4AGE
 
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4AGF
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5AGC
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8SBE
 | | Structure of the rat vesicular glutamate transporter 2 determined by single-particle Cryo-EM | | 分子名称: | Vesicular glutamate transporter 2 | | 著者 | Li, F, Finer-Moore, J, Eriksen, J, Cheng, Y, Edwards, R, Stroud, R. | | 登録日 | 2023-04-03 | | 公開日 | 2023-05-03 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Ion transport and regulation in a synaptic vesicle glutamate transporter.
Science, 368, 2020
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8ATG
 | | Pentameric ligand-gated ion channel GLIC with bound lipids | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Proton-gated ion channel | | 著者 | Bergh, C, Rovsnik, U, Howard, R.J, Lindahl, E. | | 登録日 | 2022-08-23 | | 公開日 | 2023-09-06 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Discovery of lipid binding sites in a ligand-gated ion channel by integrating simulations and cryo-EM.
Elife, 12, 2024
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8U1D
 | | Cryo-EM structure of vaccine-elicited CD4 binding site antibody DH1285 bound to HIV-1 CH505TFchim.6R.SOSIP.664v4.1 Env Local Refinement | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, DH1285 Heavy Chain, DH1285 Light Chain, ... | | 著者 | Thakur, B, Stalls, V.D, Acharya, P. | | 登録日 | 2023-08-31 | | 公開日 | 2024-01-03 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (4.25 Å) | | 主引用文献 | Vaccine induction of CD4-mimicking HIV-1 broadly neutralizing antibody precursors in macaques.
Cell, 187, 2024
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8SXI
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8SXJ
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7OBO
 | | GSTF1 from Alopecurus myosuroides | | 分子名称: | (2~{S})-2-azanyl-5-[[(2~{R})-1-(2-hydroxy-2-oxoethylamino)-3-[(7-nitro-2,1,3-benzoxadiazol-4-yl)sulfanyl]-1-oxidanylidene-propan-2-yl]amino]-5-oxidanylidene-pentanoic acid, Glutathione transferase | | 著者 | Pohl, E, Eno, R.F.M, Freitag-Pohl, S. | | 登録日 | 2021-04-23 | | 公開日 | 2022-04-20 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Flavonoid-based inhibitors of the Phi-class glutathione transferase from black-grass to combat multiple herbicide resistance.
Org.Biomol.Chem., 19, 2021
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7ODM
 | | AmGSTF1 Y118S variant | | 分子名称: | Glutathione transferase, [(2~{S})-5-[[(2~{R})-1-(2-hydroxy-2-oxoethylamino)-1-oxidanylidene-3-sulfanyl-propan-2-yl]amino]-1-oxidanyl-1,5-bis(oxidanylidene)pentan-2-yl]azanium | | 著者 | Pohl, E, Eno, R.F.M. | | 登録日 | 2021-04-30 | | 公開日 | 2022-04-20 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Flavonoid-based inhibitors of the Phi-class glutathione transferase from black-grass to combat multiple herbicide resistance.
Org.Biomol.Chem., 19, 2021
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1E6B
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6TO3
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3L6D
 | | Crystal structure of putative oxidoreductase from Pseudomonas putida KT2440 | | 分子名称: | Putative oxidoreductase | | 著者 | Malashkevich, V.N, Patskovsky, Y, Toro, R, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | | 登録日 | 2009-12-23 | | 公開日 | 2010-01-12 | | 最終更新日 | 2021-02-10 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal structure of putative oxidoreductase from Pseudomonas putida KT2440
To be Published
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3LCC
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5ELA
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5ELG
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5EL8
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3UEN
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3UEO
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3B2R
 | | Crystal Structure of PDE5A1 catalytic domain in complex with Vardenafil | | 分子名称: | 2-{2-ETHOXY-5-[(4-ETHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-5-METHYL-7-PROPYLIMIDAZO[5,1-F][1,2,4]TRIAZIN-4(1H)-ONE, cGMP-specific 3',5'-cyclic phosphodiesterase | | 著者 | Huanchen, W, Mengchun, Y, Howard, R, Sharron, H.F, Hengming, K. | | 登録日 | 2007-10-19 | | 公開日 | 2008-05-20 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | | 主引用文献 | Conformational variations of both phosphodiesterase-5 and inhibitors provide the structural basis for the physiological effects of vardenafil and sildenafil.
Mol.Pharmacol., 73, 2008
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3BJC
 | | Crystal structure of the PDE5A catalytic domain in complex with a novel inhibitor | | 分子名称: | 5-ethoxy-4-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)thiophene-2-sulfonamide, MAGNESIUM ION, ZINC ION, ... | | 著者 | Chen, G, Wang, H, Howard, R, Cai, J, Wan, Y, Ke, H. | | 登録日 | 2007-12-03 | | 公開日 | 2008-04-29 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | An insight into the pharmacophores of phosphodiesterase-5 inhibitors from synthetic and crystal structural studies
BIOCHEM.PHARM., 75, 2008
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5SYD
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5UA3
 | | Crystal Structure of a DNA G-Quadruplex with a Cytosine Bulge | | 分子名称: | DNA (5'-D(*GP*GP*GP*TP*TP*GP*CP*GP*GP*AP*GP*GP*GP*TP*GP*GP*GP*CP*CP*T)-3'), POTASSIUM ION | | 著者 | Meier, M, McDougall, M.D, Krahn, N.J, Moya-Torres, A, McRae, E.K.S, Booy, E.P, Patel, T.R, McKenna, S.A, Stetefeld, J. | | 登録日 | 2016-12-18 | | 公開日 | 2017-11-22 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.8802 Å) | | 主引用文献 | Structure and hydrodynamics of a DNA G-quadruplex with a cytosine bulge.
Nucleic Acids Res., 46, 2018
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2YEK
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2YEL
 | | Crystal Structure of the First Bromodomain of Human Brd4 with the inhibitor GW841819X | | 分子名称: | 1,2-ETHANEDIOL, BENZYL [(4R)-1-METHYL-6-PHENYL-4H-[1,2,4]TRIAZOLO[4,3-A][1,4]BENZODIAZEPIN-4-YL]CARBAMATE, HUMAN BRD4 | | 著者 | Chung, C.W. | | 登録日 | 2011-03-25 | | 公開日 | 2011-06-15 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Discovery and Characterization of Small Molecule Inhibitors of the Bet Family Bromodomains.
J.Med.Chem., 54, 2011
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