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BU of 2k1q by Molmil

NMR structure of hepatitis c virus ns3 serine protease complexed with the non-covalently bound phenethylamide inhibitor
分子名称:	NS3 PROTEASE, PHENETHYLAMIDE, ZINC ION
著者	Eliseo, T, Gallo, M, Pennestri, M, Bazzo, R, Cicero, D.O.
登録日	2008-03-13
公開日	2009-02-03
最終更新日	2023-11-15
実験手法	SOLUTION NMR
主引用文献	Binding of a noncovalent inhibitor exploiting the S' region stabilizes the hepatitis C virus NS3 protease conformation in the absence of cofactor. J.Mol.Biol., 385, 2009

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BU of 1gx5 by Molmil

Hepatitis C Virus RNA Polymerase in Complex with GTP and Manganese
分子名称:	GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE
著者	Bressanelli, S, Rey, F.A.
登録日	2002-03-27
公開日	2002-04-09
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	A Structural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with Ribonucleotides J.Virol., 76, 2002

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BU of 1gx6 by Molmil

Hepatitis C Virus RNA polymerase in complex with UTP and manganese
分子名称:	MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE, URIDINE 5'-TRIPHOSPHATE
著者	Bressanelli, S, Rey, F.A.
登録日	2002-03-27
公開日	2002-04-10
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.85 Å)
主引用文献	A Structural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with Ribonucleotides J.Virol., 76, 2002

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BU of 2who by Molmil

CRYSTAL STRUCTURE OF HEPATITIS C VIRUS NS5B POLYMERASE FROM 1B GENOTYPE IN COMPLEX WITH A NON-NUCLEOSIDE INHIBITOR
分子名称:	2-(3-bromophenyl)-6-[(2-hydroxyethyl)amino]-1h-benzo[de]isoquinoline-1,3(2h)-dione, MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE
著者	Di Marco, S.
登録日	2009-05-05
公開日	2009-08-11
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Identification and biological evaluation of a series of 1H-benzo[de]isoquinoline-1,3(2H)-diones as hepatitis C virus NS5B polymerase inhibitors. J. Med. Chem., 52, 2009

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BU of 3gsz by Molmil

Structure of the genotype 2B HCV polymerase
分子名称:	RNA-directed RNA polymerase
著者	Rydberg, E.H, Carfi, A.
登録日	2009-03-27
公開日	2009-07-07
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Structural basis for resistance of the genotype 2b hepatitis C virus NS5B polymerase to site A non-nucleoside inhibitors. J.Mol.Biol., 390, 2009

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BU of 2brk by Molmil

Crystal structure of Hepatitis C virus polymerase in complex with an allosteric inhibitor (compound 1)
分子名称:	3-CYCLOHEXYL-1-(2-MORPHOLIN-4-YL-2-OXOETHYL)-2-PHENYL-1H-INDOLE-6-CARBOXYLIC ACID, MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE
著者	Di Marco, S, Volpari, C, Carfi, A.
登録日	2005-05-06
公開日	2005-06-14
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Interdomain Communication in Hepatitis C Virus Polymerase Abolished by Small-Molecule Inhibitors Bound to a Novel Allosteric Site J.Biol.Chem., 280, 2005

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BU of 2brl by Molmil

Crystal structure of Hepatitis C virus polymerase in complex with an allosteric inhibitor (compound 2)
分子名称:	3-CYCLOHEXYL-1-(2-{METHYL[(1-METHYLPIPERIDIN-3-YL)METHYL]AMINO}-2-OXOETHYL)-2-PHENYL-1H-INDOLE-6-CARBOXYLIC ACID, MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE
著者	Di Marco, S, Volpari, C, Carfi, A.
登録日	2005-05-06
公開日	2005-06-14
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	Interdomain Communication in Hepatitis C Virus Polymerase Abolished by Small-Molecule Inhibitors Bound to a Novel Allosteric Site J.Biol.Chem., 280, 2005

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BU of 2xwy by Molmil

Structure of MK-3281, a Potent Non-Nucleoside Finger-Loop Inhibitor, in complex with the Hepatitis C Virus NS5B Polymerase
分子名称:	(7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl)amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid, MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE
著者	Di Marco, S, Baiocco, P.
登録日	2010-11-06
公開日	2010-12-22
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (2.53 Å)
主引用文献	Discovery of (7R)-14-Cyclohexyl-7-{[2-(Dimethylamino)Ethyl] (Methyl)Amino}-7,8-Dihydro-6H-Indolo[1,2-E][1,5] Benzoxazocine -11-Carboxylic Acid (Mk-3281), a Potent and Orally Bioavailable Finger-Loop Inhibitor of the Hepatitis C Virus Ns5B Polymerase J.Med.Chem., 54, 2011

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BU of 7s6i by Molmil

SARS-CoV-2-6P-Mut2 S protein
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者	Ozorowski, G, Torres, J.L, Ward, A.B.
登録日	2021-09-14
公開日	2022-05-11
最終更新日	2022-05-25
実験手法	ELECTRON MICROSCOPY (3.2 Å)
主引用文献	Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody. Proc.Natl.Acad.Sci.USA, 119, 2022

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BU of 7s6j by Molmil

J08 fragment antigen binding in complex with SARS-CoV-2-6P-Mut2 S protein (conformation 1)
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, J08 fragment antigen binding heavy chain variable domain, ...
著者	Ozorowski, G, Torres, J.L, Ward, A.B.
登録日	2021-09-14
公開日	2022-05-11
最終更新日	2022-05-25
実験手法	ELECTRON MICROSCOPY (3.4 Å)
主引用文献	Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody. Proc.Natl.Acad.Sci.USA, 119, 2022

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BU of 7sbu by Molmil

Crystal structure of SARS-CoV-2 spike protein receptor-binding domain in complex with a highly potent antibody J08 Fab
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, J08 Fab heavy chain, ...
著者	Liu, H, Wilson, I.A.
登録日	2021-09-25
公開日	2022-05-11
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (2.53 Å)
主引用文献	Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody. Proc.Natl.Acad.Sci.USA, 119, 2022

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BU of 7s6l by Molmil

J08 fragment antigen binding in complex with SARS-CoV-2-6P-Mut7 S protein (conformation 3)
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, J08 fragment antigen binding heavy chain variable domain, ...
著者	Ozorowski, G, Torres, J.L, Ward, A.B.
登録日	2021-09-14
公開日	2022-05-11
最終更新日	2022-05-25
実験手法	ELECTRON MICROSCOPY (4 Å)
主引用文献	Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody. Proc.Natl.Acad.Sci.USA, 119, 2022

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BU of 7s6k by Molmil

J08 fragment antigen binding in complex with SARS-CoV-2-6P-Mut2 S protein (conformation 2)
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, J08 fragment antigen binding heavy chain variable domain, ...
著者	Ozorowski, G, Torres, J.L, Ward, A.B.
登録日	2021-09-14
公開日	2022-05-11
最終更新日	2022-05-25
実験手法	ELECTRON MICROSCOPY (3.4 Å)
主引用文献	Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody. Proc.Natl.Acad.Sci.USA, 119, 2022

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BU of 2lfb by Molmil

HOMEODOMAIN FROM RAT LIVER LFB1/HNF1 TRANSCRIPTION FACTOR, NMR, 20 STRUCTURES
分子名称:	LFB1/HNF1 TRANSCRIPTION FACTOR
著者	Schott, O, Billeter, M, Leiting, B, Wider, G, Wuthrich, K.
登録日	1996-12-12
公開日	1997-03-12
最終更新日	2024-05-22
実験手法	SOLUTION NMR
主引用文献	The NMR solution structure of the non-classical homeodomain from the rat liver LFB1/HNF1 transcription factor. J.Mol.Biol., 267, 1997

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BU of 2wcx by Molmil

Crystal Structure of Hepatitis C Virus NS5B Polymerase in Complex with Thienopyrrole-Based Finger-Loop Inhibitors
分子名称:	6-CYCLOHEXYL-4-METHYL-5-PHENYL-4H-THIENO[3,2-B]PYRROLE-2-CARBOXYLIC ACID, MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE
著者	Di Marco, S.
登録日	2009-03-17
公開日	2009-08-18
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Optimization of Thienopyrrole-Based Finger-Loop Inhibitors of the Hepatitis C Virus Ns5B Polymerase. Chemmedchem, 4, 2009

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