6OF3
 
 | | Precursor ribosomal RNA processing complex, State 1. | | 分子名称: | CLP1_P domain-containing protein, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | | 著者 | Pillon, M.C, Hsu, A.L, Krahn, J.M, Williams, J.G, Goslen, K.H, Sobhany, M, Borgnia, M.J, Stanley, R.E. | | 登録日 | 2019-03-28 | | 公開日 | 2019-09-11 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Cryo-EM reveals active site coordination within a multienzyme pre-rRNA processing complex.
Nat.Struct.Mol.Biol., 26, 2019
|
|
6OO5
 | | Cryo-EM structure of the C2-symmetric TRPV2/RTx complex in amphipol resolved to 4.2 A | | 分子名称: | TRPV2, resiniferatoxin | | 著者 | Zubcevic, L, Hsu, A.L, Borgnia, M.J, Lee, S.-Y. | | 登録日 | 2019-04-22 | | 公開日 | 2019-05-29 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes.
Elife, 8, 2019
|
|
6OF4
 | | Precursor ribosomal RNA processing complex, apo-state. | | 分子名称: | CLP1_P domain-containing protein, Ribonuclease | | 著者 | Pillon, M.C, Hsu, A.L, Krahn, J.M, Williams, J.G, Goslen, K.H, Sobhany, M, Borgnia, M.J, Stanley, R.E. | | 登録日 | 2019-03-28 | | 公開日 | 2019-09-11 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Cryo-EM reveals active site coordination within a multienzyme pre-rRNA processing complex.
Nat.Struct.Mol.Biol., 26, 2019
|
|
6UKS
 | | ATPgammaS bound mBcs1 | | 分子名称: | MAGNESIUM ION, Mitochondrial chaperone BCS1, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | | 著者 | Tang, W.K, Borgnia, M.J, Hsu, A.L, Xia, D. | | 登録日 | 2019-10-05 | | 公開日 | 2020-02-05 | | 最終更新日 | 2020-02-26 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structures of AAA protein translocase Bcs1 suggest translocation mechanism of a folded protein.
Nat.Struct.Mol.Biol., 27, 2020
|
|
6OO3
 | | Cryo-EM structure of the C4-symmetric TRPV2/RTx complex in amphipol resolved to 2.9 A | | 分子名称: | TRPV2, resiniferatoxin | | 著者 | Zubcevic, L, Hsu, A.L, Borgnia, M.J, Lee, S.-Y. | | 登録日 | 2019-04-22 | | 公開日 | 2019-05-29 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes.
Elife, 8, 2019
|
|
6OO4
 | | Cryo-EM structure of the C2-symmetric TRPV2/RTx complex in amphipol resolved to 3.3 A | | 分子名称: | TRPV2, resiniferatoxin | | 著者 | Zubcevic, L, Hsu, A.L, Borgnia, M.J, Lee, S.-Y. | | 登録日 | 2019-04-22 | | 公開日 | 2019-05-29 | | 最終更新日 | 2019-12-18 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes.
Elife, 8, 2019
|
|
6NR3
 | | Cryo-EM structure of the TRPM8 ion channel in complex with high occupancy icilin, PI(4,5)P2, and calcium | | 分子名称: | (2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl icosa-5,8,11,14-tetraenoate, CALCIUM ION, Icilin, ... | | 著者 | Yin, Y, Le, S.C, Hsu, A.L, Borgnia, M.J, Yang, H, Lee, S.-Y. | | 登録日 | 2019-01-22 | | 公開日 | 2019-02-20 | | 最終更新日 | 2019-12-18 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel.
Science, 363, 2019
|
|
6OO7
 | | Cryo-EM structure of the C2-symmetric TRPV2/RTx complex in nanodiscs | | 分子名称: | TRPV2, resiniferatoxin | | 著者 | Zubcevic, L, Hsu, A.L, Borgnia, M.J, Lee, S.-Y. | | 登録日 | 2019-04-22 | | 公開日 | 2019-05-29 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes.
Elife, 8, 2019
|
|
6UKP
 | | Apo mBcs1 | | 分子名称: | Mitochondrial chaperone BCS1 | | 著者 | Tang, W.K, Borgnia, M.J, Hsu, A.L, Xia, D. | | 登録日 | 2019-10-05 | | 公開日 | 2020-02-12 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.81 Å) | | 主引用文献 | Structures of AAA protein translocase Bcs1 suggest translocation mechanism of a folded protein.
Nat.Struct.Mol.Biol., 27, 2020
|
|
6OF2
 | | Precursor ribosomal RNA processing complex, State 2. | | 分子名称: | CLP1_P domain-containing protein, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | | 著者 | Pillon, M.C, Hsu, A.L, Krahn, J.M, Williams, J.G, Goslen, K.H, Sobhany, M, Borgnia, M.J, Stanley, R.E. | | 登録日 | 2019-03-28 | | 公開日 | 2019-09-11 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Cryo-EM reveals active site coordination within a multienzyme pre-rRNA processing complex.
Nat.Struct.Mol.Biol., 26, 2019
|
|
6OT2
 | | Structure of the TRPV3 K169A sensitized mutant in apo form at 4.1 A resolution | | 分子名称: | Transient receptor potential cation channel subfamily V member 3 | | 著者 | Zubcevic, L, Borschel, W.F, Hsu, A.L, Borgnia, M.J, Lee, S.-Y. | | 登録日 | 2019-05-02 | | 公開日 | 2019-05-22 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Regulatory switch at the cytoplasmic interface controls TRPV channel gating.
Elife, 8, 2019
|
|
6PKW
 | | Cryo-EM structure of the zebrafish TRPM2 channel in the apo conformation, processed with C2 symmetry (pseudo C4 symmetry) | | 分子名称: | Transient receptor potential cation channel subfamily M member 2 | | 著者 | Yin, Y, Wu, M, Hsu, A.L, Borschel, W.F, Borgnia, M.J, Lander, G.C, Lee, S.-Y. | | 登録日 | 2019-06-30 | | 公開日 | 2019-08-28 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel.
Nat Commun, 10, 2019
|
|
6OT5
 | | Structure of the TRPV3 K169A sensitized mutant in the presence of 2-APB at 3.6 A resolution | | 分子名称: | 2-aminoethyl diphenylborinate, Transient receptor potential cation channel subfamily V member 3,Transient receptor potential cation channel subfamily V member 3 | | 著者 | Zubcevic, L, Borschel, W.F, Hsu, A.L, Borgnia, M.J, Lee, S.-Y. | | 登録日 | 2019-05-02 | | 公開日 | 2019-05-22 | | 最終更新日 | 2019-12-18 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Regulatory switch at the cytoplasmic interface controls TRPV channel gating.
Elife, 8, 2019
|
|
6PKV
 | | Cryo-EM structure of the zebrafish TRPM2 channel in the apo conformation, processed with C4 symmetry | | 分子名称: | Transient receptor potential cation channel subfamily M member 2 | | 著者 | Yin, Y, Wu, M, Hsu, A.L, Borschel, W.F, Borgnia, M.J, Lander, G.C, Lee, S.-Y. | | 登録日 | 2019-06-30 | | 公開日 | 2019-08-28 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel.
Nat Commun, 10, 2019
|
|
7TPR
 | | Camel nanobodies 7A3 and 8A2 broadly neutralize SARS-CoV-2 variants | | 分子名称: | Nanobody 7A3, Nanobody 8A2, Spike glycoprotein | | 著者 | Butay, K.J, Zhu, J, Dandey, V.P, Hong, J, Kwon, H.J, Chen, C.Z, Duan, Z, Li, D, Ren, H, Liang, T, Martin, N, Esposito, D, Ortega-Rodriguez, U, Xu, M, Xie, H, Ho, M, Cachau, R, Borgnia, M.J. | | 登録日 | 2022-01-25 | | 公開日 | 2022-04-20 | | 実験手法 | ELECTRON MICROSCOPY (2.39 Å) | | 主引用文献 | Camel nanobodies broadly neutralize SARS-CoV-2 variants
bioRxiv, 2021
|
|
7TU6
 | | Structure of the L. blandensis dGTPase bound to dATP | | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, dGTP triphosphohydrolase | | 著者 | Klemm, B.P, Sikkema, A.P, Hsu, A.L, Borgnia, M.J, Schaaper, R.M. | | 登録日 | 2022-02-02 | | 公開日 | 2022-06-01 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | High-resolution structures of the SAMHD1 dGTPase homolog from Leeuwenhoekiella blandensis reveal a novel mechanism of allosteric activation by dATP.
J.Biol.Chem., 298, 2022
|
|
7TU7
 | | Structure of the L. blandensis dGTPase H125A mutant bound to dGTP | | 分子名称: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, dGTP triphosphohydrolase | | 著者 | Klemm, B.P, Sikkema, A.P, Hsu, A.L, Borgnia, M.J, Schaaper, R.M. | | 登録日 | 2022-02-02 | | 公開日 | 2022-06-01 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | High-resolution structures of the SAMHD1 dGTPase homolog from Leeuwenhoekiella blandensis reveal a novel mechanism of allosteric activation by dATP.
J.Biol.Chem., 298, 2022
|
|
7U65
 | | Structure of E. coli dGTPase bound to T7 bacteriophage protein Gp1.2 | | 分子名称: | Deoxyguanosinetriphosphate triphosphohydrolase, Inhibitor of dGTPase | | 著者 | Klemm, B.P, Hsu, A.L, Borgnia, M.J, Schaaper, R.M. | | 登録日 | 2022-03-03 | | 公開日 | 2022-08-31 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Mechanism by which T7 bacteriophage protein Gp1.2 inhibits Escherichia coli dGTPase.
Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
7U67
 | | Structure of E. coli dGTPase bound to T7 bacteriophage protein Gp1.2 and GTP | | 分子名称: | Deoxyguanosinetriphosphate triphosphohydrolase, GUANOSINE-5'-TRIPHOSPHATE, Inhibitor of dGTPase, ... | | 著者 | Klemm, B.P, Hsu, A.L, Borgnia, M.J, Schaaper, R.M. | | 登録日 | 2022-03-03 | | 公開日 | 2022-08-31 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | Mechanism by which T7 bacteriophage protein Gp1.2 inhibits Escherichia coli dGTPase.
Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
7U66
 | | Structure of E. coli dGTPase bound to T7 bacteriophage protein Gp1.2 and dGTP | | 分子名称: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, Deoxyguanosinetriphosphate triphosphohydrolase, Inhibitor of dGTPase, ... | | 著者 | Klemm, B.P, Dillard, L.B, Borgnia, M.J, Schaaper, R.M. | | 登録日 | 2022-03-03 | | 公開日 | 2022-08-31 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Mechanism by which T7 bacteriophage protein Gp1.2 inhibits Escherichia coli dGTPase.
Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
7TU8
 | | Structure of the L. blandensis dGTPase H125A mutant bound to dGTP and dATP | | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Klemm, B.P, Sikkema, A.P, Hsu, A.L, Borgnia, M.J, Schaaper, R.M. | | 登録日 | 2022-02-02 | | 公開日 | 2022-06-01 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | High-resolution structures of the SAMHD1 dGTPase homolog from Leeuwenhoekiella blandensis reveal a novel mechanism of allosteric activation by dATP.
J.Biol.Chem., 298, 2022
|
|
7TU5
 | | Structure of the L. blandensis dGTPase in the apo form | | 分子名称: | MAGNESIUM ION, dGTP triphosphohydrolase | | 著者 | Klemm, B.P, Sikkema, A.P, Hsu, A.L, Borgnia, M.J, Schaaper, R.M. | | 登録日 | 2022-02-02 | | 公開日 | 2022-06-01 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (2.1 Å) | | 主引用文献 | High-resolution structures of the SAMHD1 dGTPase homolog from Leeuwenhoekiella blandensis reveal a novel mechanism of allosteric activation by dATP.
J.Biol.Chem., 298, 2022
|
|
8E4O
 | | The closed C1-state mouse TRPM8 structure in complex with putative PI(4,5)P2 | | 分子名称: | Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | | 著者 | Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y. | | 登録日 | 2022-08-18 | | 公開日 | 2022-10-26 | | 実験手法 | ELECTRON MICROSCOPY (3.43 Å) | | 主引用文献 | Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
Science, 378, 2022
|
|
8E4N
 | | The closed C1-state mouse TRPM8 structure in complex with PI(4,5)P2 | | 分子名称: | Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | | 著者 | Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y. | | 登録日 | 2022-08-18 | | 公開日 | 2022-10-26 | | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | | 主引用文献 | Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
Science, 378, 2022
|
|
8E4L
 | | The open state mouse TRPM8 structure in complex with the cooling agonist C3, AITC, and PI(4,5)P2 | | 分子名称: | 3-isothiocyanatoprop-1-ene, CALCIUM ION, Transient receptor potential cation channel subfamily M member 8, ... | | 著者 | Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y. | | 登録日 | 2022-08-18 | | 公開日 | 2022-10-26 | | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | | 主引用文献 | Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
Science, 378, 2022
|
|
