8KBE
 
 | | Structure of CbTad1 complexed with 1',3'-cADPR | | 分子名称: | (2R,3R,3aS,5S,6R,7S,8R,11R,13S,15aR)-2-(6-amino-9H-purin-9-yl)-3,6,7,11,13-pentahydroxyoctahydro-2H,5H,11H,13H-5,8-epoxy-11lambda~5~,13lambda~5~-furo[2,3-g][1,3,5,9,2,4]tetraoxadiphosphacyclotetradecine-11,13-dione, Thoeris anti-defense 1 | | 著者 | Xiao, Y, Feng, Y. | | 登録日 | 2023-08-04 | | 公開日 | 2024-08-07 | | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | | 主引用文献 | Structure of CbTad1 complexed with 1',3'-cADPR
To Be Published
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8KBF
 | | Structure of CbTad1 complexed with 1',3'-cADPR and cA3 | | 分子名称: | (2-ACETYL-5-METHYLANILINO)(2,6-DIBROMOPHENYL)ACETAMIDE, (2R,3R,3aS,5S,6R,7S,8R,11R,13S,15aR)-2-(6-amino-9H-purin-9-yl)-3,6,7,11,13-pentahydroxyoctahydro-2H,5H,11H,13H-5,8-epoxy-11lambda~5~,13lambda~5~-furo[2,3-g][1,3,5,9,2,4]tetraoxadiphosphacyclotetradecine-11,13-dione, Thoeris anti-defense 1 | | 著者 | Xiao, Y, Feng, Y. | | 登録日 | 2023-08-04 | | 公開日 | 2024-08-07 | | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | | 主引用文献 | Structure of CbTad1 complexed with 1',3'-cADPR and cA3
To Be Published
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8KBB
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8KBK
 | | Structure of AcrIIA7 complexed with 1',2'-cADPR and cGG | | 分子名称: | (1S,3R,4R,6R,9S,11R,14R,15S,16R,18R)-4-(6-amino-9H-purin-9-yl)-9,11,15,16,18-pentahydroxy-2,5,8,10,12,17-hexaoxa-9lambda~5~,11lambda~5~-diphosphatricyclo[12.2.1.1~3,6~]octadecane-9,11-dione, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Inhibitor of Type II CRISPR-Cas system | | 著者 | Xiao, Y, Feng, Y. | | 登録日 | 2023-08-04 | | 公開日 | 2024-08-07 | | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | | 主引用文献 | Structure of AcrIIA7 complexed with 1',2'-cADPR and cGG
To Be Published
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8KBI
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8KBL
 | | Structure of AcrIIA7 complexed with 1',3'-cADPR and cGG | | 分子名称: | (2R,3R,3aS,5S,6R,7S,8R,11R,13S,15aR)-2-(6-amino-9H-purin-9-yl)-3,6,7,11,13-pentahydroxyoctahydro-2H,5H,11H,13H-5,8-epoxy-11lambda~5~,13lambda~5~-furo[2,3-g][1,3,5,9,2,4]tetraoxadiphosphacyclotetradecine-11,13-dione, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Inhibitor of Type II CRISPR-Cas system | | 著者 | Xiao, Y, Feng, Y. | | 登録日 | 2023-08-04 | | 公開日 | 2024-08-07 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | Structure of AcrIIA7 complexed with 1',3'-cADPR and cGG
To Be Published
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8KBD
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8KBJ
 | | Structure of HgmTad2 complexed with 1',2'-cADPR | | 分子名称: | (1S,3R,4R,6R,9S,11R,14R,15S,16R,18R)-4-(6-amino-9H-purin-9-yl)-9,11,15,16,18-pentahydroxy-2,5,8,10,12,17-hexaoxa-9lambda~5~,11lambda~5~-diphosphatricyclo[12.2.1.1~3,6~]octadecane-9,11-dione, Inhibitor of Type II CRISPR-Cas system | | 著者 | Xiao, Y, Feng, Y. | | 登録日 | 2023-08-04 | | 公開日 | 2024-08-21 | | 最終更新日 | 2024-09-04 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structure of HgmTad2 complexed with 1',2'-cADPR
To Be Published
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8KBG
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8KBC
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8KBM
 | | Structure of AcrIIA7 complexed with cGG | | 分子名称: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Inhibitor of Type II CRISPR-Cas system | | 著者 | Xiao, Y, Feng, Y. | | 登録日 | 2023-08-04 | | 公開日 | 2024-08-07 | | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | | 主引用文献 | Structure of AcrIIA7 complexed with cGG
To Be Published
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8KBH
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6KF1
 | | Microbial Hormone-sensitive lipase- E53 mutant S162A | | 分子名称: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, HEXANOIC ACID, ... | | 著者 | Xiaochen, Y, Zhengyang, L, Xuewei, X, Jixi, L. | | 登録日 | 2019-07-05 | | 公開日 | 2020-07-08 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.996 Å) | | 主引用文献 | Functional and Structural Insights into Environmental Adaptation of a Novel Hormone-sensitive Lipase, E53, Obtained from Erythrobacter longus
To Be Published
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6KF7
 | | Microbial Hormone-sensitive lipase E53 mutant S285G | | 分子名称: | (4-nitrophenyl) hexanoate, 1,2-ETHANEDIOL, GLYCEROL, ... | | 著者 | Xiaochen, Y, Zhengyang, L, Xuewei, X, Jixi, L. | | 登録日 | 2019-07-06 | | 公開日 | 2020-07-08 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Microbial Hormone-sensitive lipase E53 mutant S285G
To Be Published
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8W4C
 | | The sigma-1 receptor from Xenopus laevis in complex with progesterone by soaking | | 分子名称: | PROGESTERONE, Sigma non-opioid intracellular receptor 1 | | 著者 | Xiao, Y, Fu, C, Sun, Z, Zhou, X. | | 登録日 | 2023-08-23 | | 公開日 | 2024-07-17 | | 実験手法 | X-RAY DIFFRACTION (2.676 Å) | | 主引用文献 | Insight into binding of endogenous neurosteroid ligands to the sigma-1 receptor.
Nat Commun, 15, 2024
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8W4B
 | | The sigma-1 receptor from Xenopus laevis in complex with progesterone by co-crystallization | | 分子名称: | PROGESTERONE, Sigma non-opioid intracellular receptor 1 | | 著者 | Xiao, Y, Fu, C, Sun, Z, Zhou, X. | | 登録日 | 2023-08-23 | | 公開日 | 2024-07-17 | | 実験手法 | X-RAY DIFFRACTION (2.152 Å) | | 主引用文献 | Insight into binding of endogenous neurosteroid ligands to the sigma-1 receptor.
Nat Commun, 15, 2024
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8W4D
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8YBB
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8W4E
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8H67
 | | type I-B Cascade bound to a PAM-containing dsDNA target at 3.8 angstrom resolution. | | 分子名称: | CRISPR RNA, CRISPR associated protein Cas11b, CRISPR associated protein Cas5, ... | | 著者 | Xiao, Y, Lu, M, Yu, C, Zhang, Y. | | 登録日 | 2022-10-15 | | 公開日 | 2024-05-01 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structure and genome editing of type I-B CRISPR-Cas.
Nat Commun, 15, 2024
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8IP0
 | | Cryo-EM structure of type I-B Cascade bound to a PAM-containing dsDNA target at 3.6 angstrom resolution | | 分子名称: | CRISPR associated protein Cas11b, DNA (41-MER), DNA (5'-D(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), ... | | 著者 | Xiao, Y, Lu, M, Yu, C, Zhang, Y. | | 登録日 | 2023-03-13 | | 公開日 | 2024-03-20 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structure and genome editing of type I-B CRISPR-Cas.
Nat Commun, 15, 2024
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7WNV
 | | Crystal structure of mutant estrogen receptor alpha Y537S in complex with CO9 | | 分子名称: | (~{Z})-4-[2-[4-[[2-(4-hydroxyphenyl)-6-oxidanyl-1-benzothiophen-3-yl]oxy]phenoxy]ethylamino]-~{N},~{N}-dimethyl-but-2-enamide, Estrogen receptor | | 著者 | Xiao, Y, Lv, Y. | | 登録日 | 2022-01-19 | | 公開日 | 2023-01-25 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | X-ray crystallography study and optimization of novel benzothiophene analogs as potent selective estrogen receptor covalent antagonists (SERCAs) with improved potency and safety profiles.
Bioorg.Chem., 141, 2023
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8IVY
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4KFP
 | | Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived Ureas as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) | | 分子名称: | 1,2-ETHANEDIOL, N-(4-{[1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl]sulfonyl}benzyl)-2H-pyrrolo[3,4-c]pyridine-2-carboxamide, Nicotinamide phosphoribosyltransferase, ... | | 著者 | Dragovich, P.S, Bair, K.W, Baumeister, T, Ho, Y, Liederer, B.M, Liu, X, O'Brien, T, Oeh, J, Sampath, D, Skelton, N, Wang, L, Wang, W, Wu, H, Xiao, Y, Yuen, P, Zak, M, Zhang, L, Zheng, X. | | 登録日 | 2013-04-27 | | 公開日 | 2013-08-14 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | | 主引用文献 | Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg.Med.Chem.Lett., 23, 2013
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5HQB
 | | A Glycoside Hydrolase Family 97 enzyme (E480Q) in complex with Panose from Pseudoalteromonas sp. strain K8 | | 分子名称: | Alpha-glucosidase, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Li, J, He, C, Xiao, Y. | | 登録日 | 2016-01-21 | | 公開日 | 2017-01-11 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structures of PspAG97A alpha-glucoside hydrolase reveal a novel mechanism for chloride induced activation.
J. Struct. Biol., 196, 2016
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