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Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 33 bound to EGFR[V948R]
分子名称:	1-cyclopropyl-~{N}-[3-[1-(1-propanoylazetidin-3-yl)-4-pyridin-4-yl-pyrazol-3-yl]phenyl]imidazole-4-carboxamide, ADENOSINE-5'-TRIPHOSPHATE, Epidermal growth factor receptor, ...
著者	Hargreaves, D.
登録日	2023-07-03
公開日	2024-06-05
最終更新日	2024-06-19
実験手法	X-RAY DIFFRACTION (1.621 Å)
主引用文献	Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. J.Med.Chem., 67, 2024

Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 16 bound to EGFR
分子名称:	1-[(3~{S})-3-[4-(6,7-dimethoxyquinazolin-4-yl)-3-(3-methoxyphenyl)pyrazol-1-yl]pyrrolidin-1-yl]propan-1-one, Epidermal growth factor receptor
著者	Hargreaves, D.
登録日	2023-07-03
公開日	2024-06-05
最終更新日	2024-06-19
実験手法	X-RAY DIFFRACTION (2.51 Å)
主引用文献	Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. J.Med.Chem., 67, 2024

crystal structure of monoclonal antibody MR78 Fab
分子名称:	SODIUM ION, marberg virus monoclonal antibody MR78 Fab heavy chain, marberg virus monoclonal antibody MR78 Fab light chain
著者	Dong, J, Crowe, J.
登録日	2016-05-06
公開日	2017-11-08
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Role of Non-local Interactions between CDR Loops in Binding Affinity of MR78 Antibody to Marburg Virus Glycoprotein. Structure, 25, 2017