4I1G
 
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8B4G
 | | Structure of a fungal LPMO bound to ligands | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACRYLIC ACID, CHLORIDE ION, ... | | 著者 | Banerjee, S, Huang, Z, Brander, S, Johansen, K.S, Lo Leggio, L. | | 登録日 | 2022-09-20 | | 公開日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.496 Å) | | 主引用文献 | Structure of a fungal LPMO bound to ligands
To Be Published
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5YHQ
 | | Cryo-EM Structure of CVA6 VLP | | 分子名称: | Capsid protein VP1, Capsid protein VP3, capsid protein VP0 | | 著者 | Chen, J, Zhang, C, Huang, Z, Cong, Y. | | 登録日 | 2017-09-29 | | 公開日 | 2017-10-25 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | A 3.0-Angstrom Resolution Cryo-Electron Microscopy Structure and Antigenic Sites of Coxsackievirus A6-Like Particles.
J. Virol., 92, 2018
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6IIO
 | | Cryo-EM structure of CV-A10 native empty particle | | 分子名称: | VP0, VP1, VP3 | | 著者 | Chen, J.H, Ye, X.H, Cong, Y, Huang, Z. | | 登録日 | 2018-10-07 | | 公開日 | 2018-11-07 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | | 主引用文献 | Coxsackievirus A10 atomic structure facilitating the discovery of a broad-spectrum inhibitor against human enteroviruses.
Cell Discov, 5, 2019
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7FJD
 | | Cryo-EM structure of a membrane protein(WT) | | 分子名称: | CHOLESTEROL, T cell receptor alpha variable 12-3,Possible J 11 gene segment,T cell receptor alpha chain constant, T cell receptor beta variable 6-5,M1-specific T cell receptor beta chain,T cell receptor beta constant 2, ... | | 著者 | Chen, Y, Zhu, Y, Gao, W, Zhang, A, Guo, C, Huang, Z. | | 登録日 | 2021-08-03 | | 公開日 | 2022-07-27 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Cholesterol inhibits TCR signaling by directly restricting TCR-CD3 core tunnel motility.
Mol.Cell, 82, 2022
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7FJE
 | | Cryo-EM structure of a membrane protein(LL) | | 分子名称: | CHOLESTEROL, T cell receptor alpha variable 12-3,Possible J 11 gene segment,T cell receptor alpha chain constant, T cell receptor beta variable 6-5,M1-specific T cell receptor beta chain,T cell receptor beta constant 2, ... | | 著者 | Chen, Y, Zhu, Y, Gao, W, Zhang, A, Guo, C, Huang, Z. | | 登録日 | 2021-08-03 | | 公開日 | 2022-07-27 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Cholesterol inhibits TCR signaling by directly restricting TCR-CD3 core tunnel motility.
Mol.Cell, 82, 2022
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7FJF
 | | Cryo-EM structure of a membrane protein(CS) | | 分子名称: | CHOLEST-5-EN-3-YL HYDROGEN SULFATE, T cell receptor alpha variable 12-3,Possible J 11 gene segment,T cell receptor alpha chain constant, T cell receptor beta variable 6-5,M1-specific T cell receptor beta chain,T cell receptor beta constant 2, ... | | 著者 | Chen, Y, Zhu, Y, Gao, W, Zhang, A, Guo, C, Huang, Z. | | 登録日 | 2021-08-03 | | 公開日 | 2022-07-27 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Cholesterol inhibits TCR signaling by directly restricting TCR-CD3 core tunnel motility.
Mol.Cell, 82, 2022
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6IIJ
 | | Cryo-EM structure of CV-A10 mature virion | | 分子名称: | SPHINGOSINE, VP1, VP2, ... | | 著者 | Chen, J.H, Ye, X.H, Cong, Y, Huang, Z. | | 登録日 | 2018-10-06 | | 公開日 | 2018-11-07 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | | 主引用文献 | Coxsackievirus A10 atomic structure facilitating the discovery of a broad-spectrum inhibitor against human enteroviruses.
Cell Discov, 5, 2019
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3WVJ
 | | The crystal structure of native glycosidic hydrolase | | 分子名称: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Beta-glucanase | | 著者 | Chen, C.C, Huang, J.W, Zhao, P, Ko, T.P, Huang, C.H, Chan, H.C, Huang, Z, Liu, W, Cheng, Y.S, Liu, J.R, Guo, R.T. | | 登録日 | 2014-05-22 | | 公開日 | 2015-06-24 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Structural analyses and yeast production of the beta-1,3-1,4-glucanase catalytic module encoded by the licB gene of Clostridium thermocellum.
Enzyme.Microb.Technol., 71, 2015
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6X5D
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6IV6
 | | Cryo-EM structure of AcrVA5-acetylated MbCas12a in complex with crRNA | | 分子名称: | RNA (59-MER), nuclease | | 著者 | Dong, L, Li, N, Guan, X, Zhu, Y, Gao, N, Huang, Z. | | 登録日 | 2018-12-02 | | 公開日 | 2019-04-10 | | 最終更新日 | 2019-11-06 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | An anti-CRISPR protein disables type V Cas12a by acetylation.
Nat. Struct. Mol. Biol., 26, 2019
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6IUF
 | | Crystal structure of Anti-CRISPR protein AcrVA5 | | 分子名称: | ACETYL COENZYME *A, GLYCEROL, protein-a | | 著者 | Dong, L, Guan, X, Zhu, Y, Huang, Z. | | 登録日 | 2018-11-28 | | 公開日 | 2019-04-10 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.052 Å) | | 主引用文献 | An anti-CRISPR protein disables type V Cas12a by acetylation.
Nat. Struct. Mol. Biol., 26, 2019
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1MA8
 | | A-DNA decamer GCGTA(UMS)ACGC with incorporated 2'-methylseleno-uridine | | 分子名称: | 5'-D(*GP*CP*GP*TP*AP*UMSP*AP*CP*GP*C)-3' | | 著者 | Teplova, M, Wilds, C.J, Wawrzak, Z, Tereshko, V, Du, Q, Carrasco, N, Huang, Z, Egli, M. | | 登録日 | 2002-08-01 | | 公開日 | 2002-12-11 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Covalent incorporation of selenium into oligonucleotides for X-ray crystal structure determination via MAD: proof of principle
BIOCHIMIE, 84, 2002
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6NUD
 | | Small conformation of ssRNA-bound CRISPR_Csm complex | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CRISPR system Cms protein Csm2, CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A), ... | | 著者 | Zhang, K, Pintilie, G, Li, S, Zhu, Y, Chiu, W, Huang, Z. | | 登録日 | 2019-01-31 | | 公開日 | 2019-03-13 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Coupling of ssRNA cleavage with DNase activity in type III-A CRISPR-Csm revealed by cryo-EM and biochemistry.
Cell Res., 29, 2019
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6NUE
 | | Small conformation of apo CRISPR_Csm complex | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CRISPR system Cms protein Csm2, CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A), ... | | 著者 | Zhang, K, Pintilie, G, Li, S, Zhu, Y, Chiu, W, Huang, Z. | | 登録日 | 2019-01-31 | | 公開日 | 2019-03-13 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Coupling of ssRNA cleavage with DNase activity in type III-A CRISPR-Csm revealed by cryo-EM and biochemistry.
Cell Res., 29, 2019
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4RHD
 | | DNA Duplex with Novel ZP Base Pair | | 分子名称: | DNA 9mer novel P nucleobase, DNA 9mer novel Z nucleobase, MAGNESIUM ION | | 著者 | Zhang, W, Zhang, L, Benner, S, Huang, Z. | | 登録日 | 2014-10-01 | | 公開日 | 2015-07-08 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Evolution of functional six-nucleotide DNA.
J.Am.Chem.Soc., 137, 2015
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3HG8
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8ILD
 | | The crystal structure of native dGTP:DNApre-I:Pol X substrate ternary complex | | 分子名称: | DNA (5'-D(*CP*AP*GP*GP*AP*TP*CP*CP*T)-3'), GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... | | 著者 | Qin, T, Chen, Y.Q, Gan, J.H, Huang, Z. | | 登録日 | 2023-03-03 | | 公開日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structural Insight into Polymerase Mechanism via a Chiral Center Generated with a Single Selenium Atom.
Int J Mol Sci, 24, 2023
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8ILH
 | | The crystal structure of dG(Se-Sp)-DNA:Pol X product binary complex | | 分子名称: | 2'-DEOXYGUANOSINE-5'-MONOSELENOPHOSPHATE, DNA (5'-D(*CP*GP*GP*AP*TP*CP*C)-3'), MAGNESIUM ION, ... | | 著者 | Qin, T, Gan, J.H, Huang, Z. | | 登録日 | 2023-03-03 | | 公開日 | 2024-01-10 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural Insight into Polymerase Mechanism via a Chiral Center Generated with a Single Selenium Atom.
Int J Mol Sci, 24, 2023
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8ILI
 | | The crystal structure of dG(Se-Rp)-DNA:Pol X product binary complex | | 分子名称: | DNA (5'-D(*CP*GP*GP*AP*TP*CP*CP*(7S8))-3'), MAGNESIUM ION, Repair DNA polymerase X, ... | | 著者 | Qin, T, Gan, J.H, Huang, Z. | | 登録日 | 2023-03-03 | | 公開日 | 2024-01-10 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural Insight into Polymerase Mechanism via a Chiral Center Generated with a Single Selenium Atom.
Int J Mol Sci, 24, 2023
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8ILE
 | | The crystal structure of dGTPalphaSe-Rp:DNApre-II:Pol X substrate ternary complex | | 分子名称: | DNA (5'-D(*CP*TP*GP*GP*AP*TP*CP*CP*A)-3'), MANGANESE (II) ION, Repair DNA polymerase X, ... | | 著者 | Qin, T, Gan, J.H, Huang, Z. | | 登録日 | 2023-03-03 | | 公開日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural Insight into Polymerase Mechanism via a Chiral Center Generated with a Single Selenium Atom.
Int J Mol Sci, 24, 2023
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8ILG
 | | The crystal structure of dG-DNA:Pol X product binary complex | | 分子名称: | DNA (5'-D(*CP*GP*GP*AP*TP*CP*CP*G)-3'), FORMIC ACID, MANGANESE (II) ION, ... | | 著者 | Qin, T, Gan, J.H, Huang, Z. | | 登録日 | 2023-03-03 | | 公開日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.805 Å) | | 主引用文献 | Structural Insight into Polymerase Mechanism via a Chiral Center Generated with a Single Selenium Atom.
Int J Mol Sci, 24, 2023
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4AQC
 | | Triazolopyridine-based Inhibitor of Janus Kinase 2 | | 分子名称: | 8-(4-methylsulfonylphenyl)-N-(4-morpholin-4-ylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine, SULFATE ION, TYROSINE-PROTEIN KINASE JAK2 | | 著者 | Dugan, B.J, Gingrich, D.E, Mesaros, E.F, Milkiewicz, K.L, Curry, M.A, Zulli, A.L, Dobrzanski, P, Serdikoff, C, Jan, M, Angeles, T.S, Albom, M.S, Mason, J.L, Aimone, L.D, Meyer, S.L, Huang, Z, Wells-Knecht, K.J, Ator, M.A, Ruggeri, B.A, Dorsey, B.D. | | 登録日 | 2012-04-16 | | 公開日 | 2012-04-25 | | 最終更新日 | 2019-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | A Selective, Orally Bioavailable 1,2,4-Triazolo[1,5-A]Pyridine-Based Inhibitor of Janus Kinase 2 for Use in Anticancer Therapy: Discovery of Cep-33779.
J.Med.Chem., 55, 2012
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7RQT
 | | THE B-DNA DODECAMER With HIGH RESOLUTION | | 分子名称: | DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'), MAGNESIUM ION | | 著者 | Chen, C, Huang, Z. | | 登録日 | 2021-08-08 | | 公開日 | 2022-08-17 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.26 Å) | | 主引用文献 | 2'-beta-Selenium Atom on Thymidine to Control beta-Form DNA Conformation and Large Crystal Formation
Cryst.Growth Des., 2022
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4GQ0
 | | Crystal structure of AKR1B10 complexed with NADP+ and Caffeic acid phenethyl ester | | 分子名称: | 2-phenylethyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate, Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Liping, Z, Xuehua, Z, Shangke, C, Jing, Z, Xiaopeng, H. | | 登録日 | 2012-08-22 | | 公開日 | 2013-08-28 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structure of AKR1B10 complexed with NADP+ and Caffeic acid phenethyl ester
To be Published
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