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Crystal structure of Ehp / C3d complex
分子名称:	Complement C3, Efb homologous protein
著者	Hammel, M, Geisbrecht, B.V.
登録日	2006-10-25
公開日	2007-08-14
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (2.7 Å)
主引用文献	Characterization of Ehp, a Secreted Complement Inhibitory Protein from Staphylococcus aureus. J.Biol.Chem., 282, 2007

1SZH

Crystal Structure of C. elegans HER-1
分子名称:	ACETATE ION, Her-1 protein
著者	Hamaoka, B.Y, Dann III, C.E, Geisbrecht, B.V, Leahy, D.J.
登録日	2004-04-05
公開日	2004-08-10
最終更新日	2021-10-27
実験手法	X-RAY DIFFRACTION (1.5 Å)
主引用文献	Crystal structure of Caenorhabditis elegans HER-1 and characterization of the interaction between HER-1 and TRA-2A. Proc.Natl.Acad.Sci.USA, 101, 2004

6AZP

A Structurally Dynamic N-terminal Region Drives Function of the Staphylococcal Peroxidase Inhibitor (SPIN)
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者	Ramyar, K.X, Geisbrecht, B.V.
登録日	2017-09-11
公開日	2017-12-27
最終更新日	2023-11-15
実験手法	X-RAY DIFFRACTION (2.291 Å)
主引用文献	A structurally dynamic N-terminal region drives function of the staphylococcal peroxidase inhibitor (SPIN). J. Biol. Chem., 293, 2018

6BMT

Crystal Structure of a Recombinant form of Human Myeloperoxidase Bound to an Inhibitor from Staphylococcus delphini
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
著者	Ploscariu, N.T, Geisbrecht, B.V.
登録日	2017-11-15
公開日	2018-01-03
最終更新日	2023-10-04
実験手法	X-RAY DIFFRACTION (2.403 Å)
主引用文献	Identification and structural characterization of a novel myeloperoxidase inhibitor from Staphylococcus delphini. Arch. Biochem. Biophys., 645, 2018

8TE6

Crystal structure of a multiple lysine-to-arginine substitution mutant of the human CRIg C3b-binding domain
分子名称:	V-set and immunoglobulin domain-containing protein 4
著者	Abram, T.G, Geisbrecht, B.V.
登録日	2023-07-05
公開日	2023-07-12
最終更新日	2024-01-24
実験手法	X-RAY DIFFRACTION (1.251 Å)
主引用文献	New Insights into the Complement Receptor of the Ig Superfamily Obtained from Structural and Functional Studies on Two Mutants. Immunohorizons, 7, 2023

8TE5

Crystal structure of a multiple lysine-to-arginine substitution mutant of the human CRIg C3b-binding domain
分子名称:	V-set and immunoglobulin domain-containing protein 4
著者	Abram, T.G, Geisbrecht, B.V.
登録日	2023-07-05
公開日	2023-07-12
最終更新日	2024-01-24
実験手法	X-RAY DIFFRACTION (1.502 Å)
主引用文献	New Insights into the Complement Receptor of the Ig Superfamily Obtained from Structural and Functional Studies on Two Mutants. Immunohorizons, 7, 2023

7JTQ

Human Complement Factor B Inhibited by a Slow Off-Rate Modified Aptamer of 31 Bases
分子名称:	Complement factor B, DNA (32-MER)
著者	Xu, X, Geisbrecht, B.V.
登録日	2020-08-18
公開日	2020-12-09
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (3.5 Å)
主引用文献	Inhibition of the Complement Alternative Pathway by Chemically Modified DNA Aptamers That Bind with Picomolar Affinity to Factor B. J Immunol., 206, 2021

7JTN

Human Complement Factor B Inhibited by a Slow Off-Rate Modified Aptamer of 29 Bases
分子名称:	Complement factor B, DNA (30-MER)
著者	Xu, X, Geisbrecht, B.V.
登録日	2020-08-18
公開日	2020-12-09
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (3.1 Å)
主引用文献	Inhibition of the Complement Alternative Pathway by Chemically Modified DNA Aptamers That Bind with Picomolar Affinity to Factor B. J Immunol., 206, 2021

4H6H

Crystal Structure of Staphylococcal Complement Inhibitor SCIN-B(4-85)
分子名称:	Fibrinogen-binding protein
著者	Garcia, B.L, Geisbrecht, B.V.
登録日	2012-09-19
公開日	2012-12-19
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.5024 Å)
主引用文献	A Structurally Dynamic N-terminal Helix Is a Key Functional Determinant in Staphylococcal Complement Inhibitor (SCIN) Proteins. J.Biol.Chem., 288, 2013

4H6I

Crystal Structure of Staphylococcal Complement Inhibitor SCIN-B
分子名称:	Fibrinogen-binding protein
著者	Garcia, B.L, Geisbrecht, B.V.
登録日	2012-09-19
公開日	2012-12-19
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (3.091 Å)
主引用文献	A Structurally Dynamic N-terminal Helix Is a Key Functional Determinant in Staphylococcal Complement Inhibitor (SCIN) Proteins. J.Biol.Chem., 288, 2013

4NZL

Extracellular proteins of Staphylococcus aureus inhibit the neutrophil serine proteases
分子名称:	Neutrophil elastase, Uncharacterized protein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose
著者	Stapels, D.A.C, von Koeckritz-Blickwede, M, Ramyar, K.X, Bischoff, M, Milder, F, Ruyken, M, Scheepmaker, L, McWhorter, W.J, Herrmann, M, van Kessel, K.P.M, Geisbrecht, B.V, Rooijakkers, S.H.M.
登録日	2013-12-12
公開日	2014-08-20
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (1.85 Å)
主引用文献	Staphylococcus aureus secretes a unique class of neutrophil serine protease inhibitors. Proc.Natl.Acad.Sci.USA, 111, 2014

8D4V

Crystal Structure of Cathepsin G Inhibited by Eap2 from S. aureus
分子名称:	Cathepsin G, C-terminal truncated form, Extracellular Adherence Protein, ...
著者	Gido, C.D, Herdendorf, T.J, Geisbrecht, B.V.
登録日	2022-06-02
公開日	2022-12-21
最終更新日	2023-10-25
実験手法	X-RAY DIFFRACTION (1.85 Å)
主引用文献	Characterization of two distinct neutrophil serine protease-binding modes within a Staphylococcus aureus innate immune evasion protein family. J.Biol.Chem., 299, 2023

8D4O

Crystal Structure of the Neutrophil Serine Protease Inhibitor Eap1 from S. aureus
分子名称:	Extracellular Adherence Protein, SODIUM ION
著者	Gido, C.D, Geisbrecht, B.V.
登録日	2022-06-02
公開日	2022-12-21
最終更新日	2024-04-03
実験手法	X-RAY DIFFRACTION (1.45 Å)
主引用文献	Characterization of two distinct neutrophil serine protease-binding modes within a Staphylococcus aureus innate immune evasion protein family. J.Biol.Chem., 299, 2023

8D4Q

Crystal Structure of Neutrophil Elastase Inhibited by Eap1 from S. aureus
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Extracellular Adherence Protein, Neutrophil elastase
著者	Gido, C.D, Herdendorf, T.J, Geisbrecht, B.V.
登録日	2022-06-02
公開日	2022-12-21
最終更新日	2023-10-25
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Characterization of two distinct neutrophil serine protease-binding modes within a Staphylococcus aureus innate immune evasion protein family. J.Biol.Chem., 299, 2023

8D4S

Crystal Structure of Cathepsin G Inhibited by Eap1 from S. aureus
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, Cathepsin G, C-terminal truncated form, ...
著者	Gido, C.D, Herdendorf, T.J, Geisbrecht, B.V.
登録日	2022-06-02
公開日	2022-12-21
最終更新日	2023-10-25
実験手法	X-RAY DIFFRACTION (1.95 Å)
主引用文献	Characterization of two distinct neutrophil serine protease-binding modes within a Staphylococcus aureus innate immune evasion protein family. J.Biol.Chem., 299, 2023

8D4U

Crystal Structure of Neutrophil Elastase Inhibited by Eap2 from S. aureus
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Extracellular Adherence Protein, ...
著者	Gido, C.D, Herdendorf, T.J, Geisbrecht, B.V.
登録日	2022-06-02
公開日	2022-12-21
最終更新日	2023-10-25
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Characterization of two distinct neutrophil serine protease-binding modes within a Staphylococcus aureus innate immune evasion protein family. J.Biol.Chem., 299, 2023

8D7I

Bifunctional Inhibition of Neutrophil Elastase and Cathepsin G by Eap1 from S. aureus
分子名称:	Cathepsin G, C-terminal truncated form, Extracellular Adherence Protein, ...
著者	Gido, C.D, Herdendorf, T.J, Geisbrecht, B.V.
登録日	2022-06-07
公開日	2023-06-14
最終更新日	2023-10-25
実験手法	X-RAY DIFFRACTION (3.63 Å)
主引用文献	Bifunctional Inhibition of Neutrophil Elastase and Cathepsin G by Eap1 from S. aureus To Be Published

8D7K

Bifunctional Inhibition of Neutrophil Elastase and Cathepsin G by Eap2 from S. aureus
分子名称:	Cathepsin G, C-terminal truncated form, Extracellular Adherence Protein, ...
著者	Gido, C.D, Herdendorf, T.J, Geisbrecht, B.V.
登録日	2022-06-07
公開日	2023-06-14
最終更新日	2023-10-25
実験手法	X-RAY DIFFRACTION (3.1 Å)
主引用文献	Bifunctional Inhibition of Neutrophil Elastase and Cathepsin G by Eap2 from S. aureus To Be Published

5UZU

Immune evasion by a Staphylococcal Peroxidase Inhibitor that blocks myeloperoxidase
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者	de Jong, N, Geisbrecht, B.V, van Strijp, J, Haas, P, Nijland, R, Ramyar, K, Fevre, C, Guerra, F, Voyich-Kane, J, van Kessel, C, Garcia, B.
登録日	2017-02-27
公開日	2017-07-26
最終更新日	2023-11-15
実験手法	X-RAY DIFFRACTION (2.403 Å)
主引用文献	Immune evasion by a staphylococcal inhibitor of myeloperoxidase. Proc. Natl. Acad. Sci. U.S.A., 114, 2017

5VJ0

Crystal Structure of heme-containing DyP Type Peroxidase from Enterobacter lignolyticus
分子名称:	Dyp-type peroxidase family, PROTOPORPHYRIN IX CONTAINING FE
著者	Meekins, D.A, Li, P, Geisbrecht, B.V.
登録日	2017-04-17
公開日	2017-08-16
最終更新日	2023-10-04
実験手法	X-RAY DIFFRACTION (1.93 Å)
主引用文献	Mechanistic Insights into Dye-Decolorizing Peroxidase Revealed by Solvent Isotope and Viscosity Effects. ACS Catal, 7, 2017

8G26

Crystal Structure of Cathepsin-G and Neutrophil Elastase Inhibited by S. aureus EapH2 at pH 8.5
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cathepsin-G, ...
著者	Mishra, N.B, Geisbrecht, B.V.
登録日	2023-02-03
公開日	2023-04-26
最終更新日	2023-10-25
実験手法	X-RAY DIFFRACTION (1.85 Å)
主引用文献	Simultaneous inhibition of two neutrophil serine proteases by the S. aureus innate immune evasion protein EapH2. J.Biol.Chem., 299, 2023

8G25

Crystal Structure of Cathepsin-G and Neutrophil Elastase Inhibited by S. aureus EapH2 at pH 7.5
分子名称:	Cathepsin-G, MAP domain-containing protein, Neutrophil elastase
著者	Mishra, N.B, Geisbrecht, B.V.
登録日	2023-02-03
公開日	2023-04-26
最終更新日	2023-10-25
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Simultaneous inhibition of two neutrophil serine proteases by the S. aureus innate immune evasion protein EapH2. J.Biol.Chem., 299, 2023

8G24

Crystal Structure of Cathepsin-G and Neutrophil Elastase Inhibited by S. aureus EapH2 at pH 5.5
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cathepsin-G, MAP domain-containing protein, ...
著者	Mishra, N.B, Geisbrecht, B.V.
登録日	2023-02-03
公開日	2023-04-26
最終更新日	2023-10-25
実験手法	X-RAY DIFFRACTION (1.82 Å)
主引用文献	Simultaneous inhibition of two neutrophil serine proteases by the S. aureus innate immune evasion protein EapH2. J.Biol.Chem., 299, 2023

8GDG

Solution structure of the Neutrophil Serine Protease Inhibitor, EapH2
分子名称:	Cell surface like-protein Map-w
著者	Mishra, N.B, Geisbrecht, B.V, Prakash, O.
登録日	2023-03-05
公開日	2023-04-26
最終更新日	2024-05-15
実験手法	SOLUTION NMR
主引用文献	Simultaneous inhibition of two neutrophil serine proteases by the S. aureus innate immune evasion protein EapH2. J.Biol.Chem., 299, 2023

8GDH

Solution structure of the Neutrophil Serine Protease Inhibitor, EapH1
分子名称:	Cell surface protein map-w
著者	Mishra, N.B, Geisbrecht, B.V, Prakash, O.
登録日	2023-03-05
公開日	2023-04-26
最終更新日	2024-05-15
実験手法	SOLUTION NMR
主引用文献	Simultaneous inhibition of two neutrophil serine proteases by the S. aureus innate immune evasion protein EapH2. J.Biol.Chem., 299, 2023

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