8BUD
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![BU of 8bud by Molmil](/molmil-images/mine/8bud) | Structure of DDB1 bound to Z7-engaged CDK12-cyclin K | 分子名称: | Cyclin-K, Cyclin-dependent kinase 12, DNA damage-binding protein 1, ... | 著者 | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BUE
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![BU of 8bue by Molmil](/molmil-images/mine/8bue) | Structure of DDB1 bound to Z11-engaged CDK12-cyclin K | 分子名称: | Cyclin-K, Cyclin-dependent kinase 12, DNA damage-binding protein 1, ... | 著者 | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BUG
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![BU of 8bug by Molmil](/molmil-images/mine/8bug) | Structure of DDB1 bound to HQ461-engaged CDK12-cyclin K | 分子名称: | 2-[2-[(6-methylpyridin-2-yl)amino]-1,3-thiazol-4-yl]-~{N}-(5-methyl-1,3-thiazol-2-yl)ethanamide, CITRIC ACID, Cyclin-K, ... | 著者 | Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (3.53 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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6TD3
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![BU of 6td3 by Molmil](/molmil-images/mine/6td3) | Structure of DDB1 bound to CR8-engaged CDK12-cyclinK | 分子名称: | (2R)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... | 著者 | Bunker, R.D, Petzold, G, Kozicka, Z, Thoma, N.H. | 登録日 | 2019-11-07 | 公開日 | 2020-06-17 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.46 Å) | 主引用文献 | The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K. Nature, 585, 2020
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6YOV
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![BU of 6yov by Molmil](/molmil-images/mine/6yov) | OCT4-SOX2-bound nucleosome - SHL+6 | 分子名称: | DNA (142-MER), Green fluorescent protein,POU domain, class 5, ... | 著者 | Michael, A.K, Kempf, G, Cavadini, S, Bunker, R.D, Thoma, N.H. | 登録日 | 2020-04-15 | 公開日 | 2020-05-06 | 最終更新日 | 2020-07-08 | 実験手法 | ELECTRON MICROSCOPY (3.42 Å) | 主引用文献 | Mechanisms of OCT4-SOX2 motif readout on nucleosomes. Science, 368, 2020
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6Y5D
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![BU of 6y5d by Molmil](/molmil-images/mine/6y5d) | Structure of human cGAS (K394E) bound to the nucleosome | 分子名称: | Cyclic GMP-AMP synthase, DNA (153-MER), Histone H2A type 2-A, ... | 著者 | Pathare, G.R, Cavadini, S, Kempf, G, Thoma, N.H. | 登録日 | 2020-02-25 | 公開日 | 2020-09-23 | 最終更新日 | 2020-12-09 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structural mechanism of cGAS inhibition by the nucleosome. Nature, 587, 2020
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6Y5E
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![BU of 6y5e by Molmil](/molmil-images/mine/6y5e) | Structure of human cGAS (K394E) bound to the nucleosome (focused refinement of cGAS-NCP subcomplex) | 分子名称: | Cyclic GMP-AMP synthase, DNA (153-MER), Histone H2A type 2-C, ... | 著者 | Pathare, G.R, Cavadini, S, Kempf, G, Thoma, N.H. | 登録日 | 2020-02-25 | 公開日 | 2020-09-23 | 最終更新日 | 2020-12-09 | 実験手法 | ELECTRON MICROSCOPY (3.15 Å) | 主引用文献 | Structural mechanism of cGAS inhibition by the nucleosome. Nature, 587, 2020
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6T90
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![BU of 6t90 by Molmil](/molmil-images/mine/6t90) | OCT4-SOX2-bound nucleosome - SHL-6 | 分子名称: | DNA (146-MER), Green fluorescent protein,POU domain, class 5, ... | 著者 | Michael, A.K, Kempf, G, Cavadini, S, Bunker, R.D, Thoma, N.H. | 登録日 | 2019-10-25 | 公開日 | 2020-05-06 | 最終更新日 | 2020-07-08 | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | 主引用文献 | Mechanisms of OCT4-SOX2 motif readout on nucleosomes. Science, 368, 2020
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6T93
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![BU of 6t93 by Molmil](/molmil-images/mine/6t93) | Nucleosome with OCT4-SOX2 motif at SHL-6 | 分子名称: | DNA (153-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | 著者 | Michael, A.K, Kempf, G, Cavadini, S, Bunker, R.D, Thoma, N.H. | 登録日 | 2019-10-25 | 公開日 | 2020-05-06 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.49 Å) | 主引用文献 | Mechanisms of OCT4-SOX2 motif readout on nucleosomes. Science, 368, 2020
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