7R4F
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![BU of 7r4f by Molmil](/molmil-images/mine/7r4f) | Bovine complex I in the presence of IM1761092, slack class i (Composite map) | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine, ... | 著者 | Bridges, H.R, Blaza, J.N, Yin, Z, Chung, I, Hirst, J. | 登録日 | 2022-02-08 | 公開日 | 2023-02-08 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides. Science, 379, 2023
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7R4G
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![BU of 7r4g by Molmil](/molmil-images/mine/7r4g) | Bovine complex I in the presence of IM1761092, slack class ii (Composite map) | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine, ... | 著者 | Bridges, H.R, Blaza, J.N, Yin, Z, Chung, I, Hirst, J. | 登録日 | 2022-02-08 | 公開日 | 2023-02-08 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides. Science, 379, 2023
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5O31
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![BU of 5o31 by Molmil](/molmil-images/mine/5o31) | Mitochondrial complex I in the deactive state | 分子名称: | Acyl carrier protein, mitochondrial, FE2/S2 (INORGANIC) CLUSTER, ... | 著者 | Blaza, J.N, Vinothkumar, K.R, Hirst, J. | 登録日 | 2017-05-23 | 公開日 | 2018-01-17 | 最終更新日 | 2019-10-23 | 実験手法 | ELECTRON MICROSCOPY (4.13 Å) | 主引用文献 | Structure of the Deactive State of Mammalian Respiratory Complex I. Structure, 26, 2018
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8CA5
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![BU of 8ca5 by Molmil](/molmil-images/mine/8ca5) | Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 3). | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... | 著者 | Yin, Z, Bridges, H.R, Agip, A.N.A, Hirst, J. | 登録日 | 2023-01-24 | 公開日 | 2023-12-20 | 最終更新日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structural insights into respiratory complex I deficiency and assembly from the mitochondrial disease-related ndufs4 -/- mouse. Embo J., 43, 2024
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8CA4
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![BU of 8ca4 by Molmil](/molmil-images/mine/8ca4) | Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 2 N-domain). | 分子名称: | FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, IRON/SULFUR CLUSTER, ... | 著者 | Yin, Z, Bridges, H.R, Agip, A.N.A, Hirst, J. | 登録日 | 2023-01-24 | 公開日 | 2023-12-20 | 最終更新日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | 主引用文献 | Structural insights into respiratory complex I deficiency and assembly from the mitochondrial disease-related ndufs4 -/- mouse. Embo J., 43, 2024
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8C2S
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![BU of 8c2s by Molmil](/molmil-images/mine/8c2s) | Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 1). | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... | 著者 | Yin, Z, Bridges, H.R, Agip, A.N.A, Hirst, J. | 登録日 | 2022-12-22 | 公開日 | 2023-12-20 | 最終更新日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structural insights into respiratory complex I deficiency and assembly from the mitochondrial disease-related ndufs4 -/- mouse. Embo J., 43, 2024
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8CA3
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![BU of 8ca3 by Molmil](/molmil-images/mine/8ca3) | Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 2). | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... | 著者 | Yin, Z, Bridges, H.R, Agip, A.N.A, Hirst, J. | 登録日 | 2023-01-24 | 公開日 | 2023-12-20 | 最終更新日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural insights into respiratory complex I deficiency and assembly from the mitochondrial disease-related ndufs4 -/- mouse. Embo J., 43, 2024
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8CA1
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![BU of 8ca1 by Molmil](/molmil-images/mine/8ca1) | Cryo-EM structure of the ACADVL dimer from Mus musculus. | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Very long-chain specific acyl-CoA dehydrogenase, mitochondrial | 著者 | Yin, Z, Bridges, H.R, Agip, A.N.A, Hirst, J. | 登録日 | 2023-01-24 | 公開日 | 2023-12-20 | 最終更新日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Structural insights into respiratory complex I deficiency and assembly from the mitochondrial disease-related ndufs4 -/- mouse. Embo J., 43, 2024
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8BA0
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![BU of 8ba0 by Molmil](/molmil-images/mine/8ba0) | Drosophila melanogaster complex I in the Twisted state (Dm2) | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, Acyl carrier protein, ... | 著者 | Agip, A.N.A, Chung, I, Sanchez-Martinez, A, Whitworth, A.J, Hirst, J. | 登録日 | 2022-10-10 | 公開日 | 2023-01-18 | 実験手法 | ELECTRON MICROSCOPY (3.68 Å) | 主引用文献 | Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster. Elife, 12, 2023
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8B9Z
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![BU of 8b9z by Molmil](/molmil-images/mine/8b9z) | Drosophila melanogaster complex I in the Active state (Dm1) | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Agip, A.A, Chung, I, Sanchez-Martinez, A, Whitworth, A.J, Hirst, J. | 登録日 | 2022-10-10 | 公開日 | 2023-01-18 | 実験手法 | ELECTRON MICROSCOPY (3.28 Å) | 主引用文献 | Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster. Elife, 12, 2023
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7PSA
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![BU of 7psa by Molmil](/molmil-images/mine/7psa) | The acetogenin-bound complex I of Mus musculus resolved to 3.4 angstroms | 分子名称: | (3~{S},5~{S})-5-methyl-3-[(13~{R})-13-oxidanyl-13-[(2~{R},5~{R})-5-[(2~{R},5~{R})-5-[(1~{R})-1-oxidanylundecyl]oxolan-2-yl]oxolan-2-yl]tridecyl]oxolan-2-one, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ... | 著者 | Grba, D, Hirst, J. | 登録日 | 2021-09-22 | 公開日 | 2022-04-06 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Cryo-electron microscopy reveals how acetogenins inhibit mitochondrial respiratory complex I. J.Biol.Chem., 298, 2022
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7QSM
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![BU of 7qsm by Molmil](/molmil-images/mine/7qsm) | Bovine complex I in lipid nanodisc, Deactive-ligand (composite) | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... | 著者 | Chung, I, Bridges, H.R, Hirst, J. | 登録日 | 2022-01-13 | 公開日 | 2022-05-25 | 最終更新日 | 2022-09-28 | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | 主引用文献 | Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy. Nat Commun, 13, 2022
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7QSL
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![BU of 7qsl by Molmil](/molmil-images/mine/7qsl) | Bovine complex I in lipid nanodisc, Active-apo | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... | 著者 | Chung, I, Bridges, H.R, Hirst, J. | 登録日 | 2022-01-13 | 公開日 | 2022-05-25 | 最終更新日 | 2022-09-28 | 実験手法 | ELECTRON MICROSCOPY (2.76 Å) | 主引用文献 | Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy. Nat Commun, 13, 2022
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7QSN
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![BU of 7qsn by Molmil](/molmil-images/mine/7qsn) | Bovine complex I in lipid nanodisc, Deactive-apo | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... | 著者 | Chung, I, Bridges, H.R, Hirst, J. | 登録日 | 2022-01-13 | 公開日 | 2022-05-25 | 最終更新日 | 2022-09-28 | 実験手法 | ELECTRON MICROSCOPY (2.81 Å) | 主引用文献 | Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy. Nat Commun, 13, 2022
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7QSK
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![BU of 7qsk by Molmil](/molmil-images/mine/7qsk) | Bovine complex I in lipid nanodisc, Active-Q10 | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... | 著者 | Chung, I, Bridges, H.R, Hirst, J. | 登録日 | 2022-01-13 | 公開日 | 2022-05-25 | 最終更新日 | 2022-09-28 | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | 主引用文献 | Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy. Nat Commun, 13, 2022
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7QSO
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![BU of 7qso by Molmil](/molmil-images/mine/7qso) | Bovine complex I in lipid nanodisc, State 3 (Slack) | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... | 著者 | Chung, I, Bridges, H.R, Hirst, J. | 登録日 | 2022-01-13 | 公開日 | 2022-05-25 | 最終更新日 | 2022-09-28 | 実験手法 | ELECTRON MICROSCOPY (3.02 Å) | 主引用文献 | Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy. Nat Commun, 13, 2022
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5LDX
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![BU of 5ldx by Molmil](/molmil-images/mine/5ldx) | Structure of mammalian respiratory Complex I, class3. | 分子名称: | Acyl carrier protein, mitochondrial, FE2/S2 (INORGANIC) CLUSTER, ... | 著者 | Vinothkumar, K.R, Zhu, J, Hirst, J. | 登録日 | 2016-06-28 | 公開日 | 2016-09-14 | 最終更新日 | 2019-10-23 | 実験手法 | ELECTRON MICROSCOPY (5.6 Å) | 主引用文献 | Structure of mammalian respiratory complex I. Nature, 536, 2016
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5LC5
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![BU of 5lc5 by Molmil](/molmil-images/mine/5lc5) | Structure of mammalian respiratory Complex I, class2 | 分子名称: | Acyl carrier protein, mitochondrial, FE2/S2 (INORGANIC) CLUSTER, ... | 著者 | Vinothkumar, K.R, Zhu, J, Hirst, J. | 登録日 | 2016-06-19 | 公開日 | 2016-09-07 | 最終更新日 | 2019-12-11 | 実験手法 | ELECTRON MICROSCOPY (4.35 Å) | 主引用文献 | Structure of mammalian respiratory complex I. Nature, 536, 2016
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5LDW
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![BU of 5ldw by Molmil](/molmil-images/mine/5ldw) | Structure of mammalian respiratory Complex I, class1 | 分子名称: | Acyl carrier protein, mitochondrial, FE2/S2 (INORGANIC) CLUSTER, ... | 著者 | Vinothkumar, K.R, Zhu, J, Hirst, J. | 登録日 | 2016-06-28 | 公開日 | 2016-09-07 | 最終更新日 | 2019-10-23 | 実験手法 | ELECTRON MICROSCOPY (4.27 Å) | 主引用文献 | Structure of mammalian respiratory complex I. Nature, 536, 2016
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1NYK
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![BU of 1nyk by Molmil](/molmil-images/mine/1nyk) | Crystal Structure of the Rieske protein from Thermus thermophilus | 分子名称: | FE2/S2 (INORGANIC) CLUSTER, MAGNESIUM ION, Rieske iron-sulfur protein | 著者 | Hunsicker-Wang, L.M, Heine, A, Chen, Y, Luna, E.P, Todaro, T, Zhang, Y.M, Williams, P.A, McRee, D.E, Hirst, J, Stout, C.D, Fee, J.A. | 登録日 | 2003-02-12 | 公開日 | 2003-06-24 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.31 Å) | 主引用文献 | High resolution structure of the soluble, respiratory-type Rieske protein from Thermus thermophilus: Analysis and Comparison Biochemistry, 42, 2003
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1PC4
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![BU of 1pc4 by Molmil](/molmil-images/mine/1pc4) | Crystal Structure of the P50A mutant of ferredoxin I at 1.65 A Resolution | 分子名称: | FE3-S4 CLUSTER, Ferredoxin I, IRON/SULFUR CLUSTER | 著者 | Camba, R, Jung, Y.S, Chen, K, Hunsicker-Wang, L.M, Burgess, B.K, Stout, C.D, Hirst, J, Armstrong, F.A. | 登録日 | 2003-05-15 | 公開日 | 2003-09-30 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Mechanisms of redox-coupled proton transfer in proteins: role of the proximal proline in reactions of the [3Fe-4S] cluster in Azotobacter vinelandii ferredoxin I Biochemistry, 42, 2003
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1PC5
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![BU of 1pc5 by Molmil](/molmil-images/mine/1pc5) | Crystal Structure of the P50G Mutant of Ferredoxin I at 1.8 A Resolution | 分子名称: | FE3-S4 CLUSTER, Ferredoxin I, IRON/SULFUR CLUSTER | 著者 | Camba, R, Jung, Y.S, Chen, K, Hunsicker-Wang, L.M, Burgess, B.K, Stout, C.D, Hirst, J, Armstrong, F.A. | 登録日 | 2003-05-15 | 公開日 | 2003-09-30 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Mechanisms of redox-coupled proton transfer in proteins: role of the proximal proline in reactions of the [3Fe-4S] cluster in Azotobacter vinelandii ferredoxin I Biochemistry, 42, 2003
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1NA8
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![BU of 1na8 by Molmil](/molmil-images/mine/1na8) | Crystal structure of ADP-ribosylation factor binding protein GGA1 | 分子名称: | ADP-ribosylation factor binding protein GGA1 | 著者 | Lui, W.W, Collins, B.M, Hirst, J, Motley, A, Millar, C, Schu, P, Owen, D.J, Robinson, M.S. | 登録日 | 2002-11-27 | 公開日 | 2003-07-29 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Binding partners for the COOH-terminal appendage domains of the GGAs and gamma-adaptin Mol.Cell.Biol., 14, 2003
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6G2J
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![BU of 6g2j by Molmil](/molmil-images/mine/6g2j) | Mouse mitochondrial complex I in the active state | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, ADENOSINE-5'-DIPHOSPHATE, ... | 著者 | Agip, A.N.A, Blaza, J.N, Bridges, H.R, Viscomi, C, Rawson, S, Muench, S.P, Hirst, J. | 登録日 | 2018-03-23 | 公開日 | 2018-06-06 | 最終更新日 | 2021-06-02 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states. Nat. Struct. Mol. Biol., 25, 2018
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6G72
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![BU of 6g72 by Molmil](/molmil-images/mine/6g72) | Mouse mitochondrial complex I in the deactive state | 分子名称: | ACETYL GROUP, ADENOSINE-5'-DIPHOSPHATE, Acyl carrier protein, ... | 著者 | Agip, A.N.A, Blaza, J.N, Bridges, H.R, Viscomi, C, Rawson, S, Muench, S.P, Hirst, J. | 登録日 | 2018-04-04 | 公開日 | 2018-06-06 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states. Nat. Struct. Mol. Biol., 25, 2018
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