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7F9V
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BU of 7f9v by Molmil
Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in Complex with inhibitor T35 and Halofuginone
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-[(3S)-3-cyano-3-(1-methylcyclopropyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, ...
著者Manickam, Y, Malhotra, N, Sharma, A.
登録日2021-07-04
公開日2022-07-06
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.816 Å)
主引用文献TgPRS with double inhibitors
To Be Published
7F9R
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BU of 7f9r by Molmil
Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in Complex with inhibitor L95, L-Proline and Febrifugine
分子名称: 1,2-ETHANEDIOL, 3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, CHLORIDE ION, ...
著者Manickam, Y, Malhotra, N, Sharma, A.
登録日2021-07-04
公開日2022-07-06
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献TgPRS with double inhibitors
To Be Published
7F9P
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Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in Complex with inhibitor L95 and azetidine
分子名称: (2S)-azetidine-2-carboxylic acid, 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
著者Manickam, Y, Malhotra, N, Sharma, A.
登録日2021-07-04
公開日2022-10-05
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献TgPRS with double inhibitors
To Be Published
7F9S
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BU of 7f9s by Molmil
Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in Complex with inhibitor T35 and Febrifugine (FF)
分子名称: 3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, 4-[(3S)-3-cyano-3-(1-methylcyclopropyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, BETA-MERCAPTOETHANOL, ...
著者Manickam, Y, Malhotra, N, Sharma, A.
登録日2021-07-04
公開日2022-10-05
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.861 Å)
主引用文献TgPRS with double inhibitors
To Be Published
7F9Q
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Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in Complex with inhibitor L97 and Febrifugine
分子名称: 3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, 4-[(3S)-3-cyclopropyl-3-(hydroxymethyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, CALCIUM ION, ...
著者Manickam, Y, Malhotra, N, Sharma, A.
登録日2021-07-04
公開日2022-10-05
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.796 Å)
主引用文献TgPRS with double inhibitors
To Be Published
6M0T
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BU of 6m0t by Molmil
Crystal Structure of Lysyl-tRNA Synthetase from Plasmodium falciparum complexed with L-lysine and Cladosporin derivative (CL-2)
分子名称: (3R)-3-[(R)-[(2R,6S)-6-methyloxan-2-yl]-oxidanyl-methyl]-6,8-bis(oxidanyl)-3,4-dihydroisochromen-1-one, LYSINE, Lysine--tRNA ligase
著者Babbar, P, Sharma, A, Manickam, Y.
登録日2020-02-22
公開日2021-04-21
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.68 Å)
主引用文献Design, Synthesis, and Structural Analysis of Cladosporin-Based Inhibitors of Malaria Parasites.
Acs Infect Dis., 7, 2021
6L4Q
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Crystal Structure of Lysyl-tRNA Synthetase from Plasmodium falciparum complexed with L-lysine and Clado-B
分子名称: (3R)-3-[[(3R)-3-methylpiperidin-1-yl]methyl]-6,8-bis(oxidanyl)-3,4-dihydroisochromen-1-one, LYSINE, Lysine--tRNA ligase
著者Babbar, P, Sharma, A, Manickam, Y, Mishra, S, Harlos, K.
登録日2019-10-19
公開日2021-05-19
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Crystal Structure of Lysyl-tRNA Synthetase from Plasmodium falciparum complexed with L-lysine and Cladosporin inhibitor, Cla-B
Chembiochem, 2021
6L3Y
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BU of 6l3y by Molmil
Crystal Structure of Lysyl-tRNA Synthetase from Plasmodium falciparum complexed with L-lysine and Clado-C
分子名称: (3R)-3-[[(3S)-3-ethylpiperidin-1-yl]methyl]-6,8-bis(oxidanyl)-3,4-dihydroisochromen-1-one, LYSINE, Lysine--tRNA ligase, ...
著者Babbar, P, Sharma, A, Mishra, S, Manickam, Y, Harlos, K.
登録日2019-10-15
公開日2021-05-19
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Crystal Structure of Lysyl-tRNA Synthetase from Plasmodium falciparum complexed with L-lysine and Cladosporin inhibitor, Cla-B
Chembiochem, 2021
4LMZ
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BU of 4lmz by Molmil
Structural insight into RNA recognition by RRM1+2 domain of human ETR-3 protein
分子名称: CUGBP Elav-like family member 2, RNA (5'-R(*GP*CP*UP*GP*CP*GP*UP*AP*UP*UP*GP*UP*UP*UP*G)-3')
著者Bhatt, H, Manickam, Y, Bhavesh, N.S.
登録日2013-07-11
公開日2014-07-16
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.78 Å)
主引用文献sequence specific RNA recognition of ETR3 RRM 1-2 domains
TO BE PUBLISHED
5ZG8
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BU of 5zg8 by Molmil
Crystal Structure of TtNRS
分子名称: Asparagine--tRNA ligase
著者Mutharasappan, N, Jain, V, Sharma, A, Manickam, Y, Jeyaraman, J.
登録日2018-03-08
公開日2019-03-13
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal Structure of TtNRS
To be published
7DPI
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BU of 7dpi by Molmil
Plasmodium falciparum cytoplasmic Phenylalanyl-tRNA synthetase in complex with BRD7929
分子名称: (8R,9S,10S)-10-[(dimethylamino)methyl]-N-(4-methoxyphenyl)-9-[4-(2-phenylethynyl)phenyl]-1,6-diazabicyclo[6.2.0]decane-6-carboxamide, MAGNESIUM ION, Phenylalanine--tRNA ligase, ...
著者Manmohan, S, Malhotra, N, Harlos, K, Manickam, Y, Sharma, A.
登録日2020-12-19
公開日2022-03-23
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (3.597 Å)
主引用文献Inhibition of Plasmodium falciparum phenylalanine tRNA synthetase provides opportunity for antimalarial drug development.
Structure, 30, 2022
7F9T
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Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in Complex with inhibitor L97 and Halofuginone
分子名称: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-[(3S)-3-cyclopropyl-3-(hydroxymethyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, ...
著者Malhotra, N, Manickam, Y, Sharma, A.
登録日2021-07-04
公開日2022-10-05
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.489 Å)
主引用文献TgPRS with double inhibitors
To Be Published
2Q2L
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BU of 2q2l by Molmil
Crystal Structure of Superoxide Dismutase from P. atrosanguina
分子名称: IODIDE ION, Superoxide Dismutase, ZINC ION
著者Manickam, Y, Gill, J, Mishra, P.C, Sharma, A.
登録日2007-05-29
公開日2008-03-25
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.367 Å)
主引用文献SAD phasing of a structure based on cocrystallized iodides using an in-house Cu Kalpha X-ray source: effects of data redundancy and completeness on structure solution
Acta Crystallogr.,Sect.D, 63, 2007
3KNP
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BU of 3knp by Molmil
Crystal structure of DTD from Plasmodium falciparum
分子名称: D-tyrosyl-tRNA(Tyr) deacylase
著者Manickam, Y, Bhatt, T.K, Sharma, A.
登録日2009-11-12
公開日2009-12-08
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Ligand-bound Structures Provide Atomic Snapshots for the Catalytic Mechanism of D-Amino Acid Deacylase
J.Biol.Chem., 285, 2010
3KOB
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BU of 3kob by Molmil
DTD from Plasmodium falciparum in complex with D-Glutamic acid
分子名称: D-GLUTAMIC ACID, D-tyrosyl-tRNA(Tyr) deacylase
著者Manickam, Y, Bhatt, T.K, Sharma, A.
登録日2009-11-13
公開日2009-12-08
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.99 Å)
主引用文献Ligand-bound Structures Provide Atomic Snapshots for the Catalytic Mechanism of D-Amino Acid Deacylase
J.Biol.Chem., 285, 2010
3KO4
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Crystal structure of D-Tyr-tRNA(Tyr) deacylase from Plasmodium falciparum in complex with ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, D-tyrosyl-tRNA(Tyr) deacylase
著者Manickam, Y, Bhatt, T.K, Sharma, A.
登録日2009-11-13
公開日2009-12-01
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Ligand-bound Structures Provide Atomic Snapshots for the Catalytic Mechanism of D-Amino Acid Deacylase
J.Biol.Chem., 285, 2010
3KOC
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DTD from Plasmodium falciparum in complex with D-Histidine
分子名称: D-HISTIDINE, D-tyrosyl-tRNA(Tyr) deacylase
著者Manickam, Y, Bhatt, T.K, Sharma, A.
登録日2009-11-13
公開日2009-12-08
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.91 Å)
主引用文献Ligand-bound Structures Provide Atomic Snapshots for the Catalytic Mechanism of D-Amino Acid Deacylase
J.Biol.Chem., 285, 2010
4HJM
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BU of 4hjm by Molmil
Crystal structure of Glutaredoxin 1 from Plasmodium falciparum (PfGrx1) solved by S-SAD
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, Glutaredoxin
著者Manickam, Y, Sharma, A.
登録日2012-10-13
公開日2013-12-25
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.5462 Å)
主引用文献Atomic resolution crystal structure of glutaredoxin 1 from Plasmodium falciparum and comparison with other glutaredoxins.
Acta Crystallogr.,Sect.D, 70, 2014
3P5V
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Actinidin from Actinidia arguta planch (Sarusashi)
分子名称: Actinidin, CADMIUM ION
著者Manickam, Y, Nirmal, N, Suzuki, A, Sugiyama, Y, Yamane, T, Devadasan, V, Sharma, A.
登録日2010-10-11
公開日2010-11-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural analysis of actinidin and a comparison of cadmium and sulfur anomalous signals from actinidin crystals measured using in-house copper- and chromium-anode X-ray sources
Acta Crystallogr.,Sect.D, 66, 2010
3P5W
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Actinidin from Actinidia arguta planch (Sarusashi)
分子名称: Actinidin, CADMIUM ION
著者Manickam, Y, Nirmal, N, Suzuki, A, Sugiyama, Y, Yamane, T, Devadasan, V, Sharma, A.
登録日2010-10-11
公開日2010-11-03
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural analysis of actinidin and a comparison of cadmium and sulfur anomalous signals from actinidin crystals measured using in-house copper- and chromium-anode X-ray sources
Acta Crystallogr.,Sect.D, 66, 2010
3P5U
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BU of 3p5u by Molmil
Actinidin from Actinidia arguta planch (Sarusashi)
分子名称: Actinidin, CADMIUM ION
著者Manickam, Y, Nirmal, N, Suzuki, A, Sugiyama, Y, Yamane, T, Devadasan, V, Sharma, A.
登録日2010-10-11
公開日2010-11-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural analysis of actinidin and a comparison of cadmium and sulfur anomalous signals from actinidin crystals measured using in-house copper- and chromium-anode X-ray sources
Acta Crystallogr.,Sect.D, 66, 2010
3P5X
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BU of 3p5x by Molmil
Actinidin from Actinidia arguta planch (Sarusashi)
分子名称: Actinidin, CADMIUM ION
著者Manickam, Y, Nirmal, N, Suzuki, A, Sugiyama, Y, Yamane, T, Devadasan, V, Sharma, A.
登録日2010-10-11
公開日2010-11-03
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural analysis of actinidin and a comparison of cadmium and sulfur anomalous signals from actinidin crystals measured using in-house copper- and chromium-anode X-ray sources
Acta Crystallogr.,Sect.D, 66, 2010
6IPA
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BU of 6ipa by Molmil
C-terminal EMAP II-like domain of p43 refined against twinned data
分子名称: aminoacyl-tRNA synthetase-interacting multifunctional protein p43
著者Manickam, Y, Harlos, K, Gupta, S, Sharma, A.
登録日2018-11-02
公開日2019-11-06
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.47 Å)
主引用文献Crystal structures of the two domains that constitute the Plasmodium vivax p43 protein.
Acta Crystallogr D Struct Biol, 76, 2020
6JRE
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BU of 6jre by Molmil
Structure of N-terminal domain of Plasmodium vivax p43 (PfNTD) solved by Co-SAD phasing
分子名称: Aminoacyl-tRNA synthetase-interacting multifunctional protein p43, COBALT (II) ION
著者Manickam, Y, Harlos, K, Sharma, M, Gupta, S, Sharma, A.
登録日2019-04-03
公開日2020-03-11
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Crystal structures of the two domains that constitute the Plasmodium vivax p43 protein.
Acta Crystallogr D Struct Biol, 76, 2020
3KNF
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BU of 3knf by Molmil
Crystal structure of D-Tyr-tRNA(Tyr) deacylase from Plasmodium falciparum
分子名称: D-tyrosyl-tRNA(Tyr) deacylase
著者Manickam, Y, Bhatt, T.K, Sharma, A.
登録日2009-11-12
公開日2009-12-01
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Ligand-bound Structures Provide Atomic Snapshots for the Catalytic Mechanism of D-Amino Acid Deacylase
J.Biol.Chem., 285, 2010

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