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2W79
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BU of 2w79 by Molmil
Establishing wild-type levels of catalytic activity on natural and artificial (ba)8-barrel protein scaffolds
分子名称: 1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO) METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE, CHLORIDE ION
著者Claren, J, Malisi, C, Hocker, B, Sterner, R.
登録日2008-12-21
公開日2009-02-17
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Establishing Wild-Type Levels of Catalytic Activity on Natural and Artificial (Beta Alpha)8- Barrel Protein Scaffolds.
Proc.Natl.Acad.Sci.USA, 106, 2009
2WJZ
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BU of 2wjz by Molmil
Crystal structure of (HisH) K181A Y138A mutant of imidazoleglycerolphosphate synthase (HisH HisF) which displays constitutive glutaminase activity
分子名称: IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISF, IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISH, PHOSPHATE ION
著者Vega, M.C, List, F, Razeto, A, Haeger, M.C, Babinger, K, Kuper, J, Sterner, R, Wilmanns, M.
登録日2009-06-02
公開日2010-08-25
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.601 Å)
主引用文献Catalysis Uncoupling in a Glutamine Amidotransferase Bienzyme by Unblocking the Glutaminase Active Site.
Chem.Biol., 19, 2012
6RG0
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BU of 6rg0 by Molmil
Structure of pdxj
分子名称: Pyridoxine 5'-phosphate synthase
著者Rohweder, B, Rajendran, C, Sterner, R.
登録日2019-04-16
公開日2020-05-13
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.074 Å)
主引用文献Library Selection with a Randomized Repertoire of ( beta alpha )8-Barrel Enzymes Results in Unexpected Induction of Gene Expression.
Biochemistry, 58, 2019
3MNP
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BU of 3mnp by Molmil
Crystal structure of the agonist form of mouse glucocorticoid receptor stabilized by (A611V, V708A, E711G) mutations at 1.50A
分子名称: DEXAMETHASONE, GLYCEROL, Glucocorticoid receptor, ...
著者Schoch, G.A, Seitz, T, Benz, J, Banner, D, Stihle, M, D'Arcy, B, Thoma, R, Sterner, R, Hennig, M, Ruf, A.
登録日2010-04-22
公開日2010-09-15
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Enhancing the stability and solubility of the glucocorticoid receptor ligand-binding domain by high-throughput library screening.
J.Mol.Biol., 403, 2010
3MNE
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BU of 3mne by Molmil
Crystal structure of the agonist form of mouse glucocorticoid receptor stabilized by F608S mutation at 1.96A
分子名称: DEXAMETHASONE, GLYCEROL, Glucocorticoid receptor, ...
著者Schoch, G.A, Seitz, T, Benz, J, Banner, D, Stihle, M, D'Arcy, B, Thoma, R, Sterner, R, Hennig, M, Ruf, A.
登録日2010-04-21
公開日2010-09-15
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Enhancing the stability and solubility of the glucocorticoid receptor ligand-binding domain by high-throughput library screening.
J.Mol.Biol., 403, 2010
3MNO
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BU of 3mno by Molmil
Crystal structure of the agonist form of mouse glucocorticoid receptor stabilized by (A611V, F608S) mutations at 1.55A
分子名称: DEXAMETHASONE, GLYCEROL, Glucocorticoid receptor, ...
著者Schoch, G.A, Seitz, T, Benz, J, Banner, D, Stihle, M, D'Arcy, B, Thoma, R, Sterner, R, Hennig, M, Ruf, A.
登録日2010-04-22
公開日2010-09-15
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Enhancing the stability and solubility of the glucocorticoid receptor ligand-binding domain by high-throughput library screening.
J.Mol.Biol., 403, 2010
1ZYK
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BU of 1zyk by Molmil
Anthranilate Phosphoribosyltransferase in complex with PRPP, anthranilate and magnesium
分子名称: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-AMINOBENZOIC ACID, Anthranilate phosphoribosyltransferase, ...
著者Marino, M, Deuss, M, Sterner, R, Mayans, O.
登録日2005-06-10
公開日2006-05-23
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural and mutational analysis of substrate complexation by anthranilate phosphoribosyltransferase from Sulfolobus solfataricus.
J.Biol.Chem., 281, 2006
1ZXY
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BU of 1zxy by Molmil
Anthranilate Phosphoribosyltransferase from Sulfolobus solfataricus in complex with PRPP and Magnesium
分子名称: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, MAGNESIUM ION
著者Marino, M, Deuss, M, Sterner, R, Mayans, O.
登録日2005-06-09
公開日2006-05-23
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.56 Å)
主引用文献Structural and mutational analysis of substrate complexation by anthranilate phosphoribosyltransferase from Sulfolobus solfataricus.
J.Biol.Chem., 281, 2006
1LBM
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BU of 1lbm by Molmil
CRYSTAL STRUCTURE OF PHOSPHORIBOSYL ANTHRANILATE ISOMERASE (PRAI) IN COMPLEX WITH REDUCED 1-(O-CARBOXYPHENYLAMINO)-1-DEOXYRIBULOSE 5-PHOSPHATE (RCDRP)
分子名称: 1-(O-CARBOXY-PHENYLAMINO)-1-DEOXY-D-RIBULOSE-5-PHOSPHATE, PHOSPHORIBOSYL ANTHRANILATE ISOMERASE
著者Hennig, M, Sterner, R, Kirschner, K.
登録日2002-04-04
公開日2002-12-18
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Two (betaalpha)(8)-barrel enzymes of histidine and tryptophan biosynthesis have similar reaction mechanisms and common strategies for protecting their labile substrates
Biochemistry, 41, 2002
5NF1
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BU of 5nf1 by Molmil
crystal structure of variants
分子名称: Geranylgeranylglyceryl phosphate synthase
著者Linde, M, Rajendran, C, Babinger, P, Sterner, R.
登録日2017-03-13
公開日2018-05-16
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.697 Å)
主引用文献crystal structure of variants
To Be Published
1ROF
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BU of 1rof by Molmil
NMR STUDY OF 4FE-4S FERREDOXIN OF THERMATOGA MARITIMA
分子名称: FERREDOXIN, IRON/SULFUR CLUSTER
著者Roesch, P, Sticht, H, Wildegger, G, Bentrop, D, Darimont, B, Sterner, R.
登録日1995-11-24
公開日1996-06-10
最終更新日2022-03-02
実験手法SOLUTION NMR
主引用文献An NMR-derived model for the solution structure of oxidized Thermotoga maritima 1[Fe4-S4] ferredoxin.
Eur.J.Biochem., 237, 1996
1K9V
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BU of 1k9v by Molmil
Structural evidence for ammonia tunelling across the (beta-alpha)8-barrel of the imidazole glycerol phosphate synthase bienzyme complex
分子名称: ACETIC ACID, Amidotransferase hisH
著者Douangamath, A, Walker, M, Beismann-Driemeyer, S, Vega-Fernandez, M.C, Sterner, R, Wilmanns, M.
登録日2001-10-31
公開日2002-02-20
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural evidence for ammonia tunneling across the (beta alpha)(8) barrel of the imidazole glycerol phosphate synthase bienzyme complex.
Structure, 10, 2002
3OG3
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BU of 3og3 by Molmil
Crystal structure of an artificial thermostable (BA)8-barrel protein from identical half barrels
分子名称: CHLORIDE ION, Imidazole glycerol phosphate synthase subunit hisF, SULFATE ION
著者Sperl, J.M, Bocola, M, List, F, Kellerer, B, Sterner, R.
登録日2010-08-16
公開日2011-08-17
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.08 Å)
主引用文献Design of an artificial thermostable (BA)8-barrel protein from identical half barrels
To be Published
4JEJ
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BU of 4jej by Molmil
GGGPS from Flavobacterium johnsoniae
分子名称: Geranylgeranylglyceryl phosphate synthase, MAGNESIUM ION, PHOSPHATE ION, ...
著者Peterhoff, D, Beer, B, Rajendran, C, Kumpula, E.P, Kapetaniou, E, Guldan, H, Wierenga, R.K, Sterner, R, Babinger, P.
登録日2013-02-27
公開日2014-06-25
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献A comprehensive analysis of the geranylgeranylglyceryl phosphate synthase enzyme family identifies novel members and reveals mechanisms of substrate specificity and quaternary structure organization.
Mol.Microbiol., 92, 2014
4J5N
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BU of 4j5n by Molmil
Crystal Structure of a Deinococcus radiodurans PTE-like lactonase (drPLL) mutant Y28L/D71N/E101G/E179D/V235L/L270M
分子名称: COBALT (II) ION, Phosphotriesterase, putative
著者Meier, M.M, Rajendran, C, Malisi, C, Fox, N.G, Xu, C, Schlee, S, Barondeau, D.P, Hocker, B, Sterner, R, Raushel, F.M.
登録日2013-02-08
公開日2013-07-24
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Molecular engineering of organophosphate hydrolysis activity from a weak promiscuous lactonase template.
J.Am.Chem.Soc., 135, 2013
4MM1
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BU of 4mm1 by Molmil
GGGPS from Methanothermobacter thermautotrophicus
分子名称: Geranylgeranylglyceryl phosphate synthase, SN-GLYCEROL-1-PHOSPHATE, TRIETHYLENE GLYCOL
著者Rajendran, C, Peterhoff, D, Beer, B, Kumpula, E.P, Kapetaniou, E, Guldan, H, Wierenga, R.K, Sterner, R, Babinger, P.
登録日2013-09-07
公開日2014-06-25
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.8004 Å)
主引用文献A comprehensive analysis of the geranylgeranylglyceryl phosphate synthase enzyme family identifies novel members and reveals mechanisms of substrate specificity and quaternary structure organization.
Mol.Microbiol., 92, 2014
8BLN
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BU of 8bln by Molmil
Structure of RutB
分子名称: Ureidoacrylate amidohydrolase RutB
著者Rajendran, C.
登録日2022-11-09
公開日2023-09-20
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Structural and Functional Characterization of the Ureidoacrylate Amidohydrolase RutB from Escherichia coli .
Biochemistry, 62, 2023
1NSJ
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BU of 1nsj by Molmil
CRYSTAL STRUCTURE OF PHOSPHORIBOSYL ANTHRANILATE ISOMERASE FROM THERMOTOGA MARITIMA
分子名称: PHOSPHATE ION, PHOSPHORIBOSYL ANTHRANILATE ISOMERASE
著者Hennig, M, Jansonius, J.N.J.
登録日1996-09-13
公開日1997-03-12
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure at 2.0 A resolution of phosphoribosyl anthranilate isomerase from the hyperthermophile Thermotoga maritima: possible determinants of protein stability.
Biochemistry, 36, 1997
6QUR
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BU of 6qur by Molmil
Mapping the allosteric communication network of aminodeoxychorismate synthase
分子名称: Glutaminase
著者Semmelmann, F, Straub, K, Rajendran, C, Nazet, J.
登録日2019-02-28
公開日2019-06-05
最終更新日2019-09-25
実験手法X-RAY DIFFRACTION (1.792 Å)
主引用文献Mapping the Allosteric Communication Network of Aminodeoxychorismate Synthase.
J.Mol.Biol., 431, 2019
8BLM
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BU of 8blm by Molmil
Structure of RutB
分子名称: Ureidoacrylate amidohydrolase RutB
著者Rajendran, C.
登録日2022-11-09
公開日2023-01-25
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and Functional Characterization of the Ureidoacrylate Amidohydrolase RutB from Escherichia coli .
Biochemistry, 62, 2023
8BKD
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BU of 8bkd by Molmil
structure of RutB
分子名称: N-(AMINOCARBONYL)-BETA-ALANINE, Ureidoacrylate amidohydrolase RutB
著者Rajendran, C.
登録日2022-11-09
公開日2023-01-25
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structural and Functional Characterization of the Ureidoacrylate Amidohydrolase RutB from Escherichia coli .
Biochemistry, 62, 2023
8BLL
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BU of 8bll by Molmil
Structure of RutB
分子名称: ACETATE ION, Ureidoacrylate amidohydrolase RutB
著者Rajendran, C.
登録日2022-11-09
公開日2023-01-25
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献Structural and Functional Characterization of the Ureidoacrylate Amidohydrolase RutB from Escherichia coli .
Biochemistry, 62, 2023
7AC8
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BU of 7ac8 by Molmil
Molecular basis for the unique allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex.
分子名称: GLUTAMINE, Imidazole glycerol phosphate synthase subunit HisF, Imidazole glycerol phosphate synthase subunit HisH, ...
著者Sung, S, Wilmanns, M.
登録日2020-09-10
公開日2021-05-19
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Molecular basis for the allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex.
Nat Commun, 12, 2021
1THF
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BU of 1thf by Molmil
CYCLASE SUBUNIT OF IMIDAZOLEGLYCEROLPHOSPHATE SYNTHASE FROM THERMOTOGA MARITIMA
分子名称: HISF PROTEIN, PHOSPHATE ION
著者Lang, D.A, Wilmanns, M.
登録日1998-09-17
公開日2000-07-14
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Structural evidence for evolution of the beta/alpha barrel scaffold by gene duplication and fusion.
Science, 289, 2000
6HTE
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BU of 6hte by Molmil
Sulfolobus solfataricus Tryptophan Synthase B2a
分子名称: DI(HYDROXYETHYL)ETHER, PYRIDOXAL-5'-PHOSPHATE, Tryptophan synthase beta chain 2
著者Fleming, J, Mayans, O, Bucher, R.
登録日2018-10-04
公開日2018-11-21
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.961 Å)
主引用文献Evolutionary Morphing of Tryptophan Synthase: Functional Mechanisms for the Enzymatic Channeling of Indole.
J.Mol.Biol., 430, 2018

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