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8C8C
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BU of 8c8c by Molmil
Crystal Structure of Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PI5P4Ka) bound to an inhibitor
分子名称: Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, ~{N}-(3-chloranyl-4-methoxy-phenyl)-7-(3,4-dimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-amine
著者Harborne, S.P.D, Howard, T.D, Ogg, D.T.
登録日2023-01-19
公開日2023-04-26
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.096 Å)
主引用文献Identification of ARUK2002821 as an isoform-selective PI5P4K alpha inhibitor.
Rsc Med Chem, 14, 2023
5I0A
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BU of 5i0a by Molmil
RecA mini intein in complex with cisplatin
分子名称: 3,3',3''-phosphanetriyltripropanoic acid, Cisplatin, Intein, ...
著者Li, Z, Zhang, J, Li, H.M.
登録日2016-02-03
公開日2016-09-21
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural insights into protein splicing inhibition by platinum therapeutics as potential anti-microbials
To be published
7QIE
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BU of 7qie by Molmil
Crystal Structure of Phosphatidylinositol 5-Phosphate 4-Kinase (PI5P4K2C) bound to an allosteric inhibitor
分子名称: 5-methyl-2-(2-propan-2-ylphenyl)-~{N}-(pyridin-2-ylmethyl)pyrrolo[3,2-d]pyrimidin-4-amine, Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
著者Howard, T.D, Ogg, D.T.
登録日2021-12-14
公開日2022-05-18
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase gamma Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode.
J.Med.Chem., 65, 2022
7QPN
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BU of 7qpn by Molmil
Crystal Structure of Phosphatidylinositol 5-Phosphate 4-Kinase (PI5P4K2C) bound to an allosteric inhibitor and AMP-PNP
分子名称: 5-methyl-2-(2-propan-2-ylphenyl)-~{N}-(pyridin-2-ylmethyl)pyrrolo[3,2-d]pyrimidin-4-amine, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Phosphatidylinositol 5-Phosphate 4-Kinase (PI5P4K2C)
著者Howard, T.D, Ogg, D.T.
登録日2022-01-05
公開日2022-05-18
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase gamma Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode.
J.Med.Chem., 65, 2022
8BQ4
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BU of 8bq4 by Molmil
Crystal Structure of Phosphatidylinositol 5-Phosphate 4-Kinase (PI5P4K2C) bound to an inhibitor
分子名称: 6-methyl-~{N}-(4-methylsulfonylphenyl)thieno[2,3-d]pyrimidin-4-amine, Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
著者Ogg, D.J, Howard, T.D.
登録日2022-11-18
公開日2022-12-28
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.42 Å)
主引用文献The Identification of Potent, Selective, and Brain Penetrant PI5P4K gamma Inhibitors as In Vivo-Ready Tool Molecules.
J.Med.Chem., 66, 2023
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件を2024-11-06に公開中

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