | | 登録日 | 2020-06-03 | | 公開日 | 2020-06-24 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | The crystal structure of COVID-19 main protease in complex with GC376
To Be Published
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5FDL
 | | Crystal Structure of K103N/Y181C Mutant HIV-1 Reverse Transcriptase (RT) in Complex with IDX899 | | 分子名称: | P51 Reverse transcriptase, P66 Reverse transcriptase, methyl (R)-(2-carbamoyl-5-chloro-1H-indol-3-yl)[3-(2-cyanoethyl)-5-methylphenyl]phosphinate | | 著者 | Dousson, C.B, Alexandre, F.-R, Convard, T, Fisher, M, Lamers, M.B.A.C, Leonard, P.M. | | 登録日 | 2015-12-16 | | 公開日 | 2016-02-17 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Discovery of the Aryl-phospho-indole IDX899, a Highly Potent Anti-HIV Non-nucleoside Reverse Transcriptase Inhibitor.
J.Med.Chem., 59, 2016
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4TYD
 | | Structure-based design of a novel series of azetidine inhibitors of the hepatitis C virus NS3/4A serine protease | | 分子名称: | (4R,6S,7Z,15S,17S)-17-[({7-methoxy-2-[4-(propan-2-yl)-1,3-thiazol-2-yl]quinolin-4-yl}oxy)methyl]-13-methyl-N-[(1-methylcyclopropyl)sulfonyl]-2,14-dioxo-1,3,13-triazatricyclo[13.2.0.0~4,6~]heptadec-7-ene-4-carboxamide, CHLORIDE ION, NS3 protease, ... | | 著者 | Parsy, C. | | 登録日 | 2014-07-08 | | 公開日 | 2014-09-10 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | | 主引用文献 | Structure-based design of a novel series of azetidine inhibitors of the hepatitis C virus NS3/4A serine protease.
Bioorg.Med.Chem.Lett., 24, 2014
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6RIU
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5K0M
 | | Targeting the PRC2 complex through a novel protein-protein interaction inhibitor of EED | | 分子名称: | (3R,4S)-1-[(1S)-7-fluoro-2,3-dihydro-1H-inden-1-yl]-N,N-dimethyl-4-{4-[4-(methylsulfonyl)piperazin-1-yl]phenyl}pyrrolidin-3-amine, Polycomb protein EED | | 著者 | Jakob, C.G, Bigelow, L.J, Zhu, H, Sun, C. | | 登録日 | 2016-05-17 | | 公開日 | 2017-01-25 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.
Nat. Chem. Biol., 13, 2017
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8PI3
 | | Cathepsin S Y132D mutant in complex with NNPI-C10 inhibitor | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, CADMIUM ION, ... | | 著者 | Petruzzella, A, Lau, K, Pojer, F, Oricchio, E. | | 登録日 | 2023-06-21 | | 公開日 | 2024-06-05 | | 最終更新日 | 2024-09-11 | | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | | 主引用文献 | Antibody-peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins.
Nat.Chem.Biol., 20, 2024
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8RND
 | | Cathepsin S in complex with NNPI-C10 inhibitor | | 分子名称: | 1,2-ETHANEDIOL, Cathepsin S, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Petruzzella, A, Lau, K, Pojer, F, Oricchio, E. | | 登録日 | 2024-01-09 | | 公開日 | 2024-06-05 | | 最終更新日 | 2024-09-11 | | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | | 主引用文献 | Antibody-peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins.
Nat.Chem.Biol., 20, 2024
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5CZB
 | | HCV NS5B IN COMPLEX WITH LIGAND IDX17119-5 | | 分子名称: | 1-[4-(7-amino-5-methylpyrazolo[1,5-a]pyrimidin-2-yl)phenyl]-3-{[(R)-(2,4-dimethylphenyl)(methoxy)phosphoryl]amino}-1H-pyrazole-4-carboxylic acid, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Pierra, C, Dousson, C, Augustin, M. | | 登録日 | 2015-07-31 | | 公開日 | 2016-06-15 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Synthesis of potent and broad genotypically active NS5B HCV non-nucleoside inhibitors binding to the thumb domain allosteric site 2 of the viral polymerase.
Bioorg.Med.Chem.Lett., 26, 2016
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